Foxp3 expression in A549 cells is regulated by toll-like receptor 4 through nuclear factor-κB

Molecular Medicine Reports

Volumn 6, Issue 1, 2012, Pages 167-172

  Ting, Jia ^a   Fu, Haiying ^a   Sun, Jitong ^a   Zhang, Yinglin ^a   Yang, Wei ^a   Li, Yi ^a  

^a Basic Medical College   (China)

Author keywords

A549 cells; Foxp3; Nuclear factor B; Toll like receptor 4

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; POLYMYXIN B; PYRROLIDINE DITHIOCARBAMATE; SYNAPTOTAGMIN I; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR FOXP3;

ARTICLE; CANCER CELL CULTURE; CANCER INVASION; CD4+ CD25+ T LYMPHOCYTE; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LUNG CANCER; LYMPHOCYTE FUNCTION; METASTASIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STIMULATION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

CELL LINE, TUMOR; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIPOPOLYSACCHARIDES; NF-KAPPA B; PROLINE; RNA, MESSENGER; SIGNAL TRANSDUCTION; THIOCARBAMATES; TOLL-LIKE RECEPTOR 4;

EID: 84861647313     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.877     Document Type: Article

References (33)

1. Hori S, Nomura T and Sakaguchi S: Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061, 2003. (Pubitemid 36222930)
2. Fontenot JD, Rasmussen JP, Williams LM, Dooley JL, Farr AG and Rudensky AY: Regulatory T cell lineage specification by the forkhead transcription factor Foxp3. Immunity 22: 329-341, 2005. (Pubitemid 40387475)
3. + regulatory T cells. J Immunol 175: 4180-4183, 2005.
4. Marson A, Kretschmer K, Frampton G, et al: Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature 445: 931-935, 2007.
5. Hinz S, Pagerols-Raluy L, Oberg HH, et al: Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer. Cancer Res 67: 8344-8350, 2007. (Pubitemid 47395173)
6. Merlo A, Casalini P, Carcangiu ML, et al: FOXP3 expression and overall survival in breast cancer. J Clin Oncol 27: 1746-1752, 2009.
7. Zuo T, Liu R, Zhang H, et al: FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SEKP2. J Clin Invest 117: 3765-3773, 2007. (Pubitemid 350224087)
8. Um SW, Lee SH, Kim H, Kwon OJ, Kim H, Kang JS and Lee WJ: The regulation of FOXP3 expression by the treatment of TGF-β and the modification of DNA methylation in lung cancer cell lines. Tuberc Respir Dis 70: 206-207, 2011.
9. Wang L, Liu R, Li W, et al: Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate. Cancer Cell 16: 336-346, 2009.
10. Ebert LM, Tan BS, Browning J, et al: The regulatory T cell-associated transcription factor Foxp3 is expressed by tumor cells. Cancer Res 68: 3001-3009, 2008. (Pubitemid 351556301)
11. O'Neill LA: When signaling pathways collide: positive and negative regulation of toll-like receptor signal transduction. Immunity 29: 12-20, 2008.
12. Kawai T and Akira S: The role of pattern recognition receptors in innate immunity: update on Toll like receptors. Nat Immunol 11: 373-384, 2010.
13. Kumagai Y, Takeuchi O and Akira S: Pathogen recognition by innate receptors. J Infect Chemother 14: 86-92, 2008. (Pubitemid 351624472)
14. Kanczkowski W, Tymoszuk P, Ehrhart-Bornstein M, Wirth MP, Zacharowski K and Bornstein SR: Abrogation of TLR4 and CD14 expression and signaling in human adrenocortical tumors. J Clin Endocrinol Metab 95: E421-E429, 2010.
15. González-Reyes S, Marín L, González L, et al: Study of TLR3, TLR4 and TLR9 in breast carcinomas and their association with metastasis. BMC Cancer 10: 665, 2010.
16. Zhang YB, He FL, Fang M, et al: Increased expression of Toll-like receptors 4 and 9 in human lung cancer. Mol Biol Rep 36: 1475-1481, 2009.
17. Qian Y, Deng J, Xie H, et al: Regulation of TLR4-induced IL-6 response in bladder cancer cells by opposing actions of MAPK and PI3K signaling. J Cancer Res Clin Oncol 135: 379-386, 2009.
18. He W, Liu Q, Wang L, Chen W, Li N and Cao X: TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance. Mol Immunol 44: 2850-2859, 2007. (Pubitemid 46412506)
19. Ostuni R, Zanoni I and Granucci F: Deciphering the complexity of Toll-like receptor signaling. Cell Mol Life Sci 67: 4109-4134, 2010.
20. Yang J, Amiri KI, Burke JR, Schmid JA and Richmond A: BMS-345541 targets inhibitor of κB kinase and induces apoptosis in melanoma: involvement of nuclear factor κB and mitochondria pathways. Clin Cance Res 12: 950-960, 2006. (Pubitemid 43259878)
21. Harmey JH, Bucana CD, Lu W, et al: Lipopolysaccharide-induced metastatic growth is associated with increased angiogenesis, vascular permeability and tumor cell invasion. Int J Cancer 101: 415-422, 2002.
22. Wang JH, Manning BJ, Wu QD, Blankson S, Bouchier-Hayes D and Redmond HP: Endotoxin/lipopolysaccharide activates NF-kappaB and enhances tumor cell adhesion and invasion through a beta I integrin-dependent mechanism. J Immunol 170: 795-804, 2003. (Pubitemid 36070531)
23. Son JS, Sahoo A, Chae CS, Hwang JS, Park ZY and Im SH: JunB and c-Rel cooperatively enhance Foxp3 expression during induced regulatory T cell differentiation. Biochem Biophys Res Commun 407: 141-147, 2011.
24. Long M, Park SG, Strickland I, Hayden MS and Ghosh S: Nuclear factor-κB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. Immunity 31: 921-931, 2009.
25. Oblak A and Jerala R: Toll-like receptor 4 activation in cancer progression and therapy. Clin Dev Immunol 2011: 609579, 2011.
26. Lu YC, Yeh WC and Ohashi PS: LPS/TLR4 signal transduction pathway. Cytokine 42: 145-151, 2008.
27. Xu Z, Ren T, Xiao C, Li H and Wu T: Nickel promotes the invasive potential of human lung cancer cells via TLR4/MyD88 signaling. Toxicology 285: 25-30, 2011.
28. Wang EL, Qian ZR, Nakasono M, et al: High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer. Br J Cancer 102: 908-915, 2010.
29. high regulatory T cells. Exp Dermatol 19: 29-37, 2010.
30. Zhang JJ, Wu HS, Wang L, Tian Y, Zhang JH and Wu HL: Expression and significance of TLR4 and HIF-1α in pancreatic ductal adenocarcinoma. World J Gastroenterol 16: 2881-2888, 2010.
31. Fendri A, Kontos CK, Khabor A, Mokdad-Gargouri R and Scorilas A: BCL2L12 is a novel biomarker for the prediction of short-term relapse in nasopharyngeal carcinoma. Mol Med 17: 163-171, 2011.
32. Wang LW, Chen H and Gong ZJ: High mobility group box-1 protein inhibits regulatory T cell immune activity in liver failure in patients with chronic hepatitis B. Hepatobiliary Pancreat Dis Int 9: 499-507, 2010.
33. Shim GS, Manandhar S, Shin DH, Kim TH and Kwak MK: Acquisition of doxorubicin resistance in ovarian carcinoma cells accompanies activation of the NRF2 pathway. Free Radical Biol Med 47: 1619-1631, 2009.