Design, synthesis and biological evaluation of a novel series of 1,3,4-oxadiazole bearing N-methyl-4-(trifluoromethyl)phenyl pyrazole moiety as cytotoxic agents

European Journal of Medicinal Chemistry

Volumn 53, Issue , 2012, Pages 203-210

  Puthiyapurayil, Pushpan ^a,b   Poojary, Boja ^a   Chikkanna, Chandrashekhar ^c   Buridipad, Sunil Kumar ^d  

^a MANGALORE UNIVERSITY   (India)

^b SYNGENE INTERNATIONAL LTD   (India)

^c SDM College   (India)

^d NET Pharmacy College   (India)

Author keywords

Cytotoxic activity; Doxorubicin; MTT assay; N Methyl 4(trifluoromethyl)phenyl Pyrazole; Nuclear overhauser effect

Indexed keywords

1 METHYL 3 [4 (TRIFLUOROMETHYL)PHENYL] 1H PYRAZOLE 5 CARBOHYDRAZIDE; 1 METHYL 3 [4 (TRIFLUOROMETHYL)PHENYL] 1H PYRAZOLE 5 CARBOXYLATE ACID METHYL ESTER; 1 METHYL 5 [4 (TRIFLUOROMETHYL)PHENYL] 1H PYRAZOLE 3 CARBOHYDRAZIDE; 1 METHYL 5 [4 (TRIFLUOROMETHYL)PHENYL] 1H PYRAZOLE 3 CARBOXYLATE ACID METHYL ESTER; 1,3,4 OXADIAZOLE DERIVATIVE; 2 (2,3 DICHLOROBENZYLTHIO) 5 [3 [4 (TRIFLUOROMETHYL)PHENYL] 1 METHYL 1H PYRAZOL 5 YL] 1,3,4 OXADIAZOLE; 2 (2,3 DICHLOROBENZYLTHIO) 5 [5 [4 (TRIFLUOROMETHYL)PHENYL] 1 METHYL 1H PYRAZOL 3 YL] 1,3,4 OXADIAZOLE; 2 (2,6 DIFLUOROBENZYLTHIO) 5 [3 [4 (TRIFLUOROMETHYL)PHENYL] 1 METHYL 1H PYRAZOL 5 YL] 1,3,4 OXADIAZOLE; 2 (2,6 DIFLUOROBENZYLTHIO) 5 [5 [4 (TRIFLUOROMETHYL)PHENYL] 1 METHYL 1H PYRAZOL 3 YL] 1,3,4 OXADIAZOLE; 2 (3 NITROBENZYLTHIO) 5 [3 [4 (TRIFLUOROMETHYL)PHENYL] 1 METHYL 1H PYRAZOL 5 YL] 1,3,4 OXADIAZOLE; 2 (3 NITROBENZYLTHIO) 5 [5 [4 (TRIFLUOROMETHYL)PHENYL] 1 METHYL 1H PYRAZOL 3 YL] 1,3,4 OXADIAZOLE; 2 (3,4 DICHLOROBENZYLTHIO) 5 [5 [4 (TRIFLUOROMETHYL)PHENYL] 1 METHYL 1H PYRAZOL 3 YL] 1,3,4 OXADIAZOLE; 2 (4 CHLORO 2 FLUOROBENZYLTHIO) 5 [5 [4 (TRIFLUOROMETHYL)PHENYL] 1 METHYL 1H PYRAZOL 3 YL] 1,3,4 OXADIAZOLE; 2 (4 FLUOROPHENETHYLTHIO) 5 [3 [4 (TRIFLUOROMETHYL)PHENYL] 1 METHYL 1H PYRAZOL 5 YL] 1,3,4 OXADIAZOLE; 2 (4 FLUOROPHENETHYLTHIO) 5 [5 [4 (TRIFLUOROMETHYL)PHENYL] 1 METHYL 1H PYRAZOL 3 YL] 1,3,4 OXADIAZOLE; 2 [2 (2 FLUOROPHENOXY)ETHYLTHIO] 5 [3 [4 (TRIFLUOROMETHYL)PHENYL] 1 METHYL 1H PYRAZOL 5 YL] 1,3,4 OXADIAZOLE; 2 [2 (2 FLUOROPHENOXY)ETHYLTHIO] 5 [5 [4 (TRIFLUOROMETHYL)PHENYL] 1 METHYL 1H PYRAZOL 3 YL] 1,3,4 OXADIAZOLE; 2 [4 (TRIFLUOROMETHYL)BENZYLTHIO] 5 [3 [4 (TRIFLUOROMETHYL)PHENYL] 1 METHYL 1H PYRAZOL 5 YL] 1,3,4 OXADIAZOLE; 2 [4 (TRIFLUOROMETHYL)BENZYLTHIO] 5 [5 [4 (TRIFLUOROMETHYL)PHENYL] 1 METHYL 1H PYRAZOL 3 YL] 1,3,4 OXADIAZOLE; 3 METHOXY CARBONYL 3 OXO 1 (4 TRIFLUOROMETHYL)PHENYL PROPEN 1 OLATE; 5 [ 5 [4 (TRIFLUOROMETHYL)PHENYL] 1 METHYL 1H PYRAZOL 3 YL] 1,3,4 OXADIAZOLE 2 THIONE; 5 [3 [4 (TRIFLUOROMETHYL) PHENYL] 1 METHYL 1H PYRAZOL 5 YL] 1,3,4 OXADIAZOLE 2 THIONE; CYTOTOXIC AGENT; DOXORUBICIN; N METHYL 4 (TRIFLUOROMETHYL)PHENYL PYRAZOLE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTON NUCLEAR MAGNETIC RESONANCE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; OXADIAZOLES; PYRAZOLES; TIME FACTORS;

EID: 84861622667     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.03.056     Document Type: Article

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