No evidence demonstrating hepatotoxicity associated with hydroxycitric acid

World Journal of Gastroenterology

Volumn 15, Issue 32, 2009, Pages 4087-4089

  Stohs, Sidney J ^a   Preuss, Harry G ^a   Ohia, Sunny E ^a   Kaats, Gilbert R ^a   Keen, Carl L ^a   Williams, Lonnie D ^a   Burdock, George A ^a  

^a CREIGHTON UNIVERSITY   (United States)

Author keywords

Garcinia cambogia; Hepatotoxicity; Hydroxycitric acid; Hydroxycitric acid SX; Hydroxycut; Liver failure; Safety and efficacy; Super CitriMax

Indexed keywords

ACETYLSALICYLIC ACID; ALCOHOL; HYDROXYCITRIC ACID; PARACETAMOL; PLACEBO; SUPER CITRIMAX; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ARTICLE; CHEMOPROPHYLAXIS; CLINICAL EVALUATION; CLINICAL TRIAL; DRUG SAFETY; HUMAN; LIVER PROTECTION; LIVER TOXICITY; NONHUMAN; POSTMARKETING SURVEILLANCE; TOXICITY TESTING; VALIDATION STUDY;

EID: 70949088691     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.15.4087     Document Type: Article

References (21)

1. Lobb A. Hepatoxicity associated with weight-loss supplements: a case for better post-marketing surveillance. World J Gastroenterol 2009; 15: 1786-1787
2. Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem 2002; 238: 89-103 (Pubitemid 35023532)
3. Shara M, Ohia SE, Yasmin T, Zardetto-Smith A, Kincaid A, Bagchi M, Chatterjee A, Bagchi D, Stohs SJ. Dose- and timedependent effects of a novel (-)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days. Mol Cell Biochem 2003; 254: 339-346
4. Shara M, Ohia SE, Schmidt RE, Yasmin T, Zardetto-Smith A, Kincaid A, Bagchi M, Chatterjee A, Bagchi D, Stohs SJ. Physico-chemical properties of a novel (-)-hydroxycitric acid extract and its effect on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathological changes over a period of 90 days. Mol Cell Biochem 2004; 260: 171-186
5. Soni MG, Burdock GA, Preuss HG, Stohs SJ, Ohia SE, Bagchi D. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem Toxicol 2004; 42: 1513-1529 (Pubitemid 38844868)
6. Deshmukh NS, Bagchi M, Yasmin T, Bagchi D. Safety of a novel calcium/potassium salt of hydroxycitric acid (HCASX): I. Two-generation reproduction toxicity study. Toxicol Mech Meth 2008; 18: 433-442 (Pubitemid 351883375)
7. Deshmukh NS, Bagchi M, Yasmin T, Bagchi D. Safety of a novel calcium/potassium salt of (-)-hydroxycitric acid(HCA-SX): II. Developmental toxicity in rats. Toxicol Mech Meth 2008, 18: 443-451 (Pubitemid 351883374)
8. Roy S, Rink C, Khanna S, Phillips C, Bagchi D, Bagchi M, Sen CK. Body weight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement. Gene Expr 2004; 11: 251-262 (Pubitemid 38744499)
9. Preuss HG, Bagchi D, Bagchi M, Rao SCV, Satyanarayana S, Dey DK. Effect of a novel, natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX, niacinbound chromium and Gymnema sylvestre extract in weight management in human volunteers. Nutr Res 2004; 24: 45-58 (Pubitemid 38121537)
10. Preuss HG, Rao SCV, Garis RI, Bramble JD, Ohia SE, Bagchi M, Bagchi D. An overview of the safety and efficacy of a novel, natural (-)-hydroxycitric acid extract (HCA-SX) for weight management. J Med 2004; 33: 33-48 (Pubitemid 47578939)
11. Preuss HG, Bagchi D, Bagchi M, Rao SCV, Dey DK, Satyanarayana S. Effects of a natural extract of (-)hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacinbound chromium and Gymnema sylvestre extract on weight loss. Diab Obes Metab 2004; 6: 171-180 (Pubitemid 38559696)
12. Preuss HG, Garis RI, Bramble JD, Bagchi D, Bagchi M, Rao SCV, Satyanarayana S. Efficacy of a novel calcium/ potassium salt of (-)-hydroxycitric acid in weight control. Int J Clin Pharm Res 2005; XXV: 133-144 (Pubitemid 41719437)
13. Mozersky DO, Klonz K, Katz LM. The Problem: Liver toxicity following consumption of dietary supplement, Hydroxycut. Health Hazard Review Board FDA 2009. http://www.fda.gov/oc/opacom/hottopics/hydroxycut/ HHE.pdf
14. Mahendran P, Devi CS. Effect of Garcinia cambogia extract on lipids and lipoprotein composition in dexamethasone administered rats. Indian J Physiol Pharmacol 2001; 45: 345-350 (Pubitemid 32776802)
15. Mahendran P, Sabitha KE, Devi CS. Prevention of HClethanol induced gastric mucosal injury in rats by Garcinia cambogia extract and its possible mechanism of action. Indian J Exp Biol 2002; 40: 58-62 (Pubitemid 34077686)
16. Mahendran P, Vanisree AJ, Shyamala Devi CS. The antiulcer activity of Garcinia cambogia extract against indomethacininduced gastric ulcer in rats. Phytother Res 2002; 16: 80-83 (Pubitemid 34116703)
17. Kaats GR. Safety and Efficacy of a (-)hydroxycitric acid containing product in human subjects. (personal communication)
18. Anon. CSFII 1994-1996(2000), Agricultural Research Service, U.S. Department of Agriculture, Washington, DC
19. Anon. Perennial Edible Fruits of the Tropics, An Inventory, U. S. Department of Agriculture Handbook No. 642, 1987
20. Shim M, Saab S. Severe hepatotoxicity due to Hydroxycut: a case report. Dig Dis Sci 2009; 54: 406-408
21. Lee WM. Acetaminophen and the U.S. Acute Liver Failure Study Group: lowering the risks of hepatic failure. Hepatology 2004; 40: 6-9