Evaluation of the Safety and Efficacy of Hydroxycitric Acid or Garcinia cambogia Extracts in Humans

Critical Reviews in Food Science and Nutrition

Volumn 52, Issue 7, 2012, Pages 585-594

  Márquez, Fabiola ^a   Babio, Nancy ^a   Bulló, Mònica ^a   Salas Salvado J ^a  

^a UNIVERSITAT ROVIRA I VIRGILI   (Spain)

Author keywords

body weight; Garcinia cambogia; lipid profile; safety

Indexed keywords

ACETYL-COA; ADVERSE EVENTS; BODY WEIGHT; CLINICAL TRIAL; EXPERIMENTAL ANIMALS; GARCINIA CAMBOGIA; HYDROXYCITRIC ACIDS; LIPID BIOSYNTHESIS; LIPID PROFILE; SHORT TERM; SIDE EFFECT; SMALL SAMPLES;

ACCIDENT PREVENTION; ANTHROPOMETRY; BIOCHEMISTRY; TOXICITY;

CITRIC ACID;

ANIMALIA; GARCINIA CAMBOGIA;

ADENOSINE TRIPHOSPHATE CITRATE LYASE; ANTILIPEMIC AGENT; ANTIOBESITY AGENT; CITRIC ACID; ENZYME INHIBITOR; HYDROXYCITRIC ACID; PLANT EXTRACT;

ANIMAL; CHEMISTRY; DIET SUPPLEMENTATION; DIET THERAPY; DRUG ANTAGONISM; DYSLIPIDEMIA; FRUIT; GARCINIA CAMBOGIA; HUMAN; OBESITY; PHYTOTHERAPY; REVIEW;

ANIMALS; ANTI-OBESITY AGENTS; ATP CITRATE (PRO-S)-LYASE; CITRATES; DIETARY SUPPLEMENTS; DYSLIPIDEMIAS; ENZYME INHIBITORS; FRUIT; GARCINIA CAMBOGIA; HUMANS; HYPOLIPIDEMIC AGENTS; OVERWEIGHT; PHYTOTHERAPY; PLANT EXTRACTS;

EID: 84861425456     PISSN: 10408398     EISSN: 15497852     Source Type: Journal    
DOI: 10.1080/10408398.2010.500551     Document Type: Article

References (57)

1. Antonio, J., Colker, C. M., Torina, G. C., Shi, Q., Brink, W. and Kalman, D. 1999. Effects of a standardized guggulsterone phosphate supplement on body composition in overweight adults: a pilot study. Curr. Ther. Res., 60: 220-227.
2. Aujoulat, M. 2003. Super CitriMax HCA-600-SXS- Bacterial reverse mutation test (Plate incorporation and preincubation methods). MDS study no. 293/001 1-52
3. Burdock, G., Soni, M., Bagchi, M. and Bagchi, D. 2005. Garcinia cambogia toxicity is misleading. Food Chem. Toxicol., 43: 1683-1684.
4. Chee, H., Romsos, D. and Leveille, G. 1977. Influence of (-)-hydroxycitrate on lipigenesis in chickens and rats. J. Nutr., 107: 112-119.
5. Conte, A. A. 1993. A non-prescription alternative in weight reduction therapy. Am. J. Bariatric. Medicine. Summer:,: 17-19.
6. Environmental Protection Agency (EPA). 2001. U.S. High Production Volume (HPV) Chemical Challenge Program Assessment Plan for Acetic Acid and Salts Category, July 8.: 1-20. Available from http://www.epa.gov/hpv/pubs/summaries/acetisalt/c13102tp.pdf, 2003
7. Fan., B., Sun, X., Wang, J. and Zhan, X. 1997. Effect of dietary energy restriction on reproduction in rats. Wei Sheng Yan Jiu., 26: 327-239.
8. Gatta, B., Zuberbuehler, C., Arnold, M., Aubert, R., Langhans, W. and Chapelot, D. 2009. Acute effects of pharmacological modifications of fatty acid metabolism on human satiety. Br J Nutr, 101: 1867-1877.
9. Girola, M., De Bernardi, M. and Contos, S. 1996. Dose effect in lipidlowering activity of a new dietary integrator (Chitosan, Garcinia cambogia extract, and Chrome). Acta Toxicol. Ther., 17: 25-40.
10. Hayamizu, K., Hirakawa, H., Oikawa, D., Nakanishi, T., Takagi, T., Tachibana, T. and Furuse, M. 2003. Effect of garcinia cambogia extract on serum leptin and insulin in mice. Fitoterapia, 74: 267-273.
11. Hayamizu, K., Ishii, Y., Kaneko, I., Shen, M., Sakaguchi, H., Okuhara, Y., Shigematsu, N., Miyazaki, S. and Shimasaki, H. 2001. Effects of long-term administration of Garcinia cambogia extract on visceral fat accumulation in humans: a placebo controlled double blind trial. J. Oleo Sci., 50: 805-812.
12. Hayamizu, K., Tomi, H., Kaneko, I., Shen, M., Soni, M. G. and Yoshino, G. 2008. Effects of Garcinia cambogia extract on serum sex hormones in overweight subjects. Fitoterapia., 79: 255-261.
13. Heymsfield, S., Allison, B., Vasselli, J., Pietrobelli, A., Greenfield, D. and Nunez, C. 1998. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: A randomized controlled trial. JAMA., 280: 1596-1600.
14. Jones, C. and Ashton, K. 1976. Lipid biosynthesis in liver slices of the foetal guinea pig. Biochem. J., 154: 149-158.
15. Kaats, G. R., Keith, S. C., Pullin, D., Squires, W. G. Jr., Wise, J. A., Hesslink, R. Jr. and Morin, R. J. 1998. Safety and efficacy evaluation of a fitness club weight-loss program. Adv. Ther., 15: 345-361.
16. Kovacs, E. M., Westerterp-Plantenga, M. S., de Vries, M., Brouns, F. and Saris, W. H. 2001. Effects of 2-week ingestion of (-)-hydroxycitrate and (-)-hydroxycitrate combined with medium-chain triglycerides on satiety and food intake. Physiol. Behav., 74: 543-549.
17. Kovacs, E. M. and Westerterp-Plantenga, M. S. 2006. Effects of (-)-hydroxycitrate on net fat synthesis as de novo lipogenesis. Physiol. Behav., 88: 371-381.
18. Leonhardt, M., Balkan, B. and Langhans, W. 2004. Effect of hydroxycitrate on respiratory quotient, energy expenditure, and glucose tolerance in male rats after a period of restrictive feeding. Nutrition., 20: 911-915.
19. Leonhardt, M., Hrupka, B. and Langhans, W. 2001. Effect of hydroxycitrate on food intake and body weight regain after a period of restrictive feeding in male rats. Physiol. Behav., 74: 191-196.
20. Leonhardt, M. and Langhans, W. 2002. Hydroxycitrate has long-term effects on feeding behavior, body weight regain and metabolism after body weight loss in male rats. J. Nutr., 132: 1977-1982.
21. Lewis, Y. S. and Neelakantan, C. 1965. (-)Hydroxycitric acid - the principal acid in the fruits of Garcinia cambogia. Phytochemistry, 4: 610-652.
22. Loe, Y. C., Bergeron, N., Rodriguez, N. and Schwarz, J. M. 2001. Gas chromatography/mass spectrometry method to quantify blood hydroxycitrate concentration. Anal. Biochem., 292: 148-154.
23. Lobb, A. 2009. Hepatoxicity associated with weight-loss supplements: a case for better post-marketing surveillance. World J Gastroenterol, 15: 1786-1787.
24. Louter-van de Haar, J., Wielinga, P., Scheurink, A. and Nieuwenhuizen, A. 2005. Comparison of the effects of three different (-)-hydroxycitric acid preparations on food intake in rats. Nutr. Metabol., 2: 1-9.
25. Lowenstein, J. 1971. Effect of (-)-hydroxycitrate on fatty acid synthesis by rat live in vivo. J. Biol. Chem., 246: 629-632.
26. Mattes, D. and Bormann, L. 2000. Effects of ()-hydroxycitric acid on appetitive variables. Physiol. Behav., 71: 87-94.
27. Ohia, S., Opere, C., Leday, A., Manáis, B., Bagchi, D. and Stohs, S. 2002. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol. Cell. Biochem., 238: 89-103.
28. Ohia, S., Awe, O., Leday, A., Opere, C. and Bagchi, D. 2001. Effect of hydroxycitric acid on serotonin release from isolated rat brain cortex. Res. Commun. Mol. Pathol. Pharmacol., 109: 210-216.
29. Oikawa, D., Hirakawa, H., Hayamizu, K., Nakamura, Y., Shiba, N., Nakanishi, T., Iwamoto, H., Tachibana, T. and Furuse, M. 2005. Dietary garcinia cambogia does not modify skin properties of mice with or without excessive sucrose intake. Phytother., 19: 294-297.
30. Oluyemi, K. A., Omotuyi, I. O., Jimoh, O. R., Adesanya, O. A., Saalu, C. L. and Josiah, S. J. 2007. Erythropoietic and anti-obesity effects of Garcinia cambogia (bitter kola) in Wistar rats. Biotechnol. Appl. Biochem., 46: 69-72.
31. Opala, T., Rzymski, P., Pischel, I., Wilczak, M. and Wozniak, J. 2006. Efficacy of 12 weeks supplementation of a botanical extract-based weight loss formula on body weight, body composition and blood chemistry in healthy, overweight subjects: A randomised double-blind placebo-controlled clinical trial. Eur. J. Med. Res., 11: 343-350.
32. Preuss, H., Bagchi, D., Bagchi, M., Rao, C., Dey, D. and Satayanarayana, S. 2004. Effects of natural extract of ())- hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacine-bound chromium and Gymnema sylvestre extract in weight loss. Diabetes Obes. Metab., 24: 45-58.
33. Preuss, H., Bagchi, D., Bagchi, M., Rao, C. and Satayanarayana, S. 2004. Efficacy of a novel, natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX, niacine-bound chromium and Gymnesa sylvestre extract in weight management in human volunteers. Nutr. Res., 24: 45-58.
34. Preuss, H., Bagchi, D., Rao, C., Echard, B., Satayanarayana, S. and Bagchi, M. 2002. Effect of hydroxycitric acid on weight loss, body mass index and plasma leptin levels in human subjects. AFASEB J., 16: 1020
35. Preuss, H., Garis, R., Bramble, J., Bagchi, D., Bagchi, M., Rao, C. and Satyanarayana, S. 2005. Efficacy of a novel calcium/potassium salt of (-)-hydroxycitric acid in weight control. J. Clin. Pharmacol. Res, 25: 133-144.
36. Ramos, R., Saenz, L. and Aguilar, C. 1995. Extract of Garcinia cambogia in the control of obesity. Invest Med Int., 22: 97-100.
37. Rao, N. and Sakariah, D. 1988. Lipid-lowering and antiobesity effect of (-) hydroxycitric acid. Nutr. Res., 8: 209-212.
38. Rothacker, D. and Waitman, B. 1997. Effectiveness of a Garcinia cambogia and natural caffeine combination in weight loss: A double-blind placebo-controlled pilot study. Int. J. Obes, 21: 53
39. Roy, S., Rink, C., Khanna, S., Phillips, C., Bagchi, D., Bagchi, M. and Sen, C. 2004. Body weight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement. Gene Expr., 11: 251-262.
40. Roy, S., Shah, H., Rink, C., Khanna, S., Bagchi, D., Bagchi, M. and Sen, C. K. 2007. Transcriptome of primary adipocytes from obese women in response to a novel hydroxycitric acid-based dietary supplement. DNA Cell. Biol., 26: 627-639.
41. Saito, M., Ueno, M., Ogino, S., Kubo, K., Nagata, J. and Takeuchi, M. 2005. High dose of garcinia cambogia is effective in suppressing fat accumulation in developing male zucker obese rats, but highly toxic to the testis. Food Chem. Toxicol., 43: 411-419.
42. Shara, M., Ohia, S., Yasmin, T., Zardetto-Smith, A., Kincaid, A., Bagchi, M., Chatterjee, A., Bagchi, D. and Stohs, S. 2003. Dose- and time-dependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days. Mol. Cell. Biochem, 254: 339-346.
43. Shara, M., Ohia, S., Schmidt, R., Yasmin, T., Zardetto-Smith, A., Kincaid, A., Bagchi, M., Chatterjee, A., Bagchi, D. and Stohs, S. 2004. Physico-chemical properties of a novel (-)-hydroxycitric acid extract and its effect on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathological changes over a period of 90 days. Mol. Cell. Biochem., 260: 171-186.
44. Stohs, S. J., Preuss, H. G., Ohia, S. E., Kaats, G. R., Keen, C. L., Williams, L. D. and Burdock, G. A. 2009. No evidence demonstrating hepatotoxicity associated with hydroxycitric acid. World J Gastroentero, 15: 4087-4089.
45. Soni, M. G., Burdock, G. A., Preuss, H. G., Stohs, S. J., Ohia, S. E. and Bagchi, D. 2004. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem. Toxicol., 42: 1513-1529.
46. Sullivan, A. C., Triscari, J., Hamilton, J. G., Miller, O. N. and Wheatley, V. R. 1974. Effect of (-) hydroxycitrate upon the accumulation of lipid in the rat. I. Lipogenesis. Lipids., 9: 121-128.
47. Sullivan, A. C., Triscari, J. and Comai, K. 1984. Pharmacological modulation of lipid metabolism for the treatment of obesity. Int. J. Obes, 8(1): 241-248.
48. Talpur, N., Echard, B., Yasmin, T., Bagchi, D. and Preuss, H. 2003. Effects of niacin-bound chromium, maitake mushroom fraction SX and (-)-hydroxycitric acid on the metabolic syndrome in aged diabetic zucker fatty rats. Mol. Cell. Biochem., 252: 369-377.
49. Terry, K. K., Chatman, L. A., Foley, G. L., Kadyszewski, E., Fleeman, T. L., Hurtt, M. E. and Chapin, R. E. 2005. Effects of feed restriction on fertility in female rats. Birth Defects Res. B. Dev. Reprod. Toxicol., 74: 431-441.
50. Thom, E. 2000. A randomized, double-blind, placebo-controlled trial of a new weight-reducing agent of natural origin. J. Int. Med. Res., 28: 229-233.
51. Thom, E. 1996. Hydroxycitrate (HCA) in the treatment of obesity. Int. J. Obes. Relat. Metab. Disord., 20: 75
52. Toromanyan, E., Aslanyan, G., Arroyan, E., Gabrielyan, E. and Panossian, A. 2007. Efficacy of Slim339 in reducing body weight of overweight and obese human subjects. Phytother. Res., 21: 1177-1181.
53. Vasques, C. A., Rossetto, S., Halmenschlager, G., Linden, R., Heckler, E., Fernandez, M. S. and Alonso, J. L. 2008. Evaluation of the pharmacotherapeutic efficacy of Garcinia cambogia plus Amorphophallus konjac for the treatment of obesity. Phytother Res, 22: 1135-1140.
54. Watson, J. and Lowenstein, J. 1970. Citrate and the conversion of carbohydrate into fat. J. Biol. Chem., 245: 5993-6002.
55. Westerterp-Plantenga, M. and Kovacs, E. 2002. The effect of (-)- hydroxycitrate on energy intake and satiety in overweight humans. Int. J. Obes. Relat. Metab. Disord., 26: 870-872.
56. Wu, A., Wan, F., Sun, X. and Liu, Y. 2002. Effects of dietary restriction on growth, neurobehavior, and reproduction in developing Kunmin mice. Toxicol. Sci., 70: 238-244.
57. Xu, Z. X., Smart, D. A. and Rooney, S. A. 1990. Glucocorticoid induction of fatty-acid synthase mediates the stimulatory effect of the hormone on choline-phospate cytidylyltrasferase activity in fetal rat lung. Biochim. Biophys. Acta., 1044: 70-76.