-
1
-
-
39549089729
-
Predicting outcome to VEGF-targeted therapy in metastatic clear-cell renal cell carcinoma: Data from recent studies
-
Golshayan AR, Brick AJ, Choueiri TK: Predicting outcome to VEGF-targeted therapy in metastatic clear-cell renal cell carcinoma: Data from recent studies. Future Oncol 2008, 4:85-92.
-
(2008)
Future Oncol
, vol.4
, pp. 85-92
-
-
Golshayan, A.R.1
Brick, A.J.2
Choueiri, T.K.3
-
4
-
-
0028929682
-
Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy
-
Fyfe G, Fisher RI, Rosenberg SA, et al.: Results of treatment of 255 patients with metastatic renal cell carcinoma who received high-dose recombinant interleukin-2 therapy. J Clin Oncol 1995, 13:688-696.
-
(1995)
J Clin Oncol
, vol.13
, pp. 688-696
-
-
Fyfe, G.1
Fisher, R.I.2
Rosenberg, S.A.3
-
5
-
-
33749443423
-
Interleukin-2 therapy of metastatic renal cell carcinoma - Predictors of response
-
McDermott DF, Atkins MB: Interleukin-2 therapy of metastatic renal cell carcinoma - predictors of response. Semin Oncol 2006, 33:583-587.
-
(2006)
Semin Oncol
, vol.33
, pp. 583-587
-
-
McDermott, D.F.1
Atkins, M.B.2
-
6
-
-
0033514050
-
Interferon-alpha and survival in metastatic renal carcinoma: Early results of a randomised controlled trial. Medical Research Council Renal Cancer Collaborators
-
Interferon-alpha and survival in metastatic renal carcinoma: Early results of a randomised controlled trial. Medical Research Council Renal Cancer Collaborators. Lancet 1999, 353:14-17.
-
(1999)
Lancet
, vol.353
, pp. 14-17
-
-
-
7
-
-
36448930484
-
Medroxyprogesterone, interferon alfa-2a, interleukin 2, or combination of both cytokines in patients with metastatic renal carcinoma of intermediate prognosis: Results of a randomized controlled trial
-
Negrier S, Perol D, Ravaud A, et al.: Medroxyprogesterone, interferon alfa-2a, interleukin 2, or combination of both cytokines in patients with metastatic renal carcinoma of intermediate prognosis: Results of a randomized controlled trial. Cancer 2007, 110:2468-2477.
-
(2007)
Cancer
, vol.110
, pp. 2468-2477
-
-
Negrier, S.1
Perol, D.2
Ravaud, A.3
-
8
-
-
4644363095
-
The von Hippel-Lindau tumor suppressor gene and kidney cancer
-
Kaelin WG Jr: The von Hippel-Lindau tumor suppressor gene and kidney cancer. Clin Cancer Res 2004, 10:6290S-6295S.
-
(2004)
Clin Cancer Res
, vol.10
-
-
Kaelin Jr., W.G.1
-
9
-
-
65349133791
-
Novel strategies in the management of advanced renal cell carcinoma
-
In Edited by Bukowski RM. Manhasset, NY: CMPMedica
-
Garcia JA: Novel strategies in the management of advanced renal cell carcinoma. In New Treatment Paradigms in Renal Cell Carcinoma. Edited by Bukowski RM. Manhasset, NY: CMPMedica; 2007:95-113.
-
(2007)
New Treatment Paradigms in Renal Cell Carcinoma
, pp. 95-113
-
-
Garcia, J.A.1
-
10
-
-
4344602002
-
The biology and clinical relevance of the PTEN tumor suppressor pathway
-
Sansal I, Sellers WR: The biology and clinical relevance of the PTEN tumor suppressor pathway. J Clin Oncol 2004, 22:2954-2963.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2954-2963
-
-
Sansal, I.1
Sellers, W.R.2
-
11
-
-
34648833206
-
Evolving role of novel targeted agents in renal cell carcinoma
-
discussion 1184, 1187, 1190
-
Hutson TE, Figlin RA: Evolving role of novel targeted agents in renal cell carcinoma. Oncology (Williston Park) 2007, 21:1175-1180; discussion 1184, 1187, 1190.
-
(2007)
Oncology (Williston Park)
, vol.21
, pp. 1175-1180
-
-
Hutson, T.E.1
Figlin, R.A.2
-
12
-
-
20044382799
-
Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors
-
Strumberg D, Richly H, Hilger RA, et al.: Phase I clinical and pharmacokinetic study of the Novel Raf kinase and vascular endothelial growth factor receptor inhibitor BAY 43-9006 in patients with advanced refractory solid tumors. J Clin Oncol 2005, 23:965-972.
-
(2005)
J Clin Oncol
, vol.23
, pp. 965-972
-
-
Strumberg, D.1
Richly, H.2
Hilger, R.A.3
-
13
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B, Eisen T, Stadler WM, et al.: Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med 2007, 356:125-134.
-
(2007)
N Engl J Med
, vol.356
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
14
-
-
33644833910
-
Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
-
Motzer RJ, Michaelson MD, Redman BG, et al.: Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J Clin Oncol 2006, 24:16-24.
-
(2006)
J Clin Oncol
, vol.24
, pp. 16-24
-
-
Motzer, R.J.1
Michaelson, M.D.2
Redman, B.G.3
-
15
-
-
33744954585
-
Sunitinib in patients with metastatic renal cell carcinoma
-
Motzer RJ, Rini BI, Bukowski RM, et al.: Sunitinib in patients with metastatic renal cell carcinoma. JAMA 2006, 295:2516-2524.
-
(2006)
JAMA
, vol.295
, pp. 2516-2524
-
-
Motzer, R.J.1
Rini, B.I.2
Bukowski, R.M.3
-
16
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, et al.: Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 2007, 356:115-124.
-
(2007)
N Engl J Med
, vol.356
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
17
-
-
48649094719
-
Overall survival with sunitinib versus interferon (IFN)-alfa as first-line treatment of metastatic renal cell carcinoma (mRCC)
-
abstract 5024
-
Figlin RA, Hutson TE, Tomczak P, et al.: Overall survival with sunitinib versus interferon (IFN)-alfa as first-line treatment of metastatic renal cell carcinoma (mRCC). J Clin Oncol 2008, 26:aBstract 5024.
-
(2008)
J Clin Oncol
, vol.26
-
-
Figlin, R.A.1
Hutson, T.E.2
Tomczak, P.3
-
18
-
-
53849125004
-
mTORC1 inhibitors: Is temsirolimus in renal cancer telling us how they really work?
-
Le Tourneau CI Faivre S, Serova M, Raymond E: MTORC1 inhibitors: is temsirolimus in renal cancer telling us how they really work? Br J Cancer 2008, 99:1197-1203.
-
(2008)
Br J Cancer
, vol.99
, pp. 1197-1203
-
-
Le Tourneau, C.1
Faivre, S.2
Serova, M.3
Raymond, E.4
-
19
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
Hudes G, Carducci M, Tomczak P, et al.: Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007, 356:2271-2281.
-
(2007)
N Engl J Med
, vol.356
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
-
20
-
-
14144252047
-
Validation and extension of the Memorial Sloan-Kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma
-
Mekhail TM, Abou-Jawde RM, Boumerhi G, et al.: Validation and extension of the Memorial Sloan-Kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma. J Clin Oncol 2005, 23:832-841.
-
(2005)
J Clin Oncol
, vol.23
, pp. 832-841
-
-
Mekhail, T.M.1
Abou-Jawde, R.M.2
Boumerhi, G.3
-
21
-
-
0032772880
-
Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma
-
Motzer RJ, Mazumdar M, Bacik J, et al.: Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol 1999, 17:2530-2540.
-
(1999)
J Clin Oncol
, vol.17
, pp. 2530-2540
-
-
Motzer, R.J.1
Mazumdar, M.2
Bacik, J.3
-
22
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
-
Motzer RJ, Escudier B, Oudard S, et al.: Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial. Lancet 2008, 372:449-456.
-
(2008)
Lancet
, vol.372
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
-
23
-
-
56749161699
-
Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206
-
Rini BI, Halabi S, Rosenberg JE, et al.: Bevacizumab plus interferon alfa compared with interferon alfa monotherapy in patients with metastatic renal cell carcinoma: CALGB 90206. J Clin Oncol 2008, 26:5422-5428.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5422-5428
-
-
Rini, B.I.1
Halabi, S.2
Rosenberg, J.E.3
-
24
-
-
37349080670
-
Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial
-
Escudier B, Pluzanska A, Koralewski P, et al.: Bevacizumab plus interferon alfa-2a for treatment of metastatic renal cell carcinoma: A randomised, double-blind phase III trial. Lancet 2007, 370:2103-2111.
-
(2007)
Lancet
, vol.370
, pp. 2103-2111
-
-
Escudier, B.1
Pluzanska, A.2
Koralewski, P.3
-
25
-
-
45549105967
-
Targeted therapy for metastatic renal cell carcinoma: A home run or a work in progress?
-
discussion 396, 402-403, 476 passim
-
Rini BI, Bukowski RM: Targeted therapy for metastatic renal cell carcinoma: A home run or a work in progress? Oncology (Williston Park) 2008, 22:388-396; discussion 396, 402-403, 476 passim.
-
(2008)
Oncology (Williston Park)
, vol.22
, pp. 388-396
-
-
Rini, B.I.1
Bukowski, R.M.2
-
26
-
-
55349124241
-
Biomarker analysis and final efficacy and safety results of a phase II renal cell carcinoma trial with pazopanib (GW786034), a multi-kinase angiogenesis inhibitor
-
abstract 5046
-
Hutson TE, Davis ID, Machiels JH, et al.: Biomarker analysis and final efficacy and safety results of a phase II renal cell carcinoma trial with pazopanib (GW786034), a multi-kinase angiogenesis inhibitor. J Clin Oncol 2008, 26:aBstract 5046.
-
(2008)
J Clin Oncol
, vol.26
-
-
Hutson, T.E.1
Davis, I.D.2
Machiels, J.H.3
-
27
-
-
35548997095
-
Pazopanib (GW786034) is active in metastatic renal cell carcinoma (RCC): Interim results of a phase II randomized discontinuation trial (RDT)
-
Hutson TE, Davis ID, Machiels JH, et al.: Pazopanib (GW786034) is active in metastatic renal cell carcinoma (RCC): Interim results of a phase II randomized discontinuation trial (RDT). J Clin Oncol 2007, 25:5031.
-
(2007)
J Clin Oncol
, vol.25
, pp. 5031
-
-
Hutson, T.E.1
Davis, I.D.2
Machiels, J.H.3
-
28
-
-
35448934762
-
Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: A phase II study
-
Rixe O, Bukowski RM, Michaelson MD, et al.: Axitinib treatment in patients with cytokine-refractory metastatic renal-cell cancer: A phase II study. Lancet Oncol 2007, 8:975-984.
-
(2007)
Lancet Oncol
, vol.8
, pp. 975-984
-
-
Rixe, O.1
Bukowski, R.M.2
Michaelson, M.D.3
-
29
-
-
57449104977
-
Phase I trial of bevacizumab plus sunitinib in patients with metastatic renal cell carcinoma
-
abstract 5100
-
Feldman DR, Ginsberg MS, Baum M, et al.: Phase I trial of bevacizumab plus sunitinib in patients with metastatic renal cell carcinoma. J Clin Oncol 2008, 26:aBstract 5100.
-
(2008)
J Clin Oncol
, vol.26
-
-
Feldman, D.R.1
Ginsberg, M.S.2
Baum, M.3
-
30
-
-
55349098735
-
Updated results of phase I trial of sorafenib (S) and bevacizumab (B) in patients with metastatic renal cell cancer (mRCC)
-
abstract 5011
-
Sosman JA, Flaherty KT, Atkins MB, et al.: Updated results of phase I trial of sorafenib (S) and bevacizumab (B) in patients with metastatic renal cell cancer (mRCC). J Clin Oncol 2008, 26:aBstract 5011.
-
(2008)
J Clin Oncol
, vol.26
-
-
Sosman, J.A.1
Flaherty, K.T.2
Atkins, M.B.3
-
31
-
-
60849086414
-
Phase I study combining treatment with temsirolimus and sunitinib malate in patients with advanced renal cell carcinoma
-
abstract 16020
-
Fischer P, Patel P, Carducci MA, et al.: Phase I study combining treatment with temsirolimus and sunitinib malate in patients with advanced renal cell carcinoma. J Clin Oncol 2008, 26:aBstract 16020.
-
(2008)
J Clin Oncol
, vol.26
-
-
Fischer, P.1
Patel, P.2
Carducci, M.A.3
-
32
-
-
0036138580
-
Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
-
Motzer RJ, Bacik J, Murphy BA, et al.: Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma. J Clin Oncol 2002, 20:289-296.
-
(2002)
J Clin Oncol
, vol.20
, pp. 289-296
-
-
Motzer, R.J.1
Bacik, J.2
Murphy, B.A.3
-
33
-
-
34547108341
-
Clinical factors associated with outcome in patients with metastatic clear-cell renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy
-
Choueiri TK, Garcia JA, Elson P, et al.: Clinical factors associated with outcome in patients with metastatic clear-cell renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy. Cancer 2007, 110:543-550.
-
(2007)
Cancer
, vol.110
, pp. 543-550
-
-
Choueiri, T.K.1
Garcia, J.A.2
Elson, P.3
-
34
-
-
48649098245
-
von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma
-
discussion 865-866
-
Choueiri TK, Vaziri SA, Jaeger E, et al.: Von Hippel-Lindau gene status and response to vascular endothelial growth factor targeted therapy for metastatic clear cell renal cell carcinoma. J Urol 2008, 180:860-865; discussion 865-866.
-
(2008)
J Urol
, vol.180
, pp. 860-865
-
-
Choueiri, T.K.1
Vaziri, S.A.2
Jaeger, E.3
-
35
-
-
65349119014
-
Hypoxiainducible factor (HIF) 1a and 2a levels in cell lines and human tumor predicts response to sunitinib in renal cell carcinoma (RCC)
-
abstract 5008
-
Patel PH, Chadalavada RS, Ishill NM, et al.: Hypoxiainducible factor (HIF) 1a and 2a levels in cell lines and human tumor predicts response to sunitinib in renal cell carcinoma (RCC). J Clin Oncol 2008, 26:aBstract 5008.
-
(2008)
J Clin Oncol
, vol.26
-
-
Patel, P.H.1
Chadalavada, R.S.2
Ishill, N.M.3
-
36
-
-
30044432434
-
Hypoxiainducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
-
Thomas GV, Tran C, Mellinghoff IK, et al.: Hypoxiainducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med 2006, 12:122-127.
-
(2006)
Nat Med
, vol.12
, pp. 122-127
-
-
Thomas, G.V.1
Tran, C.2
Mellinghoff, I.K.3
-
37
-
-
35348858663
-
Potential histologic and molecular predictors of response to temsirolimus in patients with advanced renal cell carcinoma
-
Cho D, Signoretti S, Dabora S, et al.: Potential histologic and molecular predictors of response to temsirolimus in patients with advanced renal cell carcinoma. Clin Genitourin Cancer 2007, 5:379-385.
-
(2007)
Clin Genitourin Cancer
, vol.5
, pp. 379-385
-
-
Cho, D.1
Signoretti, S.2
Dabora, S.3
-
38
-
-
65349083980
-
Analysis of pten and hif1-a and correlation with efficacy in patients with advanced renal cell carcinoma treated with temsirolimus versus interferon-a
-
[abstract 4477]. Presented at the San Diego, CA; April 12-16
-
Figlin R, De Souza PL, McDermott D, et al.: Analysis of pten and hif1-a and correlation with efficacy in patients with advanced renal cell carcinoma treated with temsirolimus versus interferon-a [abstract 4477]. Presented at the 99th Annual Meeting of the American Association for Cancer Research Annual Meeting. San Diego, CA; April 12-16, 2008.
-
(2008)
99th Annual Meeting of the American Association for Cancer Research Annual Meeting
-
-
Figlin, R.1
De Souza, P.L.2
McDermott, D.3
-
39
-
-
55049136730
-
Targeted therapies for metastatic renal cell carcinoma: An overview of toxicity and dosing strategies
-
Hutson TE, Figlin RA, Kuhn JG, Motzer RJ: Targeted therapies for metastatic renal cell carcinoma: An overview of toxicity and dosing strategies. Oncologist 2008, 13:1084-1096.
-
(2008)
Oncologist
, vol.13
, pp. 1084-1096
-
-
Hutson, T.E.1
Figlin, R.A.2
Kuhn, J.G.3
Motzer, R.J.4
-
40
-
-
55349144429
-
Potential non-synonymous single nucleotide polymorphisms (nsSNPs) associated with toxicity in metastatic clear cell renal cell carcinoma (MCCRCC) patients (pts) treated with sunitinib
-
abstract 5009
-
Faber PW, Vaziri SA, Wood L, et al.: Potential non-synonymous single nucleotide polymorphisms (nsSNPs) associated with toxicity in metastatic clear cell renal cell carcinoma (MCCRCC) patients (pts) treated with sunitinib. J Clin Oncol 2008, 26:aBstract 5009.
-
(2008)
J Clin Oncol
, vol.26
-
-
Faber, P.W.1
Vaziri, S.A.2
Wood, L.3
-
41
-
-
51849111556
-
PI3K pathway alterations in cancer: Variations on a theme
-
Yuan TL, Cantley LC: PI3K pathVay alterations in cancer: variations on a theme. Oncogene 2008, 27:5497-5510.
-
(2008)
Oncogene
, vol.27
, pp. 5497-5510
-
-
Yuan, T.L.1
Cantley, L.C.2
-
42
-
-
58149179532
-
Sunitinib reverses type-1 immune suppression and decreases T-regulatory cells in renal cell carcinoma patients
-
Finke JH, Rini B, Ireland J, et al.: Sunitinib reverses type-1 immune suppression and decreases T-regulatory cells in renal cell carcinoma patients. Clin Cancer Res 2008, 14:6674-6682.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6674-6682
-
-
Finke, J.H.1
Rini, B.2
Ireland, J.3
-
44
-
-
31144468057
-
CXCR3/CXCR3 ligand biological axis impairs RENCA tumor growth by a mechanism of immunoangiostasis
-
Pan J, Burdick MD, Belperio JA, et al.: CXCR3/CXCR3 ligand biological axis impairs RENCA tumor growth by a mechanism of immunoangiostasis. J Immunol 2006, 176:1456-1464.
-
(2006)
J Immunol
, vol.176
, pp. 1456-1464
-
-
Pan, J.1
Burdick, M.D.2
Belperio, J.A.3
-
45
-
-
0141828145
-
Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL
-
Staller P, Sulitkova J, Lisztwan J, et al.: Chemokine receptor CXCR4 downregulated by von Hippel-Lindau tumour suppressor pVHL. Nature 2003, 425:307-311.
-
(2003)
Nature
, vol.425
, pp. 307-311
-
-
Staller, P.1
Sulitkova, J.2
Lisztwan, J.3
-
46
-
-
33751319000
-
Stromal derived factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis
-
Pan J, Mestas J, Burdick MD, et al.: Stromal derived factor-1 (SDF-1/ CXCL12) and CXCR4 in renal cell carcinoma metastasis. Mol Cancer 2006, 5:56.
-
(2006)
Mol Cancer
, vol.5
, pp. 56
-
-
Pan, J.1
Mestas, J.2
Burdick, M.D.3
-
47
-
-
55949101858
-
Kinase requirements in human cells: III. Altered kinase requirements in VHL-/-cancer cells detected in a pilot synthetic lethal screen
-
Bommi-Reddy A, Almeciga I, Sawyer J, et al.: Kinase requirements in human cells: III. Altered kinase requirements in VHL-/-cancer cells detected in a pilot synthetic lethal screen. Proc Natl Acad Sci U S A 2008, 105:16484-16489.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 16484-16489
-
-
Bommi-Reddy, A.1
Almeciga, I.2
Sawyer, J.3
-
48
-
-
53649098582
-
Targeting cancer cells by synthetic lethality: Autophagy and VHL in cancer therapeutics
-
Chan DA, Giaccia AJ: Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics. Cell Cycle 2008, 7:2987-2990.
-
(2008)
Cell Cycle
, vol.7
, pp. 2987-2990
-
-
Chan, D.A.1
Giaccia, A.J.2
-
49
-
-
45849147350
-
A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy
-
Turcotte S, Chan DA, Sutphin PD, et al.: A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell 2008, 14:90-102.
-
(2008)
Cancer Cell
, vol.14
, pp. 90-102
-
-
Turcotte, S.1
Chan, D.A.2
Sutphin, P.D.3
|