Efficacy of post-insult minocycline administration to alter long-term hypoxia-ischemia-induced damage to the serotonergic system in the immature rat brain

Neuroscience

Volumn 182, Issue , 2011, Pages 184-192

  Wixey, J A ^a   Reinebrant, H E ^a   Spencer, S J ^b   Buller, K M ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Hypoxia ischemia; Minocycline; Neonate; Neuroinflammation; Raph neuron; Serotonin

Indexed keywords

INTERLEUKIN 1BETA; MINOCYCLINE; SEROTONIN; SEROTONIN TRANSPORTER; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN DAMAGE; BRAIN HYPOXIA; BRAIN ISCHEMIA; CONTROLLED STUDY; DORSAL RAPHE NUCLEUS; DRUG EFFECT; DRUG EFFICACY; DRUG TARGETING; FEMALE; FRONTAL CORTEX; INFLAMMATION; LONG TERM CARE; MALE; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEROTONIN BRAIN LEVEL; SEROTONINERGIC SYSTEM; THALAMUS;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; ENCEPHALITIS; FEMALE; HYPOXIA-ISCHEMIA, BRAIN; MALE; MINOCYCLINE; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN;

EID: 79955473599     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2011.03.033     Document Type: Article

References (35)

1. Ahuja M., Bishnoi M., Chopra K. Protective effect of minocycline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity. Toxicology 2008, 244:111-122.
2. Anderson P., Doyle L.W. Neurobehavioral outcomes of school-age children born extremely low birth weight or very preterm in the 1990s. JAMA 2003, 289:3264-3272.
3. Arvin K.L., Han B.H., Du J., Lin S.-Z., Paul S.M., Holtzman D.M. Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury. Ann Neurol 2002, 52:54-61.
4. Biran V., Joly L.-M., Heron A., Vernet A., Vega C., Mariani J., Renolleau S., Charriaut-Marlangue C. Glial activation in white matter following ischemia in the neonatal P7 rat brain. Exper Neurol 2006, 199:103-112.
5. Bona E., Andersson A.L., Blomgren K., Gilland E., Puka-Sundvall M., Gustafson K., Hagberg H. Chemokine and inflammatory cell response to hypoxia ischemia in immature rats. Pediatr Res 1999, 45:500-509.
6. Buller K.M., Carty M.L., Reinebrant H.E., Wixey J.A. Minocycline: a neuroprotective agent for hypoxic-ischemic brain injury in the neonate?. J Neurosci Res 2009, 87:599-608.
7. Buller K.M., Wixey J.A., Pathipati P., Carty M., Colditz P.B., Williams C.E., Scheepens A. Selective losses of brainstem catecholamine neurons after hypoxia-ischemia in the immature rat pup. Pediatr Res 2008, 63:364-369.
8. Cai Z., Lin S., Fan L.-W., Pang Y., Rhodes P.G. Minocycline alleviates hypoxic-ischemic injury to developing oligodendrocytes in the neonatal rat brain. Neuroscience 2006, 137:425-435.
9. Carty M.L., Wixey J.A., Colditz P.B., Buller K.M. Post-hypoxia-ischemia minocycline treatment attenuates neuroinflammation and white matter injury in the neonatal rat: a comparison of two different dose regimens. Int J Dev Neurosci 2008, 26:477-485.
10. Fan L.-W., Lin S., Pang Y., Rhodes P.G., Cai Z. Minocycline attenuates hypoxia-ischemia-induced neurological dysfunction and brain injury in the juvenile rat. Eur J Neurosci 2006, 24:341-350.
11. Farkas E., Donka G., de Vos R.A.I., Mihály A., Bari F., Luiten P.G.M. Experimental cerebral hypoperfusion induces white matter injury and microglial activation in the rat brain. Acta Neuropathol 2004, 108:57-64.
12. Hack M., Youngstrom E.A., Cartar L., Schluchter M., Taylor H.G., Flannery D., Klein N., Borawski E. Behavioral outcomes and evidence of psychopathology among very low birth weight infants at age 20 years. Pediatrics 2004, 114:932-940.
13. Hedtjarn M., Leverin A.L., Eriksson K., Blomgren K., Mallard C., Hagberg H. Interleukin-18 involvement in hypoxic-ischemic brain injury. J Neurosci 2002, 22:5910-5919.
14. Homsi S., Piaggio T., Croci N., Noble F., Plotkine M., Marchand-Leroux C., Jafarian-Tehrani M. Blockade of acute microglial activation by minocycline promotes neuroprotection and reduces locomotor hyperactivity after closed head injury in mice: a twelve-week follow-up study. J Neurotrauma 2010, 27:911-921.
15. Hornung J.P. The human raphe nuclei and the serotonergic system. J Chem Neuroanat 2003, 26:331-343.
16. Ivacko J.A., Sun R., Silverstein F.S. Hypoxic-ischemic brain injury induces an acute microglial reaction in perinatal rats. Pediatr Res 1996, 39:39-47.
17. Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci 1996, 19:312-318.
18. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
19. McRae A., Gilland E., Bona E., Hagberg H. Microglia activation after neonatal hypoxic-ischemia. Dev Br Res 1995, 84:245-252.
20. Murphy D.L., Lerner A., Rudnick G., Lesch K.P. Serotonin transporter: gene, genetic disorders, and pharmacogenetics. Mol Interv 2004, 4:109-123.
21. Nemeroff C.B., Owens M.J. The role of serotonin in the pathophysiology of depression: as important as ever. Clin Chem 2009, 55:1578-1579.
22. Pardo C.A., Eberhart C.G. The neurobiology of autism. Brain Pathol 2007, 17:434-447.
23. Paterson D.S., Trachtenberg F.L., Thompson E.G., Belliveau R.A., Beggs A.H., Darnall R., Chadwick A.E., Krous H.F., Kinney H.C. Multiple serotonergic brainstem abnormalities in sudden infant death syndrome. JAMA 2006, 296:2124-2132.
24. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1997, Academic Press, San Diego.
25. Peterson B.S., Anderson A.W., Ehrenkranz R., Staib L.H., Tageldin M., Colson E., Gore J.C., Duncan C.C., Makuch R., Ment L.R. Regional brain volumes and their later neurodevelopmental correlates in term and preterm infants. Pediatrics 2003, 111:939-948.
26. Popa D., Lena C., Alexandre C., Adrien J. Lasting syndrome of depression produced by reduction in serotonin uptake during postnatal development: evidence from sleep, stress, and behavior. J Neurosci 2008, 28:3546-3554.
27. Reinebrant H.E., Wixey J.A., Gobe G.C., Colditz P.B., Buller K.M. Differential effects of neonatal hypoxic-ischemic brain injury on brainstem serotonergic raphe nuclei. Brain Res 2010, 1322:124-133.
28. Skoff R.P., Bessert D., Barks J.D., Silverstein F.S. Plasticity of neurons and glia following neonatal hypoxic-ischemic brain injury in rats. Neurochem Res 2007, 32:331-342.
29. Smith D.W., Buller K.M., Day T.A. Role of ventrolateral medulla catecholamine cells in hypothalamic neuroendocrine cell responses to systemic hypoxia. J Neurosci 1995, 15:7979-7988.
30. Strackx E., van den Hove D.L., Steinbusch H.P., Prickaerts J., Vles J.S., Blanco C.E., Steinbusch H.W., Gavilanes A.W. Fetal asphyxia leads to a decrease in dorsal raphe serotonergic neurons. Dev Neurosci 2008, 30:358-366.
31. Takeuchi Y., Fujiwara K., Ishimura K., Aoki S., Okano S., Yamazoe I., Yoshioka H., Sawada T. Effects of neonatal asphyxia on the serotonin neuron system in the developing brain studied by immunohistochemistry. Dev Neurosci 1992, 14:394-402.
32. Vannucci R.C., Lyons D.T., Vasta F. Regional cerebral blood flow during hypoxia-ischemia in immature rats. Stroke 1988, 19:245-250.
33. Volpe J.J. Neurobiology of periventricular leukomalacia in the premature infant. Pediatr Res 2001, 50:553-562.
34. Wixey J.A., Reinebrant H.E., Buller K.M. Inhibition of neuroinflammation prevents injury to the serotonergic network after hypoxia-ischemia in the immature rat brain. J Neuropathol Exp Neurol 2011, 70:23-35.
35. Zhang L., Shirayama Y., Shimizu E., Iyo M., Hashimoto K. Protective effects of minocycline on 3,4-methylenedioxymethamphetamine-induced neurotoxicity in serotonergic and dopaminergic neurons of mouse brain. Eur J Pharmacol 2006, 544:1-9.