IKK-2 is required for TNF-α-induced invasion and proliferation of human mesenchymal stem cells

Journal of Molecular Medicine

Volumn 86, Issue 10, 2008, Pages 1183-1192

  Böcker, Wolfgang ^a   Docheva, Denitsa ^a   Prall, Wolf Christian ^a   Egea, Virginia ^a   Pappou, Emmanouil ^a   Roßmann, Oliver ^a   Popov, Cvetan ^a   Mutschler, Wolf ^a   Ries, Christian ^a   Schieker, Matthias ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

IKK 2; Invasion; Mesenchymal stem cells; Migration; NF B; Proliferation; TNF

Indexed keywords

BROXURIDINE; CYCLIN D1; GELATINASE B; HERMES ANTIGEN; I KAPPA B KINASE; I KAPPA B KINASE 2; LENTIVIRUS VECTOR; NUCLEOPLASMIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CELL FUNCTION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOPLASM; EXTRACELLULAR MATRIX; GENE OVEREXPRESSION; GENE TRANSFER; HUMAN; MESENCHYMAL STEM CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TISSUE INJURY; UPREGULATION;

5'-NUCLEOTIDASE; ANTIGENS, CD; ANTIGENS, THY-1; APOPTOSIS; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; FLOW CYTOMETRY; GENETIC VECTORS; HUMANS; I-KAPPA B KINASE; IMMUNOHISTOCHEMISTRY; LENTIVIRUS; MESENCHYMAL STEM CELLS; RECEPTORS, CELL SURFACE; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 52549118412     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-008-0378-3     Document Type: Article

References (55)

1. MF Prockop 1997 Marrow stromal cells as stem cells for non-haematopoietic tissues Science 276 71 74
2. MF Pittenger AM Mackay SC Beck 1999 Multilineage potential of adult human mesenchymal stem cells Science 284 143 147
3. D Docheva C Popov W Mutschler 2007 Human mesenchymal stem cells in contact with their environment: surface characteristics and the integrin system J Cell Mol Med 11 1 17
4. JF Ji BP He ST Dheen 2004 Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury Stem Cells 22 415 427
5. L Wang Y Li X Chen 2002 MCP-1, MIP-1, IL-8 and ischemic cerebral tissue enhance human bone marrow stromal cell migration in interface culture Hematology 7 113 117
6. CA Roufosse NC Direkze WR Otto 2004 Circulating mesenchymal stem cells Int J Biochem Cell Biol 36 585 597
7. MJ Devine CM Mierisch E Jang 2002 Transplanted bone marrow cells localize to fracture callus in a mouse model J Orthop Res 20 1232 1239
8. H Kawada J Fujita K Kinjo 2004 Nonhematopoietic mesenchymal stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction Blood 104 3581 3587
9. TC Mackenzie AW Flake 2001 Human mesenchymal stem cells persist, demonstrate site-specific multipotential differentiation, and are present in sites of wound healing and tissue regeneration after transplantation into fetal sheep Blood Cells Mol Dis 27 601 604
10. K Liechty T MacKenzie A Shaaban 2000 Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep Nat Med 6 1282 1286
11. I Kan E Melamed D Offen 2005 Integral therapeutic potential of bone marrow mesenchymal stem cells Curr Drug Targets 6 31 41
12. J Fiedler N Etzel RE Brenner 2004 To go or not to go: migration of human mesenchymal progenitor cells stimulated by isoforms of PDGF J Cell Biochem 93 990 998
13. A Schmidt DST Ladage U Klausman 2006 Basic fibroblast growth factor controls migration in human mesenchymal stem cells Stem Cells 24 1750 1758
14. J Fiedler F Leucht J Waltenberger 2005 VEGF-A and PlGF-1 stimulate chemotactic migration of human mesenchymal progenitor cells Biochem Biophys Res Commun 334 561 568
15. V Sordi ML Malosio F Marchesi 2005 Bone marrow mesenchymal stem cells express a restricted set of functionally active chemokine receptors capable of promoting migration to pancreatic islets Blood 106 419 427
16. Y Ozaki M Nishimura K Sekiya 2007 Comprehensive analysis of chemotactic factors for bone marrow mesenchymal stem cells Stem Cells Dev 16 119 129
17. C Ries V Egea M Karow 2007 MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines Blood 109 4055 4063
18. PA Efron LL Moldawer 2004 Cytokines and wound healing: the role of cytokine and anticytokine therapy in the repair response J Burn Care Rehabil 25 149 160
19. R Dimitriou E Tsiridis PV Giannoudis 2005 Current concepts of molecular aspects of bone healing Injury 36 1392 1404
20. D Widera I Mikenberg M Elvers 2006 Tumor necrosis factor alpha triggers proliferation of adult neural stem cells via IKK/NF-kappaB signaling BMC Neurosci 7 64
21. RC Bargou F Emmerich D Krappmann 1997 Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells J Clin Invest 100 2961 2969
22. DC Guttridge C Albanese JY Reuther 1999 NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1 Mol Cell Biol 19 5785 5799
23. M Hinz D Krappmann A Eichten 1999 NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition Mol Cell Biol 19 2690 2698
24. Q Li IM Verma 2002 NF-kappaB regulation in the immune system Nat Rev Immunol 2 725 734
25. S Ghosh M Karin 2002 Missing pieces in the NF-kappaB puzzle Cell 109 Suppl S81 S96
26. M Karin A Lin 2002 NF-kappaB at the crossroads of life and death Nat Immunol 3 221 227
27. R Sen D Baltimore 1986 Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism Cell 47 921 928
28. PA Baeuerle D Baltimore 1988 I kappa B: a specific inhibitor of the NF-kappa B transcription factor Science 242 540 546
29. PA Baeuerle D Baltimore 1996 NF-kappa B: ten years after Cell 87 13 20
30. Z Chen J Hagler VJ Palombella 1995 Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway Genes Dev 9 1586 1597
31. W Böcker O Rossmann D Docheva 2007 Quantitative polymerase chain reaction as a reliable method to determine functional lentiviral titer after ex vivo gene transfer in human mesenchymal stem cells J Gene Med 9 585 595
32. P Neth M Ciccarella V Egea 2006 Wnt signaling regulates the invasion capacity of human mesenchymal stem cells Stem Cells 24 1892 1903
33. M Dominici K Le Blanc I Mueller 2006 Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement Cytotherapy 8 315 317
34. MR Fahim SM Halim I Kamel 2004 Tumor necrosis factor alpha in patients with acute myocardial infarction Egypt J Immunol 11 31 37
35. J Jiang K Tian H Chen 1997 Kinetics of plasma cytokines and its clinical significance in patients with severe trauma Chin Med J (Engl) 110 923 926
36. LC Gerstenfeld TJ Cho T Kon 2003 Impaired fracture healing in the absence of TNF-alpha signaling: the role of TNF-alpha in endochondral cartilage resorption J Bone Miner Res 18 1584 1592
37. T Kon TJ Cho T Aizawa 2001 Expression of osteoprotegerin, receptor activator of NF-kappaB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing J Bone Miner Res 16 1004 1014
38. TA Einhorn RJ Majeska EB Rush 1995 The expression of cytokine activity by fracture callus J Bone Miner Res 10 1272 1281
39. B Ruster S Gottig RJ Ludwig 2006 Mesenchymal stem cells display coordinated rolling and adhesion behavior on endothelial cells Blood 108 3938 3944
40. YJ Kang ES Jeon HY Song 2005 Role of c-Jun N-terminal kinase in the PDGF-induced proliferation and migration of human adipose tissue-derived mesenchymal stem cells J Cell Biochem 95 1135 1145
41. H Schmal P Niemeyer M Roesslein 2007 Comparison of cellular functionality of human mesenchymal stromal cells and PBMC Cytotherapy 9 69 79
42. M Karin Y Yamamoto QM Wang 2004 The IKK NF-kappa B system: a treasure trove for drug development Nat Rev Drug Discov 3 17 26
43. R Kalluri 2003 Basement membranes: structure, assembly and role in tumour angiogenesis Nat Rev Cancer 3 422 433
44. R Visse H Nagase 2003 Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry Circ Res 92 827 839
45. M Egeblad Z Werb 2002 New functions for the matrix metalloproteinases in cancer progression Nat Rev Cancer 2 161 174
46. HY Lee KS Park MK Kim 2005 A small compound that inhibits tumor necrosis factor-alpha-induced matrix metalloproteinase-9 upregulation Biochem Biophys Res Commun 336 716 722
47. SO Lee YJ Jeong MH Yu 2006 Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells Biochem Biophys Res Commun 351 118 125
48. CM Isacke H Yarwood 2002 The hyaluronan receptor, CD44 Int J Biochem Cell Biol 34 718 721
49. ST Peng CH Su CC Kuo 2007 CD44 crosslinking-mediated matrix metalloproteinase-9 relocation in breast tumor cells leads to enhanced metastasis Int J Oncol 31 1119 1126
50. LY Bourguignon Z Gunja-Smith N Iida 1998 CD44v(3,8-10) is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells J Cell Physiol 176 206 215
51. L Alaniz M Garcia P Cabrera 2004 Modulation of matrix metalloproteinase-9 activity by hyaluronan is dependent on NF-kappaB activity in lymphoma cell lines with dissimilar invasive behavior Biochem Biophys Res Commun 324 736 743
52. H Zhu N Mitsuhashi A Klein 2006 The role of the hyaluronan receptor CD44 in mesenchymal stem cell migration in the extracellular matrix Stem Cells 24 928 935
53. SE Meiler RR Hung RE Gerszten 2002 Endothelial IKK beta signaling is required for monocyte adhesion under laminar flow conditions J Mol Cell Cardiol 34 349 359
54. AL Theiss JG Simmons C Jobin 2005 Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2 J Biol Chem 280 36099 36109
55. FB Mehrhof R Schmidt-Ullrich R Dietz 2005 Regulation of vascular smooth muscle cell proliferation: role of NF-kappaB revisited Circ Res 96 958 964