Abrogation of TLR4 and CD14 expression and signaling in human adrenocortical tumors

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 12, 2010, Pages

  Kanczkowski, Waldemar ^a   Tymoszuk, Piotr ^a   Ehrhart Bornstein, Monika ^a   Wirth, Manfred P ^a   Zacharowski, Kai ^b   Bornstein, Stefan R ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b Clinic of Anesthesiology   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL FACTOR; CD14 ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION PROTEIN 2; PROTEIN KINASE B; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ADRENAL CORTEX ADENOMA; ADRENAL CORTEX CARCINOMA; ADULT; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

EID: 78650074813     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-1100     Document Type: Article

References (41)

1. 2002 NIH State-of-the-Science Statement on management of the clinically inapparent adrenal mass ("incidentaloma"), NIH Consens State Sci Statements 19:1-25
2. Wajchenberg BL, Albergaria Pereira MA, Medonca BB, Latronico AC, Campos CP, Alves VA, Zerbini MC, Liberman B, Carlos GG, Kirschner MA 2000 Adrenocortical carcinoma: clinical and laboratory observations. Cancer 88:711-736
3. Soon PS, McDonald KL, Robinson BG, Sidhu SB 2008 Molecular markers and the pathogenesis of adrenocortical cancer. Oncologist 13:548-561
4. Stratakis CA 2009 New genes and/or molecular pathways associated with adrenal hyperplasias and related adrenocortical tumors. Mol Cell Endocrinol 300:152-157
5. Gross MD, Korobkin M, Bou AW, Dwamena B, Djekidel M 2009 Contemporary imaging of incidentally discovered adrenal masses. Nat Rev Urol 6:363-373
6. Ahlman H, Khorram-Manesh A, Jansson S, Wangberg B, Nilsson O, Jacobsson CE, Lindstedt S 2001 Cytotoxic treatment of adrenocortical carcinoma. World J Surg 25:927-933
7. Terzolo M, Angeli A, Fassnacht M, Daffara F, Tauchmanova L, Conton PA, Rossetto R, Buci L, Sperone P, Grossrubatscher E, Reimondo G, Bollito E, Papotti M, Saeger W, Hahner S, Koschker AC, Arvat E, Ambrosi B, Loli P, Lombardi G, Mannelli M, Bruzzi P, Mantero F, Allolio B, Dogliotti L, Berruti A 2007 Adjuvant mitotane treatment for adrenocortical carcinoma. N Engl J Med 356:2372-2380
8. Reincke M, Mora P, Beuschlein F, Arlt W, Chrousos GP, Allolio B 1997 Deletion of the adrenocorticotropin receptor gene in human adrenocortical tumors: implications for tumorigenesis. J Clin Endocrinol Metab 82:3054-3058 (Pubitemid 27385671)
9. Papewalis C, Fassnacht M, Willenberg HS, Domberg J, Fenk R, Rohr UP, Schinner S, Bornstein SR, Scherbaum WA, Schott M 2006 Dendritic cells as potential adjuvant for immunotherapy in adrenocortical carcinoma. Clin Endocrinol (Oxf) 65:215-222 (Pubitemid 44079686)
10. Willenberg HS, Stratakis CA, Marx C, Ehrhart-Bornstein M, Chrousos GP, Bornstein SR 1998 Aberrant interleukin-1 receptors in a cortisol-secreting adrenal adenoma causing Cushing's syndrome. N Engl J Med 339:27-31
11. Marx C, Wolkersdorfer GW, Brown JW, Scherbaum WA, Bornstein SR 1996 MHC class II expression - a new tool to assess dignity in adrenocortical tumours. J Clin Endocrinol Metab 81:4488-4491
12. Kanczkowski W, Ziegler CG, Zacharowski K, Bornstein SR 2008 Toll-like receptors in endocrine disease and diabetes. Neuroimmunomodulation 15:54-60
13. Kanczkowski W, Zacharowski K, Wirth MP, Ehrhart-Bornstein M, Bornstein SR 2009 Differential expression and action of Toll-like receptors in human adrenocortical cells. Mol Cell Endocrinol 300:57-65
14. Bornstein SR, Zacharowski P, Schumann RR, Barthel A, Tran N, Papewalis C, Rettori V, McCann SM, Schulze-Osthoff K, Scherbaum WA, Tarnow J, Zacharowski K 2004 Impaired adrenal stress response in Toll-like receptor 2-deficient mice. Proc Natl Acad Sci USA 101:16695-16700 (Pubitemid 39557775)
15. Zacharowski K, Zacharowski PA, Koch A, Baban A, Tran N, Berkels R, Papewalis C, Schulze-Osthoff K, Knuefermann P, Zahringer U, Schumann RR, Rettori V, McCann SM, Bornstein SR 2006 Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome. Proc Natl Acad Sci USA 103:6392-6397
16. Shechter R, Ronen A, Rolls A, London A, Bakalash S, Young MJ, Schwartz M 2008 Toll-like receptor 4 restricts retinal progenitor cell proliferation. J Cell Biol 183:393-400
17. Huang B, Zhao J, Li H, He KL, Chen Y, Chen SH, Mayer L, Unkeless JC, Xiong H 2005 Toll-like receptors on tumor cells facilitate evasion of immune surveillance. Cancer Res 65:5009-5014 (Pubitemid 40827306)
18. Szajnik M, Szczepanski MJ, Czystowska M, Elishaev E, Mandapathil M, Nowak-Markwitz E, Spaczynski M, Whiteside TL 2009 TLR4 signaling induced by lipopolysaccharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer. Oncogene 28:4353-4363
19. Mandapathil M, Szczepanski MJ, Szajnik M, Ren J, Lenzner DE, Jackson EK, Gorelik E, Lang S, Johnson JT, Whiteside TL 2009 Increased ectonucleotidase expression and activity in regulatory T cells of patients with head and neck cancer. Clin Cancer Res 15:6348-6357
20. Weiss LM 1984 Comparative histologic study of 43 metastasizing and nonmetastasizing adrenocortical tumors. Am J Surg Pathol 8:163-169
21. Gazdar AF, Oie HK, Shackleton CH, Chen TR, Triche TJ, Myers CE, Chrousos GP, Brennan MF, Stein CA, La Rocca RV 1990 Establishment and characterization of a human adrenocortical carcinoma cell line that expresses multiple pathways of steroid biosynthesis. Cancer Res 50:5488-5496
22. Parmar J, Key RE, Rainey WE 2008 Development of an adrenocorticotropin- responsive human adrenocortical carcinoma cell line. J Clin Endocrinol Metab 93:4542-4546 (Pubitemid 352789558)
23. Path G, Bornstein SR, Ehrhart-Bornstein M, Scherbaum WA 1997 Interleukin-6 and the interleukin-6 receptor in the human adrenal gland: expression and effects on steroidogenesis. J Clin Endocrinol Metab 82:2343-2349
24. Kanczkowski W, Zacharowski K, Wirth MP, Ehrhart-Bornstein M, Bornstein SR 2009 Differential expression and action of Toll-like receptors in human adrenocortical cells. Mol Cell Endocrinol 300:57-65
25. Bornstein SR, Schumann RR, Rettori V, McCann SM, Zacharowski K 2004 Toll-like receptor 2 and Toll-like receptor 4 expression in human adrenals. Horm Metab Res 36:470-473
26. Andreani V, Gatti G, Simonella L, Rivero V, Maccioni M 2007 Activation of Toll-like receptor 4 on tumor cells in vitro inhibits subsequent tumor growth in vivo. Cancer Res 67:10519-10527
27. Conroy H, Marshall NA, Mills KH 2008 TLR ligand suppression or enhancement of Treg cells? A double-edged sword in immunity to tumours. Oncogene 27:168-180
28. Poltorak A, He X, Smirnova I, Liu MY, Van HC, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B 1998 Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085-2088
29. Webb RN, Cruse JM, Lewis RE 2009 Decreased TLR4 gene expression in leukemic leukocyte populations. Exp Mol Pathol 87:117-126
30. Giordano TJ, Thomas DG, Kuick R, Lizyness M, Misek DE, Smith AL, Sanders D, Aljundi RT, Gauger PG, Thompson NW, Taylor JM, Hanash SM 2003 Distinct transcriptional profiles of adrenocortical tumors uncovered by DNA microarray analysis. Am J Pathol 162:521-531 (Pubitemid 36267859)
31. Stojadinovic A, Ghossein RA, Hoos A, Nissan A, Marshall D, Dudas M, Cordon-Cardo C, Jaques DP, Brennan MF 2002 Adrenocortical carcinoma: clinical, morphologic, and molecular characterization. J Clin Oncol 20:941-950 (Pubitemid 34141836)
32. Soon PS, Gill AJ, Benn DE, Clarkson A, Robinson BG, McDonald KL, Sidhu SB 2009 Microarray gene expression and immunohistochemistry analyses of adrenocortical tumors identify IGF2 and Ki-67 as useful in differentiating carcinomas from adenomas. Endocr Relat Cancer 16:573-583
33. He W, Liu Q, Wang L, Chen W, Li N, Cao X 2007 TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance. Mol Immunol 44:2850-2859
34. Fassnacht M, Weismann D, Ebert S, Adam P, Zink M, Beuschlein F, Hahner S, Allolio B 2005 AKT is highly phosphorylated in pheochromocytomas but not in benign adrenocortical tumors. J Clin Endocrinol Metab 90:4366-4370
35. Pignatelli D, Ferreira J, Soares P, Costa MJ, Magalhaes MC 2003 Immunohistochemical study of heat shock proteins 27, 60 and 70 in the normal human adrenal and in adrenal tumors with suppressed ACTH production. Microsc Res Tech 61:315-323
36. Cohen-Sfady M, Nussbaum G, Pevsner-Fischer M, Mor F, Carmi P, Zanin-Zhorov A, Lider O, Cohen IR 2005 Heat shock protein 60 activates B cells via the TLR4-MyD88 pathway. J Immunol 175:3594-3602 (Pubitemid 41292018)
37. Kim SC, Stice JP, Chen L, Jung JS, Gupta S, Wang Y, Baumgarten G, Trial J, Knowlton AA 2009 Extracellular heat shock protein 60, cardiac myocytes, and apoptosis. Circ Res 105:1186-1195
38. Salaun B, Coste I, Rissoan MC, Lebecque SJ, Renno T 2006 TLR3 can directly trigger apoptosis in human cancer cells. J Immunol 176:4894-4901
39. El Andaloussi A, Sonabend AM, Han Y, Lesniak MS 2006 Stimulation of TLR9 with CpG ODN enhances apoptosis of glioma and prolongs the survival of mice with experimental brain tumors. Glia 54:526-535 (Pubitemid 44449333)
40. Haimovitz-Friedman A, Cordon-Cardo C, Bayoumy S, Garzotto M, McLoughlin M, Gallily R, Edwards III CK, Schuchman EH, Fuks Z, Kolesnick R 1997 Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation. J Exp Med 186:1831-1841 (Pubitemid 27524593)
41. Tichomirowa M, Theodoropoulou M, Lohrer P, Schaaf L, Losa M, Uhl E, Lange M, Arzt E, Stalla GK, Renner U 2005 Bacterial endotoxin (lipopolysaccharide) stimulates interleukin-6 production and inhibits growth of pituitary tumour cells expressing the toll-like receptor 4. J Neuroendocrinol 17:152-160 (Pubitemid 40553014)