메뉴 건너뛰기




Volumn 11, Issue 3, 2009, Pages 218-226

Optimizing recent advances in metastatic renal cell carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ALPHA2A INTERFERON; AXITINIB; BEVACIZUMAB; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR4; EPIDERMAL GROWTH FACTOR RECEPTOR; EVEROLIMUS; INTERFERON; PAZOPANIB; PLACEBO; PLATELET DERIVED GROWTH FACTOR; RAPAMYCIN; SORAFENIB; SUNITINIB; TEMSIROLIMUS; TRANSFORMING GROWTH FACTOR ALPHA; VASCULOTROPIN;

EID: 65349147015     PISSN: 15233790     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11912-009-0031-5     Document Type: Review
Times cited : (8)

References (49)
  • 1
    • 39549089729 scopus 로고    scopus 로고
    • Predicting outcome to VEGF-targeted therapy in metastatic clear-cell renal cell carcinoma: Data from recent studies
    • Golshayan AR, Brick AJ, Choueiri TK: Predicting outcome to VEGF-targeted therapy in metastatic clear-cell renal cell carcinoma: Data from recent studies. Future Oncol 2008, 4:85-92.
    • (2008) Future Oncol , vol.4 , pp. 85-92
    • Golshayan, A.R.1    Brick, A.J.2    Choueiri, T.K.3
  • 4
    • 0028929682 scopus 로고
    • Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy
    • Fyfe G, Fisher RI, Rosenberg SA, et al.: Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J Clin Oncol 1995, 13:688-696.
    • (1995) J Clin Oncol , vol.13 , pp. 688-696
    • Fyfe, G.1    Fisher, R.I.2    Rosenberg, S.A.3
  • 5
    • 33749443423 scopus 로고    scopus 로고
    • Interleukin-2 therapy of metastatic renal cell carcinoma - Predictors of response
    • McDermott DF, Atkins MB: Interleukin-2 therapy of metastatic renal cell carcinoma - predictors of response. Semin Oncol 2006, 33:583-587.
    • (2006) Semin Oncol , vol.33 , pp. 583-587
    • McDermott, D.F.1    Atkins, M.B.2
  • 6
    • 0033514050 scopus 로고    scopus 로고
    • Interferon-alpha and survival in metastatic renal carcinoma: Early results of a randomised controlled trial. Medical Research Council Renal Cancer Collaborators
    • Interferon-alpha and survival in metastatic renal carcinoma: Early results of a randomised controlled trial. Medical Research Council Renal Cancer Collaborators. Lancet 1999, 353:14-17.
    • (1999) Lancet , vol.353 , pp. 14-17
  • 7
    • 36448930484 scopus 로고    scopus 로고
    • Medroxyprogesterone, interferon alfa-2a, interleukin 2, or combination of both cytokines in patients with metastatic renal carcinoma of intermediate prognosis: Results of a randomized controlled trial
    • Negrier S, Perol D, Ravaud A, et al.: Medroxyprogesterone, interferon alfa-2a, interleukin 2, or combination of both cytokines in patients with metastatic renal carcinoma of intermediate prognosis: Results of a randomized controlled trial. Cancer 2007, 110:2468-2477.
    • (2007) Cancer , vol.110 , pp. 2468-2477
    • Negrier, S.1    Perol, D.2    Ravaud, A.3
  • 8
    • 4644363095 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene and kidney cancer
    • Kaelin WG Jr: The von Hippel-Lindau tumor suppressor gene and kidney cancer. Clin Cancer Res 2004, 10:6290S-6295S.
    • (2004) Clin Cancer Res , vol.10
    • Kaelin Jr., W.G.1
  • 9
    • 65349133791 scopus 로고    scopus 로고
    • Novel strategies in the management of advanced renal cell carcinoma
    • In Edited by Bukowski RM. Manhasset, NY: CMPMedica
    • Garcia JA: Novel strategies in the management of advanced renal cell carcinoma. In New Treatment Paradigms in Renal Cell Carcinoma. Edited by Bukowski RM. Manhasset, NY: CMPMedica; 2007:95-113.
    • (2007) New Treatment Paradigms in Renal Cell Carcinoma , pp. 95-113
    • Garcia, J.A.1
  • 10
    • 4344602002 scopus 로고    scopus 로고
    • The biology and clinical relevance of the PTEN tumor suppressor pathway
    • Sansal I, Sellers WR: The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol 2004, 22:2954-2963.
    • (2004) J Clin Oncol , vol.22 , pp. 2954-2963
    • Sansal, I.1    Sellers, W.R.2
  • 11
    • 34648833206 scopus 로고    scopus 로고
    • Evolving role of novel targeted agents in renal cell carcinoma
    • discussion 1184, 1187, 1190
    • Hutson TE, Figlin RA: Evolving role of novel targeted agents in renal cell carcinoma. Oncology (Williston Park) 2007, 21:1175-1180; discussion 1184, 1187, 1190.
    • (2007) Oncology (Williston Park) , vol.21 , pp. 1175-1180
    • Hutson, T.E.1    Figlin, R.A.2
  • 12
    • 20044382799 scopus 로고    scopus 로고
    • Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors
    • Strumberg D, Richly H, Hilger RA, et al.: Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors. J Clin Oncol 2005, 23:965-972.
    • (2005) J Clin Oncol , vol.23 , pp. 965-972
    • Strumberg, D.1    Richly, H.2    Hilger, R.A.3
  • 13
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • Escudier B, Eisen T, Stadler WM, et al.: Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007, 356:125-134.
    • (2007) N Engl J Med , vol.356 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 14
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
    • Motzer RJ, Michaelson MD, Redman BG, et al.: Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 2006, 24:16-24.
    • (2006) J Clin Oncol , vol.24 , pp. 16-24
    • Motzer, R.J.1    Michaelson, M.D.2    Redman, B.G.3
  • 15
    • 33744954585 scopus 로고    scopus 로고
    • Sunitinib in patients with metastatic renal cell carcinoma
    • Motzer RJ, Rini BI, Bukowski RM, et al.: Sunitinib in patients with metastatic renal cell carcinoma. JAMA 2006, 295:2516-2524.
    • (2006) JAMA , vol.295 , pp. 2516-2524
    • Motzer, R.J.1    Rini, B.I.2    Bukowski, R.M.3
  • 16
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P, et al.: Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007, 356:115-124.
    • (2007) N Engl J Med , vol.356 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 17
    • 48649094719 scopus 로고    scopus 로고
    • Overall survival with sunitinib versus interferon (IFN)-alfa as first-line treatment of metastatic renal cell carcinoma (mRCC)
    • abstract 5024
    • Figlin RA, Hutson TE, Tomczak P, et al.: Overall survival with sunitinib versus interferon (IFN)-alfa as first-line treatment of metastatic renal cell carcinoma (mRCC). J Clin Oncol 2008, 26:aBstract 5024.
    • (2008) J Clin Oncol , vol.26
    • Figlin, R.A.1    Hutson, T.E.2    Tomczak, P.3
  • 18
    • 53849125004 scopus 로고    scopus 로고
    • mTORC1 inhibitors: Is temsirolimus in renal cancer telling us how they really work?
    • Le Tourneau CI Faivre S, Serova M, Raymond E: MTORC1 inhibitors: is temsirolimus in renal cancer telling us how they really work? Br J Cancer 2008, 99:1197-1203.
    • (2008) Br J Cancer , vol.99 , pp. 1197-1203
    • Le Tourneau, C.1    Faivre, S.2    Serova, M.3    Raymond, E.4
  • 19
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • Hudes G, Carducci M, Tomczak P, et al.: Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007, 356:2271-2281.
    • (2007) N Engl J Med , vol.356 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 20
    • 14144252047 scopus 로고    scopus 로고
    • Validation and extension of the Memorial Sloan-Kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma
    • Mekhail TM, Abou-Jawde RM, Boumerhi G, et al.: Validation and extension of the Memorial Sloan-Kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma. J Clin Oncol 2005, 23:832-841.
    • (2005) J Clin Oncol , vol.23 , pp. 832-841
    • Mekhail, T.M.1    Abou-Jawde, R.M.2    Boumerhi, G.3
  • 21
    • 0032772880 scopus 로고    scopus 로고
    • Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma
    • Motzer RJ, Mazumdar M, Bacik J, et al.: Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol 1999, 17:2530-2540.
    • (1999) J Clin Oncol , vol.17 , pp. 2530-2540
    • Motzer, R.J.1    Mazumdar, M.2    Bacik, J.3
  • 22
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
    • Motzer RJ, Escudier B, Oudard S, et al.: Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial. Lancet 2008, 372:449-456.
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 23
    • 56749161699 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
    • Rini BI, Halabi S, Rosenberg JE, et al.: Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol 2008, 26:5422-5428.
    • (2008) J Clin Oncol , vol.26 , pp. 5422-5428
    • Rini, B.I.1    Halabi, S.2    Rosenberg, J.E.3
  • 24
    • 37349080670 scopus 로고    scopus 로고
    • Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial
    • Escudier B, Pluzanska A, Koralewski P, et al.: Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial. Lancet 2007, 370:2103-2111.
    • (2007) Lancet , vol.370 , pp. 2103-2111
    • Escudier, B.1    Pluzanska, A.2    Koralewski, P.3
  • 25
    • 45549105967 scopus 로고    scopus 로고
    • Targeted therapy for metastatic renal cell carcinoma: A home run or a work in progress?
    • discussion 396, 402-403, 476 passim
    • Rini BI, Bukowski RM: Targeted therapy for metastatic renal cell carcinoma: A home run or a work in progress? Oncology (Williston Park) 2008, 22:388-396; discussion 396, 402-403, 476 passim.
    • (2008) Oncology (Williston Park) , vol.22 , pp. 388-396
    • Rini, B.I.1    Bukowski, R.M.2
  • 26
    • 55349124241 scopus 로고    scopus 로고
    • Biomarker analysis and final efficacy and safety results of a phase II renal cell carcinoma trial with pazopanib (GW786034), a multi-kinase angiogenesis inhibitor
    • abstract 5046
    • Hutson TE, Davis ID, Machiels JH, et al.: Biomarker analysis and final efficacy and safety results of a phase II renal cell carcinoma trial with pazopanib (GW786034), a multi-kinase angiogenesis inhibitor. J Clin Oncol 2008, 26:aBstract 5046.
    • (2008) J Clin Oncol , vol.26
    • Hutson, T.E.1    Davis, I.D.2    Machiels, J.H.3
  • 27
    • 35548997095 scopus 로고    scopus 로고
    • Pazopanib (GW786034) is active in metastatic renal cell carcinoma (RCC): Interim results of a phase II randomized discontinuation trial (RDT)
    • Hutson TE, Davis ID, Machiels JH, et al.: Pazopanib (GW786034) is active in metastatic renal cell carcinoma (RCC): Interim results of a phase II randomized discontinuation trial (RDT). J Clin Oncol 2007, 25:5031.
    • (2007) J Clin Oncol , vol.25 , pp. 5031
    • Hutson, T.E.1    Davis, I.D.2    Machiels, J.H.3
  • 28
    • 35448934762 scopus 로고    scopus 로고
    • Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: A phase II study
    • Rixe O, Bukowski RM, Michaelson MD, et al.: Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: A phase II study. Lancet Oncol 2007, 8:975-984.
    • (2007) Lancet Oncol , vol.8 , pp. 975-984
    • Rixe, O.1    Bukowski, R.M.2    Michaelson, M.D.3
  • 29
    • 57449104977 scopus 로고    scopus 로고
    • Phase I trial of bevacizumab plus sunitinib in patients with metastatic renal cell carcinoma
    • abstract 5100
    • Feldman DR, Ginsberg MS, Baum M, et al.: Phase I trial of bevacizumab plus sunitinib in patients with metastatic renal cell carcinoma. J Clin Oncol 2008, 26:aBstract 5100.
    • (2008) J Clin Oncol , vol.26
    • Feldman, D.R.1    Ginsberg, M.S.2    Baum, M.3
  • 30
    • 55349098735 scopus 로고    scopus 로고
    • Updated results of phase I trial of sorafenib (S) and bevacizumab (B) in patients with metastatic renal cell cancer (mRCC)
    • abstract 5011
    • Sosman JA, Flaherty KT, Atkins MB, et al.: Updated results of phase I trial of sorafenib (S) and bevacizumab (B) in patients with metastatic renal cell cancer (mRCC). J Clin Oncol 2008, 26:aBstract 5011.
    • (2008) J Clin Oncol , vol.26
    • Sosman, J.A.1    Flaherty, K.T.2    Atkins, M.B.3
  • 31
    • 60849086414 scopus 로고    scopus 로고
    • Phase I study combining treatment with temsirolimus and sunitinib malate in patients with advanced renal cell carcinoma
    • abstract 16020
    • Fischer P, Patel P, Carducci MA, et al.: Phase I study combining treatment with temsirolimus and sunitinib malate in patients with advanced renal cell carcinoma. J Clin Oncol 2008, 26:aBstract 16020.
    • (2008) J Clin Oncol , vol.26
    • Fischer, P.1    Patel, P.2    Carducci, M.A.3
  • 32
    • 0036138580 scopus 로고    scopus 로고
    • Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
    • Motzer RJ, Bacik J, Murphy BA, et al.: Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol 2002, 20:289-296.
    • (2002) J Clin Oncol , vol.20 , pp. 289-296
    • Motzer, R.J.1    Bacik, J.2    Murphy, B.A.3
  • 33
    • 34547108341 scopus 로고    scopus 로고
    • Clinical factors associated with outcome in patients with metastatic clear-cell renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy
    • Choueiri TK, Garcia JA, Elson P, et al.: Clinical factors associated with outcome in patients with metastatic clear-cell renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy. Cancer 2007, 110:543-550.
    • (2007) Cancer , vol.110 , pp. 543-550
    • Choueiri, T.K.1    Garcia, J.A.2    Elson, P.3
  • 34
    • 48649098245 scopus 로고    scopus 로고
    • von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma
    • discussion 865-866
    • Choueiri TK, Vaziri SA, Jaeger E, et al.: Von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma. J Urol 2008, 180:860-865; discussion 865-866.
    • (2008) J Urol , vol.180 , pp. 860-865
    • Choueiri, T.K.1    Vaziri, S.A.2    Jaeger, E.3
  • 35
    • 65349119014 scopus 로고    scopus 로고
    • Hypoxiainducible factor (HIF) 1a and 2a levels in cell lines and human tumor predicts response to sunitinib in renal cell carcinoma (RCC)
    • abstract 5008
    • Patel PH, Chadalavada RS, Ishill NM, et al.: Hypoxiainducible factor (HIF) 1a and 2a levels in cell lines and human tumor predicts response to sunitinib in renal cell carcinoma (RCC). J Clin Oncol 2008, 26:aBstract 5008.
    • (2008) J Clin Oncol , vol.26
    • Patel, P.H.1    Chadalavada, R.S.2    Ishill, N.M.3
  • 36
    • 30044432434 scopus 로고    scopus 로고
    • Hypoxiainducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
    • Thomas GV, Tran C, Mellinghoff IK, et al.: Hypoxiainducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med 2006, 12:122-127.
    • (2006) Nat Med , vol.12 , pp. 122-127
    • Thomas, G.V.1    Tran, C.2    Mellinghoff, I.K.3
  • 37
    • 35348858663 scopus 로고    scopus 로고
    • Potential histologic and molecular predictors of response to temsirolimus in patients with advanced renal cell carcinoma
    • Cho D, Signoretti S, Dabora S, et al.: Potential histologic and molecular predictors of response to temsirolimus in patients with advanced renal cell carcinoma. Clin Genitourin Cancer 2007, 5:379-385.
    • (2007) Clin Genitourin Cancer , vol.5 , pp. 379-385
    • Cho, D.1    Signoretti, S.2    Dabora, S.3
  • 38
    • 65349083980 scopus 로고    scopus 로고
    • Analysis of pten and hif1-a and correlation with efficacy in patients with advanced renal cell carcinoma treated with temsirolimus versus interferon-a
    • [abstract 4477]. Presented at the San Diego, CA; April 12-16
    • Figlin R, De Souza PL, McDermott D, et al.: Analysis of pten and hif1-a and correlation with efficacy in patients with advanced renal cell carcinoma treated with temsirolimus versus interferon-a [abstract 4477]. Presented at the 99th Annual Meeting of the American Association for Cancer Research Annual Meeting. San Diego, CA; April 12-16, 2008.
    • (2008) 99th Annual Meeting of the American Association for Cancer Research Annual Meeting
    • Figlin, R.1    De Souza, P.L.2    McDermott, D.3
  • 39
    • 55049136730 scopus 로고    scopus 로고
    • Targeted therapies for metastatic renal cell carcinoma: An overview of toxicity and dosing strategies
    • Hutson TE, Figlin RA, Kuhn JG, Motzer RJ: Targeted therapies for metastatic renal cell carcinoma: An overview of toxicity and dosing strategies. Oncologist 2008, 13:1084-1096.
    • (2008) Oncologist , vol.13 , pp. 1084-1096
    • Hutson, T.E.1    Figlin, R.A.2    Kuhn, J.G.3    Motzer, R.J.4
  • 40
    • 55349144429 scopus 로고    scopus 로고
    • Potential non-synonymous single nucleotide polymorphisms (nsSNPs) associated with toxicity in metastatic clear cell renal cell carcinoma (MCCRCC) patients (pts) treated with sunitinib
    • abstract 5009
    • Faber PW, Vaziri SA, Wood L, et al.: Potential non-synonymous single nucleotide polymorphisms (nsSNPs) associated with toxicity in metastatic clear cell renal cell carcinoma (MCCRCC) patients (pts) treated with sunitinib. J Clin Oncol 2008, 26:aBstract 5009.
    • (2008) J Clin Oncol , vol.26
    • Faber, P.W.1    Vaziri, S.A.2    Wood, L.3
  • 41
    • 51849111556 scopus 로고    scopus 로고
    • PI3K pathway alterations in cancer: Variations on a theme
    • Yuan TL, Cantley LC: PI3K pathVay alterations in cancer: variations on a theme. Oncogene 2008, 27:5497-5510.
    • (2008) Oncogene , vol.27 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 42
    • 58149179532 scopus 로고    scopus 로고
    • Sunitinib reverses type-1 immune suppression and decreases T-regulatory cells in renal cell carcinoma patients
    • Finke JH, Rini B, Ireland J, et al.: Sunitinib reverses type-1 immune suppression and decreases T-regulatory cells in renal cell carcinoma patients. Clin Cancer Res 2008, 14:6674-6682.
    • (2008) Clin Cancer Res , vol.14 , pp. 6674-6682
    • Finke, J.H.1    Rini, B.2    Ireland, J.3
  • 44
    • 31144468057 scopus 로고    scopus 로고
    • CXCR3/CXCR3 ligand biological axis impairs RENCA tumor growth by a mechanism of immunoangiostasis
    • Pan J, Burdick MD, Belperio JA, et al.: CXCR3/CXCR3 ligand biological axis impairs RENCA tumor growth by a mechanism of immunoangiostasis. J Immunol 2006, 176:1456-1464.
    • (2006) J Immunol , vol.176 , pp. 1456-1464
    • Pan, J.1    Burdick, M.D.2    Belperio, J.A.3
  • 45
    • 0141828145 scopus 로고    scopus 로고
    • Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
    • Staller P, Sulitkova J, Lisztwan J, et al.: Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 2003, 425:307-311.
    • (2003) Nature , vol.425 , pp. 307-311
    • Staller, P.1    Sulitkova, J.2    Lisztwan, J.3
  • 46
    • 33751319000 scopus 로고    scopus 로고
    • Stromal derived factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis
    • Pan J, Mestas J, Burdick MD, et al.: Stromal derived factor-1 (SDF-1/ CXCL12) and CXCR4 in renal cell carcinoma metastasis. Mol Cancer 2006, 5:56.
    • (2006) Mol Cancer , vol.5 , pp. 56
    • Pan, J.1    Mestas, J.2    Burdick, M.D.3
  • 47
    • 55949101858 scopus 로고    scopus 로고
    • Kinase requirements in human cells: III. Altered kinase requirements in VHL-/-cancer cells detected in a pilot synthetic lethal screen
    • Bommi-Reddy A, Almeciga I, Sawyer J, et al.: Kinase requirements in human cells: III. Altered kinase requirements in VHL-/-cancer cells detected in a pilot synthetic lethal screen. Proc Natl Acad Sci U S A 2008, 105:16484-16489.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 16484-16489
    • Bommi-Reddy, A.1    Almeciga, I.2    Sawyer, J.3
  • 48
    • 53649098582 scopus 로고    scopus 로고
    • Targeting cancer cells by synthetic lethality: Autophagy and VHL in cancer therapeutics
    • Chan DA, Giaccia AJ: Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics. Cell Cycle 2008, 7:2987-2990.
    • (2008) Cell Cycle , vol.7 , pp. 2987-2990
    • Chan, D.A.1    Giaccia, A.J.2
  • 49
    • 45849147350 scopus 로고    scopus 로고
    • A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy
    • Turcotte S, Chan DA, Sutphin PD, et al.: A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell 2008, 14:90-102.
    • (2008) Cancer Cell , vol.14 , pp. 90-102
    • Turcotte, S.1    Chan, D.A.2    Sutphin, P.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.