Proton magnetic resonance spectroscopic imaging of cortical gray and white matter in schizophrenia

Archives of General Psychiatry

Volumn 55, Issue 4, 1998, Pages 346-352

  Lim, Kelvin O ^a,b,d   Adalstcinsson, Elfar ^b   Spielman, Daniel ^b   Sullivan, Edith V ^b,c   Roscnbloom, Margaret J ^b   Pfefferbaum, Adolf ^b,c  

^a Psychiatry Service   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SRI INTERNATIONAL   (United States)

^d NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N ACETYLASPARTIC ACID;

ADULT; ARTICLE; BRAIN CORTEX; BRAIN METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; GRAY MATTER; HUMAN; MALE; MENTAL DISEASE; NERVE CELL DEGENERATION; NEURORADIOLOGY; PROTON NUCLEAR MAGNETIC RESONANCE; SCHIZOPHRENIA; WHITE MATTER;

ADULT; AGE OF ONSET; ASPARTIC ACID; BRAIN; BRAIN CHEMISTRY; CHOLINE; CREATINE; EDUCATIONAL STATUS; HUMANS; INTELLIGENCE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA;

EID: 0031898773     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.55.4.346     Document Type: Article

References (61)

1. Zipursky RB, Lim KO, Sullivan EV, Brown BW, Pfefferbaum A, Widespread cerebral gray matter volume deficits in schizophrenia. Arch Gen Psychiatry. 1992;49:195-205.
2. Sullivan E, Mathalon DH, Lim KO, Marsh L. Pfefferbaum A. Patterns of regional cortical dysmorphology distinguishing schizophrenia and chronic alcoholism. Biol Psychiatry. 1998;43:118-131.
3. Lim KO, Harris D, Beal M, Minn K. Hoff A. Csernansky J, Faustman W, Marsh L, Sullivan EV, Pfefferbaum A, Gray matter volume deficits in young onset schizophrenia are independent of age of onset. Biol Psychiatry. 1996;40:4-13.
4. Lauriello J, Hoff A, Weineke M, Blankfeld H. Faustman WO. Rosenbloom M. DeMent S. Sullivan EV, Lim KO, Pfeflerbaum A. Similar extent of brain dysmorphology in women and men with schizophrenia, Am J Psychiatry, 1997;154:819-825.
5. Lim KO, Tew W, Kushner M, Chow K, Matsumoto B, DeLisi LE, Cortical gray matter volume deficit in patients with first-episode schizophrenia. Am J Psychiatry. 1996;153:1548-1553.
6. Schlaepfer TE, Harris GJ, Tien AY. Peng LW, Lee S, Federman EB. Chase GA, Barta PE, Pearlson GD, Decreased regional cortical gray matter volume in schizophrenia. Am J Psychiatry. 1994;151:842-848.
7. Harvey I, Ron M, du Bouley G, Wicks D, Lewis S, Murray RM. Reduction of cortical volume in schizophrenia on magnetic resonance imaging. Psychol Med. 1993;23:591-604.
8. Woods BT, Yurgelun-Todd D, Goldstein JM, Seidman LJ, Tsuang MT, MRI brain abnormalities in chronic schizophrenia: one process or more? Biol Psychiatry. 1996;40:585-596.
9. Marsh L, Suddath RL, Higgins N, Weinberger DR, Medial temporal lobe structures in schizophrenia: relationship of size to duration of illness. Schizophr Res. 1994;11:225-238.
10. Pfefferbaum A, Mathalon DH, Sullivan EV, Rawles JM, Zipursky RB, Lim KO. A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Arch Neurol. 1994;51:874-887.
11. Weinberger DR. Implications of normal brain development for the pathogenesis of schizophrenia, Arch Gen Psychiatry, 1987;44:660-669.
12. Andrew ER, Bydder G, Griffiths J, Iles R, Styles P. Clinical Magnetic Resonance: Imaging and Spectroscopy. New York, NY: John Wiley & Sons Inc; 1990.
13. Bottomley PA. Human in vivo NMR Spectroscopy in diagnostic medicine: clinical tool or research probe? Radiology. 1989;170:1-15.
14. Miller BL. A review of chemical issues in 'H NMR Spectroscopy: N-acetyl-Laspartate, creatine and choline. NMR Biomed. 1991;4:47-52.
15. Urenjak J, Williams SR, Gadian DG, Noble M, Proton nuclear magnetic resonance Spectroscopy unambiguously identifies different neural cell types. J Neurosci. 1993;13:981-989.
16. Urenjak J, Williams SR, Gadian DG, Noble M. Specific expression of Nacetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro. J Neurochem. 1992;59:55-61.
17. Kwo-On-Yuen PF, Newmark RD, Budinger TF, Kaye JA, Ball MJ, Jagust WJ. Brain N-acetyl-aspartic acid in Alzheimer's disease: a proton magnetic resonance Spectroscopy study, Brain Res. 1994;667:167-174.
18. Barker PB, Lee RR, McArthur JC. AIDS dementia complex: evaluation with proton MR spectroscopic imaging. Radiology. 1995;195:58-64.
19. Stanley JA, Wiliiamson PC, Drost DJ, Rylett RJ, Carr TJ, Malla A, Thompson RT. An in vivo proton magnetic resonance Spectroscopy study of schizophrenia patients. Schizophr Bull. 1996;22:597-609.
20. Nasrallah HA, Skinner TE, Schmalbrock P, Robitaille PM. Proton magnetic resonance Spectroscopy ('H MRS) of the hippocampal formation in schizophrenia: a pilot study, Br J Psychiatry. 1994;165:481-485.
21. Fujimoto T, Nakano T, Takano T, Takeuchi K, Yamada K, Fukuzako T, Akimoto H. Proton magnetic resonance Spectroscopy of basal ganglia in chronic schizophrenia. Biol Psychiatry. 1996;40:14-18.
22. Yurgelun-Todd DA, Renshaw PF, Gruber SA, Ed M, Waternaux C, Cohen BM. Proton magnetic resonance Spectroscopy of the temporal lobes in schizophrenics and normal controls. Schizophr Res. 1996;19:55-59.
23. Maier M, Ron MA, Barker GJ, Tofts PS. Proton magnetic resonance Spectroscopy: an in vivo method of estimating hippocampal neuronal depletion in schizophrenia, Psychol Med. 1995;25:1201-1209.
24. Fukuzako H, Takeuchi K, Hokazono Y, Fukuzako T, Yamada K, Hashiguchi T, Obo Y, Ueyama K, Takigawa M, Fujimoto T, Proton magnetic resonance Spectroscopy of the left medial temporal and frontal lobes in chronic schizophrenia: preliminary report. Psychiatry Res Neuroimaging. 1995;61:193-200.
25. Bertolino A, Nawroz S, Mattay VS, Barnett AS, Duyn JH, Moonen CTW, Frank JA, Tedeschi G, Weinberger DR, Regionally specific pattern of neurochemical pathology in schizophrenia as assessed by multlslice proton magnetic resonance spectroscopic imaging. Am J Psychiatry. 1996;153:1554-1563.
26. Renshaw P, Yurgelun-Todd DA, Tohen M, Gruber S, Cohen BM. Temporal lobe proton magnetic resonance Spectroscopy of patients with first-episode psychosis, Am J Psychiatry. 1995;152:444-446.
27. Lim KO, Pfefferbaum A. Segmentation of MR brain images into cerebrosplnal fluid spaces, white and gray matter, J Comput Assist Tomogr. 1989;13:588-593.
28. Woods RP, Cherry SR, Mazziotta JC. Rapid automated algorithm for aligning and reslicing PET images. J Comput Assist Tomogr. 1992;16:620-633.
29. Hetherington HP, Pan JW, Mason GF, Adams D, Vaughn MJ, Tweig DB, Pohost GM. Quantitative 'H spectroscopic imaging of human brain at 4.1 T using image segmentation, Magn Reson Med. 1996;36:21-29.
30. Michaelis T, Merboldt KD, Brunn H, Hanicke W, Frahm J. Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra, Radiology, 1993;187:219-227.
31. Doyle TJ, Beddell BJ. Narayana PA. Relative concentration of proton MR visible neurochemicals in gray and white matter in human brain. Magn Reson Med. 1995;33:755-759.
32. Kreis R, Ernst T, Ross BD. Absolute quantitation of water and metabolites in the human brain, II: metabolite concentrations. J Magn Reson. 1993;B102:9-19.
33. Soher BJ, van Zijl PCM, Duyn JH, Barker PB. Quantitative proton MR spectroscopic imaging of the human brain. Magn Reson Med. 1996;35:356-363.
34. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, DC: American Psychiatric Association:1994.
35. Overall JE, Gorham DR. The Brief Psychiatric Rating Scale (BPRS): recent developments in ascertainment and scaling. Psychopharmacol Bull. 1988;24:97-99.
36. Nelson HE. The National Adult Reading Test (MART). Windsor, Ontario: Nelson Publishing Co; 1982.
37. Hollingshead A. Redlich F. Social Class and Mental IIIness. New York, NY: John Wiley & Sons Inc; 1958.
38. Pfefferbaum A, Lim KO, Zipursky RB, Mathalon DH, Lane B, Ha CN, Rosenbloom MJ, Sullivan EV, Brain gray and white matter volume loss accelerates with aging in chronic alcoholics: a quantitative MRI study. Alcohol Clin Exp Res. 1992;16:1078-1089.
39. Mathalon DH. Sullivan EV, Rawles JM, Pfefferbaum A, Correction for head size in brain-imaging measurements. Psychiatry Res: Neuroimaging. 1993;50:121-139.
40. Sullivan EV, Marsh L, Mathalon DH, Lim KO, Pfefferbaum A. Age-related decline in MRI volumes of temporal lobe gray matter but not hippocampus, Neurobiol Aging. 1995;16:591-606.
41. Lim KO, Beal M, Harvey RL Jr, Myers T. Lane B, Sullivan EV, Faustman WO, Pfefferbaum A. Brain dysmorphology in adults with congenital rubella plus schizophrenia-like symptoms. Biol Psychiatry. 1995;37:764-776.
42. Webb P, Macovski A, Rapid, fully-automatic, arbitrary volume, in-vivo shimming. Magn Reson Med. 1991;20:113-122.
43. Spielman D, Adalsteinsson E, Lim KO. Quantitative analysis of improved homogeneity using linear versus higher order shims for CSF of the brain. Paper presented at: Fifth Scientific Meeting of the International Society for Magnetic Resonance in Medicine; April 12-18, 1997; Vancouver, British Columbia.
44. Adalsteinsson E, Irarrazabal P, Spielman DM, Macovski A, Three-dimensional spectroscopic imaging with time-varying gradients. Magn Reson Med. 1995;33:461-466.
45. Spielman D, Pauly J, Macovski A, Glover G, Enzmann D. Lipid-suppressed single-and multisection proton spectroscopic imaging of the human brain, J Magn Reson imaging. 1992;2:253-262.
46. 1H spectroscopic imaging using a spectral-spatial excitation pulse. Magn Reson Med. 1991;18:269-279.
47. Kittler J, Illingworth J.Minimum error thresholding. Pattern Recognition. 1986;19: 41-47.
48. Otsu N. Athreshold selection method from gray-level histograms. IEEE Trans (SMC). 1979;9:63-66.
49. Lim KO, Zipursky RB, Watts MC, Pfefferbaum A. Decreased grey matter in normal aging: an In vivo magnetic resonance study, J Gerontol. 1992;47:B26-B30.
50. Lim KO, Spielman DM, Estimating NAA In cortical gray matter with applications for measuring changes due to aging. Magn Reson Med. 1997;37:372-377.
51. Koller KJ, Zaczek R, Coyle JT. N-acetyl-aspartyl-glutamate: regional levels in rat brain and the effects of brain lesions as determined by a new HPLC method. J Neurochem. 1984;43:1136-1142.
52. Narayana PA, Fotedar LK, Jackson EF, Bohan TP, Butler U, Wolinsky JS, Regional in vivo proton magnetic resonance spectroscopy of brain. J Magn Reson. 1989;83:44-52.
53. Tedeschi G, Bertolino A, Righini A, Campbell G, Raman R, Duyn JH, Moonen CTW, Alger JR, Di Chiro G. Brain regional distribution pattern of metabolite signal intensities in young adults by proton magnetic resonance spectroscopic Imaging. Neurology. 1995;45:1384-1391.
54. Pakkenberg B. Total nerve cell number in neocortex in chronic schizophrenics and controls estimated using optical dissectors. Biol Psychiatry. 1993;34:768-772.
55. Selemon LD, Rajkowska G, Goldman-Rakic PS. Abnormally high neuronal density in the schizophrenic cortex: a morphometric analysis of prefrontal area 9 and occipital area 17, Aren Gen Psychiatry. 1995;52:805-818.
56. Rajkowska G, Selemon LD, Goldman-Rakic PS. Reduction in neuronal size in prefrontal cortex of schizophrenics and Huntington patients [abstract]. Abstract presented at: 24th Annual Meeting of Society for Neuroscience; November 13-18,1994; Miami Beach, Fla.
57. Pearlson GD, Petty RG, Ross CA, Tien AY, Schizophrenia: a disease of heteromodal association cortex? Neuropsychopharmacology. 1996;14:1-17.
58. McGuire PK, Frith CD. Disordered functional connectivity in schizophrenia. Psychol Med. 1996;26:663-667.
59. Fristen KJ. Theoretical neurobiology and schizophrenia. Br Med Bull. 1996;52:644-655.
60. Andreasen NC, Arndt S, Swayze V, Clzadlo T, Flaum M, Oleary D, Ehrhardt JC, Yuh WTC. Thalamic abnormalities in schizophrenia visualized through magnetic resonance image averaging, Science. 1994;266:294-298.
61. Akbarian S, Kim JJ, Potkin SG, Hetrick WP, Bunney WE, Jones EG. Maldistribution of interstitial neurons in prefrontal white matter of the brains of schizophrenic patients, Arch Gen Psychiatry. 1996;53:425-436.