Evaluation of 64Cu labeled GX1: A phage display peptide probe for PET imaging of tumor vasculature

Molecular Imaging and Biology

Volumn 14, Issue 1, 2012, Pages 96-105

  Chen, Kai ^a,b   Sun, Xilin ^b   Niu, Gang ^b   Ma, Ying ^b   Yap, Li Peng ^a   Hui, Xiaoli ^c   Wu, Kaichun ^c   Fan, Daiming ^c   Conti, Peter S ^a   Chen, Xiaoyuan ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

64Cu Labeled GX1 peptide; PET imaging; Phage display; Tumor vasculature

Indexed keywords

COPPER GX1 PEPTIDE TETRAXETAN CU 64; TETRAXETAN; TRACER; UNCLASSIFIED DRUG; COPPER; DIAGNOSTIC AGENT; PEPTIDE; RADIOPHARMACEUTICAL AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CELL TRANSPORT; CONTROLLED STUDY; DRUG DISTRIBUTION; FEMALE; GLIOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MOLECULAR IMAGING; MOLECULAR PROBE; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PHAGE DISPLAY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; ANALYSIS OF VARIANCE; ANIMAL; CHEMISTRY; DRUG STABILITY; GLIOMA; METABOLISM; METHODOLOGY; NEOVASCULARIZATION (PATHOLOGY); NUDE MOUSE; PEPTIDE LIBRARY; SCINTISCANNING; TISSUE DISTRIBUTION; TUMOR CELL LINE; VASCULARIZATION; XENOGRAFT;

ANIMALIA;

ANALYSIS OF VARIANCE; ANIMALS; CELL LINE, TUMOR; COPPER RADIOISOTOPES; DRUG STABILITY; FEMALE; GLIOMA; HUMANS; MICE; MICE, NUDE; MOLECULAR IMAGING; MOLECULAR PROBES; NEOVASCULARIZATION, PATHOLOGIC; PEPTIDE LIBRARY; PEPTIDES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; TISSUE DISTRIBUTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 84861481511     PISSN: 15361632     EISSN: 18602002     Source Type: Journal    
DOI: 10.1007/s11307-011-0479-1     Document Type: Article

References (39)

1. Weissleder R, Mahmood U (2001) Molecular imaging. Radiology 219:316-333 (Pubitemid 32336342)
2. Chen K, Chen X (2010) Design and development of molecular imaging probes. Curr Top Med Chem 10:1227-1236
3. Massoud TF, Gambhir SS (2003) Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev 17:545-580 (Pubitemid 36307540)
4. Chen K, Conti PS (2010) Target-specific delivery of peptide-based probes for PET imaging. Adv Drug Deliv Rev 62:1005-1022
5. Deutscher SL (2010) Phage display in molecular imaging and diagnosis of cancer. Chem Rev 110:3196-3211
6. Chen B, Cao S, Zhang Y, Wang X, Liu J, Hui X, Wan Y, Du W, Wang L, Wu K, Fan D (2009) A novel peptide (GX1) homing to gastric cancer vasculature inhibits angiogenesis and cooperates with TNF alpha in anti-tumor therapy. BMC Cell Biol 10:63
7. Zhi M, Wu KC, Dong L, Hao ZM, Deng TZ, Hong L, Liang SH, Zhao PT, Qiao TD, Wang Y, Xu X, Fan DM (2004) Characterization of a specific phage-displayed peptide binding to vasculature of human gastric cancer. Cancer Biol Ther 3:1232-1235 (Pubitemid 41350958)
8. Hui X, Han Y, Liang S, Liu Z, Liu J, Hong L, Zhao L, He L, Cao S, Chen B, Yan K, Jin B, Chai N, Wang J, Wu K, Fan D (2008) Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC. J Control Release 131:86-93
9. Cai W, Gambhir SS, Chen X (2008) Chapter 7. Molecular imaging of tumor vasculature. Methods Enzymol 445:141-176
10. Weissleder R (2006) Molecular imaging in cancer. Science 312:1168-1171
11. Weissleder R (2002) Scaling down imaging: molecular mapping of cancer in mice. Nat Rev Cancer 2:11-18
12. Cai W, Rao J, Gambhir SS, Chen X (2006) How molecular imaging is speeding up antiangiogenic drug development. Mol Cancer Ther 5:2624-2633 (Pubitemid 44848989)
13. Blower PJ, Lewis JS, Zweit J (1996) Copper radionuclides and radiopharmaceuticals in nuclear medicine. Nucl Med Biol 23:957-980 (Pubitemid 27050682)
14. Liu S (2008) Bifunctional coupling agents for radiolabeling of biomolecules and target-specific delivery of metallic radionuclides. Adv Drug Deliv Rev 60:1347-1370
15. Sun X, Anderson CJ (2004) Production and applications of copper-64 radiopharmaceuticals. Methods Enzymol 386:237-261 (Pubitemid 38657596)
16. Anderson CJ, Ferdani R (2009) Copper-64 radiopharmaceuticals for PET imaging of cancer: advances in preclinical and clinical research. Cancer Biother Radiopharm 24:379-393
17. Shokeen M, Anderson CJ (2009) Molecular imaging of cancer with copper-64 radiopharmaceuticals and positron emission tomography (PET). Acc Chem Res 42:832-841
18. Liu Z, Niu G, Wang F, Chen X (2009) (68)Ga-labeled NOTA-RGD-BBN peptide for dual integrin and GRPR-targeted tumor imaging. Eur J Nucl Med Mol Imaging 36:1483-1494
19. Sun X, Niu G, Yan Y, Yang M, Chen K, Ma Y, Chan N, Shen B, Chen X (2010) Phage display-derived peptides for osteosarcoma imaging. Clin Cancer Res 16:4268-4277
20. Chen K, Chen X (2011) PET Imaging of cancer biology: current status and future prospects. Semin Oncol 38:70-86
21. Ellis LM, Liu W, Ahmad SA, Fan F, Jung YD, Shaheen RM, Reinmuth N (2001) Overview of angiogenesis: biologic implications for antiangiogenic therapy. Semin Oncol 28:94-104 (Pubitemid 33065115)
22. Kuwano M, Fukushi J, Okamoto M, Nishie A, Goto H, Ishibashi T, Ono M (2001) Angiogenesis factors. Intern Med 40:565-572 (Pubitemid 32799384)
23. Yancopoulos GD, Davis S, Gale NW, Rudge JS, Wiegand SJ, Holash J (2000) Vascular-specific growth factors and blood vessel formation. Nature 407:242-248
24. Bergers G, Benjamin LE (2003) Tumorigenesis and the angiogenic switch. Nat Rev Cancer 3:401-410 (Pubitemid 37328844)
25. Hanahan D, Folkman J (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86:353-364 (Pubitemid 26272076)
26. Ueberberg S, Schneider S (2010) Phage library-screening: a powerful approach for generation of targeting-agents specific for normal pancreatic islet-cells and islet-cell carcinoma in vivo. Regul Pept 160:1-8
27. Soda Y, Marumoto T, Friedmann-Morvinski D, Soda M, Liu F, Michiue H, Pastorino S, Yang M, Hoffman RM, Kesari S, Verma IM (2011) Feature article: transdifferentiation of glioblastoma cells into vascular endothelial cells. Proc Natl Acad Sci U S A (in press)
28. Chen X, Park R, Hou Y, Tohme M, Shahinian AH, Bading JR, Conti PS (2004) microPET and autoradiographic imaging of GRP receptor expression with 64Cu-DOTA-[Lys3]bombesin in human prostate adenocarcinoma xenografts. J Nucl Med 45:1390-1397 (Pubitemid 47618540)
29. Wu Y, Zhang X, Xiong Z, Cheng Z, Fisher DR, Liu S, Gambhir SS, Chen X (2005) microPET imaging of glioma integrin {alpha}v{beta}3 expression using (64)Cu-labeled tetrameric RGD peptide. J Nucl Med 46:1707-1718 (Pubitemid 46211595)
30. Li ZB, Cai W, Cao Q, Chen K, Wu Z, He L, Chen X (2007) (64)Culabeled tetrameric and octameric RGD peptides for small-animal PET of tumor alpha(v)beta(3) integrin expression. J Nucl Med 48:1162-1171 (Pubitemid 47052657)
31. Cai W, Wu Y, Chen K, Cao Q, Tice DA, Chen X (2006) In vitro and in vivo characterization of 64Cu-labeled Abegrin, a humanized monoclonal antibody against integrin alpha v beta 3. Cancer Res 66:9673-9681 (Pubitemid 44623667)
32. Chen X, Liu S, Hou Y, Tohme M, Park R, Bading JR, Conti PS (2004) MicroPET imaging of breast cancer alphav-integrin expression with 64Cu-labeled dimeric RGD peptides. Mol Imaging Biol 6:350-359 (Pubitemid 39243068)
33. Boswell CA, Sun X, Niu W, Weisman GR, Wong EH, Rheingold AL, Anderson CJ (2004) Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes. J Med Chem 47:1465-1474 (Pubitemid 38327472)
34. Sun X, Wuest M, Weisman GR, Wong EH, Reed DP, Boswell CA, Motekaitis R, Martell AE, Welch MJ, Anderson CJ (2002) Radio-labeling and in vivo behavior of copper-64-labeled cross-bridged cyclam ligands. J Med Chem 45:469-477 (Pubitemid 34073464)
35. Cai H, Li Z, Huang CW, Shahinian AH, Wang H, Park R, Conti PS (2010) Evaluation of copper-64 labeled AmBaSar conjugated cyclic RGD peptide for improved MicroPET imaging of integrin alphavbeta3 expression. Bioconjug Chem 21:1417-1424
36. Cai H, Li Z, Huang CW, Park R, Shahinian AH, Conti PS (2010) An improved synthesis and biological evaluation of a new cage-like bifunctional chelator, 4-((8-amino-3, 6, 10, 13, 16, 19-hexaazabicyclo [6.6.6]icosane-1-ylamino)methyl) benzoic acid, for 64Cu radiopharmaceuticals. Nucl Med Biol 37:57-65
37. Chen X (2006) Multimodality imaging of tumor integrin alphavbeta3 expression. Mini Rev Med Chem 6:227-234
38. Haubner R, Wester HJ, Weber WA, Mang C, Ziegler SI, Goodman SL, Senekowitsch-Schmidtke R, Kessler H, Schwaiger M (2001) Noninvasive imaging of alpha(v)beta3 integrin expression using 18 F-labeled RGD-containing glycopeptide and positron emission tomography. Cancer Res 61:1781-1785 (Pubitemid 32691983)
39. Shi J, Kim YS, Zhai S, Liu Z, Chen X, Liu S (2009) Improving tumor uptake and pharmacokinetics of (64)Cu-labeled cyclic RGD peptide dimers with Gly(3) and PEG(4) linkers. Bioconjug Chem 20:750-759