Combination of RGD compound and low-dose paclitaxel induces apoptosis in human glioblastoma cells

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Chang, Ming Wei ^a   Lo, Jem Mau ^a   Juan, Hsueh Fen ^b   Chang, Hsin Yi ^b   Chuang, Chun Yu ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; CASPASE 3; CASPASE 8; CASPASE 9; ENZYME INHIBITOR; PACLITAXEL; VITRONECTIN RECEPTOR; ANTINEOPLASTIC AGENT; CASPASE; CYCLIC ARGININE GLYCINE ASPARTIC ACID PEPTIDE; CYCLIC ARGININE-GLYCINE-ASPARTIC ACID PEPTIDE; CYCLOPEPTIDE;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL PROTECTION; CELL SURFACE; CONTROLLED STUDY; DRUG EFFICACY; DRUG EXPOSURE; DRUG MECHANISM; DRUG STRUCTURE; GLIOBLASTOMA; HUMAN; HUMAN CELL; LOW DRUG DOSE; MONOTHERAPY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; TUMOR CELL; DRUG EFFECT; METABOLISM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CASPASES; CELL LINE, TUMOR; GLIOBLASTOMA; HUMANS; INTEGRIN ALPHAVBETA3; PACLITAXEL; PEPTIDES, CYCLIC;

EID: 84861382389     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037935     Document Type: Article

References (44)

1. Chatterjee S, Matsumura A, Schradermeier J, Gillespie GY, (2000) Human malignant glioma therapy using anti-alpha(v)beta3 integrin agents. J Neurooncol 46: 135-144.
2. Buckner JC, Ballman KV, Michalak JC, Burton GV, Cascino TL, et al. (2006) Phase III trial of carmustine and cisplatin compared with carmustine alone and standard radiation therapy or accelerated radiation therapy in patients with glioblastoma multiforme: North Central Cancer Treatment Group 93-72-52 and Southwest Oncology Group 9503 Trials. J Clin Oncol 24: 3871-3879.
3. Ng SS, Gao Y, Chau DH, Li GH, Lai LH, et al. (2007) A novel glioblastoma cancer gene therapy using AAV-mediated long-term expression of human TERT C-terminal polypeptide. Cancer Gene Ther 14: 561-572.
4. Louis DN, Holland EC, Cairncross JG, (2001) Glioma classification: a molecular reappraisal. Am J Pathol 159: 779-786.
5. Stupack DG, Cheresh DA, (2002) Get a ligand, get a life: integrins, signaling and cell survival. J Cell Sci 115: 3729-3738.
6. Xiong JP, Stehle T, Diefenbach B, Zhang R, Dunker R, et al. (2001) Crystal structure of the extracellular segment of integrin alpha Vbeta3. Science 294: 339-345.
7. Giancotti FG, Ruoslahti E, (1999) Integrin signaling. Science 285: 1028-1032.
8. Lai TH, Fong YC, Fu WM, Yang RS, Tang CH, (2009) Stromal cell-derived factor-1 increase alphavbeta3 integrin expression and invasion in human chondrosarcoma cells. J Cell Physiol 218: 334-342.
9. Landen CN, Kim TJ, Lin YG, Merritt WM, Kamat AA, et al. (2008) Tumor-selective response to antibody-mediated targeting of alphavbeta3 integrin in ovarian cancer. Neoplasia 10: 1259-1267.
10. Sheppard D, (2003) Functions of pulmonary epithelial integrins: from development to disease. Physiol Rev 83: 673-686.
11. Mulgrew K, Kinneer K, Yao XT, Ward BK, Damschroder MM, et al. (2006) Direct targeting of alphavbeta3 integrin on tumor cells with a monoclonal antibody, Abegrin. Mol Cancer Ther 5: 3122-3129.
12. Edlund M, Miyamoto T, Sikes RA, Ogle R, Laurie GW, et al. (2001) Integrin expression and usage by prostate cancer cell lines on laminin substrata. Cell Growth Differ 12: 99-107.
13. Hadden HL, Henke CA, (2000) Induction of lung fibroblast apoptosis by soluble fibronectin peptides. Am J Respir Crit Care Med 162: 1553-1560.
14. Wang TH, Wang HS, Soong YK, (2000) Paclitaxel-induced cell death: where the cell cycle and apoptosis come together. Cancer 88: 2619-2628.
15. Menendez JA, Vellon L, Mehmi I, Teng PK, Griggs DW, et al. (2005) A novel CYR61-triggered 'CYR61-alphavbeta3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway. Oncogene 24: 761-779.
16. Reardon DA, Fink KL, Mikkelsen T, Cloughesy TF, O'Neill A, et al. (2008) Randomized phase II study of cilengitide, an integrin-targeting arginine-glycine-aspartic acid peptide, in recurrent glioblastoma multiforme. J Clin Oncol 26: 5610-5617.
17. Reardon DA, Nabors LB, Stupp R, Mikkelsen T, (2008) Cilengitide: an integrin-targeting arginine-glycine-aspartic acid peptide with promising activity for glioblastoma multiforme. Expert Opin Investig Drugs 17: 1225-1235.
18. Haas MJ, (2009) Integrins' prime syndecan. SciBX 12: 1-3.
19. Andre N, Braguer D, Brasseur G, Goncalves A, Lemesle-Meunier D, et al. (2000) Paclitaxel induces release of cytochrome c from mitochondria isolated from human neuroblastoma cells'. Cancer Res 60: 5349-5353.
20. Nemeth JA, Nakada MT, Trikha M, Lang Z, Gordon MS, et al. (2007) Alpha-v integrins as therapeutic targets in oncology. Cancer Invest 25: 632-646.
21. Alghisi GC, Ruegg C, (2006) Vascular integrins in tumor angiogenesis: mediators and therapeutic targets. Endothelium 13: 113-135.
22. Chen X, Hou Y, Tohme M, Park R, Khankaldyyan V, et al. (2004) Pegylated Arg-Gly-Asp peptide: 64Cu labeling and PET imaging of brain tumor alphavbeta3-integrin expression. J Nucl Med 45: 1776-1783.
23. Boatright KM, Salvesen GS, (2003) Mechanisms of caspase activation. Curr Opin Cell Biol 15: 725-731.
24. Kim R, Emi M, Tanabe K, (2005) Caspase-dependent and-independent cell death pathways after DNA damage (Review). Oncol Rep 14: 595-599.
25. Venkatachalam CM, Jiang X, Oldfield T, Waldman M, (2003) LigandFit: a novel method for the shape-directed rapid docking of ligands to protein active sites. J Mol Graph Model 21: 289-307.
26. Huang TC, Huang HC, Chang CC, Chang HY, Ou CH, et al. (2007) An apoptosis-related gene network induced by novel compound-cRGD in human breast cancer cells. FEBS Lett 581: 3517-3522.
27. Kanu OO, Mehta A, Di C, Lin N, Bortoff K, et al. (2009) Glioblastoma multiforme: a review of therapeutic targets. Expert Opin Ther Targets 13: 701-718.
28. Reardon DA, Wen PY, (2006) Therapeutic advances in the treatment of glioblastoma: rationale and potential role of targeted agents. Oncologist 11: 152-164.
29. Lanni JS, Lowe SW, Licitra EJ, Liu JO, Jacks T, (1997) p53-independent apoptosis induced by paclitaxel through an indirect mechanism. Proc Natl Acad Sci U S A 94: 9679-9683.
30. Trusolino L, Serini G, Cecchini G, Besati C, Ambesi-Impiombato FS, et al. (1998) Growth factor-dependent activation of alphavbeta3 integrin in normal epithelial cells: implications for tumor invasion. J Cell Biol 142: 1145-1156.
31. Liu Z, Liu S, Wang F, Chen X, (2009) Noninvasive imaging of tumor integrin expression using (18)F-labeled RGD dimer peptide with PEG (4) linkers. Eur J Nucl Med Mol Imaging 36: 1296-1307.
32. Tseng SH, Bobola MS, Berger MS, Silber JR, (1999) Characterization of paclitaxel (Taxol) sensitivity in human glioma- and medulloblastoma-derived cell lines. Neuro Oncol 1: 101-108.
33. Heimans JJ, Vermorken JB, Wolbers JG, Eeltink CM, Meijer OW, et al. (1994) Paclitaxel (Taxol) concentrations in brain tumor tissue. Ann Oncol 5: 951-953.
34. Banno A, Ginsberg MH, (2008) Integrin activation. Biochem Soc Trans 36: 229-234.
35. Zhou X, Li J, Kucik DF, (2001) The microtubule cytoskeleton participates in control of beta2 integrin avidity. J Biol Chem 276: 44762-44769.
36. Puklin-Faucher E, Vogel V, (2009) Integrin activation dynamics between the RGD-binding site and the headpiece hinge. J Biol Chem 284: 36557-36568.
37. Kong F, Garcia AJ, Mould AP, Humphries MJ, Zhu C, (2009) Demonstration of catch bonds between an integrin and its ligand. J Cell Biol 185: 1275-1284.
38. Creagh EM, Martin SJ, (2001) Caspases: cellular demolition experts. Biochem Soc Trans 29: 696-702.
39. Kurenova E, Xu LH, Yang X, Baldwin AS Jr, Craven RJ, et al. (2004) Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein. Mol Cell Biol 24: 4361-4371.
40. Maubant S, Saint-Dizier D, Boutillon M, Perron-Sierra F, Casara PJ, et al. (2006) Blockade of alpha v beta3 and alpha v beta5 integrins by RGD mimetics induces anoikis and not integrin-mediated death in human endothelial cells. Blood 108: 3035-3044.
41. Buckley CD, Pilling D, Henriquez NV, Parsonage G, Threlfall K, et al. (1999) RGD peptides induce apoptosis by direct caspase-3 activation. Nature 397: 534-539.
42. Park SJ, Wu CH, Gordon JD, Zhong X, Emami A, et al. (2004) Taxol induces caspase-10-dependent apoptosis. J Biol Chem 279: 51057-51067.
43. Karmakar S, Banik NL, Ray SK, (2008) Combination of all-trans retinoic acid and paclitaxel-induced differentiation and apoptosis in human glioblastoma U87MG xenografts in nude mice. Cancer 112: 596-607.
44. Lu Y, Yang J, Sega E, (2006) Issues related to targeted delivery of proteins and peptides. AAPS J 8: E466-478.