Extracellular GC-rich DNA activates TLR9- and NF-kB-dependent signaling pathways in human adipose-derived mesenchymal stem cells (haMSCs)

Expert Opinion on Biological Therapy

Volumn 12, Issue SUPPL. 1, 2012, Pages

  Kostjuk, Svetlana ^a   Loseva, Polina ^a   Chvartatskaya, Oksana ^b   Ershova, Elizaveta ^a   Smirnova, Tatyana ^a   Malinovskaya, Elena ^a   Roginko, Olga ^c   Kuzmin, Vladimir ^c   Izhevskaia, Vera ^a   Baranova, Ancha ^a,d   Ginter, Evgeny ^a   Veiko, Natalia ^a  

^a RESEARCH CENTRE FOR MEDICAL GENETICS   (Russian Federation)

^b MOSCOW STATE PEDAGOGICAL UNIVERSITY   (Russian Federation)

^c EMANUEL INSTITUTE OF BIOCHEMICAL PHYSICS   (Russian Federation)

^d GEORGE MASON UNIVERSITY   (United States)

Author keywords

Adipose derived MSCs; CfDNA; Cytokine production; Extracellular DNA; NF kB pathway; Stem cells; TLR9

Indexed keywords

CYTOKINE; HISTONE H2AX; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE DERIVED STEM CELL; CELL SURVIVAL; CONFERENCE PAPER; DNA FRAGMENTATION; GC RICH SEQUENCE; HUMAN; HUMAN CELL; MESENCHYMAL STEM CELL; MOLECULAR CLONING; PROTEIN EXPRESSION; RADIATION DOSE; SIGNAL TRANSDUCTION; UPREGULATION;

ADIPOSE TISSUE; CELLS, CULTURED; DNA; FLOW CYTOMETRY; GC RICH SEQUENCE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-10; MESENCHYMAL STEM CELLS; NF-KAPPA B; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84861440805     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.2012.690028     Document Type: Conference Paper

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