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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 12, 2012, Pages 3946-3950

Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists

(17) Perez, Heidi L a Banfi, Patrizia b Bertrand, Jay b Cai, Zhen Wei a,c Grebinski, James W a Kim, Kyoung a Lippy, Jonathan a Modugno, Michele b Naglich, Joseph a Schmidt, Robert J a Tebben, Andrew a Vianello, Paola b,d Wei, Donna D a Zhang, Liping a Galvani, Arturo b Lombardo, Louis J a,e Borzilleri, Robert M a

a BRISTOL MYERS SQUIBB (United States)

b NERVIANO MEDICAL SCIENCES (Italy)

c Building 1B (China)

d EUROPEAN INSTITUTE OF ONCOLOGY (Italy)

e HOFFMANN LA ROCHE INC (United States)

Author keywords

Apoptosis; Bcl 2; Bcl xL; Isolated mitochondria; Protein protein interaction

Indexed keywords

AMINE; AMINOMETHYL DERIVATIVE; ANTINEOPLASTIC AGENT; CYTOCHROME C; ETHYL 5 METHYL 1H PYRAZOLE 3 CARBOXYLATE; NAVITOCLAX; PHENYLACYLSULFONAMIDE DERIVATIVE; PROTEIN BAK; PROTEIN BCL 2; PROTEIN BCL 2 ANTAGONIST; PROTEIN BCL XL; PROTEIN BCL XL ANTAGONIST; TETRAHYDROQUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; MITOCHONDRION; OLIGOMERIZATION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; CYTOCHROMES C; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MITOCHONDRIA; MODELS, MOLECULAR; SULFONAMIDES;

EID: 84861570613 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.04.103 Document Type: Article

Times cited : (30)

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