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Volumn 49, Issue 2, 1998, Pages 119-128

Constitutively tyrosine phosphorylated p52 Shc in breast cancer cells: Correlation with ErbB2 and p66 Shc expression

Author keywords

Breast cancer; EGFR; ErbB2; Phosphotyrosine; Shc; Signal transduction

Indexed keywords

PHOSPHOPROTEIN; PROTEIN; PROTEIN P52; PROTEIN P66; UNCLASSIFIED DRUG;

EID: 0031812342     PISSN: 01676806     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006007227747     Document Type: Article
Times cited : (36)

References (59)
  • 1
    • 0030968146 scopus 로고    scopus 로고
    • Recognition of activated CSF-1 receptor in breast carcinomas by a tyrosine 723 phosphospecific antibody
    • Flick MB, Sapi E, Perrotta PL, Maher MG, Halaban R, Carter D, Kacinski BM: Recognition of activated CSF-1 receptor in breast carcinomas by a tyrosine 723 phosphospecific antibody. Oncogene 14: 2553-2561, 1997
    • (1997) Oncogene , vol.14 , pp. 2553-2561
    • Flick, M.B.1    Sapi, E.2    Perrotta, P.L.3    Maher, M.G.4    Halaban, R.5    Carter, D.6    Kacinski, B.M.7
  • 3
    • 0026696081 scopus 로고
    • Expression of basic fibroblast growth factor, FGFR1 and FGFR2 in normal and malignant human breast, and comparison with other normal tissues
    • Luqmani YA, Graham M, Coombes RC: Expression of basic fibroblast growth factor, FGFR1 and FGFR2 in normal and malignant human breast, and comparison with other normal tissues. Br J Cancer 66: 273-280, 1992
    • (1992) Br J Cancer , vol.66 , pp. 273-280
    • Luqmani, Y.A.1    Graham, M.2    Coombes, R.C.3
  • 4
    • 0030054076 scopus 로고    scopus 로고
    • Coexpression of hepatocyte growth factor and receptor (Met) in human breast carcinoma
    • Tuck AB, Park M, Sterns EE, Boag A, Elliott BE: Coexpression of hepatocyte growth factor and receptor (Met) in human breast carcinoma. Am J Pathol 148: 225-232, 1996
    • (1996) Am J Pathol , vol.148 , pp. 225-232
    • Tuck, A.B.1    Park, M.2    Sterns, E.E.3    Boag, A.4    Elliott, B.E.5
  • 5
    • 15644378821 scopus 로고    scopus 로고
    • Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells
    • Kannan S, De Santis M, Lohmeyer M et al.: Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells. J Biol Chem 272: 3330-3335, 1997
    • (1997) J Biol Chem , vol.272 , pp. 3330-3335
    • Kannan, S.1    De Santis, M.2    Lohmeyer, M.3
  • 6
    • 0028884216 scopus 로고
    • Growth factors in breast cancer
    • Dickson RB, Lippman ME: Growth factors in breast cancer. Endocr Rev 16: 559-589, 1995
    • (1995) Endocr Rev , vol.16 , pp. 559-589
    • Dickson, R.B.1    Lippman, M.E.2
  • 7
    • 0029015913 scopus 로고
    • Coexpression of the c-kit and stem cell factor genes in breast carcinomas
    • Hines SJ, Organ C, Kornstein MJ, Krystal GW: Coexpression of the c-kit and stem cell factor genes in breast carcinomas. Cell Growth Differ 6: 769-779, 1995
    • (1995) Cell Growth Differ , vol.6 , pp. 769-779
    • Hines, S.J.1    Organ, C.2    Kornstein, M.J.3    Krystal, G.W.4
  • 9
    • 0028176477 scopus 로고
    • A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling
    • Carraway KL, Cantley LC: A neu acquaintance for ErbB3 and ErbB4: a role for receptor heterodimerization in growth signaling. Cell 78: 5-8, 1994
    • (1994) Cell , vol.78 , pp. 5-8
    • Carraway, K.L.1    Cantley, L.C.2
  • 10
    • 0030614530 scopus 로고    scopus 로고
    • Dimerization of the p185neu transmembrane domain is necessary but not sufficient for transformation
    • Burke CL, Lemmon MA, Coren BA, Engelman DM, Stern DF: Dimerization of the p185neu transmembrane domain is necessary but not sufficient for transformation. Oncogene 14: 687-696, 1997
    • (1997) Oncogene , vol.14 , pp. 687-696
    • Burke, C.L.1    Lemmon, M.A.2    Coren, B.A.3    Engelman, D.M.4    Stern, D.F.5
  • 11
    • 0029021518 scopus 로고
    • Heterodimerization and functional interaction between EGF receptor family members: A new signaling paradigm with implications for breast cancer research
    • Earp HS, Dawson TL, Li X, Yu H: Heterodimerization and functional interaction between EGF receptor family members: a new signaling paradigm with implications for breast cancer research. Breast Cancer Res Treat 35: 115-132, 1995
    • (1995) Breast Cancer Res Treat , vol.35 , pp. 115-132
    • Earp, H.S.1    Dawson, T.L.2    Li, X.3    Yu, H.4
  • 13
    • 37049183697 scopus 로고
    • Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
    • Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL: Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235: 177-182, 1987
    • (1987) Science , vol.235 , pp. 177-182
    • Slamon, D.J.1    Clark, G.M.2    Wong, S.G.3    Levin, W.J.4    Ullrich, A.5    McGuire, W.L.6
  • 14
    • 0027548648 scopus 로고
    • Amplification and overexpression of the ErbB-2 gene in human tumors: Its involvement in tumor development, significance as a prognostic factor, and potential as a target for cancer therapy
    • Hynes N: Amplification and overexpression of the ErbB-2 gene in human tumors: its involvement in tumor development, significance as a prognostic factor, and potential as a target for cancer therapy. Sem Cancer Biol 4: 19-26, 1993
    • (1993) Sem Cancer Biol , vol.4 , pp. 19-26
    • Hynes, N.1
  • 15
    • 0025279110 scopus 로고
    • How to use prognostic factors in axillary node-negative breast cancer patients
    • McGuire W, Tandon A, Allred D, Chamness G, Clark G: How to use prognostic factors in axillary node-negative breast cancer patients. J Natl Cancer Inst 82: 1006-1012, 1990
    • (1990) J Natl Cancer Inst , vol.82 , pp. 1006-1012
    • McGuire, W.1    Tandon, A.2    Allred, D.3    Chamness, G.4    Clark, G.5
  • 16
    • 0027207581 scopus 로고
    • Induction of epithelial abnormalities that resemble human breast lesions by the expression of the neu/erbB-2 oncogene in reconstituted mouse mammary gland
    • Bradbury J, Arno J, Edwards P: Induction of epithelial abnormalities that resemble human breast lesions by the expression of the neu/erbB-2 oncogene in reconstituted mouse mammary gland. Oncogene 8: 1551-1558, 1993
    • (1993) Oncogene , vol.8 , pp. 1551-1558
    • Bradbury, J.1    Arno, J.2    Edwards, P.3
  • 17
    • 0023430930 scopus 로고
    • Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH3T3 cells
    • Hudziak R, Schlessinger J, Ullrich A: Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH3T3 cells. Proc Natl Acad Sci 84: 7159-7163, 1987
    • (1987) Proc Natl Acad Sci , vol.84 , pp. 7159-7163
    • Hudziak, R.1    Schlessinger, J.2    Ullrich, A.3
  • 18
    • 0026472124 scopus 로고
    • Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease
    • Guy C, Webster M, Schaller M, Parsons T, Cardiff R, Muller W: Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc Natl Acad Sci 89: 10578-10582, 1992
    • (1992) Proc Natl Acad Sci , vol.89 , pp. 10578-10582
    • Guy, C.1    Webster, M.2    Schaller, M.3    Parsons, T.4    Cardiff, R.5    Muller, W.6
  • 21
    • 0028000009 scopus 로고
    • Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2
    • Janes PW, Daly RJ, deFazio A, Sutherland RL: Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2. Oncogene 9: 3601-3608, 1994
    • (1994) Oncogene , vol.9 , pp. 3601-3608
    • Janes, P.W.1    Daly, R.J.2    DeFazio, A.3    Sutherland, R.L.4
  • 22
    • 0029584473 scopus 로고
    • Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/ Neu
    • Xie Y, Pendergast AM, Hung MC: Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/ Neu. J Biol Chem 270: 30717-30724, 1995
    • (1995) J Biol Chem , vol.270 , pp. 30717-30724
    • Xie, Y.1    Pendergast, A.M.2    Hung, M.C.3
  • 24
    • 0027910431 scopus 로고
    • Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation
    • see comments
    • Egan SE, Giddings BW, Brooks MW, Buday L, Sizeland AM, Weinberg RA: Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation [see comments]. Nature 363: 45-51, 1993
    • (1993) Nature , vol.363 , pp. 45-51
    • Egan, S.E.1    Giddings, B.W.2    Brooks, M.W.3    Buday, L.4    Sizeland, A.M.5    Weinberg, R.A.6
  • 27
    • 0028859279 scopus 로고
    • Protein modules and signalling networks
    • Pawson T: Protein modules and signalling networks. Nature 373: 573-580, 1995
    • (1995) Nature , vol.373 , pp. 573-580
    • Pawson, T.1
  • 28
    • 0028568639 scopus 로고
    • A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors
    • Blaikie P, Immanuel D, Wu J, Li N, Yajnik V, Margolis B: A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors. J Biol Chem 269: 32031-32034, 1994
    • (1994) J Biol Chem , vol.269 , pp. 32031-32034
    • Blaikie, P.1    Immanuel, D.2    Wu, J.3    Li, N.4    Yajnik, V.5    Margolis, B.6
  • 29
    • 0028596158 scopus 로고
    • An alternative to SH2 domains for binding tyrosine-phosphorylated proteins
    • Kavanaugh WM, Williams LT: An alternative to SH2 domains for binding tyrosine-phosphorylated proteins. Science 266: 1862-1865, 1994
    • (1994) Science , vol.266 , pp. 1862-1865
    • Kavanaugh, W.M.1    Williams, L.T.2
  • 30
    • 0028040812 scopus 로고
    • Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor
    • Batzer AG, Rotin D, Urena JM, Skolnik EY, Schlessinger J: Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor. Mol Cell Biol 14: 5192-5201, 1994
    • (1994) Mol Cell Biol , vol.14 , pp. 5192-5201
    • Batzer, A.G.1    Rotin, D.2    Urena, J.M.3    Skolnik, E.Y.4    Schlessinger, J.5
  • 31
    • 0028888604 scopus 로고
    • The PTB domain: A new protein module implicated in signal transduction
    • Van der Geer P, Pawson T: The PTB domain: a new protein module implicated in signal transduction. Trends Biochem Sci 20: 277-280, 1995
    • (1995) Trends Biochem Sci , vol.20 , pp. 277-280
    • Van Der Geer, P.1    Pawson, T.2
  • 32
    • 0029640799 scopus 로고
    • A phosphotyrosine interaction domain
    • Bork P, Margolis B: A phosphotyrosine interaction domain. Cell 80: 693-694, 1995
    • (1995) Cell , vol.80 , pp. 693-694
    • Bork, P.1    Margolis, B.2
  • 33
    • 0027934261 scopus 로고
    • Formation of Shc-Grb2 complexes is necessary to induce neoplastic tranformation by overexpression of Shc proteins
    • Salcini AE, McGlade J, Pelicci G, Nicoletti I, Pawson T, Pelicci PG: Formation of Shc-Grb2 complexes is necessary to induce neoplastic tranformation by overexpression of Shc proteins. Oncogene 9: 2827-2836, 1994
    • (1994) Oncogene , vol.9 , pp. 2827-2836
    • Salcini, A.E.1    McGlade, J.2    Pelicci, G.3    Nicoletti, I.4    Pawson, T.5    Pelicci, P.G.6
  • 35
    • 0026608178 scopus 로고
    • C. elegans cell signalling gene Sem-5 encodes a protein with SH2 and SH3 domains
    • Clark S, Stern M, Horovitz H: C. elegans cell signalling gene Sem-5 encodes a protein with SH2 and SH3 domains. Nature 356: 593-600, 1992
    • (1992) Nature , vol.356 , pp. 593-600
    • Clark, S.1    Stern, M.2    Horovitz, H.3
  • 37
    • 0027153103 scopus 로고
    • Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adaptor protein, and Sos nucleotide exchange factor
    • Buday L, Downward J: Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adaptor protein, and Sos nucleotide exchange factor. Cell 73: 611-620, 1993
    • (1993) Cell , vol.73 , pp. 611-620
    • Buday, L.1    Downward, J.2
  • 38
    • 0027288587 scopus 로고
    • The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: Implications for insulin control of ras signalling
    • Skolnik EY, Lee CH, Batzer A, Vicentini LM, Zhou M, Daly R, Myers MJ Jr, Backer JM, Ullrich A, White MF et al.: The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. EMBO J 12: 1929-1936, 1993
    • (1993) EMBO J , vol.12 , pp. 1929-1936
    • Skolnik, E.Y.1    Lee, C.H.2    Batzer, A.3    Vicentini, L.M.4    Zhou, M.5    Daly, R.6    Myers Jr., M.J.7    Backer, J.M.8    Ullrich, A.9    White, M.F.10
  • 39
    • 0027294981 scopus 로고
    • The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1
    • see comments
    • Rozakis-Adcock M, Fernley R, Wade J, Pawson T, Bowtell D: The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1 [see comments]. Nature 363: 83-85, 1993
    • (1993) Nature , vol.363 , pp. 83-85
    • Rozakis-Adcock, M.1    Fernley, R.2    Wade, J.3    Pawson, T.4    Bowtell, D.5
  • 40
    • 0028605310 scopus 로고
    • The signaling pathway coupling epidermal growth factor receptors to activation of p21ras
    • Sasaoka T, Langlois WJ, Leitner JW, Draznin B, Olefsky JM: The signaling pathway coupling epidermal growth factor receptors to activation of p21ras. J Biol Chem 269: 32621-32625, 1994
    • (1994) J Biol Chem , vol.269 , pp. 32621-32625
    • Sasaoka, T.1    Langlois, W.J.2    Leitner, J.W.3    Draznin, B.4    Olefsky, J.M.5
  • 41
    • 0030043293 scopus 로고    scopus 로고
    • Type 1 receptor tyrosine kinases are differentially phosphorylated in mammary carcinoma and differentially associated with steroid receptors
    • Bacus SS, Chin D, Yarden Y, Zelnick CR, Stern DF: Type 1 receptor tyrosine kinases are differentially phosphorylated in mammary carcinoma and differentially associated with steroid receptors. Am J Pathol 148: 549-558, 1996
    • (1996) Am J Pathol , vol.148 , pp. 549-558
    • Bacus, S.S.1    Chin, D.2    Yarden, Y.3    Zelnick, C.R.4    Stern, D.F.5
  • 42
    • 0027536097 scopus 로고
    • Demonstration of ligand-dependent signalling by the erbB-3 tyrosine kinase and its constitutive activation in human breast tumor cells
    • Kraus M, Fedi P, Starks V, Muraro R, Aaronson S: Demonstration of ligand-dependent signalling by the erbB-3 tyrosine kinase and its constitutive activation in human breast tumor cells. Proc Natl Acad Sci 90: 2900-2904, 1993
    • (1993) Proc Natl Acad Sci , vol.90 , pp. 2900-2904
    • Kraus, M.1    Fedi, P.2    Starks, V.3    Muraro, R.4    Aaronson, S.5
  • 43
    • 0028290891 scopus 로고
    • The neu-oncogene: Signal transduction pathways, transformation mechanisms and evolving therapies
    • Dougall WC, Qian X, Peterson NC, Miller MJ, Samanta A, Greene MI: The neu-oncogene: signal transduction pathways, transformation mechanisms and evolving therapies. Oncogene 9: 2109-2123, 1994
    • (1994) Oncogene , vol.9 , pp. 2109-2123
    • Dougall, W.C.1    Qian, X.2    Peterson, N.C.3    Miller, M.J.4    Samanta, A.5    Greene, M.I.6
  • 44
    • 0028670125 scopus 로고
    • The biology of erbB-2/neu/HER-2 and its role in cancer
    • Hynes NE, Stern DF: The biology of erbB-2/neu/HER-2 and its role in cancer. Biochim Biophys Acta 1198: 165-184, 1994
    • (1994) Biochim Biophys Acta , vol.1198 , pp. 165-184
    • Hynes, N.E.1    Stern, D.F.2
  • 45
    • 0025343230 scopus 로고
    • Signal transduction by receptors with tyrosine kinase activity
    • Ullrich A, Schlessinger J: Signal transduction by receptors with tyrosine kinase activity. Cell 61: 203-212, 1990
    • (1990) Cell , vol.61 , pp. 203-212
    • Ullrich, A.1    Schlessinger, J.2
  • 47
    • 0028234532 scopus 로고
    • Recombinant human betacellulin. Molecular structure, biological activities, and receptor interaction
    • Watanabe T, Shintani A, Nakata M, Shing Y, Folkman J, Igarashi K, Sasada R: Recombinant human betacellulin. Molecular structure, biological activities, and receptor interaction. J Biol Chem 269: 9966-9973, 1994
    • (1994) J Biol Chem , vol.269 , pp. 9966-9973
    • Watanabe, T.1    Shintani, A.2    Nakata, M.3    Shing, Y.4    Folkman, J.5    Igarashi, K.6    Sasada, R.7
  • 48
    • 0027935422 scopus 로고
    • Epidermal growth factor receptors in human breast carcinoma cells: A potential selective target for transforming growth factor alpha-Pseudomonas exotoxin 40 fusion protein
    • Arteaga CL, Hurd SD, Dugger TC, Winnier AR, Robertson JB: Epidermal growth factor receptors in human breast carcinoma cells: a potential selective target for transforming growth factor alpha-Pseudomonas exotoxin 40 fusion protein. Cancer Res 54: 4703-4709, 1994
    • (1994) Cancer Res , vol.54 , pp. 4703-4709
    • Arteaga, C.L.1    Hurd, S.D.2    Dugger, T.C.3    Winnier, A.R.4    Robertson, J.B.5
  • 49
    • 0029023438 scopus 로고
    • Tyrosine phosphorylation of Shc proteins and formation of Shc/Grb2 complex correlate to the transformation of NIH3T3 cells mediated by the point-mutation activated neu
    • Xie Y, Li K, Hung MC: Tyrosine phosphorylation of Shc proteins and formation of Shc/Grb2 complex correlate to the transformation of NIH3T3 cells mediated by the point-mutation activated neu. Oncogene 10: 2409-2413, 1995
    • (1995) Oncogene , vol.10 , pp. 2409-2413
    • Xie, Y.1    Li, K.2    Hung, M.C.3
  • 52
    • 0028968949 scopus 로고
    • Tyrosine kinase inhibition: An approach to drug development
    • Levitzki A, Gazit A: Tyrosine kinase inhibition: an approach to drug development. Science 267: 1782-1788, 1995
    • (1995) Science , vol.267 , pp. 1782-1788
    • Levitzki, A.1    Gazit, A.2
  • 53
    • 0030071724 scopus 로고    scopus 로고
    • Effects of tyrosine kinase inhibitors on the proliferation of human breast cancer cell lines and proteins important in the Ras signaling pathway
    • Clark JW, Santos-Moore A, Stevenson LE, Frackelton AR Jr: Effects of tyrosine kinase inhibitors on the proliferation of human breast cancer cell lines and proteins important in the Ras signaling pathway. Int J Cancer 65: 186-191, 1996
    • (1996) Int J Cancer , vol.65 , pp. 186-191
    • Clark, J.W.1    Santos-Moore, A.2    Stevenson, L.E.3    Frackelton Jr., A.R.4
  • 54
    • 0028937151 scopus 로고
    • Activation state-specific monoclonal antibody detects tyrosine phosphorylated p185neu/ erbB-2 in a subset of human breast tumors overexpressing this receptor
    • DiGiovanna MP, Stern DF: Activation state-specific monoclonal antibody detects tyrosine phosphorylated p185neu/ erbB-2 in a subset of human breast tumors overexpressing this receptor. Cancer Res 55: 1946-1955, 1995
    • (1995) Cancer Res , vol.55 , pp. 1946-1955
    • DiGiovanna, M.P.1    Stern, D.F.2
  • 55
    • 0029162564 scopus 로고
    • Heregulin-dependent regulation of HER2/neu oncogenic signalling by heterodimerization with HER3
    • Wallasch C, Weiss FU, Niederfellner G, Jallal B, Issing W, Ullrich A: Heregulin-dependent regulation of HER2/neu oncogenic signalling by heterodimerization with HER3. EMBO J 14: 4267-4275, 1995
    • (1995) EMBO J , vol.14 , pp. 4267-4275
    • Wallasch, C.1    Weiss, F.U.2    Niederfellner, G.3    Jallal, B.4    Issing, W.5    Ullrich, A.6
  • 57
    • 0028048206 scopus 로고
    • FGF2 as an autocrine growth factor for immortal human breast epithelial cells
    • Souttou B, Hamelin R, Crepin M: FGF2 as an autocrine growth factor for immortal human breast epithelial cells. Cell Growth Differ 5: 615-623, 1994
    • (1994) Cell Growth Differ , vol.5 , pp. 615-623
    • Souttou, B.1    Hamelin, R.2    Crepin, M.3
  • 58
    • 0030946366 scopus 로고    scopus 로고
    • Hyperexpression of mitogen-activated protein kinase in human breast cancer
    • Sivaraman V, Wang H, Nuovo G, Malbon C: Hyperexpression of mitogen-activated protein kinase in human breast cancer. J Clin Invest 99: 1478-1483, 1997
    • (1997) J Clin Invest , vol.99 , pp. 1478-1483
    • Sivaraman, V.1    Wang, H.2    Nuovo, G.3    Malbon, C.4
  • 59
    • 0027934898 scopus 로고
    • Overexpression of the Grb2 gene in human breast cancer cell lines
    • Daly RJ, Binder MD, Sutherland RL: Overexpression of the Grb2 gene in human breast cancer cell lines. Oncogene 9: 2723-2727, 1994
    • (1994) Oncogene , vol.9 , pp. 2723-2727
    • Daly, R.J.1    Binder, M.D.2    Sutherland, R.L.3


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