Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure

Journal of Medicinal Chemistry

Volumn 49, Issue 11, 2006, Pages 3412-3415

  Tamamura, Hirokazu ^a   Ojida, Akio ^b   Ogawa, Teppei ^b   Tsutsumi, Hiroshi ^a   Masuno, Hiroyuki ^a   Nakashima, Hideki ^c   Yamamoto, Naoki ^d   Hamachi, Itaru ^b   Fujii, Nobutaka ^b  

^a Tokyo Medical and Dental University ^*  (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,1' [1,4 PHENYLENEBIS(METHYLENE)]BIS(1,4,8,11 TETRAAZACYCLOTETRADECANE); BIS(DIPICOLYLAMINE) PARA XYLENE ZINC; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; FC 131; KRH 1636; T 140; UNCLASSIFIED DRUG; ZINC COMPLEX;

ANTIVIRAL ACTIVITY; ARTICLE; CYTOPATHOGENIC EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR MODEL; MOLECULAR WEIGHT; NONHUMAN; RECEPTOR BINDING;

ANIMALS; ANTI-HIV AGENTS; CALCIUM; CELL LINE; CHELATING AGENTS; CRICETINAE; CRICETULUS; HIV-1; MODELS, MOLECULAR; ORGANOMETALLIC COMPOUNDS; PICOLINES; RADIOLIGAND ASSAY; RECEPTORS, CXCR4; ZINC;

EID: 33744830581     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060025u     Document Type: Article

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