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Volumn 7, Issue 5, 2012, Pages

Rgnef (p190RhoGEF) knockout inhibits RhoA activity, focal adhesion establishment, and cell motility downstream of integrins

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; EPITOPE; FIBRONECTIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INTEGRIN; PRIMER DNA; RASGRF1 PROTEIN, MOUSE;

EID: 84861395057     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037830     Document Type: Article
Times cited : (28)

References (56)
  • 2
    • 80053298724 scopus 로고    scopus 로고
    • Molecular architecture and function of matrix adhesions
    • Geiger B, Yamada KM, (2011) Molecular architecture and function of matrix adhesions. Cold Spring Harb Perspect Biol 3: a005033.
    • (2011) Cold Spring Harb Perspect Biol , vol.3
    • Geiger, B.1    Yamada, K.M.2
  • 4
    • 77956064817 scopus 로고    scopus 로고
    • Cell adhesion: integrating cytoskeletal dynamics and cellular tension
    • Parsons JT, Horwitz AR, Schwartz MA, (2010) Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol 11: 633-643.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 633-643
    • Parsons, J.T.1    Horwitz, A.R.2    Schwartz, M.A.3
  • 5
    • 27944479854 scopus 로고    scopus 로고
    • Rho GTPases: biochemistry and biology
    • Jaffe AB, Hall A, (2005) Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 21: 247-269.
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 247-269
    • Jaffe, A.B.1    Hall, A.2
  • 6
    • 13444252631 scopus 로고    scopus 로고
    • GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
    • Rossman KL, Der CJ, Sondek J, (2005) GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol 6: 167-180.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 167-180
    • Rossman, K.L.1    Der, C.J.2    Sondek, J.3
  • 7
    • 34249018367 scopus 로고    scopus 로고
    • GEFs and GAPs: critical elements in the control of small G proteins
    • Bos JL, Rehmann H, Wittinghofer A, (2007) GEFs and GAPs: critical elements in the control of small G proteins. Cell 129: 865-877.
    • (2007) Cell , vol.129 , pp. 865-877
    • Bos, J.L.1    Rehmann, H.2    Wittinghofer, A.3
  • 8
    • 0033081753 scopus 로고    scopus 로고
    • Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton
    • Ren XD, Kiosses WB, Schwartz MA, (1999) Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. Embo J 18: 578-585.
    • (1999) Embo J , vol.18 , pp. 578-585
    • Ren, X.D.1    Kiosses, W.B.2    Schwartz, M.A.3
  • 9
    • 0033731010 scopus 로고    scopus 로고
    • Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover
    • Ren X, Kiosses WB, Sieg DJ, Otey CA, Schlaepfer DD, et al. (2000) Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover. J Cell Sci 113: 3673-3678.
    • (2000) J Cell Sci , vol.113 , pp. 3673-3678
    • Ren, X.1    Kiosses, W.B.2    Sieg, D.J.3    Otey, C.A.4    Schlaepfer, D.D.5
  • 10
    • 0034659526 scopus 로고    scopus 로고
    • Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism
    • Arthur WT, Petch LA, Burridge K, (2000) Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism. Curr Biol 10: 719-722.
    • (2000) Curr Biol , vol.10 , pp. 719-722
    • Arthur, W.T.1    Petch, L.A.2    Burridge, K.3
  • 11
    • 0035158377 scopus 로고    scopus 로고
    • RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity
    • Arthur WT, Burridge K, (2001) RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity. Mol Biol Cell 12: 2711-2720.
    • (2001) Mol Biol Cell , vol.12 , pp. 2711-2720
    • Arthur, W.T.1    Burridge, K.2
  • 12
    • 69449103232 scopus 로고    scopus 로고
    • A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells
    • Tomar A, Lim ST, Lim Y, Schlaepfer DD, (2009) A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells. J Cell Sci 122: 1852-1862.
    • (2009) J Cell Sci , vol.122 , pp. 1852-1862
    • Tomar, A.1    Lim, S.T.2    Lim, Y.3    Schlaepfer, D.D.4
  • 13
    • 33644855668 scopus 로고    scopus 로고
    • Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability
    • Holinstat M, Knezevic N, Broman M, Samarel AM, Malik AB, et al. (2006) Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability. J Biol Chem 281: 2296-2305.
    • (2006) J Biol Chem , vol.281 , pp. 2296-2305
    • Holinstat, M.1    Knezevic, N.2    Broman, M.3    Samarel, A.M.4    Malik, A.B.5
  • 14
    • 77954351473 scopus 로고    scopus 로고
    • Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation
    • Lim ST, Chen XL, Tomar A, Miller NL, Yoo J, et al. (2010) Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation. J Biol Chem 285: 21526-21536.
    • (2010) J Biol Chem , vol.285 , pp. 21526-21536
    • Lim, S.T.1    Chen, X.L.2    Tomar, A.3    Miller, N.L.4    Yoo, J.5
  • 15
    • 0036644975 scopus 로고    scopus 로고
    • Guanine nucleotide exchange factors for Rho GTPases: turning on the switch
    • Schmidt A, Hall A, (2002) Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev 16: 1587-1609.
    • (2002) Genes Dev , vol.16 , pp. 1587-1609
    • Schmidt, A.1    Hall, A.2
  • 16
    • 0024121513 scopus 로고
    • The predicted DBL oncogene product defines a distinct class of transforming proteins
    • Eva A, Vecchio G, Rao CD, Tronick SR, Aaronson SA, (1988) The predicted DBL oncogene product defines a distinct class of transforming proteins. Proc Natl Acad Sci USA 85: 2061-2065.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 2061-2065
    • Eva, A.1    Vecchio, G.2    Rao, C.D.3    Tronick, S.R.4    Aaronson, S.A.5
  • 17
    • 0026044409 scopus 로고
    • Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product
    • Hart MJ, Eva A, Evans T, Aaronson SA, Cerione RA, (1991) Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product. Nature 354: 311-314.
    • (1991) Nature , vol.354 , pp. 311-314
    • Hart, M.J.1    Eva, A.2    Evans, T.3    Aaronson, S.A.4    Cerione, R.A.5
  • 18
    • 38549092474 scopus 로고    scopus 로고
    • Membrane recognition by phospholipid-binding domains
    • Lemmon MA, (2008) Membrane recognition by phospholipid-binding domains. Nat Rev Mol Cell Biol 9: 99-111.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 99-111
    • Lemmon, M.A.1
  • 19
    • 83455173724 scopus 로고    scopus 로고
    • Targeting of the RhoGEF Ect2 to the Equatorial Membrane Controls Cleavage Furrow Formation during Cytokinesis
    • Su KC, Takaki T, Petronczki M, (2011) Targeting of the RhoGEF Ect2 to the Equatorial Membrane Controls Cleavage Furrow Formation during Cytokinesis. Dev Cell 21: 1104-1115.
    • (2011) Dev Cell , vol.21 , pp. 1104-1115
    • Su, K.C.1    Takaki, T.2    Petronczki, M.3
  • 20
    • 37249071435 scopus 로고    scopus 로고
    • A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin
    • Dubash AD, Wennerberg K, Garcia-Mata R, Menold MM, Arthur WT, et al. (2007) A novel role for Lsc/p115 RhoGEF and LARG in regulating RhoA activity downstream of adhesion to fibronectin. J Cell Sci 120: 3989-3998.
    • (2007) J Cell Sci , vol.120 , pp. 3989-3998
    • Dubash, A.D.1    Wennerberg, K.2    Garcia-Mata, R.3    Menold, M.M.4    Arthur, W.T.5
  • 21
    • 38349058006 scopus 로고    scopus 로고
    • PyK2 and FAK connections to p190RhoGEF regulate RhoA activity, focal adhesion formation, and cell motility
    • Lim Y, Lim ST, Tomar A, Gardel M, Bernard-Trifilo JA, et al. (2008) PyK2 and FAK connections to p190RhoGEF regulate RhoA activity, focal adhesion formation, and cell motility. J Cell Biol 180: 187-203.
    • (2008) J Cell Biol , vol.180 , pp. 187-203
    • Lim, Y.1    Lim, S.T.2    Tomar, A.3    Gardel, M.4    Bernard-Trifilo, J.A.5
  • 22
    • 70350647605 scopus 로고    scopus 로고
    • Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge
    • Nalbant P, Chang YC, Birkenfeld J, Chang ZF, Bokoch GM, (2009) Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge. Mol Biol Cell 20: 4070-4082.
    • (2009) Mol Biol Cell , vol.20 , pp. 4070-4082
    • Nalbant, P.1    Chang, Y.C.2    Birkenfeld, J.3    Chang, Z.F.4    Bokoch, G.M.5
  • 24
    • 0042090404 scopus 로고    scopus 로고
    • Direct interaction of focal adhesion kinase with p190RhoGEF
    • Zhai J, Lin H, Nie Z, Wu J, Canete-Soler R, et al. (2003) Direct interaction of focal adhesion kinase with p190RhoGEF. J Biol Chem 278: 24865-24873.
    • (2003) J Biol Chem , vol.278 , pp. 24865-24873
    • Zhai, J.1    Lin, H.2    Nie, Z.3    Wu, J.4    Canete-Soler, R.5
  • 25
    • 78751559107 scopus 로고    scopus 로고
    • p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase
    • Yu HG, Nam JO, Miller NL, Tanjoni I, Walsh C, et al. (2011) p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase. Cancer Res 71: 360-370.
    • (2011) Cancer Res , vol.71 , pp. 360-370
    • Yu, H.G.1    Nam, J.O.2    Miller, N.L.3    Tanjoni, I.4    Walsh, C.5
  • 26
    • 70349332774 scopus 로고    scopus 로고
    • Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility
    • Tomar A, Schlaepfer DD, (2009) Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. Curr Opin Cell Biol 21: 676-683.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 676-683
    • Tomar, A.1    Schlaepfer, D.D.2
  • 27
    • 0030929149 scopus 로고    scopus 로고
    • Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology
    • Gebbink MF, Kranenburg O, Poland M, van Horck FP, Houssa B, et al. (1997) Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology. J Cell Biol 137: 1603-1613.
    • (1997) J Cell Biol , vol.137 , pp. 1603-1613
    • Gebbink, M.F.1    Kranenburg, O.2    Poland, M.3    van Horck, F.P.4    Houssa, B.5
  • 28
    • 0035895915 scopus 로고    scopus 로고
    • Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules
    • van Horck FP, Ahmadian MR, Haeusler LC, Moolenaar WH, Kranenburg O, (2001) Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules. J Biol Chem 276: 4948-4956.
    • (2001) J Biol Chem , vol.276 , pp. 4948-4956
    • van Horck, F.P.1    Ahmadian, M.R.2    Haeusler, L.C.3    Moolenaar, W.H.4    Kranenburg, O.5
  • 29
    • 0035943731 scopus 로고    scopus 로고
    • p190RhoGEF Binds to a destabilizing element in the 3′ untranslated region of light neurofilament subunit mRNA and alters the stability of the transcript
    • Canete-Soler R, Wu J, Zhai J, Shamim M, Schlaepfer WW, (2001) p190RhoGEF Binds to a destabilizing element in the 3′ untranslated region of light neurofilament subunit mRNA and alters the stability of the transcript. J Biol Chem 276: 32046-32050.
    • (2001) J Biol Chem , vol.276 , pp. 32046-32050
    • Canete-Soler, R.1    Wu, J.2    Zhai, J.3    Shamim, M.4    Schlaepfer, W.W.5
  • 30
  • 31
    • 0033520918 scopus 로고    scopus 로고
    • Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190RhoGEF and its localization in differentiated neurons
    • Meyer D, Liu A, Margolis B, (1999) Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190RhoGEF and its localization in differentiated neurons. J Biol Chem 274: 35113-35118.
    • (1999) J Biol Chem , vol.274 , pp. 35113-35118
    • Meyer, D.1    Liu, A.2    Margolis, B.3
  • 32
    • 0029566108 scopus 로고
    • A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells
    • Schwenk F, Baron U, Rajewsky K, (1995) A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res 23: 5080-5081.
    • (1995) Nucleic Acids Res , vol.23 , pp. 5080-5081
    • Schwenk, F.1    Baron, U.2    Rajewsky, K.3
  • 33
    • 79958232399 scopus 로고    scopus 로고
    • RhoA and RhoC have distinct roles in migration and invasion by acting through different targets
    • Vega FM, Fruhwirth G, Ng T, Ridley AJ, (2011) RhoA and RhoC have distinct roles in migration and invasion by acting through different targets. J Cell Biol 193: 655-665.
    • (2011) J Cell Biol , vol.193 , pp. 655-665
    • Vega, F.M.1    Fruhwirth, G.2    Ng, T.3    Ridley, A.J.4
  • 34
    • 50149083752 scopus 로고    scopus 로고
    • Mammalian Rho GTPases: new insights into their functions from in vivo studies
    • Heasman SJ, Ridley AJ, (2008) Mammalian Rho GTPases: new insights into their functions from in vivo studies. Nat Rev Mol Cell Biol 9: 690-701.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 690-701
    • Heasman, S.J.1    Ridley, A.J.2
  • 35
    • 0034808219 scopus 로고    scopus 로고
    • RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells
    • Liu AX, Rane N, Liu JP, Prendergast GC, (2001) RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells. Mol Cell Biol 21: 6906-6912.
    • (2001) Mol Cell Biol , vol.21 , pp. 6906-6912
    • Liu, A.X.1    Rane, N.2    Liu, J.P.3    Prendergast, G.C.4
  • 36
    • 24344486013 scopus 로고    scopus 로고
    • RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis
    • Hakem A, Sanchez-Sweatman O, You-Ten A, Duncan G, Wakeham A, et al. (2005) RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes Dev 19: 1974-1979.
    • (2005) Genes Dev , vol.19 , pp. 1974-1979
    • Hakem, A.1    Sanchez-Sweatman, O.2    You-Ten, A.3    Duncan, G.4    Wakeham, A.5
  • 37
    • 79952329256 scopus 로고    scopus 로고
    • RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes
    • Jackson B, Peyrollier K, Pedersen E, Basse A, Karlsson R, et al. (2011) RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes. Mol Biol Cell 22: 593-605.
    • (2011) Mol Biol Cell , vol.22 , pp. 593-605
    • Jackson, B.1    Peyrollier, K.2    Pedersen, E.3    Basse, A.4    Karlsson, R.5
  • 38
    • 79955382980 scopus 로고    scopus 로고
    • RhoA GTPase Is Dispensable for Actomyosin Regulation but Is Essential for Mitosis in Primary Mouse Embryonic Fibroblasts
    • Melendez J, Stengel K, Zhou X, Chauhan BK, Debidda M, et al. (2011) RhoA GTPase Is Dispensable for Actomyosin Regulation but Is Essential for Mitosis in Primary Mouse Embryonic Fibroblasts. J Biol Chem 286: 15132-15137.
    • (2011) J Biol Chem , vol.286 , pp. 15132-15137
    • Melendez, J.1    Stengel, K.2    Zhou, X.3    Chauhan, B.K.4    Debidda, M.5
  • 39
    • 77950638532 scopus 로고    scopus 로고
    • The Rho guanine nucleotide exchange factor AKAP13 (BRX) is essential for cardiac development in mice
    • Mayers CM, Wadell J, McLean K, Venere M, Malik M, et al. (2010) The Rho guanine nucleotide exchange factor AKAP13 (BRX) is essential for cardiac development in mice. J Biol Chem 285: 12344-12354.
    • (2010) J Biol Chem , vol.285 , pp. 12344-12354
    • Mayers, C.M.1    Wadell, J.2    McLean, K.3    Venere, M.4    Malik, M.5
  • 40
    • 0034710926 scopus 로고    scopus 로고
    • Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos
    • O'Brien SP, Seipel K, Medley QG, Bronson R, Segal R, et al. (2000) Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos. Proc Natl Acad Sci USA 97: 12074-12078.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12074-12078
    • O'Brien, S.P.1    Seipel, K.2    Medley, Q.G.3    Bronson, R.4    Segal, R.5
  • 41
    • 32644446913 scopus 로고    scopus 로고
    • Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils
    • Francis SA, Shen X, Young JB, Kaul P, Lerner DJ, (2006) Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils. Blood 107: 1627-1635.
    • (2006) Blood , vol.107 , pp. 1627-1635
    • Francis, S.A.1    Shen, X.2    Young, J.B.3    Kaul, P.4    Lerner, D.J.5
  • 42
    • 27744520373 scopus 로고    scopus 로고
    • Lsc regulates marginal-zone B cell migration and adhesion and is required for the IgM T-dependent antibody response
    • Rubtsov A, Strauch P, Digiacomo A, Hu J, Pelanda R, et al. (2005) Lsc regulates marginal-zone B cell migration and adhesion and is required for the IgM T-dependent antibody response. Immunity 23: 527-538.
    • (2005) Immunity , vol.23 , pp. 527-538
    • Rubtsov, A.1    Strauch, P.2    Digiacomo, A.3    Hu, J.4    Pelanda, R.5
  • 43
    • 38049017120 scopus 로고    scopus 로고
    • G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension
    • Wirth A, Benyo Z, Lukasova M, Leutgeb B, Wettschureck N, et al. (2008) G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension. Nature Med 14: 64-68.
    • (2008) Nature Med , vol.14 , pp. 64-68
    • Wirth, A.1    Benyo, Z.2    Lukasova, M.3    Leutgeb, B.4    Wettschureck, N.5
  • 44
    • 0038450313 scopus 로고    scopus 로고
    • Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death
    • Thumkeo D, Keel J, Ishizaki T, Hirose M, Nonomura K, et al. (2003) Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death. Mol Cell Biol 23: 5043-5055.
    • (2003) Mol Cell Biol , vol.23 , pp. 5043-5055
    • Thumkeo, D.1    Keel, J.2    Ishizaki, T.3    Hirose, M.4    Nonomura, K.5
  • 45
    • 20144379401 scopus 로고    scopus 로고
    • ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles
    • Shimizu Y, Thumkeo D, Keel J, Ishizaki T, Oshima H, et al. (2005) ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles. J Cell Biol 168: 941-953.
    • (2005) J Cell Biol , vol.168 , pp. 941-953
    • Shimizu, Y.1    Thumkeo, D.2    Keel, J.3    Ishizaki, T.4    Oshima, H.5
  • 46
    • 0033594123 scopus 로고    scopus 로고
    • Rho GTPases control polarity, protrusion, and adhesion during cell movement
    • Nobes CD, Hall A, (1999) Rho GTPases control polarity, protrusion, and adhesion during cell movement. The Journal of cell biology 144: 1235-1244.
    • (1999) The Journal of Cell Biology , vol.144 , pp. 1235-1244
    • Nobes, C.D.1    Hall, A.2
  • 47
    • 79955425392 scopus 로고    scopus 로고
    • A Novel Spatiotemporal RhoC Activation Pathway Locally Regulates Cofilin Activity at Invadopodia
    • Bravo-Cordero JJ, Oser M, Chen X, Eddy R, Hodgson L, et al. (2011) A Novel Spatiotemporal RhoC Activation Pathway Locally Regulates Cofilin Activity at Invadopodia. Curr Biol 21: 635-644.
    • (2011) Curr Biol , vol.21 , pp. 635-644
    • Bravo-Cordero, J.J.1    Oser, M.2    Chen, X.3    Eddy, R.4    Hodgson, L.5
  • 48
    • 0017375736 scopus 로고
    • Binding of soluble form of fibroblast surface protein, fibronectin, to collagen
    • Engvall E, Ruoslahti E, (1977) Binding of soluble form of fibroblast surface protein, fibronectin, to collagen. Int J Can 20: 1-5.
    • (1977) Int J Can , vol.20 , pp. 1-5
    • Engvall, E.1    Ruoslahti, E.2
  • 51
    • 0034532347 scopus 로고    scopus 로고
    • p125 focal adhesion kinase promotes malignant astrocytoma cell proliferation in vivo
    • Wang D, Grammer JR, Cobbs CS, Stewart JE, Liu Z, et al. (2000) p125 focal adhesion kinase promotes malignant astrocytoma cell proliferation in vivo. J Cell Sci 113: 4221-4230.
    • (2000) J Cell Sci , vol.113 , pp. 4221-4230
    • Wang, D.1    Grammer, J.R.2    Cobbs, C.S.3    Stewart, J.E.4    Liu, Z.5
  • 52
    • 0036239645 scopus 로고    scopus 로고
    • Defective dendrite elongation but normal fertility in mice lacking the Rho-like GTPase activator Dbl
    • Hirsch E, Pozzato M, Vercelli A, Barberis L, Azzolino O, et al. (2002) Defective dendrite elongation but normal fertility in mice lacking the Rho-like GTPase activator Dbl. Mol Cell Biol 22: 3140-3148.
    • (2002) Mol Cell Biol , vol.22 , pp. 3140-3148
    • Hirsch, E.1    Pozzato, M.2    Vercelli, A.3    Barberis, L.4    Azzolino, O.5
  • 53
    • 0028904413 scopus 로고
    • Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes
    • Fischer KD, Zmuldzinas A, Gardner S, Barbacid M, Bernstein A, et al. (1995) Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes. Nature 374: 474-477.
    • (1995) Nature , vol.374 , pp. 474-477
    • Fischer, K.D.1    Zmuldzinas, A.2    Gardner, S.3    Barbacid, M.4    Bernstein, A.5
  • 54
    • 0028956337 scopus 로고
    • Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav
    • Tarakhovsky A, Turner M, Schaal S, Mee PJ, Duddy LP, et al. (1995) Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav. Nature 374: 467-470.
    • (1995) Nature , vol.374 , pp. 467-470
    • Tarakhovsky, A.1    Turner, M.2    Schaal, S.3    Mee, P.J.4    Duddy, L.P.5
  • 55
    • 0035378223 scopus 로고    scopus 로고
    • Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation
    • Doody GM, Bell SE, Vigorito E, Clayton E, McAdam S, et al. (2001) Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation. Nature Immunol 2: 542-547.
    • (2001) Nature Immunol , vol.2 , pp. 542-547
    • Doody, G.M.1    Bell, S.E.2    Vigorito, E.3    Clayton, E.4    McAdam, S.5
  • 56
    • 10744222965 scopus 로고    scopus 로고
    • Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells
    • Fujikawa K, Miletic AV, Alt FW, Faccio R, Brown T, et al. (2003) Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J Exp Med 198: 1595-1608.
    • (2003) J Exp Med , vol.198 , pp. 1595-1608
    • Fujikawa, K.1    Miletic, A.V.2    Alt, F.W.3    Faccio, R.4    Brown, T.5


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