Polynitroxyl hemoglobin: A pharmacokinetic study of covalently bound nitroxides to hemoglobin platforms

Free Radical Biology and Medicine

Volumn 37, Issue 1, 2004, Pages 124-135

  Buehler, Paul W ^a   Haney, Chad R ^b   Gulati, Anil ^a   Ma, Li ^c,d   Hsia, Carleton J C ^c  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b University of Illinois at Chicago   (United States)

^c Synzyme Technologies Inc   (United States)

^d GEORGIA SOUTHERN UNIVERSITY   (United States)

Author keywords

AUC 0 C last; Clast; Cmax; Free radicals; Last measured plasma concentration; Maximum plasma concentration; Nitroxide; Nitroxide bioreduction; Noncompartmental pharmacokinetics; PNH; Polynitroxyl hemoglobin; PolyPNH

Indexed keywords

4 (2 BROMOACETAMIDO) 2,2,6,6 TETRAMETHYLPIPERIDINE 1 OXYL; DEXTRAN; HEMOGLOBIN DERIVATIVE; HYDROXYLAMINE; NITROXIDE; NITROXIDE DERIVATIVE; PIPERIDINE DERIVATIVE; POLYNITROXYLHEMOGLOBIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; COVALENT BOND; CROSS LINKING; ELECTRON SPIN RESONANCE; EVALUATION; EXCHANGE BLOOD TRANSFUSION; HUMAN; HUMAN CELL; MALE; MOLECULAR WEIGHT; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL;

ANIMALS; ELECTRON SPIN RESONANCE SPECTROSCOPY; GUINEA PIGS; HEMOGLOBINS; HUMANS; NITROGEN OXIDES; PIPERIDINES; REACTIVE OXYGEN SPECIES;

CAVIA PORCELLUS; SUS SCROFA;

EID: 2942525386     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2004.04.008     Document Type: Article

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