-
2
-
-
33751270698
-
Short hairpin RNA knockdown of the androgen receptor attenuates ligand-independent activation and delays tumor progression
-
Cheng H, Snoek R, Ghaidi F, Cox ME, Rennie PS (2006) Short hairpin RNA knockdown of the androgen receptor attenuates ligand-independent activation and delays tumor progression. Cancer Res 66: 10613-10620.
-
(2006)
Cancer Res
, vol.66
, pp. 10613-10620
-
-
Cheng, H.1
Snoek, R.2
Ghaidi, F.3
Cox, M.E.4
Rennie, P.S.5
-
3
-
-
0028944138
-
In vivo amplification of the androgen receptor gene and progression of human prostate cancer
-
Visakorpi T, Hyytinen E, Koivisto P et al (1995) In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Nat Genet 9: 401-406.
-
(1995)
Nat Genet
, vol.9
, pp. 401-406
-
-
Visakorpi, T.1
Hyytinen, E.2
Koivisto, P.3
-
4
-
-
1842612441
-
Molecular determinants of resistance to antiandrogen therapy
-
Chen CD, Welsbie DS, Tran C et al (2004) Molecular determinants of resistance to antiandrogen therapy. Nat Med 10: 33-39.
-
(2004)
Nat Med
, vol.10
, pp. 33-39
-
-
Chen, C.D.1
Welsbie, D.S.2
Tran, C.3
-
5
-
-
0033767930
-
Androgen receptor gene amplification at primary progression predicts response to combined androgen blockade as second line therapy for advanced prostate cancer
-
Palmberg C, Koivisto P, Kakkola L, Tammela TLJ, Kallioniemi OP, Visakorpi T (2000) Androgen receptor gene amplification at primary progression predicts response to combined androgen blockade as second line therapy for advanced prostate cancer. J Urol 164: 1992-1995.
-
(2000)
J Urol
, vol.164
, pp. 1992-1995
-
-
Palmberg, C.1
Koivisto, P.2
Kakkola, L.3
Tammela, T.L.J.4
Kallioniemi, O.P.5
Visakorpi, T.6
-
6
-
-
33644675811
-
Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis
-
Scher HI, Sawyers CL (2005) Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis. J Clin Oncol 23: 8253-8261.
-
(2005)
J Clin Oncol
, vol.23
, pp. 8253-8261
-
-
Scher, H.I.1
Sawyers, C.L.2
-
7
-
-
77956443521
-
Androgen receptor signaling and mutations in prostate cancer
-
Koochekpour S (2010) Androgen receptor signaling and mutations in prostate cancer. Asian J Androl 12: 639-657.
-
(2010)
Asian J Androl
, vol.12
, pp. 639-657
-
-
Koochekpour, S.1
-
8
-
-
65949113815
-
The role of androgen receptor mutations in prostate cancer progression
-
Brooke GN, Bevan CL (2009) The role of androgen receptor mutations in prostate cancer progression. Curr Genomics 10: 18-25.
-
(2009)
Curr Genomics
, vol.10
, pp. 18-25
-
-
Brooke, G.N.1
Bevan, C.L.2
-
9
-
-
4444288439
-
Structural and functional consequences of glutamine tract variation in the androgen receptor
-
Buchanan G, Yang M, Cheong A et al (2004) Structural and functional consequences of glutamine tract variation in the androgen receptor. Hum Mol Genet 13: 1677-1692.
-
(2004)
Hum Mol Genet
, vol.13
, pp. 1677-1692
-
-
Buchanan, G.1
Yang, M.2
Cheong, A.3
-
10
-
-
17744378148
-
Mutations at the boundary of the hinge and ligand binding domain of the androgen receptor confer increased transactivation function
-
Buchanan G, Yang M, Harris JM et al (2001) Mutations at the boundary of the hinge and ligand binding domain of the androgen receptor confer increased transactivation function. Mol Endocrinol 15: 46-56.
-
(2001)
Mol Endocrinol
, vol.15
, pp. 46-56
-
-
Buchanan, G.1
Yang, M.2
Harris, J.M.3
-
11
-
-
77954255681
-
Integrative genomic profiling of human prostate cancer
-
Taylor BS, Schultz N, Hieronymus H et al (2010) Integrative genomic profiling of human prostate cancer. Cancer Cell 18: 11-22.
-
(2010)
Cancer Cell
, vol.18
, pp. 11-22
-
-
Taylor, B.S.1
Schultz, N.2
Hieronymus, H.3
-
12
-
-
77956357165
-
Detection of androgen receptor mutations in circulating tumor cells in castration-resistant prostate cancer
-
Jiang Y, Palma JF, Agus DB, Wang Y, Gross ME (2010) Detection of androgen receptor mutations in circulating tumor cells in castration-resistant prostate cancer. Clin Chem 56: 1492-1495.
-
(2010)
Clin Chem
, vol.56
, pp. 1492-1495
-
-
Jiang, Y.1
Palma, J.F.2
Agus, D.B.3
Wang, Y.4
Gross, M.E.5
-
13
-
-
66249135684
-
Treatment-dependent androgen receptor mutations in prostate cancer exploit multiple mechanisms to evade Therapy
-
Steinkamp MP, O'Mahony OA, Brogley M et al (2009) Treatment-dependent androgen receptor mutations in prostate cancer exploit multiple mechanisms to evade Therapy. Cancer Res 69: 4434-4442.
-
(2009)
Cancer Res
, vol.69
, pp. 4434-4442
-
-
Steinkamp, M.P.1
O'Mahony, O.A.2
Brogley, M.3
-
14
-
-
67649425225
-
ETS gene fusions in prostate cancer: from discovery to daily clinical practice
-
Tomlins SA, Bjartell A, Chinnaiyan AM et al (2009) ETS gene fusions in prostate cancer: from discovery to daily clinical practice. Eur Urol 56: 275-286.
-
(2009)
Eur Urol
, vol.56
, pp. 275-286
-
-
Tomlins, S.A.1
Bjartell, A.2
Chinnaiyan, A.M.3
-
15
-
-
33645750799
-
TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer
-
Tomlins SA, Mehra R, Rhodes DR et al (2006) TMPRSS2: ETV4 gene fusions define a third molecular subtype of prostate cancer. Cancer Res 66: 3396-3400.
-
(2006)
Cancer Res
, vol.66
, pp. 3396-3400
-
-
Tomlins, S.A.1
Mehra, R.2
Rhodes, D.R.3
-
17
-
-
34248510706
-
TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort
-
Demichelis F, Fall K, Perner S et al (2007) TMPRSS2: ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort. Oncogene 26: 4596-4599.
-
(2007)
Oncogene
, vol.26
, pp. 4596-4599
-
-
Demichelis, F.1
Fall, K.2
Perner, S.3
-
18
-
-
66149098947
-
Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer
-
Attard G, Swennenhuis JF, Olmos D et al (2009) Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer. Cancer Res 69: 2912-2918.
-
(2009)
Cancer Res
, vol.69
, pp. 2912-2918
-
-
Attard, G.1
Swennenhuis, J.F.2
Olmos, D.3
-
19
-
-
41149097040
-
A causal role for ERG in neoplastic transformation of prostate epithelium
-
Klezovitch O, Risk M, Coleman I et al (2008) A causal role for ERG in neoplastic transformation of prostate epithelium. Proc Natl Acad Sci USA 105: 2105-2110.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 2105-2110
-
-
Klezovitch, O.1
Risk, M.2
Coleman, I.3
-
20
-
-
78649966606
-
Androgen-induced TMPRSS2:ERG fusion in nonmalignant prostate epithelial cells
-
Bastus NC, Boyd LK, Mao X et al (2010) Androgen-induced TMPRSS2: ERG fusion in nonmalignant prostate epithelial cells. Cancer Res 70: 9544-9548.
-
(2010)
Cancer Res
, vol.70
, pp. 9544-9548
-
-
Bastus, N.C.1
Boyd, L.K.2
Mao, X.3
-
21
-
-
77957604323
-
TMPRSS2-ERG gene fusion is associated with low Gleason scores and not with high-grade morphological features
-
Fine SW, Gopalan A, Leversha MA et al (2010) TMPRSS2-ERG gene fusion is associated with low Gleason scores and not with high-grade morphological features. Mod Pathol 23: 1325-1333.
-
(2010)
Mod Pathol
, vol.23
, pp. 1325-1333
-
-
Fine, S.W.1
Gopalan, A.2
Leversha, M.A.3
-
22
-
-
77952103123
-
An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression
-
Yu J, Yu J, Mani R-S et al (2010) An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression. Cancer Cell 17: 443-454.
-
(2010)
Cancer Cell
, vol.17
, pp. 443-454
-
-
Yu, J.1
Yu, J.2
Mani, R.-S.3
-
23
-
-
66749188650
-
Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate
-
Carver BS, Tran J, Gopalan A et al (2009) Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate. Nat Genet 41: 619-624.
-
(2009)
Nat Genet
, vol.41
, pp. 619-624
-
-
Carver, B.S.1
Tran, J.2
Gopalan, A.3
-
24
-
-
56649091295
-
Absence of TMPRSS2:ERG fusions and PTEN losses in prostate cancer is associated with a favorable outcome
-
Yoshimoto M, Joshua AM, Cunha IW et al (2008) Absence of TMPRSS2: ERG fusions and PTEN losses in prostate cancer is associated with a favorable outcome. Mod Pathol 21: 1451-1460.
-
(2008)
Mod Pathol
, vol.21
, pp. 1451-1460
-
-
Yoshimoto, M.1
Joshua, A.M.2
Cunha, I.W.3
-
25
-
-
84872755324
-
Combining urinary detection of TMPRSS2: ERG and CaP3 with serum PSA to predict diagnosis of prostate cancer
-
(in press, corrected proof)
-
Salami SS, Schmidt F, Laxman B et al Combining urinary detection of TMPRSS2: ERG and CaP3 with serum PSA to predict diagnosis of prostate cancer. Urologic oncology: seminars and original investigations. (in press, corrected proof).
-
Urologic oncology: Seminars and original investigations
-
-
Salami, S.S.1
Schmidt, F.2
Laxman, B.3
-
26
-
-
79955968629
-
Mechanistic rationale for inhibition of poly(ADP-Ribose) polymerase in ETS gene fusion-positive prostate cancer
-
Brenner JC, Ateeq B, Li Y et al (2011) Mechanistic rationale for inhibition of poly (ADP-Ribose) polymerase in ETS gene fusion-positive prostate cancer. Cancer Cell 19: 664-678.
-
(2011)
Cancer Cell
, vol.19
, pp. 664-678
-
-
Brenner, J.C.1
Ateeq, B.2
Li, Y.3
-
27
-
-
24044540381
-
Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking
-
Wang Q, Carroll JS, Brown M (2005) Spatial and temporal recruitment of androgen receptor and its coactivators involves chromosomal looping and polymerase tracking. Mol Cell 19: 631-642.
-
(2005)
Mol Cell
, vol.19
, pp. 631-642
-
-
Wang, Q.1
Carroll, J.S.2
Brown, M.3
-
28
-
-
0033215443
-
Looping versus linking: toward a model for long-distance gene activation
-
Bulger M, Groudine M (1999) Looping versus linking: toward a model for long-distance gene activation. Genes Dev 13: 2465-2477.
-
(1999)
Genes Dev
, vol.13
, pp. 2465-2477
-
-
Bulger, M.1
Groudine, M.2
-
29
-
-
0032479079
-
Going the distance: the current view of enhancer action
-
Blackwood EM, Kadonaga JT (1998) Going the distance: the current view of enhancer action. Science 281: 60-63.
-
(1998)
Science
, vol.281
, pp. 60-63
-
-
Blackwood, E.M.1
Kadonaga, J.T.2
-
30
-
-
34547214787
-
A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth
-
Wang Q, Li W, Liu XS et al (2007) A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. Mol Cell 27: 380-392.
-
(2007)
Mol Cell
, vol.27
, pp. 380-392
-
-
Wang, Q.1
Li, W.2
Liu, X.S.3
-
31
-
-
67650758019
-
Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer
-
Wang Q, Li W, Zhang Y et al (2009) Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell 138: 245-256.
-
(2009)
Cell
, vol.138
, pp. 245-256
-
-
Wang, Q.1
Li, W.2
Zhang, Y.3
-
33
-
-
0037112372
-
Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell line
-
Tepper CG, Boucher DL, Ryan PE et al (2002) Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell line. Cancer Res 62: 6606-6614.
-
(2002)
Cancer Res
, vol.62
, pp. 6606-6614
-
-
Tepper, C.G.1
Boucher, D.L.2
Ryan, P.E.3
-
34
-
-
48549089747
-
Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance
-
Dehm SM, Schmidt LJ, Heemers HV, Vessella RL, Tindall DJ (2008) Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance. Cancer Res 68: 5469-5477.
-
(2008)
Cancer Res
, vol.68
, pp. 5469-5477
-
-
Dehm, S.M.1
Schmidt, L.J.2
Heemers, H.V.3
Vessella, R.L.4
Tindall, D.J.5
-
35
-
-
65549168746
-
A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth
-
Guo Z, Yang X, Sun F et al (2009) A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth. Cancer Res 69: 2305-2313.
-
(2009)
Cancer Res
, vol.69
, pp. 2305-2313
-
-
Guo, Z.1
Yang, X.2
Sun, F.3
-
36
-
-
58249110391
-
Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer
-
Hu R, Dunn TA, Wei S et al (2009) Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer. Cancer Res 69: 16-22.
-
(2009)
Cancer Res
, vol.69
, pp. 16-22
-
-
Hu, R.1
Dunn, T.A.2
Wei, S.3
-
37
-
-
78049280194
-
Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor
-
Watson PA, Chen YF, Balbas MD et al Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor. In: Proceedings of the national academy of sciences 107: 16759-16765.
-
Proceedings of the national academy of sciences
, vol.107
, pp. 16759-16765
-
-
Watson, P.A.1
Chen, Y.F.2
Balbas, M.D.3
-
38
-
-
79955719838
-
Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival
-
Hornberg E, Ylitalo EB, Crnalic S et al (2011) Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival. PLoS One 6: e19059.
-
(2011)
PLoS One
, vol.6
-
-
Hornberg, E.1
Ylitalo, E.B.2
Crnalic, S.3
-
39
-
-
8444231965
-
The influence of androgen deprivation therapy on dihydrotestosterone levels in the prostatic tissue of patients with prostate cancer
-
Nishiyama T, Hashimoto Y, Takahashi K (2004) The influence of androgen deprivation therapy on dihydrotestosterone levels in the prostatic tissue of patients with prostate cancer. Clin Cancer Res 10: 7121-7126.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 7121-7126
-
-
Nishiyama, T.1
Hashimoto, Y.2
Takahashi, K.3
-
40
-
-
27644452640
-
Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer
-
Titus MA, Schell MJ, Lih FB, Tomer KB, Mohler JL (2005) Testosterone and dihydrotestosterone tissue levels in recurrent prostate cancer. Clin Cancer Res 11: 4653-4657.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 4653-4657
-
-
Titus, M.A.1
Schell, M.J.2
Lih, F.B.3
Tomer, K.B.4
Mohler, J.L.5
-
41
-
-
20144389477
-
In situ androgen producing enzymes in human prostate cancer
-
Nakamura Y, Suzuki T, Nakabayashi M et al (2005) In situ androgen producing enzymes in human prostate cancer. Endocr Relat Cancer 12: 101-107.
-
(2005)
Endocr Relat Cancer
, vol.12
, pp. 101-107
-
-
Nakamura, Y.1
Suzuki, T.2
Nakabayashi, M.3
-
42
-
-
33749550602
-
Persistent intraprostatic androgen concentrations after medical castration in healthy men
-
Page ST, Lin DW, Mostaghel EA et al (2006) Persistent intraprostatic androgen concentrations after medical castration in healthy men. Clin Endocrinol Metab 91: 3850-3856.
-
(2006)
Clin Endocrinol Metab
, vol.91
, pp. 3850-3856
-
-
Page, S.T.1
Lin, D.W.2
Mostaghel, E.A.3
-
43
-
-
54849435425
-
Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol
-
Dillard PR, Lin M-F, Khan SA (2008) Androgen-independent prostate cancer cells acquire the complete steroidogenic potential of synthesizing testosterone from cholesterol. Mol Cell Endocrinol 295: 115-120.
-
(2008)
Mol Cell Endocrinol
, vol.295
, pp. 115-120
-
-
Dillard, P.R.1
Lin, M.-F.2
Khan, S.A.3
-
44
-
-
34250331066
-
Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer
-
Mostaghel EA, Page ST, Lin DW et al (2007) Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer. Cancer Res 67: 5033-5041.
-
(2007)
Cancer Res
, vol.67
, pp. 5033-5041
-
-
Mostaghel, E.A.1
Page, S.T.2
Lin, D.W.3
-
45
-
-
76149137405
-
Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model
-
Leon CG, Locke JA, Adomat HH et al (2010) Alterations in cholesterol regulation contribute to the production of intratumoral androgens during progression to castration-resistant prostate cancer in a mouse xenograft model. Prostate 70: 390-400.
-
(2010)
Prostate
, vol.70
, pp. 390-400
-
-
Leon, C.G.1
Locke, J.A.2
Adomat, H.H.3
-
46
-
-
79960738374
-
Steroidogenic enzymes and stem cell markers are upregulated during androgen deprivation in prostate cancer
-
doi: 10. 2119/molmed.2010.00143
-
Pfeiffer MJ, Smit FP, Sedelaar JP, Schalken JA (2011) Steroidogenic enzymes and stem cell markers are upregulated during androgen deprivation in prostate cancer. Mol Med. doi: 10. 2119/molmed. 2010. 00143.
-
(2011)
Mol Med.
-
-
Pfeiffer, M.J.1
Smit, F.P.2
Sedelaar, J.P.3
Schalken, J.A.4
-
47
-
-
42949144171
-
Intracrine androgen metabolism in prostate cancer progression: mechanisms of castration resistance and therapeutic implications
-
Mostaghel EA, Nelson PS (2008) Intracrine androgen metabolism in prostate cancer progression: mechanisms of castration resistance and therapeutic implications. Best Pract Res Clin Endocrinol Metab 22: 243-258.
-
(2008)
Best Pract Res Clin Endocrinol Metab
, vol.22
, pp. 243-258
-
-
Mostaghel, E.A.1
Nelson, P.S.2
-
48
-
-
76249096762
-
Evidence of limited contributions for intratumoral steroidogenesis in prostate cancer
-
Hofland J, van Weerden WM, Dits NFJ et al (1999) Evidence of limited contributions for intratumoral steroidogenesis in prostate cancer. Cancer Res 70: 1256-1264.
-
(1999)
Cancer Res
, vol.70
, pp. 1256-1264
-
-
Hofland, J.1
van Weerden, W.M.2
Dits, N.F.J.3
-
49
-
-
65349151253
-
Castration-resistant prostate cancer: targeting androgen metabolic pathways in recurrent disease
-
Mostaghel EA, Montgomery B, Nelson PS (2009) Castration-resistant prostate cancer: targeting androgen metabolic pathways in recurrent disease. Urol Oncol Semin Orig Investig 27: 251-257.
-
(2009)
Urol Oncol Semin Orig Investig
, vol.27
, pp. 251-257
-
-
Mostaghel, E.A.1
Montgomery, B.2
Nelson, P.S.3
-
50
-
-
16344365813
-
The prognostic significance of plasma interleukin-6 levels in patients with metastatic hormone-refractory prostate cancer: results from cancer and leukemia group B 9480
-
George DJ, Halabi S, Shepard TF et al (2005) The prognostic significance of plasma interleukin-6 levels in patients with metastatic hormone-refractory prostate cancer: results from cancer and leukemia group B 9480. Clin Cancer Res 11: 1815-1820.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 1815-1820
-
-
George, D.J.1
Halabi, S.2
Shepard, T.F.3
-
51
-
-
0035667565
-
Plasma levels of interleukin-6 and its soluble receptor are associated with prostate cancer progression and metastasis
-
Shariat SF, Andrews B, Kattan MW, Kim J, Wheeler TM, Slawin KM (2001) Plasma levels of interleukin-6 and its soluble receptor are associated with prostate cancer progression and metastasis. Urology 58: 1008-1015.
-
(2001)
Urology
, vol.58
, pp. 1008-1015
-
-
Shariat, S.F.1
Andrews, B.2
Kattan, M.W.3
Kim, J.4
Wheeler, T.M.5
Slawin, K.M.6
-
52
-
-
0037690822
-
Interleukin-6: minor player or starring role in the development of hormone-refractory prostate cancer?
-
Corcoran NM, Costello AJ (2003) Interleukin-6: minor player or starring role in the development of hormone-refractory prostate cancer? BJU Int 91: 545-553.
-
(2003)
BJU Int
, vol.91
, pp. 545-553
-
-
Corcoran, N.M.1
Costello, A.J.2
-
53
-
-
34248188794
-
Interleukin-6 undergoes transition from growth inhibitor associated with neuroendocrine differentiation to stimulator accompanied by androgen receptor activation during LNCaP prostate cancer cell progression
-
Lee SO, Chun JY, Nadiminty N, Lou W, Gao AC (2007) Interleukin-6 undergoes transition from growth inhibitor associated with neuroendocrine differentiation to stimulator accompanied by androgen receptor activation during LNCaP prostate cancer cell progression. Prostate 67: 764-773.
-
(2007)
Prostate
, vol.67
, pp. 764-773
-
-
Lee, S.O.1
Chun, J.Y.2
Nadiminty, N.3
Lou, W.4
Gao, A.C.5
-
54
-
-
66449085018
-
Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2
-
Feng S, Tang Q, Sun M, Chun JY, Evans CP, Gao AC (2009) Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2. Mol Cancer Ther 8: 665-671.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 665-671
-
-
Feng, S.1
Tang, Q.2
Sun, M.3
Chun, J.Y.4
Evans, C.P.5
Gao, A.C.6
-
55
-
-
0037064106
-
Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells
-
Ueda T, Mawji NR, Bruchovsky N, Sadar MD (2002) Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells. J Chem Biol 277: 38087-38094.
-
(2002)
J Chem Biol
, vol.277
, pp. 38087-38094
-
-
Ueda, T.1
Mawji, N.R.2
Bruchovsky, N.3
Sadar, M.D.4
-
56
-
-
68049117221
-
Interleukin-6 regulates androgen synthesis in prostate cancer cells
-
Chun JY, Nadiminty N, Dutt S et al (2009) Interleukin-6 regulates androgen synthesis in prostate cancer cells. Clin Cancer Res 15: 4815-4822.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4815-4822
-
-
Chun, J.Y.1
Nadiminty, N.2
Dutt, S.3
-
58
-
-
77449146168
-
Interleukin-6 trans-signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cells
-
Santer FdrR, Malinowska K, Culig Z, Cavarretta IT (2010) Interleukin-6 trans-signalling differentially regulates proliferation, migration, adhesion and maspin expression in human prostate cancer cells. Endocr Relat Cancer 17: 241-253.
-
(2010)
Endocr Relat Cancer
, vol.17
, pp. 241-253
-
-
Santer, F.R.1
Malinowska, K.2
Culig, Z.3
Cavarretta, I.T.4
-
59
-
-
0031795161
-
Interleukin-6-type cytokines stimulate mesenchymal progenitor differentiation toward the osteoblastic lineage
-
Taguchi Y, Yamamoto M, Yamate T et al (1998) Interleukin-6-type cytokines stimulate mesenchymal progenitor differentiation toward the osteoblastic lineage. Proc Assoc Am Physicians 110: 559-574.
-
(1998)
Proc Assoc Am Physicians
, vol.110
, pp. 559-574
-
-
Taguchi, Y.1
Yamamoto, M.2
Yamate, T.3
-
60
-
-
0036187204
-
Human prostatic carcinoma cells produce an increase in the synthesis of interleukin-6 by human osteoblasts
-
García-Moreno C, Méndez-Dávila C, de la Piedra C, Castro-Errecaborde NA, Traba ML (2002) Human prostatic carcinoma cells produce an increase in the synthesis of interleukin-6 by human osteoblasts. Prostate 50: 241-246.
-
(2002)
Prostate
, vol.50
, pp. 241-246
-
-
García-Moreno, C.1
Méndez-Dávila, C.2
de la Piedra, C.3
Castro-Errecaborde, N.A.4
Traba, M.L.5
-
61
-
-
0035875931
-
Anti-interleukin-6 monoclonal antibody induces regression of human prostate cancer xenografts in nude mice
-
Smith PC, Keller ET (2001) Anti-interleukin-6 monoclonal antibody induces regression of human prostate cancer xenografts in nude mice. Prostate 48: 47-53.
-
(2001)
Prostate
, vol.48
, pp. 47-53
-
-
Smith, P.C.1
Keller, E.T.2
-
62
-
-
33645514605
-
Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice
-
Wallner L, Dai J, Escara-Wilke J et al (2006) Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice. Cancer Res 66: 3087-3095.
-
(2006)
Cancer Res
, vol.66
, pp. 3087-3095
-
-
Wallner, L.1
Dai, J.2
Escara-Wilke, J.3
-
63
-
-
77953091816
-
Clinical and correlative results of SWOG S0354: a phase II trial of CNTO328 (Siltuximab), a monoclonal antibody against interleukin-6, in chemotherapy-pretreated patients with castration-resistant prostate cancer
-
Dorff TB, Goldman B, Pinski JK et al (2010) Clinical and correlative results of SWOG S0354: a phase II trial of CNTO328 (Siltuximab), a monoclonal antibody against interleukin-6, in chemotherapy-pretreated patients with castration-resistant prostate cancer. Clin Cancer Res 16: 3028-3034.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3028-3034
-
-
Dorff, T.B.1
Goldman, B.2
Pinski, J.K.3
-
64
-
-
79956160855
-
The anti-interleukin-6 antibody siltuximab down-regulates genes implicated in tumorigenesis in prostate cancer patients from a phase I study
-
(Epub ahead of print)
-
Karkera J, Steiner H, Li W et al (2011) The anti-interleukin-6 antibody siltuximab down-regulates genes implicated in tumorigenesis in prostate cancer patients from a phase I study. Prostate (Epub ahead of print).
-
(2011)
Prostate
-
-
Karkera, J.1
Steiner, H.2
Li, W.3
-
65
-
-
28444450417
-
Interleukin-4 in patients with prostate cancer
-
Takeshi U, Sadar MD, Suzuki H et al (2005) Interleukin-4 in patients with prostate cancer. Anticancer Res 25: 4595-4598.
-
(2005)
Anticancer Res
, vol.25
, pp. 4595-4598
-
-
Takeshi, U.1
Sadar, M.D.2
Suzuki, H.3
-
66
-
-
0345549484
-
Interleukin-4 enhances prostate-specific antigen expression by activation of the androgen receptor and Akt pathway
-
Lee SO, Lou W, Hou M, Onate SA, Gao AC (2003) Interleukin-4 enhances prostate-specific antigen expression by activation of the androgen receptor and Akt pathway. Oncogene 22: 7981-7988.
-
(2003)
Oncogene
, vol.22
, pp. 7981-7988
-
-
Lee, S.O.1
Lou, W.2
Hou, M.3
Onate, S.A.4
Gao, A.C.5
-
67
-
-
58849116423
-
Interleukin-4 activates androgen receptor through CBP/p300
-
Lee SO, Chun JY, Nadiminty N, Lou W, Feng S, Gao AC (2009) Interleukin-4 activates androgen receptor through CBP/p300. Prostate 69: 126-132.
-
(2009)
Prostate
, vol.69
, pp. 126-132
-
-
Lee, S.O.1
Chun, J.Y.2
Nadiminty, N.3
Lou, W.4
Feng, S.5
Gao, A.C.6
-
68
-
-
20344407552
-
Requirement for NF-κB in interleukin-4-induced androgen receptor activation in prostate cancer cells
-
Lee SO, Lou W, Nadiminty N, Lin X, Gao AC (2005) Requirement for NF-κB in interleukin-4-induced androgen receptor activation in prostate cancer cells. Prostate 64: 160-167.
-
(2005)
Prostate
, vol.64
, pp. 160-167
-
-
Lee, S.O.1
Lou, W.2
Nadiminty, N.3
Lin, X.4
Gao, A.C.5
-
69
-
-
37449002885
-
Interleukin-4 stimulates androgen-independent growth in LNCaP human prostate cancer cells
-
Lee SO, Pinder E, Chun JY, Lou W, Sun M, Gao AC (2008) Interleukin-4 stimulates androgen-independent growth in LNCaP human prostate cancer cells. Prostate 68: 85-91.
-
(2008)
Prostate
, vol.68
, pp. 85-91
-
-
Lee, S.O.1
Pinder, E.2
Chun, J.Y.3
Lou, W.4
Sun, M.5
Gao, A.C.6
-
70
-
-
19544377849
-
Differential expression of interleukin-8 and Its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate can./cer
-
Huang J, Yao JL, Zhang L et al (2005) Differential expression of interleukin-8 and Its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate can./cer. Am J Pathol 166: 1807-1815.
-
(2005)
Am J Pathol
, vol.166
, pp. 1807-1815
-
-
Huang, J.1
Yao, J.L.2
Zhang, L.3
-
71
-
-
0032937653
-
Interleukin-8 serum levels in patients with benign prostatic hyperplasia and prostate cancer
-
Veltri RW, Miller MC, Zhao G et al (1999) Interleukin-8 serum levels in patients with benign prostatic hyperplasia and prostate cancer. Urology 53: 139-147.
-
(1999)
Urology
, vol.53
, pp. 139-147
-
-
Veltri, R.W.1
Miller, M.C.2
Zhao, G.3
-
72
-
-
46949098184
-
Interleukin-8 signaling promotes androgen-independent proliferation of prostate cancer cells via induction of androgen receptor expression and activation
-
Seaton A, Scullin P, Maxwell PJ et al (2008) Interleukin-8 signaling promotes androgen-independent proliferation of prostate cancer cells via induction of androgen receptor expression and activation. Carcinogenesis 29: 1148-1156.
-
(2008)
Carcinogenesis
, vol.29
, pp. 1148-1156
-
-
Seaton, A.1
Scullin, P.2
Maxwell, P.J.3
-
73
-
-
1842434391
-
Interleukin-8 confers androgen-independent growth and migration of LNCaP: differential effects of tyrosine kinases Src and FAK
-
Lee L-F, Louie MC, Desai SJ et al (2004) Interleukin-8 confers androgen-independent growth and migration of LNCaP: differential effects of tyrosine kinases Src and FAK. Oncogene 23: 2197-2205.
-
(2004)
Oncogene
, vol.23
, pp. 2197-2205
-
-
Lee, L.-F.1
Louie, M.C.2
Desai, S.J.3
-
74
-
-
58149232586
-
The interleukin-8 pathway in cancer
-
Waugh DJJ, Wilson C (2008) The interleukin-8 pathway in cancer. Clin Cancer Res 14: 6735-6741.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6735-6741
-
-
Waugh, D.J.J.1
Wilson, C.2
-
75
-
-
34547112049
-
Interleukin-8 signaling promotes translational regulation of cyclin D in androgen-independent prostate cancer cells
-
MacManus CF, Pettigrew J, Seaton A et al (2007) Interleukin-8 signaling promotes translational regulation of cyclin D in androgen-independent prostate cancer cells. Mol Cancer Res 5: 737-748.
-
(2007)
Mol Cancer Res
, vol.5
, pp. 737-748
-
-
Macmanus, C.F.1
Pettigrew, J.2
Seaton, A.3
-
76
-
-
54049086233
-
Interleukin-8 signaling attenuates TRAIL- and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells
-
Wilson C, Wilson T, Johnston PG, Longley DB, Waugh DJJ (2008) Interleukin-8 signaling attenuates TRAIL- and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells. Mol Cancer Ther 7: 2649-2661.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2649-2661
-
-
Wilson, C.1
Wilson, T.2
Johnston, P.G.3
Longley, D.B.4
Waugh, D.J.J.5
-
78
-
-
69249182671
-
Depletion of intrinsic expression of Interleukin-8 in prostate cancer cells causes cell cycle arrest, spontaneous apoptosis and increases the efficacy of chemotherapeutic drugs
-
Singh R, Lokeshwar B (2009) Depletion of intrinsic expression of Interleukin-8 in prostate cancer cells causes cell cycle arrest, spontaneous apoptosis and increases the efficacy of chemotherapeutic drugs. Mol Cancer 8: 57.
-
(2009)
Mol Cancer
, vol.8
, pp. 57
-
-
Singh, R.1
Lokeshwar, B.2
-
79
-
-
0036604124
-
Stat3 activation in prostatic carcinomas
-
Dhir R, Ni Z, Lou W, DeMiguel F, Grandis JR, Gao AC (2002) Stat3 activation in prostatic carcinomas. Prostate 51: 241-246.
-
(2002)
Prostate
, vol.51
, pp. 241-246
-
-
Dhir, R.1
Ni, Z.2
Lou, W.3
Demiguel, F.4
Grandis, J.R.5
Gao, A.C.6
-
80
-
-
3943103442
-
RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells
-
Ok Lee S, Lou W, Qureshi KM, Mehraein-Ghomi F, Trump DL, Gao AC (2004) RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells. Prostate 60: 303-309.
-
(2004)
Prostate
, vol.60
, pp. 303-309
-
-
Ok Lee, S.1
Lou, W.2
Qureshi, K.M.3
Mehraein-Ghomi, F.4
Trump, D.L.5
Gao, A.C.6
-
81
-
-
0034794822
-
Cross-talk between signal transducer and activator of transcription 3 and androgen receptor signaling in prostate carcinoma cells
-
Matsuda T, Junicho A, Yamamoto T et al (2001) Cross-talk between signal transducer and activator of transcription 3 and androgen receptor signaling in prostate carcinoma cells. Biochem Biophys Res Commun 283: 179-187.
-
(2001)
Biochem Biophys Res Commun
, vol.283
, pp. 179-187
-
-
Matsuda, T.1
Junicho, A.2
Yamamoto, T.3
-
82
-
-
4344603767
-
Stat3 enhances transactivation of steroid hormone receptors
-
De Miguel F, Lee S, Onate S, Gao A (2003) Stat3 enhances transactivation of steroid hormone receptors. Nucl Recept 1: 3.
-
(2003)
Nucl Recept
, vol.1
, pp. 3
-
-
de Miguel, F.1
Lee, S.2
Onate, S.3
Gao, A.4
-
83
-
-
0036603046
-
Stat3 enhances the growth of LNCaP human prostate cancer cells in intact and castrated male nude mice
-
De Miguel F, Lee SO, Lou W et al (2002) Stat3 enhances the growth of LNCaP human prostate cancer cells in intact and castrated male nude mice. Prostate 52: 123-129.
-
(2002)
Prostate
, vol.52
, pp. 123-129
-
-
de Miguel, F.1
Lee, S.O.2
Lou, W.3
-
84
-
-
13644252492
-
Stable expression of constitutively-activated STAT3 in benign prostatic epithelial cells changes their phenotype to that resembling malignant cells
-
Huang H, Murphy T, Shu P, Barton A, Barton B (2005) Stable expression of constitutively-activated STAT3 in benign prostatic epithelial cells changes their phenotype to that resembling malignant cells. Mol Cancer 4: 2.
-
(2005)
Mol Cancer
, vol.4
, pp. 2
-
-
Huang, H.1
Murphy, T.2
Shu, P.3
Barton, A.4
Barton, B.5
-
85
-
-
77949379050
-
B-cell-derived lymphotoxin promotes castration-resistant prostate cancer
-
Ammirante M, Luo J-L, Grivennikov S, Nedospasov S, Karin M (2010) B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature 464: 302-305.
-
(2010)
Nature
, vol.464
, pp. 302-305
-
-
Ammirante, M.1
Luo, J.-L.2
Grivennikov, S.3
Nedospasov, S.4
Karin, M.5
-
86
-
-
0029793331
-
Mutual transcriptional interference between RelA and androgen receptor
-
Palvimo JJ, Reinikainen P, Ikonen T, Kallio PJ, Moilanen A, Jänne OA (1996) Mutual transcriptional interference between RelA and androgen receptor. J Biol Chem 271: 24151-24156.
-
(1996)
J Biol Chem
, vol.271
, pp. 24151-24156
-
-
Palvimo, J.J.1
Reinikainen, P.2
Ikonen, T.3
Kallio, P.J.4
Moilanen, A.5
Jänne, O.A.6
-
87
-
-
2342645462
-
Identification of a negative regulatory cis-element in the enhancer core region of the prostate-specific antigen promoter: implications for intersection of androgen receptor and nuclear factor-kappaB signalling in prostate cancer cells
-
Cinar B, Yeung F, Konaka H et al (2004) Identification of a negative regulatory cis-element in the enhancer core region of the prostate-specific antigen promoter: implications for intersection of androgen receptor and nuclear factor-kappaB signalling in prostate cancer cells. Biochem J 379: 421-431.
-
(2004)
Biochem J
, vol.379
, pp. 421-431
-
-
Cinar, B.1
Yeung, F.2
Konaka, H.3
-
88
-
-
68449103870
-
NF-[kappa]B regulates androgen receptor expression and prostate cancer growth
-
Zhang L, Altuwaijri S, Deng F et al (2009) NF-[kappa]B regulates androgen receptor expression and prostate cancer growth. Am J Pathol 175: 489-499.
-
(2009)
Am J Pathol
, vol.175
, pp. 489-499
-
-
Zhang, L.1
Altuwaijri, S.2
Deng, F.3
-
89
-
-
53049103521
-
The nuclear factor-kappaB pathway controls the progression of prostate cancer to androgen-independent growth
-
Jin RJ, Lho Y, Connelly L et al (2008) The nuclear factor-kappaB pathway controls the progression of prostate cancer to androgen-independent growth. Cancer Res 68: 6762-6769.
-
(2008)
Cancer Res
, vol.68
, pp. 6762-6769
-
-
Jin, R.J.1
Lho, Y.2
Connelly, L.3
-
90
-
-
70349485623
-
aPKCε promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6
-
Ishiguro H, Akimoto K, Nagashima Y et al (2009) aPKCε promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6. Proc Natl Acad Sci 106: 16369-16374.
-
(2009)
Proc Natl Acad Sci
, vol.106
, pp. 16369-16374
-
-
Ishiguro, H.1
Akimoto, K.2
Nagashima, Y.3
-
91
-
-
78751623400
-
Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-[kappa]B signalling
-
Rajasekhar VK, Studer L, Gerald W, Socci ND, Scher HI (2011) Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-[kappa]B signalling. Nat Commun 2: 162.
-
(2011)
Nat Commun
, vol.2
, pp. 162
-
-
Rajasekhar, V.K.1
Studer, L.2
Gerald, W.3
Socci, N.D.4
Scher, H.I.5
-
92
-
-
79951841313
-
oB by TMPRSS2/ERG fusion isoforms through toll-like receptor-4
-
oB by TMPRSS2/ERG fusion isoforms through toll-like receptor-4. Cancer Res 71: 1325-1333.
-
(2010)
Cancer Res
, vol.71
, pp. 1325-1333
-
-
Wang, J.1
Cai, Y.2
Shao, L.-j.3
-
93
-
-
27644466358
-
Nuclear localisation of nuclear factor-kappaB transcription factors in prostate cancer: an immunohistochemical study
-
Lessard L, Begin LR, Gleave ME, Mes-Masson AM, Saad F (2005) Nuclear localisation of nuclear factor-kappaB transcription factors in prostate cancer: an immunohistochemical study. Br J Cancer 93: 1019-1023.
-
(2005)
Br J Cancer
, vol.93
, pp. 1019-1023
-
-
Lessard, L.1
Begin, L.R.2
Gleave, M.E.3
Mes-Masson, A.M.4
Saad, F.5
-
94
-
-
56049083009
-
NF-κB2/p52 enhances androgen-independent growth of human LNCaP cells via protection from apoptotic cell death and cell cycle arrest induced by androgen-deprivation
-
Nadiminty N, Chun JY, Lou W, Lin X, Gao AC (2008) NF-κB2/p52 enhances androgen-independent growth of human LNCaP cells via protection from apoptotic cell death and cell cycle arrest induced by androgen-deprivation. Prostate 68: 1725-1733.
-
(2008)
Prostate
, vol.68
, pp. 1725-1733
-
-
Nadiminty, N.1
Chun, J.Y.2
Lou, W.3
Lin, X.4
Gao, A.C.5
-
95
-
-
33947233680
-
NF-[kappa]B2 processing and p52 nuclear accumulation after androgenic stimulation of LNCaP prostate cancer cells
-
Lessard L, Saad F, Le Page C et al (2007) NF-[kappa]B2 processing and p52 nuclear accumulation after androgenic stimulation of LNCaP prostate cancer cells. Cell Signal 19: 1093-1100.
-
(2007)
Cell Signal
, vol.19
, pp. 1093-1100
-
-
Lessard, L.1
Saad, F.2
Le Page, C.3
-
96
-
-
77951036849
-
Aberrant activation of the androgen receptor by NF-kappaB2/p52 in prostate cancer cells
-
Nadiminty N, Lou W, Sun M et al (2010) Aberrant activation of the androgen receptor by NF-kappaB2/p52 in prostate cancer cells. Cancer Res 70: 3309-3319.
-
(2010)
Cancer Res
, vol.70
, pp. 3309-3319
-
-
Nadiminty, N.1
Lou, W.2
Sun, M.3
-
97
-
-
75649120392
-
Microarray analysis reveals potential target genes of NF-κB2/p52 in LNCaP prostate cancer cells
-
Nadiminty N, Dutt S, Tepper C, Gao AC (2010) Microarray analysis reveals potential target genes of NF-κB2/p52 in LNCaP prostate cancer cells. prostate 70: 276-287.
-
(2010)
Prostate
, vol.70
, pp. 276-287
-
-
Nadiminty, N.1
Dutt, S.2
Tepper, C.3
Gao, A.C.4
-
98
-
-
34249931559
-
LIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway
-
Nadiminty N, Chun JY, Hu Y, Dutt S, Lin X, Gao AC (2007) LIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway. Biochem Biophys Res Commun 359: 379-384.
-
(2007)
Biochem Biophys Res Commun
, vol.359
, pp. 379-384
-
-
Nadiminty, N.1
Chun, J.Y.2
Hu, Y.3
Dutt, S.4
Lin, X.5
Gao, A.C.6
|