The heritability of brain metabolites on proton magnetic resonance spectroscopy in older individuals

NeuroImage

Volumn 62, Issue 1, 2012, Pages 281-289

  Batouli, Seyed Amir Hossein ^a   Sachdev, Perminder S ^a   Wen, Wei ^a,b   Wright, Margaret J ^c   Suo, Chao ^a,b   Ames, David ^d,e   Trollor, Julian N ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b PRINCE OF WALES HOSPITAL   (Australia)

^c ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^d NATIONAL AGEING RESEARCH INSTITUTE   (Australia)

^e UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Aging; Dementia; Heritability; Magnetic resonance spectroscopy; N Acetyl Aspartate; Twin study

Indexed keywords

CHOLINE; CREATINE; INOSITOL; N ACETYLASPARTIC ACID;

AGED; AGING; ARTICLE; BRAIN METABOLISM; DIZYGOTIC TWINS; FEMALE; HERITABILITY; HUMAN; MALE; MOLECULAR GENETICS; MONOZYGOTIC TWINS; POSTERIOR CINGULATE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

AGED; AGED, 80 AND OVER; ASPARTIC ACID; BRAIN; CHOLINE; FEMALE; GENETIC MARKERS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; PROTONS; TWINS;

EID: 84861616804     PISSN: 10538119     EISSN: 10959572     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2012.04.043     Document Type: Article

References (75)

1. Adalsteinsson E., Sullivan E.V., Kleinhans N., Spielman D.M., Pfefferbaum A. Longitudinal decline of the neuronal marker N-acetyl aspartate in Alzheimer's disease. Lancet 2000, 355:1696-1697.
2. Akaike H. Factor analysis and AIC. Psychometrika 1987, 52:317-332.
3. Ashburner J. VBM tutorial available at. http://www.fil.ion.ucl.ac.uk/.
4. Ashburner J., Friston K. Unified segmentation. Neuroimage 2005, 26:839-851.
5. Bartley A., Jones D., Weinberger D. Genetic variability of human brain size and cortical gyral patterns. Brain 1997, 120:257-269.
6. Bearden C.E., Glahn D.C., Lee A.D., Chiang M.C., van Erp T.G.M., Cannon T.D., Reiss A.L., Toga A.W., Thompson P.M. Neural phenotypes of common and rare genetic variants. Biol. Psychol. 2008, 79:43-57.
7. Blokland G.A.M., McMahon K.L., Thompson P.M., Martin N.G., GId Zubicaray, Wright M.J. Heritability of working memory brain activation. J. Neurosci. 2011, 31.
8. Brans R.G.H., van Haren N.E.M., van Baal G.C.M., Schnack H.G., Kahn R.S., Hulshoff Pol H.E. Heritability of changes in brain volume over time in twin pairs discordant for schizophrenia. Arch. Gen. Psychiatry 2008, 65:1259-1268.
9. 1H-magnetic resonance spectroscopy of the left temporal and frontal lobes in schizophrenia: clinical, neurodevelopmental, and cognitive correlates. Biol. Psychiatry 1994, 36:792-800.
10. Burtscher I.M., Holtås S. Proton MR spectroscopy in clinical routine. J. Magn. Reson. Imaging 2001, 13:560-567.
11. Callicott J.H., Egan M.F., Bertolino A., Mattay V.S., Langheim F.J.P., Frank J.A., Weinberger D.R. Hippocampal N-acetyl aspartate in unaffected siblings of patients with schizophrenia: a possible intermediate neurobiological phenotype. Biol. Psychiatry 1998, 44:941-950.
12. Carey G. Cholesky problems. Behav. Genet. 2005, 35.
13. Carmelli D., DeCarli C., Swan G.E., Jack L.M., Reed T., Wolf P.A., Miller B.L. Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins. Stroke 1998, 29:1177-1181.
14. Carmelli D., Reed T., DeCarli C. A bivariate genetic analysis of cerebral white matter hyperintensities and cognitive performance in elderly male twins. Neurobiol. Aging 2002, 23:413-420.
15. 1H-MR spectroscopy differentiates mild cognitive impairment from normal brain aging. Neuroreport 2001, 12:2315-2317.
16. Chang L., Ernst T., Poland R.E., Jenden D.J. In vivo proton magnetic resonance spectroscopy of the normal aging human brain. Life Sci. 1996, 58:2049-2056.
17. Chang L., Ernst T., Witt M.D., Ames N., Gaiefsky M., Miller E. Relationships among brain metabolites, cognitive function, and viral loads in antiretroviral-naïve HIV patients. Neuroimage 2002, 17:1638-1648.
18. Colla M., Ende G., Bohrer M., Deuschle M., Kronenberg G., Henn F., Heuser I. MR spectroscopy in Alzheimer's disease: gender differences in probabilistic learning capacity. Neurobiol. Aging 2003, 24:545-552.
19. Cote J., Clobert J., Fitze P.S. Mother-offspring competition promotes colonization success. Proc. Natl. Acad. Sci. 2007, 104:9703-9708.
20. Dager S., Oskin N., Richards T., Posse S. Research applications of magnetic resonance spectroscopy (MRS) to investigate psychiatric disorders. Top Magn. Reson. Imaging 2008, 19:81-96.
21. De Stefano N., Matthews P.M., Arnold D.L. Reversible decreases in N-Acetylaspartate after acute brain injury. Magn. Reson. Med. 1995, 34:721-727.
22. Delano D., Eberle M., Galver L., Rosenow C. Array differences in genomic coverage and data quality impact GWAS success. 2011:Illumina Omni Express 2011.
23. Folstein M.F., Folstein S.E., McHugh P.R. "Mini-mental state": a practical method for grading the cognitive state of patients for the clinician. J. Psychiatr. Res. 1975, 12:189-198.
24. Franz C., York T., Eaves L., Mendoza S., Hauger R., Hellhammer D., Jacobson K., Levine S., Lupien S., Lyons M., Prom-Wormley E., Xian H., Kremen W. Genetic and environmental influences on cortisol regulation across days and contexts in middle-aged men. Behav. Genet. 2010, 40:467-479.
25. Friston K. Introduction: Experimental Design and Statistical Parametric Mapping 2003, Academic Press.
26. Giedd J.N., Schmitt J.E., Neale M.C. Structural brain magnetic resonance imaging of pediatric twins. Hum. Brain Mapp. 2007, 28:474-481.
27. Glahn D.C., Paul M., Thompson aJB Neuroimaging endophenotypes: strategies for finding genes influencing brain structure and function. Hum. Brain Mapp. 2007, 28:488-501.
28. Glahn D.C., Winkler A.M., Kochunov P., Almasy L., Duggirala R., Carless M.A., Curran J.C., Olvera R.L., Laird A.R., Smith S.M., Beckmann C.F., Fox P.T., Blangero J. Genetic control over the resting brain. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:1223-1228.
29. Griffith H.R., Okonkwo O.C., den Hollander J.A., Belue K., Copeland J., Harrell L.E., Brockington J.C., Clark D.G., Marson D.C. Brain metabolic correlates of decision making in amnestic mild cognitive impairment. Aging Neuropsychol. Cogn. 2010, 17:492-504.
30. Gujar S.K., Maheshwari S., Björkman-Burtscher I., Sundgren P.C. Magnetic resonance spectroscopy. J. Neuroophthalmol. 2005, 25:217-226.
31. 1H-MR spectroscopic volumes. World Congress on Medical Physics and Biomedical Engineering, September 7-12, 2009, Munich, Germany 2009, vol. 25/2:489-492. Springer Berlin Heidelberg. O. Dössel, W.C. Schlegel (Eds.).
32. Hulshoff Pol H.E., Schnack H.G., Posthuma D., Mandl R.C.W., Baare W.F., van Oel C., van Haren N.E., Collins D.L., Evans A.C., Amunts K., Burgel U., Zilles K., de Geus E., Boomsma D.I., Kahn R.S. Genetic contributions to human brain morphology and intelligence. J. Neurosci. 2006, 26:10235-10242.
33. Kantarci K., Jack C.R., Xu Y.C., Campeau N.G., O'Brien P.C., Smith G.E., Ivnik R.J., Boeve B.F., Kokmen E., Tangalos E.G., Petersen R.C. Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease. Neurology 2000, 55:210-217.
34. 1H MRS changes in mild cognitive impairment and Alzheimer's disease. Neurobiol. Aging 2007, 28:1330-1339.
35. Kato T., Inubushi T., Kato N. Magnetic resonance spectroscopy in affective disorders. J. Neuropsychiatry Clin. Neurosci. 1998, 10:133-147.
36. Katz-Brull R., Alsop D.C., Marquis R.P., Lenkinski R.E. Limits on activation-induced temperature and metabolic changes in the human primary visual cortex. Magn. Reson. Med. 2006, 56:348-355.
37. Kremen W.S., Prom-Wormley E., Panizzon M.S., Eyler L.T., Fischl B., Neale M.C., Franz C.E., Lyons M.J., Pacheco J., Perry M.E., Stevens A., Schmitt J.E., Grant M.D., Seidman L.J., Thermenos H.W., Tsuang M.T., Eisen S.A., Dale A.M., Fennema-Notestine C. Genetic and environmental influences on the size of specific brain regions in midlife: the VETSA MRI study. Neuroimage 2010, 49:1213-1223.
38. Lim K.O., Adalsteinsson E., Spielman D., Sullivan E.V., Rosenbloom M.J., Pfefferbaum A. Proton magnetic resonance spectroscopic imaging of cortical gray and white matter in schizophrenia. Arch. Gen. Psychiatry 1998, 55:346-352.
39. 1H MRS of brain. Magn. Reson. Imaging 1996, 14:281-292.
40. 1H MRS choline: correlation with in vitro chemistry/histology. Life Sci. 1996, 58:1929-1935.
41. Neale M. Mx graphical user interface 2011, vol. 2011. Virginia Commonwealth University.
42. Peper J.S., Brouwer R.M., Boomsma D.I., Kahn R.S., Pol H.E.H. Genetic influences on human brain structure: a review of brain imaging studies in twins. Hum. Brain Mapp. 2007, 28:464-473.
43. Human brain volume: what's in the genes? 2009, Springer Science+Business Media. J.S. Peper, M.P. Zwiers, D.I. Boomsma, K. ReS, H.E. Hulshoff Pol (Eds.).
44. Pettegrew J.W., Klunk W.E., Panchalingam K., McClure R.J., Stanley J.A. Magnetic resonance spectroscopic changes in Alzheimer's disease. Ann. N. Y. Acad. Sci. 1997, 826:282-306.
45. Pfefferbaum A., Adalsteinsson E., Spielman D., Sullivan E.V., Lim K.O. In vivo brain concentrations of N-Acetyl compounds, creatine, and choline in Alzheimer disease. Arch. Gen. Psychiatry 1999, 56:185-192.
46. Pfefferbaum A., Sullivan E.V., Swan G.E., Carmelli D. Brain structure in men remains highly heritable in the seventh and eighth decades of life. Neurobiol. Aging 2000, 21:63-74.
47. Plomin R., Pedersen N.L., Lichtenstein P., McClearn G.E. Variability and stability in cognitive abilities are largely genetic later in life. Behav. Genet. 1994, 24:207-215.
48. Posthuma D., de Geus E.J.C., Neale M.C., Hulshoff Pol H.E., Baaré W.E.C., Kahn R.S., Boomsma D. Multivariate genetic analysis of brain structure in an extended twin design. Behav. Genet. 2000, 30:311-319.
49. Posthuma D., Geus E.J.C.D., Baaré W.F.C., Pol H.E.H., Kahn R.S., Boomsma D.I. The association between brain volume and intelligence is of genetic origin. Nat. Neurosci. 2002, 5:83-84.
50. Posthuma D., Baaré W.F.C., Hulshoff Pol H.E., Kahn R.S., Boomsma D.I., Geus E.J.C.D. Genetic correlations between brain volumes and the WAIS-III dimensions of verbal comprehension, working memory, perceptual organization, and processing speed. Twin Res. 2003, 6.
51. Pouwels P.J.W., Frahm J. Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS. Magn. Reson. Med. 1998, 39:53-60.
52. Raz N., Rodrigue K.M. Differential aging of the brain: patterns, cognitive correlates and modifiers. Neurosci. Biobehav. Rev. 2006, 30:730-748.
53. Rijsdijk F. Independent pathway model. Encyclopedia of Statistics in Behavioral Science 2005, John Wiley & Sons, Ltd.
54. 1H MRS study of probable Alzheimer's disease and normal aging: implications for longitudinal monitoring of dementia progression. Magn. Reson. Imaging 1999, 17:291-299.
55. Ross A.J., Sachdev P.S. Magnetic resonance spectroscopy in cognitive research. Brain Res. Rev. 2004, 44:83-102.
56. 1H MRS in stroke patients with and without cognitive impairment. Neurobiol. Aging 2005, 26:873-882.
57. Sachdev P.S., Lammel A., Trollor J.N., Lee T., Wright M.J., Ames D., Wen W., Martin N.G., Brodaty H., Schofield P.R., team Or A comprehensive neuropsychiatric study of elderly twins: the Older Australian Twins Study. Twin Res. Hum. Genet. 2009, 12:573-582.
58. 1H-MRS and un-biased stereology: can non-invasive measures of N-acetyl-aspartate following global ischemia be used as a reliable measure of neuronal damage?. Brain Res. 2001, 892:166-175.
59. Sajjad Z., Alam S. Magnetic resonance spectroscopy (MRS): basic principles and applications in focal brain lesions. Pak. J. Neurosci. 2007, 2:42-46.
60. Sappey-Marinier D., Calabrese G., Hetherington H.P., Fisher S.N.G., Deicken R., Dyke C.V., Fein G., Weiner M.W. Proton magnetic resonance spectroscopy of human brain: applications to normal white matter, chronic infarction, and MRI white matter signal hyperintensities. Magn. Reson. Med. 1992, 26:313-327.
61. Schmitt J.E., Lenroot R.K., Wallace G.L., Ordaz S., Taylor K.N., Kabani N., Greenstein D., Lerch J.P., Kendler K.S., Neale M.C., Giedd J.N. Identification of genetically mediated cortical networks: a multivariate study of pediatric twins and siblings. Cereb. Cortex 2008, 18:1737-1747.
62. Shah S.H., Hauser E.R., Bain J.R., Muehlbauer M.J., Haynes C., Stevens R.D., Wenner B.R., Dowdy Z.E., Granger C.B., Ginsburg G.S., Newgard C.B., Kraus W.E. High heritability of metabolomic profiles in families burdened with premature cardiovascular disease. Mol. Syst. Biol. 2009, 5.
63. Sheikh R.L., Yesavage J.A. Geriatric Depression Scale (GDS). Recent evidence and development of a shorter version. Clin. Gerontol. 1986, 5:165-173.
64. Simmons M.L., Frondoza C.G., Coyle J.T. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience 1991, 45:37-45.
65. Singh S., Mistry S., Jefferson S., Davies K., Rothwell J., Williams S., Hamdy S. A magnetic resonance spectroscopy study of brain glutamate in a model of plasticity in human pharyngeal motor cortex. Gastroenterology 2009, 136:417-424.
66. Stankoff B., Tourbah A., Suarez S., Turell E., Stievenart J.L., Payan C., Coutellier A., Herson S., Baril L., Bricaire F., Calvez V., Cabanis E.A., Lacomblez L., Lubetzki C. Clinical and spectroscopic improvement in HIV-associated cognitive impairment. Neurology 2001, 56:112-115.
67. Swan G.E., Carmelli D. Evidence for genetic mediation of executive control. J. Gerontol. B: Psychol. Sci. Soc. Sci. 2002, 57:133-143.
68. Taylor D.L., Davies S.E.C., Obrenovitch T.P., Doheny M.H., Patsalos P.N., Clark J.B., Symon L. Investigation into the role of N-Acetylaspartate in cerebral osmoregulation. J. Neurochem. 1995, 65:275-281.
69. Thompson P., Cannon T.D., Toga A.W. Mapping genetic influences on human brain structure. Ann. Med. 2002, 34:523-536.
70. Videen J.S., Michaelis T., Pinto P., Ross B.D. Human cerebral osmolytes during chronic hyponatremia. A proton magnetic resonance spectroscopy study. J. Clin. Invest. 1995, 95:788-793.
71. Visscher P.M. Sizing up human height variation. Nat. Genet. 2008, 40:489-490.
72. Weiss B., Landrigan P. The developing brain and the environment: an introduction. Environ. Health Perspect. 2000, 3:373-374.
73. White T., Andreasen N.C., Nopoulos P. Brain volumes and surface morphology in monozygotic twins. Cereb. Cortex 2002, 12:486-493.
74. Wright I.C., Sham P., Murray R.M., Weinberger D.R., Bullmore E.T. Genetic contributions to regional variability in human brain structure: methods and preliminary results. Neuroimage 2002, 17:256-271.
75. Yesavage J.A., Brink T.L., Rose T.L., Lum O., Huang V., Adey M., Leirer V.O. Development and validation of a geriatric depression screening scale: a preliminary report. J. Psychiatr. Res. 1983, 17:37-49.