Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment

Nature Cell Biology

Volumn 14, Issue 6, 2012, Pages 593-603

  Varma, Dileep ^a   Chandrasekaran, Srikripa ^b   Sundin, Lynsie J R ^c   Reidy, Karen T ^a   Wan, Xiaohu ^a   Chasse, Dawn A D ^d   Nevis, Kathleen R ^e   Deluca, Jennifer G ^c   Salmon, E D ^a   Cook, Jeanette Gowen ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c Veterinary Dentistry and Oral Surgery   (United States)

^d DUKE UNIVERSITY MEDICAL CENTER   (United States)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NDC80 COMPLEX; PROTEIN HEC1; PROTEIN MAD1; REPLICATION LICENSING FACTOR CDT1; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CENTROMERE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; MICROTUBULE; MITOSIS; MUTATION; PRIORITY JOURNAL; PROMETAPHASE; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION;

AMINO ACID SEQUENCE; CELL CYCLE CHECKPOINTS; CELL CYCLE PROTEINS; HELA CELLS; HUMANS; KINETOCHORES; MICROTUBULES; MITOSIS; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS;

EID: 84861602372     PISSN: 14657392     EISSN: 14764679     Source Type: Journal    
DOI: 10.1038/ncb2489     Document Type: Article

References (43)

1. DeLuca, J. G. et al. Kinetochore microtubule dynamics and attachment stability are regulated by Hec1. Cell 127, 969-982 (2006).
2. Cheeseman, I. M., Chappie, J. S., Wilson-Kubalek, E. M. & Desai, A. The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. Cell 127, 983-997 (2006). (Pubitemid 44792248)
3. Alushin, G. M. et al. The Ndc80 kinetochore complex forms oligomeric arrays along microtubules. Nature 467, 805-810 (2010).
4. Hsu, K. S. & Toda, T. Ndc80 internal loop interacts with Dis1/TOG to ensure proper kinetochore-spindle attachment in-ssion yeast. Curr. Biol. 21, 214-220 (2011).
5. Maure, J. F. et al. The Ndc80 loop region facilitates formation of kinetochore attachment to the dynamic microtubule plus end. Curr. Biol. 21, 207-213 (2011).
6. Machida, Y. J., Hamlin, J. L. & Dutta, A. Right place, right time, and only once: replication initiation in metazoans. Cell 123, 13-24 (2005). (Pubitemid 41414525)
7. Sclafani, R. A. & Holzen, T. M. Cell cycle regulation of DNA replication. Annu. Rev. Genet. 41, 237-280 (2007).
8. Snyder, M., He, W. & Zhang, J. J. The DNA replication factor MCM5 is essential for Stat1-mediated transcriptional activation. Proc. Natl Acad. Sci. USA 102, 14539-14544 (2005). (Pubitemid 41457093)
9. Fitch, M. J., Donato, J. J. & Tye, B. K. Mcm7, a subunit of the presumptive MCM helicase, modulates its own expression in conjunction with Mcm1. J. Biol. Chem. 278, 25408-25416 (2003). (Pubitemid 36835291)
10. Clay-Farrace, L., Pelizon, C., Santamaria, D., Pines, J. & Laskey, R. A. Human replication protein Cdc6 prevents mitosis through a checkpoint mechanism that implicates Chk1. EMBO J. 22, 704-712 (2003). (Pubitemid 36193614)
11. Yoshida, K. et al. CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells. J. Cell Sci. 123, 225-235 (2010).
12. Tachibana, K. E., Gonzalez, M. A., Guarguaglini, G., Nigg, E. A. & Laskey, R. A. Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects. EMBO Rep. 6, 1052-1057 (2005). (Pubitemid 41637650)
13. Prasanth, S. G., Prasanth, K. V., Siddiqui, K., Spector, D. L. & Stillman, B. Human Orc2 localizes to centrosomes, centromeres and heterochromatin during chromosome inheritance. EMBO J. 23, 2651-2663 (2004). (Pubitemid 38988236)
14. Prasanth, S. G., Prasanth, K. V. & Stillman, B. Orc6 involved in DNA replication, chromosome segregation, and cytokinesis. Science 297, 1026-1031 (2002). (Pubitemid 34856038)
15. Feng, D., Tu, Z., Wu, W. & Liang, C. Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells. Cancer Res 63, 7356-7364 (2003). (Pubitemid 37413477)
16. Nevis, K. R., Cordeiro-Stone, M. & Cook, J. G. Origin licensing and p53 status regulate Cdk2 activity during G1. Cell Cycle 8, 1952-1963 (2009).
17. Nishitani, H., Taraviras, S., Lygerou, Z. & Nishimoto, T. The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase. J. Biol. Chem. 276, 44905-44911 (2001).
18. Chandrasekaran, S., Tan, T. X., Hall, J. R. & Cook, J. G. Stress-stimulated mitogen-activated protein kinases control the stability and activity of the Cdt1 DNA replication licensing factor. Mol. Cell. Biol. 31, 4405-4416 (2011).
19. Wohlschlegel, J. A. et al. Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science 290, 2309-2312 (2000). (Pubitemid 32041574)
20. McGarry, T. J. & Kirschner, M. W. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell 93, 1043-1053 (1998). (Pubitemid 28280797)
21. Maiorano, D., Moreau, J. & Mechali, M. XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis. Nature 404, 622-625 (2000). (Pubitemid 30205062)
22. Chen, S., de Vries, M. A. & Bell, S. P. Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading. Genes Dev. 21, 2897-2907 (2007). (Pubitemid 350133438)
23. Bernal, J. A. & Venkitaraman, A. R. A vertebrate N-end rule degron reveals that Orc6 is required in mitosis for daughter cell abscission. J. Cell Biol. 192, 969-978 (2011).
24. Leonhardt, H. et al. Dynamics of DNA replication factories in living cells. J. Cell Biol. 149, 271-280 (2000).
25. Meraldi, P., Draviam, V. M. & Sorger, P. K. Timing and checkpoints in the regulation of mitotic progression. Dev. Cell 7, 45-60 (2004). (Pubitemid 39172687)
26. Wan, X. et al. Protein architecture of the human kinetochore microtubule attachment site. Cell 137, 672-684 (2009).
27. Wei, R. R., Al-Bassam, J. & Harrison, S. C. The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment. Nat. Struct. Mol. Biol. 14, 54-59 (2007). (Pubitemid 46067423)
28. Guimaraes, G. J., Dong, Y., McEwen, B. F. & Deluca, J. G. Kinetochore-microtubule attachment relies on the disordered N-terminal tail domain of Hec1. Curr. Biol. 18, 1778-1784 (2008).
29. Miller, S. A., Johnson, M. L. & Stukenberg, P. T. Kinetochore attachments require an interaction between unstructured tails on microtubules and Ndc80(Hec1). Curr. Biol. 18, 1785-1791 (2008).
30. Cimini, D., Wan, X., Hirel, C. B. & Salmon, E. D. Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors. Curr. Biol. 16, 1711-1718 (2006). (Pubitemid 44691779)
31. Yang, Z., Tulu, U. S., Wadsworth, P. & Rieder, C. L. Kinetochore dynein is required for chromosome motion and congression independent of the spindle checkpoint. Curr. Biol. 17, 973-980 (2007). (Pubitemid 46829839)
32. Arias, E. E. & Walter, J. C. Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts. Genes Dev. 19, 114-126 (2005). (Pubitemid 40095821)
33. Nishitani, H. et al. Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis. EMBO J. 25, 1126-1136 (2006). (Pubitemid 43372125)
34. Devault, A. et al. Identi-cation of Tah11/Sid2 as the ortholog of the replication licensing factor Cdt1 in Saccharomyces cerevisiae. Curr. Biol. 12, 689-694 (2002). (Pubitemid 34315856)
35. Hofmann, J. F. & Beach, D. cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis. EMBO J. 13, 425-434 (1994).
36. Arentson, E. et al. Oncogenic potential of the DNA replication licensing protein CDT1. Oncogene 21, 1150-1158 (2002). (Pubitemid 34185231)
37. Liontos, M. et al. Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior. Cancer Res. 67, 10899-10909 (2007). (Pubitemid 350145919)
38. Ciferri, C. et al. Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex. Cell 133, 427-439 (2008). (Pubitemid 351622013)
39. Starr, D. A., Williams, B. C., Hays, T. S. & Goldberg, M. L. ZW10 helps recruit dynactin and dynein to the kinetochore. J. Cell Biol. 142, 763-774 (1998). (Pubitemid 28381493)
40. Varma, D., Monzo, P., Stehman, S. A. & Vallee, R. B. Direct role of dynein motor in stable kinetochore-microtubule attachment, orientation, and alignment. J. Cell Biol. 182, 1045-1054 (2008).
41. Cook, J. G., Chasse, D. A. & Nevins, J. R. The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells. J. Biol. Chem. 279, 9625-9633 (2004). (Pubitemid 38296031)
42. Maddox, P. S., Moree, B., Canman, J. C. & Salmon, E. D. Spinning disk confocal microscope system for rapid high-resolution, multimode,-uorescence speckle microscopy and green-uorescent protein imaging in living cells. Methods Enzymol. 360, 597-617 (2003). (Pubitemid 36207285)
43. James, P., Halladay, J. & Craig, E. A. Genomic libraries and a host strain designed for highly ef-cient two-hybrid selection in yeast. Genetics 144, 1425-1436 (1996).