Reactive oxygen species induced by p66Shc longevity protein mediate nongenomic androgen action via tyrosine phosphorylation signaling to enhance tumorigenicity of prostate cancer cells

Free Radical Biology and Medicine

Volumn 53, Issue 1, 2012, Pages 95-108

  Veeramani, Suresh ^a   Chou, Yu Wei ^a   Lin, Frank C ^a   Muniyan, Sakthivel ^a   Lin, Fen Fen ^a   Kumar, Satyendra ^a   Xie, Yan ^c   Lele, Subodh M ^a   Tu, Yaping ^c   Lin, Ming Fong ^a,b,d  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Androgen; Free radicals; p66Shc; Reactive oxygen species; Tyrosine phosphorylation

Indexed keywords

ACID PHOSPHATASE PROSTATE ISOENZYME; ANDROGEN; COMPLEMENTARY DNA; EPIDERMAL GROWTH FACTOR RECEPTOR 2; MUTANT PROTEIN; PROTEIN P66; PROTEIN SHC; PROTEIN TYROSINE PHOSPHATASE; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER GROWTH; CARCINOGENICITY; CELL PROLIFERATION; CONTROLLED STUDY; DNA TRANSFECTION; ENZYME ACTIVITY; FEMALE; HUMAN; MALE; MOUSE; NONHUMAN; OXIDATION; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT;

ANDROGENS; ANIMALS; BLOTTING, WESTERN; CELL PROLIFERATION; HUMANS; HYDROGEN PEROXIDE; IMMUNOENZYME TECHNIQUES; IMMUNOPRECIPITATION; LONGEVITY; MALE; MICE; OXIDANTS; OXIDATION-REDUCTION; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN TYROSINE PHOSPHATASES; PROTEIN-TYROSINE KINASES; REACTIVE OXYGEN SPECIES; SHC SIGNALING ADAPTOR PROTEINS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TYROSINE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ANIMALIA;

EID: 84861608177     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.03.024     Document Type: Article

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