Structural stabilization in tetrameric or polymeric hemoglobin determines its interaction with endogenous antioxidant scavenger pathways

Antioxidants and Redox Signaling

Volumn 10, Issue 8, 2008, Pages 1449-1462

  Buehler, Paul W ^a   Vallelian, Florence ^b   Mikolajczyk, Malgorzata G ^a   Schoedon, Gabriele ^b   Schweizer, Thomas ^c   Alayash, Abdu I ^a   Schaer, Dominik J ^b,d  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c ETH ZURICH   (Switzerland)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLOBIN; ANTIOXIDANT; BETA GLOBIN; CD163 ANTIGEN; FERRITIN; HAPTOGLOBIN; HEMOGLOBIN; HEMOGLOBIN A;

ARTICLE; BINDING AFFINITY; CELL STRAIN HEK293; CONTROLLED STUDY; CROSS LINKING; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; MOLECULAR SIZE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN POLYMERIZATION; PROTEIN STRUCTURE; PROTEIN TRANSPORT;

ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; ANTIOXIDANTS; CELL LINE; CHROMATOGRAPHY, GEL; DIMERIZATION; FERRITINS; GLOBINS; HAPTOGLOBINS; HEMOGLOBINS; HUMANS; MODELS, BIOLOGICAL; PROTEIN BINDING; RECEPTORS, CELL SURFACE; RECEPTORS, SCAVENGER; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SURFACE PLASMON RESONANCE;

EID: 51749109815     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2008.2028     Document Type: Article

References (39)

1. Abraham NG and Drummond G. CD163-Mediated hemoglobin-heme uptake activates macrophage HO-1, providing an antiinflammatory function. Circ Res 99: 911-914, 2006.
2. Asleh R, Guetta J, Kalet-Litman S, Miller-Lotan R, and Levy AP. Haptoglobin genotype- and diabetes-dependent differences in iron-mediated oxidative stress in vitro and in vivo. Circ Res 96: 435-441, 2005.
3. Benesch RE, Ikeda S, and Benesch R. Reaction of haptoglobin with hemoglobin covalently cross-linked between the alpha beta dimers. J Biol Chem 251: 465-470, 1976.
4. Buehler PW, Boykins RA, Jia Y, Norris S, Freedberg DI, and Alayash AI. Structural and functional characterization of glutaraldehyde-polymerized bovine hemoglobin and its isolated fractions. Analyt Chem 77: 3466-3478, 2005.
5. Buehler PW, Boykins RA, Norris S, and Alayash AI. Chemical characterization of diaspirin cross-linked hemoglobin polymerized with poly(ethylene glycol). Analyt Chem 78: 4634-4641, 2006.
6. Bunn HF. Effect of sulfhydryl reagents on the binding of human hemoglobin to haptoglobin. J Lab Clin Med 70: 606-618, 1967.
7. Cid MC, Grant DS, Hoffman GS, Auerbach R, Fauci AS, and Kleinman HK. Identification of haptoglobin as an angiogenic factor in sera from patients with systemic vasculitis. J Clin Invest 91: 977-985, 1993.
8. D'Agnillo F and Alayash AI. Redox cycling of diaspirin cross-linked hemoglobin induces G2/M arrest and apoptosis in cultured endothelial cells. Blood 98: 3315-3323, 2001.
9. Graca-Souza AV, Arruda MA, de Freitas MS, Barja-Fidalgo C, and Oliveira PL. Neutrophil activation by heme: implications for inflammatory processes. Blood 99: 4160-4165, 2002.
10. Hai TT, Pereira DE, Nelson DJ, Catarello J, and Srnak A. Surface modification of diaspirin cross-linked hemoglobin (DCLHb) with chondroitin-4-sulfate derivatives: Part 1. Bioconjug Chem 11: 705-713, 2000.
11. Hai TT, Pereira DE, Nelson DJ, Srnak A, and Catarello J. Polymerization of diaspirin cross-linked hemoglobin (DCLHb) with water-soluble, nonimmunogenic polyamide cross-linking agents. Bioconjug Chem 10: 1013-1020, 1999.
12. Jeney V, Balla J, Yachie A, Varga Z, Vercellotti GM, Eaton JW, and Balla G. Pro-oxidant and cytotoxic effects of circulating heme. Blood 100: 879-887, 2002.
13. Jia Y, Wood F, Menu P, Faivre B, Caron A, and Alayash AI. Oxygen binding and oxidation reactions of human hemoglobin conjugated to carboxylate dextran. Biochim Biophys Acta 1672: 164-173, 2004.
14. Kazim AL and Atassi MZ. Haemoglobin binding with haptoglobin: localization of the haptoglobin-binding site on the alpha-chain of human haemoglobin. Biochem J 197: 507-510, 1981.
15. Kazim AL and Atassi MZ. Haemoglobin binding with haptoglobin: unequivocal demonstration that the beta-chains of human haemoglobin bind to haptoglobin. Biochem J 185: 285-287, 1980.
16. Kristiansen M, Graversen JH, Jacobsen C, Sonne O, Hoffman HJ, Law SK, and Moestrup SK. Identification of the haemoglobin scavenger receptor. Nature 409: 198-201, 2001.
17. Lim SK, Kim H, Lim SK, bin Ali A, Lim YK, Wang Y, Chong SM, Costantini F, and Baumman H. Increased susceptibility in Hp knockout mice during acute hemolysis. Blood 92: 1870-1877, 1998.
18. Manjula BN, Tsai A, Upadhya R, Perumalsamy K, Smith PK, Malavalli A, Vandegriff K, Winslow RM, Intaglietta M, Prabhakaran M, Friedman JM, and Acharya AS. Site-specific PEGylation of hemoglobin at Cys-93(beta): correlation between the colligative properties of the PEGylated protein and the length of the conjugated PEG chain. Bioconjug Chem 14: 464-472, 2003.
19. McCormick DJ and Atassi MZ. Hemoglobin binding with haptoglobin: delineation of the haptoglobin binding site on the alphachain of human hemoglobin. J Protein Chem 9: 735-742, 1990.
20. Minneci PC, Deans KJ, Zhi H, Yuen PS, Star RA, Banks SM, Schechter AN, Natanson C, Gladwin MT, and Solomon SB. Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin. J Clin Invest 115: 3409-3417, 2005.
21. Moestrup SK and Moller HJ. CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response. Ann Med 36: 347-354, 2004.
22. Adamson JG and Moore C. Hemolink, an o-raffinose cross-linked hemoglobin-based oxygen carrier. In: Blood Substitutes: Principles, Methods, Products and Clinical Trials, edited by Chang TMS. Basel: Karger, 1998, p. 62-79.
23. Nielsen MJ, Petersen SV, Jacobsen C, Thirup S, Enghild JJ, Graversen JH, and Moestrup SK. A unique loop extension in the serine protease domain of haptoglobin is essential for CD163 recognition of the haptoglobin-hemoglobin complex. J Biol Chem 282: 1072-1079, 2007.
24. Porto BN, Alves LS, Fernandez PL, Dutra TP, Figueiredo RT, Graca-Souza AV, and Bozza MT. Heme induces neutrophil migration and reactive oxygen species generation through signaling pathways characteristic of chemotactic receptors. J Biol Chem 282: 24430-24436, 2007.
25. Prouchayret F, Fasan G, Grandgeorge M, Vigneron C, Menu P, and Dellacherie E. A potential blood substitute from carboxylic dextran and oxyhemoglobin: I. Preparation, purification and characterization. Biomater Artif Cells Immobil Biotechnol 20: 319-322, 1992.
26. Rich RL and Myszka DG. Survey of the year 2006 commercial optical biosensor literature. J Mol Recognit 20: 300-366, 2007.
27. Riess JG. Oxygen carriers ("blood substitutes"): raison d'etre, chemistry, and some physiology. Chem Rev 101: 2797-2920, 2001.
28. Ryter SW, Alam J, and Choi AM. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev 86: 583-650, 2006.
29. Schaer CA, Schoedon G, Imhof A, Kurrer MO, and Schaer DJ. Constitutive endocytosis of CD163 mediates hemoglobin-heme uptake and determines the noninflammatory and protective transcriptional response of macrophages to hemoglobin. Circ Res 99: 943-950, 2006.
30. Schaer CA, Vallelian F, Imhof A, Schoedon G, and Schaer DJ. CD163-expressing monocytes constitute an endotoxin-sensitive Hb clearance compartment within the vascular system. J Leukoc Biol 82: 106-110, 2007.
31. Schaer DJ, Alayash AI, and Buehler PW. Gating the radical hemoglobin to macrophages: the anti-inflammatory role of CD163, a scavenger receptor. Antioxid Redox Signal 9: 991-999, 2007.
32. Schaer DJ, Boretti FS, Schoedon G, and Schaffner A. Induction of the CD163-dependent haemoglobin uptake by macrophages as a novel anti-inflammatory action of glucocorticoids. Br J Haematol 119: 239-243, 2002.
33. Schaer DJ, Schaer CA, Buehler PW, Boykins RA, Schoedon G, Alayash AI, and Schaffner A. CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin. Blood 107: 373-380, 2006.
34. Ship NJ, Toprak A, Lai RP, Tseng E, Kluger R, and Pang KS. Binding of acellular, native and cross-linked human hemoglobins to haptoglobin: enhanced distribution and clearance in the rat. Am J Physiol 288: G1301-G1309, 2005.
35. Svergun DI, Ekstrom F, Vandegriff KD, Malavalli A, Baker DA, Nilsson C, and Winslow RM. Solution structure of poly(ethylene) glycol-conjugated hemoglobin revealed by small-angle X-ray scattering: implications for a new oxygen therapeutic. Biophys J 94: 173-181, 2008.
36. Theilgaard-Monch K, Jacobsen LC, Nielsen MJ, Rasmussen T, Udby L, Gharib M, Arkwright PD, Gombart AF, Calafat J, Moestrup SK, Porse BT, and Borregaard N. Haptoglobin is synthesized during granulocyte differentiation, stored in specific granules, and released by neutrophils in response to activation. Blood 108: 353-361, 2006.
37. Wagner VE and Bryers JD. Poly(ethylene glycol)-polyacrylate copolymers modified to control adherent monocyte-macrophage physiology: interactions with attaching Staphylococcus epidermidis or Pseudomonas aeruginosa bacteria. J Biomed Mater Res 69: 79-90, 2004.
38. Winslow RM. Current status of oxygen carriers ("blood substitutes"): 2006. Vox Sang 91: 102-110, 2006.
39. Yoshioka N and Atassi MZ. Haemoglobin binding with haptoglobin: localization of the haptoglobin-binding sites on the beta-chain of human haemoglobin by synthetic overlapping peptides encompassing the entire chain. Biochem J 234: 453-456, 1986.