Anti-angiogenesis and disintegrins

Toxins and Hemostasis: From Bench to Bedside

Volumn , Issue , 2011, Pages 301-329

  Swenson, Stephen ^a   Minea, Radu ^a   Zidovetzki, Samuel ^a   Helchowski, Corey ^a   Costa, Fritz ^a   Markland, Francis S ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84861488229     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-90-481-9295-3_19     Document Type: Chapter

References (101)

1. Adler, M., Lazarus, R.A., Dennis, M.S., Wagner, G., 1991. Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist. Science 253, 445-448.
2. Aragon-Ching, J.B., Dahut, W.L., 2008. The role of angiogenesis inhibitors in prostate cancer. Cancer. J. 14, 20-25.
3. Aragon-Ching, J.B., Dahut, W.L., 2009. VEGF inhibitors and prostate cancer therapy. Curr. Mol. Pharmacol. 2, 161-168.
4. Banno, A., Ginsberg, M.H., 2008. Integrin activation. Biochem. Soc. Trans. 36, 229-34.
5. Bayless, K.J., Salazar, R., Davis, G.E., 2000. RGD-dependent vacuolation and lumen formation observed during endothelial cell morphogenesis in three-dimensional fibrin matrices involves the αvβ3 and α5β1 integrins. Am. J. Pathol. 156, 1673-1683.
6. Beekman, K.W., Colevas, A.D., Cooney, K., Dipaola, R., Dunn, R.L., Gross, M., Keller, E.T., Pienta, K.J., Ryan, C.J., Smith, D., Hussain, M., 2006. Phase II evaluations of cilengitide in asymptomatic patients with androgen-independent prostate cancer: scientific rationale and study design. Clin. Genitourin. Cancer 4, 299-302.
7. Beekman, K.W., Hussain, M., 2006. Targeted approaches for the management of metastatic prostate cancer. Curr. Oncol. Rep. 8, 206-212.
8. Boehm, T., Folkman, J., Browder, T., O'Reilly, M.S., 1997. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature 390, 404-407.
9. Brooks, P.C., Montgomery, A.M., Rosenfeld, M., Reisfeld, R.A., Hu, T., Klier, G., Cheresh, D.A., 1994. Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79, 1157-1164.
10. Brown, M.C., Eble, J.A., Calvete, J.J., Marcinkiewicz, C., 2009. Structural requirements of KTSdisintegrins for inhibition of α1β1 integrin. Biochem. J. 417, 95-101.
11. Calderwood, D.A., 2004. Talin controls integrin activation. Biochem. Soc. Trans. 32, 434-437.
12. Calvete, J.J., Marcinkiewicz, C., Monleon, D., Esteve, V., Celda, B., Juarez, P., Sanz, L., 2005. Snake venom disintegrins: evolution of structure and function. Toxicon 45, 1063-1074.
13. Chen, H.X., Cleck, J.N., 2009. Adverse effects of anticancer agents that target the VEGF pathway. Nat. Rev. Clin. Oncol. 6, 465-477.
14. Cheresh, D.A., 1992. Structural and biologic properties of integrin-mediated cell adhesion. Clin. Lab. Med. 12, 217-236.
15. Choueiri, T.K., Duh, M.S., Clement, J., Brick, A.J., Rogers, M.J., Kwabi, C., Shah, K., Percy, A. G., Antras, L., Jayawant, S.S., Chen, K., Wang, S.T., Luka, A., Neary, M.P., McDermott, D., Oh, W.K., 2009. Angiogenesis inhibitor therapies for metastatic renal cell carcinoma: effectiveness, safety and treatment patterns in clinical practice-based on medical chart review. BJU Int. 105(9), 1247-1254.
16. Choy, M., Rafii, S., 2001. Role of angiogenesis in the progression and treatment of prostate cancer. Cancer Invest. 19, 181-91.
17. Concato, J., Jain, D., Uchio, E., Risch, H., Li, W.W., Wells, C.K., 2009. Molecular markers and death from prostate cancer. Ann. Intern. Med. 150, 595-603.
18. Cooper, C.R., Chay, C.H., Pienta, K.J., 2002. The role of αvβ3 in prostate cancer progression. Neoplasia 4, 191-194.
19. Courtney, K.D., Choueiri, T.K., 2009. Optimizing recent advances in metastatic renal cell carcinoma. Curr. Oncol. Rep. 11, 218-226.
20. Cousins, G.R., Sudo, Y., Friedrichs, G.R., Markland, F.S., Lucchesi, B.R., 1995. Contortrostatin prevents reocclusion after thrombolytic therapy in a canine model of carotid artery thrombosis. FASEB J. 9, A938.
21. Cox, M.C., Permenter, M., Figg, W.D., 2005. Angiogenesis and prostate cancer: important laboratory and clinical findings. Curr. Oncol. Rep. 7, 215-219.
22. Cress, A.E., Rabinovitz, I., Zhu, W., Nagle, R.B., 1995. The alpha 6 beta 1 and alpha 6 beta 4 integrins in human prostate cancer progression. Cancer Metastasis Rev. 14, 219-228.
23. Demirgoz, D., Garg, A., Kokkoli, E., 2008. PR-b-targeted PEGylated liposomes for prostate cancer therapy. Langmuir 24, 13518-13524.
24. Dennis, M.S., Henzel, W.J., Pitti, R.M., Lipari, M.T., Napier, M.A., Deisher, T.A., Bunting, S., Lazarus, R.A., 1990. Platelet glycoprotein IIb/IIIa protein antagonists from snake venoms: evidence for a family of platelet-aggregation inhibitors. Proc. Natl. Acad. Sci. U.S.A. 87, 2471-2475.
25. Di Lorenzo, G., De Placido, S., 2006. Hormone refractory prostate cancer (HRPC): present and future approaches of therapy. Int. J. Immunopathol. Pharmacol. 19, 11-34.
26. Ebos, J.M., Lee, C.R., Cruz-Munoz, W., Bjarnason, G.A., Christensen, J.G., Kerbel, R.S., 2009. Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 15, 232-239.
27. Erbersdobler, A., Isbarn, H., Dix, K., Steiner, I., Schlomm, T., Mirlacher, M., Sauter, G., Haese, A., 2009. Prognostic value of microvessel density in prostate cancer: A tissue microarray study. World J. Urol. In Press
28. Fox, W.D., Higgins, B., Maiese, K.M., Drobnjak, M., Cordon-Cardo, C., Scher, H.I., Agus, D.B., 2002. Antibody to vascular endothelial growth factor slows growth of an androgen-independent xenograft model of prostate cancer. Clin. Cancer Res. 8, 3226-3231.
29. Friedlander, M., Brooks, P.C., Shaffer, R.W., Kincaid, C.M., Varner, J.A., Cheresh, D.A., 1995. Definition of two angiogenic pathways by distinct αv integrins. Science 270, 1500-1502.
30. Fujii, G., 1996. Liposomal amphotericin B(AmBisome): realization of the drug delivery concept, in: Rosoff, M. (Ed.), Vesicles. Marcel Dekker, New York, pp. 491-526.
31. Fujii, Y., Okuda, D., Fujimoto, Z., Horii, K., Morita, T., Mizuno, H., 2003. Crystal structure of trimestatin, a disintegrin containing a cell adhesion recognition motif RGD. J. Mol. Biol. 332, 1115-1122.
32. Garrison, J.B., Kyprianou, N., 2004. Novel targeting of apoptosis pathways for prostate cancer therapy. Curr. Cancer Drug Targets 4, 85-95.
33. Gasparini, G., Brooks, P.C., Biganzoli, E., Vermeulen, P.B., Bonoldi, E., Dirix, L.Y., Ranieri, G., Miceli, R., Cheresh, D.A., 1998. Vascular integrin αvβ3: A new prognostic indicator in breast cancer. Clin. Cancer. Res. 4, 2625-2634.
34. Gleave, M., Miyake, H., Chi, K., 2005. Beyond simple castration: Targeting the molecular basis of treatment resistance in advanced prostate cancer. Cancer Chemother. Pharmacol. 56 Suppl 1, 47-57.
35. Goel, H.L., Li, J., Kogan, S., Languino, L.R., 2008. Integrins in prostate cancer progression. Endocr. Relat. Cancer 15, 657-664.
36. Golubkov, V., Hawes, D., Markland, F.S., 2003. Anti-angiogenic activity of contortrostatin, a disintegrin from Agkistrodon contortrix contortrix snake venom. Angiogenesis 6, 213-224.
37. Gould, R.J., Polokoff, M.A., Friedman, P.A., Huang, T.F., Holt, J.C., Cook, J.J., Niewiarowski, S., 1990. Disintegrins: A family of integrin inhibitory proteins from viper venoms. Proc. Soc. Exptl. Biol. Med. 195, 168-171.
38. Grothey, A., Galanis, E., 2009. Targeting angiogenesis: progress with anti-VEGF treatment with large molecules. Nat. Rev. Clin. Oncol. 6, 507-518.
39. Gutheil, J.C., Campbel, T.N., Pierce, P.R., Watkins, J.D., Huse, W.D., Bodkin, D.J., Cheresh, D.A., 2000. Targeted antiangiogenic therapy for cancer using vitaxin: A humanized monoclonal antibody to the integrin αvβ3. Clin. Cancer Res. 6, 3056-3061.
40. Harris, W.P., Mostaghel, E.A., Nelson, P.S., Montgomery, B., 2009. Androgen deprivation therapy: progress in understanding mechanisms of resistance and optimizing androgen depletion. Nat. Clin. Pract. Urol. 6, 76-85.
41. Hiles, J.J., Kolesar, J.M., 2008. Role of sunitinib and sorafenib in the treatment of metastatic renal cell carcinoma. Am. J. Health Syst. Pharm. 65, 123-131.
42. Hood, J.D., Bednarski, M., Frausto, R., Guccione, S., Reisfeld, R.A., Xiang, R., Cheresh, D.A., 2002. Tumor regression by targeted gene delivery to the neovasculature. Science 296, 2404-2407.
43. Huang, T.F., Holt, J.C., Kirby, E.R., Niewiarowski, S., 1989. Trigramin: primary structure and its inhibition of von willebrand factor binding to glycoprotein IIb-IIIa complex on human platelets. Biochemistry 28, 661-666.
44. Humphries, M.J., 1996. Integrin activation: The link between ligand binding and signal transduction. Curr. Opin. Cell Biol. 8, 632-640.
45. Hynes, R.O., 1992. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69, 11-25.
46. Jameson, D.M., Seifried, S.E., 1999. Quantification of protein-protein interactions using fluorescence polarization. Methods 19, 222-233.
47. Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., Thun, M.J., 2009. Cancer statistics, 2009. CA. Cancer J. Clin. 59, 225-249.
48. Jimenez, J.A., Kao, C., Raikwar, S., Gardner, T.A., 2006. Current status of anti-angiogenesis therapy for prostate cancer. Urol. Oncol. 24, 260-268.
49. Kerbel, R.S., 2001a. Clinical trials of antiangiogenic drugs: opportunities, problems, and assessment of initial results. J. Clin. Oncol. 19, 45S-51S.
50. Kerbel, R. S., 2001b. Molecular and physiologic mechanisms of drug resistance in cancer: An overview. Cancer Metastasis Rev. 20, 1-2.
51. Kumar, C.C., 2003. Integrin alpha v beta 3 as a therapeutic target for blocking tumor-induced angiogenesis. Curr. Drug. Targets. 4, 123-311.
52. Kwabi-Addo, B., Ozen, M., Ittmann, M., 2004. The role of fibroblast growth factors and their receptors in prostate cancer. Endocr. Relat. Cancer 11, 709-724.
53. Liotta, L.A., Kohn, E.C., 2001. The microenvironment of the tumour-host interface. Nature 411, 375-379.
54. Madan, R.A., Dahut, W.L., 2009. Angiogenesis inhibition in the treatment of prostate cancer. Anticancer Agents Med. Chem. 27, 5627-5633.
55. Marcinkiewicz, C., Vijay-Kumar, S., McLane, M.A., Niewiarowski, S., 1997. Significance of RGD loop and C-terminal domain of echistatin for recognition of αIIbβ3 and αvβ3 integrins and expression of ligand-induced binding site. Blood 90, 1565-1575.
56. Markland, F.S., Shieh, K., Zhou, Q., Golubkov, V., Sherwin, R.P., Richters, V., Sposto, R., 2001. A novel snake venom disintegrin that inhibits human ovarian cancer dissemination and angiogenesis in an orthotopic nude mouse model. Haemostasis 31, 183-191.
57. McLane, M.A., Joerger, T., Mahmoud, A., 2008. Disintegrins in health and disease. Front. Biosci. 13, 6617-6637.
58. McLane, M.A., Marcinkiewicz, C., Vijay-Kumar, S., Wierzbicka-Patynowski, I., Niewiarowski, S., 1998. Viper venom disintegrins and related molecules. Proc. Soc. Exp. Biol. Med. 219, 109-119.
59. Merseburger, A.S., Simon, A., Waalkes, S., Kuczyk, M.A., 2009. Sorafenib reveals efficacy in sequential treatment of metastatic renal cell cancer. Expert Rev. Anticancer Ther. 9, 1429-1434.
60. Minea, R., Swenson, S., Costa, F., Chen, T.C., Markland, F.S., 2005. Development of a novel recombinant disintegrin, contortrostatin, as an effective anti-tumor and anti-angiogenic agent. Pathophysiol. Haemost. Thromb. 34, 177-183.
61. Montagnani, F., Migali, C., Fiorentini, G., 2009. Progression-free survival in bevacizumab-based first-line treatment for patients with metastatic colorectal cancer: is it a really good end point? J. Clin. Oncol. 27, e132-e133; author reply e134-e135.
62. Mucci, L.A., Powolny, A., Giovannucci, E., Liao, Z., Kenfield, S.A., Shen, R., Stampfer, M.J., Clinton, S.K., 2009. Prospective study of prostate tumor angiogenesis and cancer-specific mortality in the health professionals follow-up study. J. Clin. Oncol. 9, 1070-1078.
63. Nemeth, J.A., Cher, M.L., Zhou, Z., Mullins, C., Bhagat, S., Trikha, M., 2003. Inhibition of αvβ3 integrin reduces angiogenesis, bone turnover, and tumor cell proliferation in experimental prostate cancer bone metastases. Clin. Exp. Metastasis 20, 413-420.
64. Niewiarowski, S., McLane, M.A., Kloczewiak, M., Stewart, G.J., 1994. Disintegrins and other naturally occurring antagonists of platelet fibrinogen receptors. Semin. Hematol. 31, 289-300.
65. Paez-Ribes, M., Allen, E., Hudock, J., Takeda, T., Okuyama, H., Vinals, F., Inoue, M., Bergers, G., Hanahan, D., Casanovas, O., 2009. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 15, 220-231.
66. Pallares, J., Rojo, F., Iriarte, J., Morote, J., Armadans, L.I., de Torres, I., 2006. Study of microvessel density and the expression of the angiogenic factors VEGF, bFGF and the receptors Flt-1 and FLK-1 in benign, premalignant and malignant prostate tissues. Histol. Histopathol. 21, 857- 865.
67. Phillips, D.R., Charo, I.F., Scarborough, R.M., 1991. GP IIb-IIIa: The responsive integrin. Cell 65, 359-362.
68. Pignatelli, M., Cardillo, M.R., Hanby, A., Stamp, G.W., 1992. Integrins and their accessory adhesion molecules in mammary carcinomas: loss of polarization in poorly differentiated tumors. Human Pathol. 23, 1159-1166.
69. Pinski, J., Markland, F., Wang, Q., Horiatis, D., Swenson, S., Costa, F. (2003). A novel therapy for prostate cancer based on the disintegrin contortrostatin. ASCO Annual Meeting. Chicago, IL.
70. Polnaszek, N., Kwabi-Addo, B., Peterson, L.E., Ozen, M., Greenberg, N.M., Ortega, S., Basilico, C., Ittmann, M., 2003. Fibroblast growth factor 2 promotes tumor progression in an autochthonous mouse model of prostate cancer. Cancer Res. 63, 5754-5760.
71. Pyrko, P., Wang, W., Markland, F.S., Swenson, S.D., Schmitmeier, S., Schonthal, A.H., Chen, T.C., 2005. The role of contortrostatin, a snake venom disintegrin, in the inhibition of tumor progression and prolongation of survival in a rodent glioma model. J. Neurosurg. 103, 526-537.
72. Ranieri, G., Patruno, R., Ruggieri, E., Montemurro, S., Valerio, P., Ribatti, D., 2006. Vascular endothelial growth factor (VEGF) as a target of bevacizumab in cancer: from the biology to the clinic. Curr. Med. Chem. 13, 1845-1857.
73. Reardon, D.A., Fink, K.L., Mikkelsen, T., Cloughesy, T.F., O'Neill, A., Plotkin, S., Glantz, M., Ravin, P., Raizer, J.J., Rich, K.M., Schiff, D., Shapiro, W.R., Burdette-Radoux, S., Dropcho, E.J., Wittemer, S.M., Nippgen, J., Picard, M., Nabors, L.B., 2008. Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme. J. Clin. Oncol. 26, 5610-5617.
74. Romanov, V.I., Goligorsky, M.S., 1999. RGD-recognizing integrins mediate interactions of human prostate carcinoma cells with endothelial cells in vitro. Prostate 39, 108-118.
75. Ruoslahti, E., 1991. Integrins. J. Clin. Invest. 87, 1-5.
76. Sanz, L., Chen, R.Q., Perez, A., Hilario, R., Juarez, P., Marcinkiewicz, C., Monleon, D., Celda, B., Xiong, Y.L., Perez-Paya, E., Calvete, J.J., 2005. cDNA cloning and functional expression of jerdostatin, a novel RTS-disintegrin from Trimeresurus jerdonii and a specific antagonist of the α1β1 integrin. J. Biol. Chem. 280, 40714-40722.
77. Saudek, V., Atkinson, R.A., Lepage, P., Pelton, J.T., 1991. The secondary structure of echistatin from 1H-NMR. Eur. J. Biochem. 202, 329-338.
78. Scarborough, R.M., Rose, J.W., Naughton, M.A., Phillips, D.R., Nannizzi, L., Arfsten, A., Campbell, A.M., Charo, I.F., 1993. Characterization of the integrin specificities of disintegrins isolated from American pit viper venoms. J. Biol. Chem. 268, 1058-1065.
79. Sharifi, N., Dahut, W.L., Figg, W.D., 2008. The genetics of castration-resistant prostate cancer: what can the germline tell us? Clin. Cancer Res. 14, 4691-4693.
80. Shebuski, R.J., Ramjit, D.R., Bencen, G.H., Polokoff, M.A., 1989. Characterization and platelet inhibitor activity of bitistatin, a potent arginine-glycine-aspartic acid-containing peptide from the venom of viper Bitis arietans. J. Biol. Chem. 264, 21550-21556.
81. Stoeltzing, O., Liu, W., Reinmuth, N., Fan, F., Parry, G.C., Parikh, A.A., McCarty, M.F., Bucana, C.D., Mazar, A.P., Ellis, L.M., 2003. Inhibition of integrin α5β1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice. Int. J. Cancer 104, 496-503.
82. Strohmeyer, D., Strauss, F., Rossing, C., Roberts, C., Kaufmann, O., Bartsch, G., Effert, P., 2004. Expression of bFGF, VEGF and c-met and their correlation with microvessel density and progression in prostate carcinoma. Anticancer Res. 24, 1797-1804.
83. Strömblad, S., Becker, J.C., Yebra, M., Brooks, P.C., Cheresh, D. A., 1996. Suppression of p53 activity and p21WAF1/CIP1 expression by vascular cell integrin αvβ3 during angiogenesis. J. Clin. Invest. 98, 426-433.
84. Sun, X.T., Ding, Y.T., Yan, X.G., Wu, L.Y., Li, Q., Cheng, N., Qiu, Y.D., Zhang, M.Y., 2004. Angiogenic synergistic effect of basic fibroblast growth factor and vascular endothelial growth factor in an in vitro quantitative microcarrier-based three-dimensional fibrin angiogenesis system. World J. Gastroenterol. 10, 2524-2528.
85. Sun, Y.X., Fang, M., Wang, J., Cooper, C.R., Pienta, K.J., Taichman, R.S., 2007. Expression and activation of αvβ3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells. Prostate 67, 61-73.
86. Swenson, S., Costa, F., Minea, R., Sherwin, R.P., Ernst, W., Fujii, G., Yang, D., Markland, F.S. Jr., 2004. Intravenous liposomal delivery of the snake venom disintegrin contortrostatin limits breast cancer progression. Mol. Cancer. Ther. 3, 499-511.
87. Trikha, M., De Clerck, Y.A., Markland, F.S., 1994a. Contortrostatin, a snake venom disintegrin, inhibits β1 integrin-mediated human metastatic melanoma cell adhesion and blocks experimental metastasis. Cancer Res. 54, 4993-4998.
88. Trikha, M., Rote, W.E., Manley, P.J., Lucchesi, B.R., Markland, F.S., 1994b. Purification and characterization of platelet aggregation inhibitors from snake venoms. Thromb. Res. 73, 39-52.
89. van Moorselaar, R.J., Voest, E.E., 2002. Angiogenesis in prostate cancer: its role in disease progression and possible therapeutic approaches. Mol. Cell. Endocrinol. 197, 239-250.
90. Weidner, N., Carroll, P.R., Flax, J., Blumenfeld, W., Folkman, J., 1993. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am. J. Pathol. 143, 401-409.
91. Witkowski, C.M., Rabinovitz, I., Nagle, R.B., Affinito, K.S., Cress, A.E., 1993. Characterization of integrin subunits, cellular adhesion and tumorgenicity of four human prostate cell lines. J. Cancer. Res. Clin. Oncol. 119, 637-644.
92. Woodle, M.C., 1993. Surface-modified liposomes: Assessment and characterization for increased stability and prolonged blood circulation. Chem. Phys. Lipids 64, 249-262.
93. Wu, I., Moses, M.A., 2000. Angiogenic molecules and mechanisms in breast cancer. Curr. Oncol. Rep. 2, 566-571.
94. Xiong, J.P., Stehle, T., Goodman, S.L., Arnaout, M.A., 2003. New insights into the structural basis of integrin activation. Blood 102, 1155-1159.
95. Yahalom, D., Wittelsberger, A., Mierke, D.F., Rosenblatt, M., Alexander, J.M., Chorev, M., 2002. Identification of the principal binding site for RGD-containing ligands in the αvβ3 integrin: A photoaffinity cross-linking study. Biochemistry 41, 8321-8331.
96. Yasuda, T., Gold, H.K., Leinbach, R.C., Yaoita, H., Fallon, J.T., Guerrero, L., Napier, M.A., Bunting, S., Collen, D., 1991. Kistrin, a polypeptide platelet GPIIb/IIIa receptor antagonist, enhances and sustains coronary arterial thrombolysis with recombinant tissue-type plasminogen activator in a canine preparation. Circulation 83, 1038-1047.
97. Zheng, D.Q., Woodard, A.S., Fornaro, M., Tallini, G., Languino, L.R., 1999. Prostatic carcinoma cell migration via αvβ3 integrin is modulated by a focal adhesion kinase pathway. Cancer Res. 59, 1655-1664.
98. Zhou, Q., Nakada, M.T., Arnold, C., Markland, F.S., 1999. Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits angiogenesis. Angiogenesis 3, 259-269.
99. Zhou, Q., Nakada, M.T., Brooks, P.C., Swenson, S.D., Ritter, M.R., Argounova, S., Arnold, C., Markland, F.S., 2000a. Contortrostatin, a homodimeric disintegrin, binds to integrin αvβ5. Biochem. Biophys. Res. Commun. 267, 350-355.
100. Zhou, Q., Sherwin, R.P., Parrish, C., Richters, V., Groshen, S.G., Tsao-Wei, D., Markland, F.S., 2000b. Contortrostatin, a dimeric disintegrin from Agkistrodon contortrix contortrix, inhibits breast cancer progression. Breast Cancer Res. Treat. 61, 249-260.
101. Zhu, A.X., Duda, D.G., Sahani, D.V., Jain, R.K., 2009. Development of sunitinib in hepatocellular carcinoma: rationale, early clinical experience, and correlative studies. Cancer J. 15, 263-268.