-
2
-
-
10744226316
-
Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice
-
Bayer T.A., Schäfer S., Simons A., Kemmling A., Kamer T., Tepest R., Eckert A., Schüssel K., Eikenberg O., Sturchler-Pierrat C., Abramowski D., Staufenbiel M., Multhaup G. Dietary Cu stabilizes brain superoxide dismutase 1 activity and reduces amyloid Abeta production in APP23 transgenic mice. Proceedings of the National Academy of Sciences of the United States of America 2003, 100:14187-14192.
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, pp. 14187-14192
-
-
Bayer, T.A.1
Schäfer, S.2
Simons, A.3
Kemmling, A.4
Kamer, T.5
Tepest, R.6
Eckert, A.7
Schüssel, K.8
Eikenberg, O.9
Sturchler-Pierrat, C.10
Abramowski, D.11
Staufenbiel, M.12
Multhaup, G.13
-
3
-
-
0037931743
-
Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis
-
Barnham K.J., McKinstry W.J., Multhaup G., Galatis D., Morton C.J., Curtain C.C., Williamson N.A., White A.R., Hinds M.G., Norton R.S., Beyreuther K., Masters C.L., Parker M.W., Cappai R. Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis. Journal of Biological Chemistry 2003, 278:17401-17407.
-
(2003)
Journal of Biological Chemistry
, vol.278
, pp. 17401-17407
-
-
Barnham, K.J.1
McKinstry, W.J.2
Multhaup, G.3
Galatis, D.4
Morton, C.J.5
Curtain, C.C.6
Williamson, N.A.7
White, A.R.8
Hinds, M.G.9
Norton, R.S.10
Beyreuther, K.11
Masters, C.L.12
Parker, M.W.13
Cappai, R.14
-
4
-
-
43549091337
-
Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms
-
Cater M.A., McInnes K.T., Li Q.X., Volitakis I., La Fontaine S., Mercer J.F., Bush A.I. Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms. Biochemical Journal 2008, 412:141-152.
-
(2008)
Biochemical Journal
, vol.412
, pp. 141-152
-
-
Cater, M.A.1
McInnes, K.T.2
Li, Q.X.3
Volitakis, I.4
La Fontaine, S.5
Mercer, J.F.6
Bush, A.I.7
-
5
-
-
58849090893
-
Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation
-
Crouch P.J., Hung L.W., Adlard P.A., Cortes M., Lal V., Filiz G., Perez K.A., Nurjono M., Caragounis A., Du T., Laughton K., Volitakis I., Bush A.I., Li Q.X., Masters C.L., Cappai R., Cherny R.A., Donnelly P.S., White A.R., Barnham K.J. Increasing Cu bioavailability inhibits Abeta oligomers and tau phosphorylation. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:381-386.
-
(2009)
Proceedings of the National Academy of Sciences of the United States of America
, vol.106
, pp. 381-386
-
-
Crouch, P.J.1
Hung, L.W.2
Adlard, P.A.3
Cortes, M.4
Lal, V.5
Filiz, G.6
Perez, K.A.7
Nurjono, M.8
Caragounis, A.9
Du, T.10
Laughton, K.11
Volitakis, I.12
Bush, A.I.13
Li, Q.X.14
Masters, C.L.15
Cappai, R.16
Cherny, R.A.17
Donnelly, P.S.18
White, A.R.19
Barnham, K.J.20
more..
-
6
-
-
0035816661
-
A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60
-
Cao X., Sudhof T.C. A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 2001, 293:115-120.
-
(2001)
Science
, vol.293
, pp. 115-120
-
-
Cao, X.1
Sudhof, T.C.2
-
7
-
-
33947646259
-
Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases
-
Farkas E., Luiten P.G., Bari F. Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases. Brain Research Reviews 2007, 54:162-180.
-
(2007)
Brain Research Reviews
, vol.54
, pp. 162-180
-
-
Farkas, E.1
Luiten, P.G.2
Bari, F.3
-
8
-
-
33745893209
-
Amyloid at the blood vessel wall
-
Hardy J., Cullen K. Amyloid at the blood vessel wall. Nature Medicine 2006, 12:756-757.
-
(2006)
Nature Medicine
, vol.12
, pp. 756-757
-
-
Hardy, J.1
Cullen, K.2
-
9
-
-
43349100174
-
Neurotoxicological evaluation of long-term lanthanum chloride exposure in rats
-
He X., Zhang Z., Zhang H., Zhao Y., Chai Z. Neurotoxicological evaluation of long-term lanthanum chloride exposure in rats. Toxicological Sciences 2008, 103:354-361.
-
(2008)
Toxicological Sciences
, vol.103
, pp. 354-361
-
-
He, X.1
Zhang, Z.2
Zhang, H.3
Zhao, Y.4
Chai, Z.5
-
10
-
-
12144282992
-
Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides
-
Huang X., Atwood C.S., Moir R.D., Hartshorn M.A., Tanzi R.E., Bush A.I. Trace metal contamination initiates the apparent auto-aggregation, amyloidosis, and oligomerization of Alzheimer's Abeta peptides. Journal of Biological Inorganic Chemistry 2004, 9:954-960.
-
(2004)
Journal of Biological Inorganic Chemistry
, vol.9
, pp. 954-960
-
-
Huang, X.1
Atwood, C.S.2
Moir, R.D.3
Hartshorn, M.A.4
Tanzi, R.E.5
Bush, A.I.6
-
11
-
-
0033601338
-
Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction
-
Huang X., Cuajungco M.P., Atwood C.S., Hartshorn M.A., Tyndall J.D., Hanson G.R., Stokes K.C., Leopold M., Multhaup G., Goldstein L.E., Scarpa R.C., Saunders A.J., Lim J., Moir R.D., Glabe C., Bowden E.F., Masters C.L., Fairlie D.P., Tanzi R.E., Bush A.I. Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. Journal of Biological Chemistry 1999, 274:37111-37116.
-
(1999)
Journal of Biological Chemistry
, vol.274
, pp. 37111-37116
-
-
Huang, X.1
Cuajungco, M.P.2
Atwood, C.S.3
Hartshorn, M.A.4
Tyndall, J.D.5
Hanson, G.R.6
Stokes, K.C.7
Leopold, M.8
Multhaup, G.9
Goldstein, L.E.10
Scarpa, R.C.11
Saunders, A.J.12
Lim, J.13
Moir, R.D.14
Glabe, C.15
Bowden, E.F.16
Masters, C.L.17
Fairlie, D.P.18
Tanzi, R.E.19
Bush, A.I.20
more..
-
12
-
-
79952701977
-
Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease?
-
Humpel C. Chronic mild cerebrovascular dysfunction as a cause for Alzheimer's disease?. Experimental Gerontology 2011, 46:225-232.
-
(2011)
Experimental Gerontology
, vol.46
, pp. 225-232
-
-
Humpel, C.1
-
14
-
-
61349110122
-
Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD
-
Kitazawa M., Cheng D., LaFerla F.M. Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD. Journal of Neurochemistry 2009, 108:1550-1560.
-
(2009)
Journal of Neurochemistry
, vol.108
, pp. 1550-1560
-
-
Kitazawa, M.1
Cheng, D.2
LaFerla, F.M.3
-
15
-
-
79955019165
-
Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia
-
Koike M.A., Garcia F.G., Kitazawa M., Green K.N., Laferla F.M. Long term changes in phospho-APP and tau aggregation in the 3xTg-AD mice following cerebral ischemia. Neuroscience Letters 2011, 495:55-59.
-
(2011)
Neuroscience Letters
, vol.495
, pp. 55-59
-
-
Koike, M.A.1
Garcia, F.G.2
Kitazawa, M.3
Green, K.N.4
Laferla, F.M.5
-
16
-
-
59649125004
-
Copper suppresses hippocampus LTP in the rat, but does not alter learning or memory in the morris water maze
-
Leiva J., Palestini M., Infante C., Goldschmidt A., Motles E. Copper suppresses hippocampus LTP in the rat, but does not alter learning or memory in the morris water maze. Brain Research 2009, 1256:69-75.
-
(2009)
Brain Research
, vol.1256
, pp. 69-75
-
-
Leiva, J.1
Palestini, M.2
Infante, C.3
Goldschmidt, A.4
Motles, E.5
-
17
-
-
45849148467
-
Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin
-
Lin R., Chen X., Li W., Han Y., Liu P., Pi R. Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin. Neuroscience Letters 2008, 440:344-347.
-
(2008)
Neuroscience Letters
, vol.440
, pp. 344-347
-
-
Lin, R.1
Chen, X.2
Li, W.3
Han, Y.4
Liu, P.5
Pi, R.6
-
18
-
-
0032507975
-
Copper, iron and zinc in Alzheimer's disease senile plaques
-
Lovell M.A., Robertson J.D., Teesdale W.J., Campbell J.L., Markesbery W.R. Copper, iron and zinc in Alzheimer's disease senile plaques. Journal of the Neurological Sciences 1998, 158:47-52.
-
(1998)
Journal of the Neurological Sciences
, vol.158
, pp. 47-52
-
-
Lovell, M.A.1
Robertson, J.D.2
Teesdale, W.J.3
Campbell, J.L.4
Markesbery, W.R.5
-
19
-
-
58549116872
-
Trace amounts of copper exacerbate beta amyloid-induced neurotoxicity in the cholesterol-fed mice through TNF-mediated inflammatory pathway
-
Lu J., Wu D.M., Zheng Y.L., Sun D.X., Hu B., Shan Q., Zhang Z.F., Fan S.H. Trace amounts of copper exacerbate beta amyloid-induced neurotoxicity in the cholesterol-fed mice through TNF-mediated inflammatory pathway. Brain, Behavior, and Immunity 2009, 23:193-203.
-
(2009)
Brain, Behavior, and Immunity
, vol.23
, pp. 193-203
-
-
Lu, J.1
Wu, D.M.2
Zheng, Y.L.3
Sun, D.X.4
Hu, B.5
Shan, Q.6
Zhang, Z.F.7
Fan, S.H.8
-
20
-
-
54249100455
-
Alzheimer's disease: cerebrovascular dysfunction, oxidative stress, and advanced clinical therapies
-
Marlatt M.W., Lucassen P.J., Perry G., Smith M.A., Zhu X. Alzheimer's disease: cerebrovascular dysfunction, oxidative stress, and advanced clinical therapies. Journal of Alzheimer's Disease 2008, 15:199-210.
-
(2008)
Journal of Alzheimer's Disease
, vol.15
, pp. 199-210
-
-
Marlatt, M.W.1
Lucassen, P.J.2
Perry, G.3
Smith, M.A.4
Zhu, X.5
-
21
-
-
0043023877
-
Neuroscience Possible role for environmental copper in Alzheimer's disease
-
Marx J., Neuroscience Possible role for environmental copper in Alzheimer's disease. Science 2003, 301:905.
-
(2003)
Science
, vol.301
, pp. 905
-
-
Marx, J.1
-
22
-
-
67649185049
-
Genetics Environmental factors and the emerging role of epigenetics in neurodegenerative diseases
-
Migliore L., Coppede F., Genetics environmental factors and the emerging role of epigenetics in neurodegenerative diseases. Mutation Research 2009, 667:82-97.
-
(2009)
Mutation Research
, vol.667
, pp. 82-97
-
-
Migliore, L.1
Coppede, F.2
-
23
-
-
33747204555
-
Dietary copper and high saturated and trans fat intakes associated with cognitive decline
-
Morris M.C., Evans D.A., Tangney C.C., Bienias J.L., Schneider J.A., Wilson R.S., Scherr P.A. Dietary copper and high saturated and trans fat intakes associated with cognitive decline. Archives of Neurology 2006, 63:1085-1088.
-
(2006)
Archives of Neurology
, vol.63
, pp. 1085-1088
-
-
Morris, M.C.1
Evans, D.A.2
Tangney, C.C.3
Bienias, J.L.4
Schneider, J.A.5
Wilson, R.S.6
Scherr, P.A.7
-
24
-
-
0029935396
-
The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I)
-
Multhaup G., Schlicksupp A., Hesse L., Beher D., Ruppert T., Masters C.L., Beyreuther K. The amyloid precursor protein of Alzheimer's disease in the reduction of copper(II) to copper(I). Science 1996, 271:1406-1409.
-
(1996)
Science
, vol.271
, pp. 1406-1409
-
-
Multhaup, G.1
Schlicksupp, A.2
Hesse, L.3
Beher, D.4
Ruppert, T.5
Masters, C.L.6
Beyreuther, K.7
-
25
-
-
64749089732
-
Copper intoxication; antioxidant defenses and oxidative damage in rat brain
-
Ozcelik D., Uzun H. Copper intoxication; antioxidant defenses and oxidative damage in rat brain. Biological Trace Element Research 2009, 127:45-52.
-
(2009)
Biological Trace Element Research
, vol.127
, pp. 45-52
-
-
Ozcelik, D.1
Uzun, H.2
-
26
-
-
77950808419
-
Consideration of the ischaemic basis and treatment of Alzheimer's disease
-
Pluta R., Ulamek M., Jablonski M. Consideration of the ischaemic basis and treatment of Alzheimer's disease. Folia Neuropathologica 2010, 48:11-26.
-
(2010)
Folia Neuropathologica
, vol.48
, pp. 11-26
-
-
Pluta, R.1
Ulamek, M.2
Jablonski, M.3
-
27
-
-
79955642440
-
The effect of metals on spatial memory in a transgenic mouse model of Alzheimer's disease
-
Railey A.M., Groeber C.M., Flinn J.M. The effect of metals on spatial memory in a transgenic mouse model of Alzheimer's disease. Journal of Alzheimer's Disease 2011, 24:375-381.
-
(2011)
Journal of Alzheimer's Disease
, vol.24
, pp. 375-381
-
-
Railey, A.M.1
Groeber, C.M.2
Flinn, J.M.3
-
28
-
-
67149139988
-
The role of vascular factors in late-onset sporadic Alzheimer's disease. Genetic and molecular aspects
-
Rocchi A., Orsucci D., Tognoni G., Ceravolo R., Siciliano G. The role of vascular factors in late-onset sporadic Alzheimer's disease. Genetic and molecular aspects. Current Alzheimer's Research 2009, 6:224-237.
-
(2009)
Current Alzheimer's Research
, vol.6
, pp. 224-237
-
-
Rocchi, A.1
Orsucci, D.2
Tognoni, G.3
Ceravolo, R.4
Siciliano, G.5
-
29
-
-
0035950225
-
Clearing the brain's amyloid cobwebs
-
Selkoe D.J. Clearing the brain's amyloid cobwebs. Neuron 2001, 32:177-180.
-
(2001)
Neuron
, vol.32
, pp. 177-180
-
-
Selkoe, D.J.1
-
30
-
-
33947383715
-
Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels
-
Schäfer S., Pajonk F.G., Multhaup G., Bayer T.A. Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels. Journal of Molecular Medicine (Berlin) 2007, 85:405-413.
-
(2007)
Journal of Molecular Medicine (Berlin)
, vol.85
, pp. 405-413
-
-
Schäfer, S.1
Pajonk, F.G.2
Multhaup, G.3
Bayer, T.A.4
-
31
-
-
33645554445
-
Effects of amelioration of total flavonoids from stems and leaves of Scutellaria baicalensis Georgi on cognitive deficits, neuronal damage and free radicals disorder induced by cerebral ischemia in rats
-
Shang Y.Z., Miao H., Cheng J.J., Qi J.M. Effects of amelioration of total flavonoids from stems and leaves of Scutellaria baicalensis Georgi on cognitive deficits, neuronal damage and free radicals disorder induced by cerebral ischemia in rats. Biological and Pharmaceutical Bulletin 2006, 29:805-810.
-
(2006)
Biological and Pharmaceutical Bulletin
, vol.29
, pp. 805-810
-
-
Shang, Y.Z.1
Miao, H.2
Cheng, J.J.3
Qi, J.M.4
-
32
-
-
0037159210
-
Elevation of serum copper levels in Alzheimer's disease
-
Squitti R., Lupoi D., Pasqualetti P., Dal Forno G., Vernieri F., Chiovenda P., Rossi L., Cortesi M., Cassetta E., Rossini P.M. Elevation of serum copper levels in Alzheimer's disease. Neurology 2002, 59:1153-1161.
-
(2002)
Neurology
, vol.59
, pp. 1153-1161
-
-
Squitti, R.1
Lupoi, D.2
Pasqualetti, P.3
Dal Forno, G.4
Vernieri, F.5
Chiovenda, P.6
Rossi, L.7
Cortesi, M.8
Cassetta, E.9
Rossini, P.M.10
-
33
-
-
4444276735
-
Clearance of Alzheimer's Abeta peptide: the many roads to perdition
-
Tanzi R.E., Moir R.D., Wagner S.L. Clearance of Alzheimer's Abeta peptide: the many roads to perdition. Neuron 2004, 43:605-608.
-
(2004)
Neuron
, vol.43
, pp. 605-608
-
-
Tanzi, R.E.1
Moir, R.D.2
Wagner, S.L.3
-
34
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R., Bennett B.D., Babu-Khan S., Kahn S., Mendiaz E.A., Denis P., Teplow D.B., Ross S., Amarante P., Loeloff R., Luo Y., Fisher S., Fuller J., Edenson S., Lile J., Jarosinski M.A., Biere A.L., Curran E., Burgess T., Louis J.C., Collins F., Treanor J., Rogers G., Citron M. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999, 286:735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
Luo, Y.11
Fisher, S.12
Fuller, J.13
Edenson, S.14
Lile, J.15
Jarosinski, M.A.16
Biere, A.L.17
Curran, E.18
Burgess, T.19
Louis, J.C.20
Collins, F.21
Treanor, J.22
Rogers, G.23
Citron, M.24
more..
-
35
-
-
74049090496
-
Alterations in mRNA expression of BACE1, cathepsin B, and glutaminyl cyclase in mice ischemic brain
-
Ye J.T., Pi R.B., Mao X.X., Chen X.H., Qin J., Xu S.W., Liu P.Q. Alterations in mRNA expression of BACE1, cathepsin B, and glutaminyl cyclase in mice ischemic brain. Neuroreport 2009, 20:1456-1460.
-
(2009)
Neuroreport
, vol.20
, pp. 1456-1460
-
-
Ye, J.T.1
Pi, R.B.2
Mao, X.X.3
Chen, X.H.4
Qin, J.5
Xu, S.W.6
Liu, P.Q.7
-
36
-
-
34249337528
-
Iron dysregulation in Alzheimer's disease: multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents
-
Youdim M.B.H., Mandel S., Amit T., Bar-Am O. Iron dysregulation in Alzheimer's disease: multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents. Progress in Neurobiology 2007, 82:348-360.
-
(2007)
Progress in Neurobiology
, vol.82
, pp. 348-360
-
-
Youdim, M.B.H.1
Mandel, S.2
Amit, T.3
Bar-Am, O.4
-
37
-
-
33750503794
-
Fermented papaya preparation attenuates beta-amyloid precursor protein: beta-amyloid-mediated copper neurotoxicity in beta-amyloid precursor protein and beta-amyloid precursor protein Swedish mutation overexpressing SH-SY5Y cells
-
Zhang J., Mori A., Chen Q., Zhao B. Fermented papaya preparation attenuates beta-amyloid precursor protein: beta-amyloid-mediated copper neurotoxicity in beta-amyloid precursor protein and beta-amyloid precursor protein Swedish mutation overexpressing SH-SY5Y cells. Neuroscience 2006, 143:63-72.
-
(2006)
Neuroscience
, vol.143
, pp. 63-72
-
-
Zhang, J.1
Mori, A.2
Chen, Q.3
Zhao, B.4
|