Enhancer of Zeste homolog 2 induces Pulmonary artery Smooth Muscle cell proliferation

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Aljubran, Salman A ^a   Cox, Ruan ^a   Tamarapu Parthasarathy, Prasanna ^a   Kollongod Ramanathan, Gurukumar ^a   Rajanbabu, Venugopal ^a   Bao, Huynh ^a   Mohapatra, Shyam M ^a   Lockey, Richard ^a   Kolliputi, Narasaiah ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GREEN FLUORESCENT PROTEIN; LIPOCORTIN 5; MESSENGER RNA; TRANSCRIPTION FACTOR EZH2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL ASSAY; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENHANCER OF ZESTE HOMOLOG 2 GENE; FLOW CYTOMETRY; GENE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HEART RIGHT VENTRICLE HYPERTROPHY; HEART RIGHT VENTRICLE PRESSURE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PULMONARY ARTERY; PULMONARY ARTERY SMOOTH MUSCLE CELL; PULMONARY HYPERTENSION; SMOOTH MUSCLE FIBER; STAINING; SYSTOLIC BLOOD PRESSURE;

MAMMALIA;

EID: 84861463292     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037712     Document Type: Article

References (38)

1. Archer S, Rich S, (2000) Primary pulmonary hypertension: A vascular biology and translational research "work in progress". Circulation 102 (22): 2781-2791.
2. McMurtry MS, Archer SL, Altieri DC, Bonnet S, Haromy A, et al. (2005) Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. J Clin Invest 115 (6): 1479-1491.
3. McMurtry MS, Bonnet S, Wu X, Dyck JR, Haromy A, et al. (2004) Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ Res 95 (8): 830-840.
4. Gladwin MT, Ghofrani HA, (2010) Update on pulmonary hypertension 2009. Am J Respir Crit Care Med 181 (10): 1020-1026.
5. Hansmann G, de Jesus Perez VA, Alastalo TP, Alvira CM, Guignabert C, et al. (2008) An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. J Clin Invest 118 (5): 1846-1857.
6. Archer SL, Weir EK, Wilkins MR, (2010) Basic science of pulmonary arterial hypertension for clinicians: New concepts and experimental therapies. Circulation 121 (18): 2045-2066.
7. Archer SL, Michelakis ED, (2006) An evidence-based approach to the management of pulmonary arterial hypertension. Curr Opin Cardiol 21 (4): 385-392.
8. Stenmark KR, Fagan KA, Frid MG, (2006) Hypoxia-induced pulmonary vascular remodeling: Cellular and molecular mechanisms. Circ Res 99 (7): 675-691.
9. Arias-Stella J, Saldana M, (1963) The terminal portion of the pulmonary arterial tree in people native to high altitudes. Circulation 28: 915-925.
10. Houston CS, Sutton JR, Cymerman A, Reeves JT, (1987) Operation everest II: Man at extreme altitude. J Appl Physiol 63 (2): 877-882.
11. Groves BM, Reeves JT, Sutton JR, Wagner PD, Cymerman A, et al. (1987) Operation everest II: Elevated high-altitude pulmonary resistance unresponsive to oxygen. J Appl Physiol 63 (2): 521-530.
12. Dromparis P, Sutendra G, Michelakis ED, (2010) The role of mitochondria in pulmonary vascular remodeling. J Mol Med (Berl) 88 (10): 1003-1010.
13. Feinberg AP, Ohlsson R, Henikoff S, (2006) The epigenetic progenitor origin of human cancer. Nat Rev Genet 7 (1): 21-33.
14. Varambally S, Dhanasekaran SM, Zhou M, Barrette TR, Kumar-Sinha C, et al. (2002) The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419 (6907): 624-629.
15. Varambally S, Cao Q, Mani RS, Shankar S, Wang X, et al. (2008) Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science 322 (5908): 1695-1699.
16. Zakrzewicz D, Eickelberg O, (2009) From arginine methylation to ADMA: A novel mechanism with therapeutic potential in chronic lung diseases. BMC Pulm Med 9: 5.
17. Sklepkiewicz P, Schermuly RT, Tian X, Ghofrani HA, Weissmann N, et al. (2011) Glycogen synthase kinase 3beta contributes to proliferation of arterial smooth muscle cells in pulmonary hypertension. PLoS One 6 (4): e18883.
18. Steiner MK, Syrkina OL, Kolliputi N, Mark EJ, Hales CA, et al. (2009) Interleukin-6 overexpression induces pulmonary hypertension. Circ Res 104 (2): 236-44, 28p following 244.
19. Caruso P, MacLean MR, Khanin R, McClure J, Soon E, et al. (2010) Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline. Arterioscler Thromb Vasc Biol 30 (4): 716-723.
20. Frank DB, Abtahi A, Yamaguchi DJ, Manning S, Shyr Y, et al. (2005) Bone morphogenetic protein 4 promotes pulmonary vascular remodeling in hypoxic pulmonary hypertension. Circ Res 97 (5): 496-504.
21. Kolliputi N, Waxman AB, (2009) IL-6 cytoprotection in hyperoxic acute lung injury occurs via suppressor of cytokine signaling-1-induced apoptosis signal-regulating kinase-1 degradation. Am J Respir Cell Mol Biol 40 (3): 314-324.
22. Yu L, Hales CA, (2011) Silencing of sodium-hydrogen exchanger 1 attenuates the proliferation, hypertrophy, and migration of pulmonary artery smooth muscle cells via E2F1. Am J Respir Cell Mol Biol 45 (5): 923-930.
23. Kolliputi N, Shaik RS, Waxman AB, (2010) The inflammasome mediates hyperoxia-induced alveolar cell permeability. J Immunol 184 (10): 5819-5826.
24. Kolliputi N, Waxman AB, (2009) IL-6 cytoprotection in hyperoxic acute lung injury occurs via PI3K/Akt-mediated bax phosphorylation. Am J Physiol Lung Cell Mol Physiol 297 (1): L6-16.
25. Miano JM, Olson EN, (1996) Expression of the smooth muscle cell calponin gene marks the early cardiac and smooth muscle cell lineages during mouse embryogenesis. J Biol Chem 271 (12): 7095-7103.
26. Duband JL, Gimona M, Scatena M, Sartore S, Small JV, (1993) Calponin and SM 22 as differentiation markers of smooth muscle: Spatiotemporal distribution during avian embryonic development. Differentiation 55 (1): 1-11.
27. Durak H, Comunoglu NU, Comunoglu C, Guven A, Cam M, et al. (2010) Specificity and sensitivity of differentiation antigens in superficial soft tissue tumors: Comparison of SMA, calponin, H-caldesmon, C-kit, PLAP and HPL. Bratisl Lek Listy 111 (8): 432-438.
28. Xu XF, Cheng F, Du LZ, (2011) Epigenetic regulation of pulmonary arterial hypertension. Hypertens Res 34 (9): 981-6.
29. Margueron R, Justin N, Ohno K, Sharpe ML, Son J, et al. (2009) Role of the polycomb protein EED in the propagation of repressive histone marks. Nature 461 (7265): 762-767.
30. Margueron R, Reinberg D, (2011) The polycomb complex PRC2 and its mark in life. Nature 469 (7330): 343-349.
31. Sakao S, Tatsumi K, (2011) Vascular remodeling in pulmonary arterial hypertension: Multiple cancer-like pathways and possible treatment modalities. Int J Cardiol 147 (1): 4-12.
32. Rai PR, Cool CD, King JA, Stevens T, Burns N, et al. (2008) The cancer paradigm of severe pulmonary arterial hypertension. Am J Respir Crit Care Med 178 (6): 558-564.
33. Sutendra G, Dromparis P, Wright P, Bonnet S, Haromy A, et al. (2011) The role of nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension. Sci Transl Med 3 (88): 88ra55.
34. Tonini T, D'Andrilli G, Fucito A, Gaspa L, Bagella L, (2008) Importance of Ezh2 polycomb protein in tumorigenesis process interfering with the pathway of growth suppressive key elements. J Cell Physiol 214 (2): 295-300.
35. Gong Y, Huo L, Liu P, Sneige N, Sun X, et al. (2011) Polycomb group protein EZH2 is frequently expressed in inflammatory breast cancer and is predictive of worse clinical outcome. Cancer 117 (24): 5476-84.
36. Wu ZL, Zheng SS, Li ZM, Qiao YY, Aau MY, et al. (2010) Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating bim expression. Cell Death Differ 17 (5): 801-810.
37. Cheng Y, Liu X, Yang J, Lin Y, Xu DZ, et al. (2009) MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation. Circ Res 105 (2): 158-166.
38. Jiang Z, Grange RW, Walsh MP, Kamm KE, (1997) Adenovirus-mediated transfer of the smooth muscle cell calponin gene inhibits proliferation of smooth muscle cells and fibroblasts. FEBS Lett 413 (3): 441-445.