NF-κB activation in human dental pulp stem cells by TNF and LPS

Journal of Dental Research

Volumn 84, Issue 11, 2005, Pages 994-998

  Chang, J ^a   Zhang, C ^b   Tani Ishii, N ^c   Shi, S ^d   Wang, C Y ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b PEKING UNIVERSITY SCHOOL AND HOSPITAL OF STOMATOLOGY   (China)

^c KANAGAWA DENTAL COLLEGE   (Japan)

^d NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

Dental pulp stem cells; Inflammation; LPS; NF B; Tumor necrosis factor

Indexed keywords

ENZYME ACTIVATOR; I KAPPA B; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GEL MOBILITY SHIFT ASSAY; HUMAN; IMMUNOLOGY; MESENCHYMAL STEM CELL; MULTIPOTENT STEM CELL; NORTHERN BLOTTING; PHOSPHORYLATION; PHYSIOLOGY; PORPHYROMONAS ENDODONTALIS; PORPHYROMONAS GINGIVALIS; SIGNAL TRANSDUCTION; TOOTH PULP; TRANSACTIVATION; WESTERN BLOTTING;

BLOTTING, NORTHERN; BLOTTING, WESTERN; CELLS, CULTURED; DENTAL PULP; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME ACTIVATORS; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; MESENCHYMAL STEM CELLS; MULTIPOTENT STEM CELLS; NF-KAPPA B; PHOSPHORYLATION; PORPHYROMONAS ENDODONTALIS; PORPHYROMONAS GINGIVALIS; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33644641369     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910508401105     Document Type: Article

References (28)

1. Baldwin AS (2001). Series introduction: the transcription factor NF-kappaB and human disease. J Clin Invest 107:3-6.
2. Baqui AA, Meiller TF, Chon JJ, Turng BF, Falkler WA Jr (1998). Granulocyte-macrophage colony-stimulating factor amplification of interleukin-1beta and tumor necrosis factor alpha production in THP-1 human monocytic cells stimulated with lipopolysaccharide of oral microorganisms. Clin Diag Lab Immun 5:341-347.
3. Chiang CY, Kyritsis G, Graves DT, Amar S (1999). Interleukin-1 and tumor necrosis factor activities partially account for calvarial bone resorption induced by local injection of lipopolysaccharide. Infect Immun 67:4231-4236.
4. Coil J, Tam E, Waterfield JD (2004). Proinflammatory cytokine profiles in pulp fibroblasts stimulated with lipopolysaccharide and methyl mercaptan. J Endodont 30:88-91.
5. Darveau RP, Arbabi S, Garcia I, Bainbridge B, Maier RV (2002). Porphyromonas gingivalis lipopolysaccharide is both agonist and antagonist for p38 mitogen-activated protein kinase activation. Infect Immun 70:1867-1873.
6. Fouad AF, Acosta AW (2001). Periapical lesion progression and cytokine expression in an LPS hyporesponsive model. Int Endodont J 34:506-513.
7. Gronthos S, Mankani M, Brahim J, Robey PG, Shi S (2000). Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proc Natl Acad Sci USA 97:13625-13630.
8. Gronthos S, Brahim J, Li W, Fisher LW, Cherman N, Boyde A, et al. (2002). Stem cell properties of human dental pulp stem cells. J Dent Res 81:531-535.
9. Kawashima N, Stashenko P (1999). Expression of bone-resorptive and regulatory cytokines in murine periapical inflammation. Arch Oral Biol 44:55-66.
10. Kent LW, Rahemtulla F, Michalek SM (1999). Interleukin (IL)-1 and Porphyromonas gingivalis lipopolysaccharide stimulation of IL-6 production by fibroblasts derived from healthy or periodontally diseased human gingival tissue. J Periodontol 70:274-282.
11. Liu ZG, Hsu H, Goeddel DV, Karin M (1996). Dissection of TNF receptor 1 effector function: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87:565-576.
12. Martin M, Katz J, Vogel SN, Michalek SM (2001). Differential induction of endotoxin tolerance by lipopolysaccharides derived from Porphyromonas gingivalis and Escherichia coli. J Immunol 167:5278-5285.
13. Nagaoka S, Tokuda M, Sakuta T, Taketoshi Y, Tamura M, Takada H, et al. (1996). Interleukin-8 gene expression by human dental pulp fibroblast in cultures stimulated with Prevotella intermedia lipopolysaccharide. J Endod 22:9-12, 19.
14. Nakane A, Yoshida T, Nakata K, Horiba N, Nakamura H (1995). Effects of lipopolysaccharides on human dental pulp cells. J Endod 21:128-130.
15. Nociti FH Jr, Foster BL, Barros SP, Darveau RP, Somerman MJ (2004). Cementoblast gene expression is regulated by Porphyromonas gingivalis lipopolysaccharide partially via toll-like receptor-4/MD-2. J Dent Res 83:602-607.
16. Ogawa T, Asai Y, Hashimoto M, Takeuchi O, Kurita T, Yoshikai Y, et al. (2002). Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88-dependent signaling pathway. Infect Immun 14:1325-1332.
17. Rupf S, Kannengiesser S, Merte K, Pfister W, Sigusch B, Eschrich K (2000). Comparison of profiles of key periodontal pathogens in periodontium and endodontium. Endod Dent Traumatol 16:269-275.
18. Rutherford RB, Gu K (2000). Treatment of inflamed ferret dental pulps with recombinant bone morphogenetic protein-7. Eur J Oral Sci 108:202-206.
19. Salvi GE, Collins JG, Yalda B, Arnold RR, Lang NP, Offenbacher S (1997). Monocytic TNF alpha secretion patterns in IDDM patients with periodontal diseases. J Clin Periodontol 24:8-16.
20. Stashenko P, Teles R, D'Souza R (1998). Periapical inflammatory responses and their modulation. Crit Rev Oral Biol Med 9:498-521.
21. Wang CY, Mayo M, Baldwin AS (1996). TNF- and cancer therapy-induced apoptosis potentiation by inhibition of NF-κB. Science 274:784-787.
22. Wang CY, Tani-Ishii N, Stashenko P (1997). Bone-resorptive cytokine gene expression in periapical lesions in the rat. Oral Microbiol Immunol 12:65-71.
23. Wang CY, Mayo MW, Korneluk RC, Goeddel DV, Baldwin AS (1998). NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281:1680-1683.
24. Wang CY, Cusack J, Liu R, Baldwin AS (1999a). Control of inducible chemoresistance: enhanced anti-tumor therapy via increased apoptosis through inhibition of NF-κB. Nature Med 5:412-417.
25. Wang CY, Guttridge DC, Mayo MW, Baldwin AS (1999b). NF-κB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol Cell Biol 19:5923-5929.
26. Yang F, Tang E, Guan K, Wang CY (2003). IKKβ plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide. J Immunol 170:5630-5635.
27. Yang F, Yamashita J, Tang E, Wang H, Guan G, Wang CY (2004). The zinc finger mutation C417R of I-κB kinase g impairs lipopolysaccharide- and TNF-mediated NF-κB activation through inhibiting phosphorylation of the I-κB kinase B activation loop. J Immunol 172:2446-2452.
28. You Z, Ouyang H, Lopatin D, Polverini PJ, Wang CY (2001). Nuclear factor-kappa B-inducible death effector domain-containing protein suppresses TNF-mediated apoptosis by inhibiting caspase-8 activity. J Biol Chem 276:26398-26404.