Evidence that the serotonin transporter does not shift into the cytosol of remaining neurons after neonatal brain injury

Neuroscience Research

Volumn 73, Issue 3, 2012, Pages 252-256

  Wixey, Julie A ^a   Reinebrant, Hanna E ^a   Buller, Kathryn M ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Astrocytes; Hypoxia ischemia; Microglia; Neonate; Raph ; Serotonin transporter

Indexed keywords

SEROTONIN; SEROTONIN TRANSPORTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CAROTID ARTERY LIGATION; CELL MEMBRANE; CONTROLLED STUDY; CYTOSOL; GLIA CELL; HYPOXIC ISCHEMIC ENCEPHALOPATHY; NERVE CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT;

ANIMALS; ANIMALS, NEWBORN; CYTOSOL; DISEASE MODELS, ANIMAL; FEMALE; HYPOXIA, BRAIN; HYPOXIA-ISCHEMIA, BRAIN; MALE; NEURONS; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 84861577299     PISSN: 01680102     EISSN: 18728111     Source Type: Journal    
DOI: 10.1016/j.neures.2012.04.002     Document Type: Article

References (38)

1. Anderson P., Doyle L.W. Neurobehavioural outcomes of school-age children born extremely low birth weight or very preterm in the 1990. JAMA 2003, 289:3264-3272.
2. Bel N., Figueras G., Vilaro T., Sunol C., Artigas F. Antidepressant drugs inhibit a Gial 5-hydroxytryptamine transporter in rat brain. Eur. J. Neurosci. 1997, 9:1728-1738.
3. Blakely R.D., Berson H.E., Fremeau R.T., Caron M.G., Peek M.M., Prince H.K., Bradley C.C. Cloning and expression of a functional serotonin transporter from rat brain. Nature 1991, 354:66-70.
4. Buller K.M., Wixey J.A., Pathipati P., Carty M., Colditz P.B., Williams C.E., Scheepens A. Selective losses of brainstem catecholamine neurons after hypoxia-ischemia in the immature rat pup. Pediatr. Res. 2008, 63:364-369.
5. Carty M.L., Wixey J.A., Colditz P.B., Buller K.M. Post-hypoxia-ischemia minocycline treatment attenuates neuroinflammation and white matter injury in the neonatal rat; a comparison of two different dose regimens. Int. J. Dev. Neurosci. 2008, 26:477-485.
6. Duncan J.R., Paterson D.S., Hoffman J.M., Mokler D.J., Borenstein N.S., Belliveau R.A., Krous H.F., Haas E.A., Stanley C., Nattie E.E., Trachtenberg F., Kinney H.C. Brainstem serotonergic deficiency in sudden infant death syndrome. JAMA 2010, 303:430-437.
7. Ferriero D.M. Neonatal brain injury. N. Engl. J. Med. 2004, 351:1985-1995.
8. Gartside S.E., Johnson D.A., Leitch M.M., Troakes C., Ingram C.D. Early life adversity programs changes in central 5-HT neuronal function in adulthood. Eur. J. Neurosci. 2003, 17:2401-2408.
9. Gaspar P., Cases O., Maroteaux L. The developmental role of serotonin: news from mouse molecular genetics. Nat. Rev. Neurosci. 2003, 4:1002-1012.
10. Hack M., Youngstrom E.A., Cartar L., Schluchter M., Taylor H.G., Flannery D., Klein N., Borawski E. Behavioral outcomes and evidence of psychopathology among very low birth weight infants at age 20 years. Pediatrics 2004, 114:932-940.
11. Horikawa H., Kato T.A., Mizoguchi Y., Monji A., Seki Y., Ohkuri T., Gotoh L., Yonaha M., Ueda T., Hashioka S. Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracellular calcium. Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2010, 34:1306-1316.
12. Inazu M., Takeda H., Ikoshi H., Sugisawa M., Uchida Y., Matsumiya T. Pharmacological characterization and visualization of the glial serotonin transporter. Neurochem. Int. 2001, 39:39-49.
13. Ivacko J.A., Sun R., Silverstein F.S. Hypoxic-ischemic brain injury induces an acute microglial reaction in perinatal rats. Pediatr. Res. 1996, 39:39-47.
14. Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996, 19:312-318.
15. Kubota N., Kiuchi Y., Nemoto M., Oyamada H., Ohno M., Funahashi H., Shioda S., Oguchi K. Regulation of serotonin transporter gene expression in human glial cells by growth factors. Eur. J. Pharmacol. 2001, 417:69-76.
16. McRae A., Gilland E., Bona E., Hagberg H. Microglia activation after neonatal hypoxic-ischemia. Dev. Brain Res. 1995, 84:245-252.
17. Nemeroff C.B., Owens M.J. The role of serotonin in the pathophysiology of depression: as important as ever. Clin. Chem. 2009, 55:1578-1579.
18. Pardo C.A., Eberhart C.G. The neurobiology of autism. Brain Pathol. 2007, 17:434-447.
19. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1997, Academic Press, San Diego.
20. Pekny M., Nilsson M. Astrocyte activation and reactive gliosis. Glia 2005, 50:427-434.
21. Peterson B.S., Anderson A.W., Ehrenkranz R., Staib L.H., Tageldin M., Colson E., Gore J.C., Duncan C.C., Makuch R., Ment L.R. Regional brain volumes and their later neurodevelopmental correlates in term and preterm infants. Pediatrics 2003, 111:939-948.
22. Qian Y., Galli A., Ramamoorthy S., Risso S., Defelice L.J., Blakely R.D. Protein kinase C activation regulates human serotonin transporters in HEK-293 cells via altered cell surface expression. J. Neurosci. 1997, 17:45-57.
23. Qian Y., Melikian H.E., Rye D.B., Levey A.I., Blakely R.D. Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies. J. Neurosci. 1995, 15:1261-1274.
24. Ramamoorthy S., Melikian H.E., Qian Y., Blakely R.D. Biosynthesis, N-glycosylation, and surface trafficking of biogenic amine transporter proteins. Methods Enzymol. 1998, 296:347-370.
25. Reinebrant H.E., Wixey J.A., Gobe G.C., Colditz P.B., Buller K.M. Differential effects of neonatal hypoxic-ischemic brain injury on brainstem serotonergic raphe nuclei. Brain Res. 2010, 1322C:124-133.
26. Samuvel D.J., Jayanthi L.D., Bhat N.R., Ramamoorthy S. A role for p38 mitogen-activated protein kinase in the regulation of the serotonin transporter: evidence for distinct cellular mechanisms involved in transporter surface expression. J. Neurosci. 2005, 25:29-41.
27. Schimmel S., Kent C., Bischoff R., Vagelos P.R. Plasma membranes from cultured muscle cells: isolation procedures and separation of putative plasma-membrane marker enzymes. Proc. Natl. Acad. Sci. U. S. A. 1973, 70:3195-3199.
28. Smith H.R., Porrino L.J. The comparative distributions of the monoamine transporters in the rodent, monkey, and human amygdala. Brain Struct. Funct. 2008, 213:73-91.
29. Sur C., Betz H., Schloss P. Immunocytochemical detection of the serotonin transporter in rat brain. Neuroscience 1996, 73:217-231.
30. Tao-Cheng J.H., Zhou F.C. Differential polarization of serotonin transporters in axons versus soma-dendrites: an immunogold electron microscopy study. Neuroscience 1999, 94:821-830.
31. Wang X., Baumann M.H., Heng X., Morales M., Rothman R.B. (±)-3,4 Methylenedioxymethamphetamine administration to rats does not decrease levels of the serotonin transporter protein or alter its distribution between endosomes and the plasma membrane. J. Pharm. Exp. Ther. 2005, 314:1002-1012.
32. Wilk S., Wilk E., Magnusson R. Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase. J. Biol. Chem. 1998, 273:15961-15970.
33. Wixey J.A., Reinebrant H.E., Carty M.L., Buller K.M. Delayed P2X4R expression after hypoxia-ischemia is associated with microglia in the immature rat brain. J. Neuroimmunol. 2009, 212:35-43.
34. Wixey J.A., Reinebrant H.E., Buller K.M. Inhibition of neuroinflammation prevents injury to the serotonergic network after hypoxia-ischemia in the immature rat brain. J. Neuropathol. Exp. Neurol. 2011, 70:23-35.
35. Wixey J.A., Reinebrant H.E., Spencer S.J., Buller K.M. Efficacy of post-insult minocycline administration to alter long-term hypoxia-ischemia-induced damage to the serotonergic system in the immature rat brain. Neuroscience 2011, 182:184-192.
36. Xie T., Tong L., McLane M.W., Hatzidimitriou G., Yuan J., McCann U., Ricaurte G. Loss of serotonin transporter protein after MDMA and other ring-substituted amphetamines. Neuropsychopharmacology 2006, 31:2639-2651.
37. Zhou F.C., Sari Y., Zhang J.K. Expression of serotonin transporter protein in developing rat brain. Brain Res. Dev. Brain Res. 2000, 119:33-45.
38. Zhu C.B., Blakely R.D., Hewlett W.A. The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters. Neuropsychopharmacology 2006, 31:2121-2131.