NHE-1 relocation outside cholesterol-rich membrane microdomains is associated with its benzo[a]pyrene-related apoptotic function

Cellular Physiology and Biochemistry

Volumn 29, Issue 5-6, 2012, Pages 657-666

  Tekpli, Xavier ^a,c   Huc, Laurence ^a,d   Sergent, Odile ^a   Dendelé, Béatrice ^a   Dimanche Boitrel, Marie Thérèse ^a   Holme, Jørn A ^b   Lagadic Gossmann, Dominique ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

^b NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^c Center for Molecular Medecine   (Norway)

^d TOXALIM RESEARCH CENTRE IN FOOD TOXICOLOGY   (France)

Author keywords

Apoptosis; Benzo a pyrene; Calmodulin; Cholesterol rich microdomains; NHE 1

Indexed keywords

BENZO[A]PYRENE; CALMODULIN; CHOLESTEROL; SODIUM PROTON EXCHANGE PROTEIN 1;

ALKALINIZATION; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN LOCALIZATION; RAT;

EID: 84861356037     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000171027     Document Type: Article

References (49)

1. + exchanger 1 (NHE1) in the control of apoptotic pathways; in Pickens CO (ed): Cell Apoptotic Signaling Pathways. Hauppage, NY, Nova science Publishers Inc, 2007.
2. Lagadic-Gossmann D, Huc L, Lecureur V: Alterations of intracellular pH homeostasis in apoptosis: Origins and roles. Cell Death Differ 2004;11:953-961. (Pubitemid 39232355)
3. Lemarie A, Huc L, Pazarentzos E, Mahul-Mellier AL, Grimm S: Specific disintegration of complex II succinate: Ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction. Cell Death Differ 2011;18:338-349.
4. Shrode LD, Tapper H, Grinstein S: Role of intracellular pH in proliferation, transformation, and apoptosis. J Bioenerg Biomembr 1997;29:393-399. (Pubitemid 27498419)
5. Izumi H, Torigoe T, Ishiguchi H, Uramoto H, Yoshida Y, Tanabe M, Ise T, Murakami T, Yoshida T, Nomoto M, Kohno K: Cellular pH regulators: Potentially promising molecular targets for cancer chemotherapy. Cancer Treat Rev 2003;29:541-549. (Pubitemid 37428326)
6. Matsuyama S, Llopis J, Deveraux QL, Tsien RY, Reed JC: Changes in intramitochondrial and cytosolic pH: Early events that modulate caspase activation during apoptosis. Nat Cell Biol 2000;2:318-325.
7. Zedeck MS: Polycyclic aromatic hydrocarbons: A review. J Environ Pathol Toxicol 1980;3:537-567.
8. Pelkonen O, Nebert DW: Metabolism of polycyclic aromatic hydrocarbons: Etiologic role in carcinogenesis. Pharmacol Rev 1982;34:189-222. (Pubitemid 13048212)
9. + exchange as a new target for toxic polycyclic aromatic hydrocarbons. Faseb J 2004;18:344-346.
10. + exchanger NHE1 as plasma membrane scaffold in the assembly of signaling complexes. Am J Physiol Cell Physiol 2004;287:C844-850. (Pubitemid 39238307)
11. + exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion. J Biol Chem 2004;279:26991-27007. (Pubitemid 38812535)
12. + exchanger protein. Detergent-resistant aggregation and membrane microdistribution. Eur J Biochem 2002;269:4887-4895. (Pubitemid 35205332)
13. Karmazyn M: The sodium-hydrogen exchange system in the heart: Its role in ischemic and reperfusion injury and therapeutic implications. Can J Cardiol 1996;12:1074-1082. (Pubitemid 26379804)
14. Karmazyn M: Role of sodium-hydrogen exchange in cardiac hypertrophy and heart failure: A novel and promising therapeutic target. Basic Res Cardiol 2001;96:325-328. (Pubitemid 32700569)
15. Young M, Funder J: Mineralocorticoid action and sodium-hydrogen exchange: Studies in experimental cardiac fibrosis. Endocrinology 2003;144:3848-3851. (Pubitemid 37088738)
16. Cardone RA, Bagorda A, Bellizzi A, Busco G, Guerra L, Paradiso A, Casavola V, Zaccolo M, Reshkin SJ: Protein kinase a gating of a pseudopodial-located RhoA/ROCK/p38/NHE1 signal module regulates invasion in breast cancer cell lines. Mol Biol Cell 2005;16:3117-3127. (Pubitemid 40962585)
17. Khaled AR, Moor AN, Li A, Kim K, Ferris DK, Muegge K, Fisher RJ, Fliegel L, Durum SK: Trophic factor withdrawal: P38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization. Mol Cell Biol 2001;21:7545-7557. (Pubitemid 32988766)
18. + exchanger isoform 1 activation controls hexokinase II expression in benzo (a) pyrene-induced apoptosis. Cancer Res 2007;67:1696-1705. (Pubitemid 46383396)
19. Tekpli X, Holme JA, Sergent O, Lagadic-Gossmann D: Importance of plasma membrane dynamics in chemical-induced carcinogenesis. Recent Pat Anticancer Drug Discov 2011;6:347-353.
20. Staubach S, Hanisch FG: Lipid rafts: Signaling and sorting platforms of cells and their roles in cancer. Expert Rev Proteomics 2011;8:263-277.
21. + exchanger NHE3 activity and trafficking are lipid raft-dependent. J Biol Chem 2006;281:17845-17855. (Pubitemid 44035583)
22. + exchanger 3 (NHE3) is present in lipid rafts in the rabbit ileal brush border: A role for rafts in trafficking and rapid stimulation of NHE3. J Physiol 2001;537:537-552. (Pubitemid 33130508)
23. + exchanger NHE-1 by osmotic shocks. Biochemistry 2008;47:13674-13685.
24. 2+ /regulated adenylyl cyclases from changes in intracellular pH. J Biol Chem 2005;280:30864-30872. (Pubitemid 41291817)
25. + exchanger 1 allosteric balance by its localization in cholesterol-and caveolin-rich membrane microdomains. J Cell Physiol 2008;216:207-220. (Pubitemid 351813112)
26. Payen L, Courtois A, Langouet S, Guillouzo A, Fardel O: Unaltered expression of multidrug resistance transporters in polycyclic aromatic hydrocarbon-resistant rat liver cells. Toxicology 2001;156:109-117. (Pubitemid 32119483)
27. Joannard F, Rissel M, Gilot D, Anderson A, Orfila-Lefeuvre L, Guillouzo A, Atfi A, Lagadic-Gossmann D: Role for mitogen-activated protein kinases in phenobarbital-induced expression of cytochrome P450 2B in primary cultures of rat hepatocytes. Toxicol Lett 2006;161:61-72. (Pubitemid 41770877)
28. + exchanger NHE1. Circ Res 2008;103:881-890.
29. Tekpli X, Rissel M, Huc L, Catheline D, Sergent O, Rioux V, Legrand P, Holme JA, Dimanche-Boitrel MT, Lagadic-Gossmann D: Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis. Toxicol Appl Pharmacol 2010;243:68-76.
30. Gorria M, Tekpli X, Sergent O, Huc L, Gaboriau F, Rissel M, Chevanne M, Dimanche-Boitrel MT, Lagadic-Gossmann D: Membrane fluidity changes are associated with benzo[a]pyreneinduced apoptosis in F258 cells: Protection by exogenous cholesterol. Ann N Y Acad Sci 2006;1090:108-112. (Pubitemid 47092113)
31. 2+ regulation-defective. J Biol Chem 1994;269:13710-13715.
32. + exchanger isoform 1 (NHE1) is a novel member of the calmodulin-binding proteins. Identification and characterization of calmodulin-binding sites. J Biol Chem 1994;269:13703-13709.
33. + exchanger, NHE1: Structure, regulation, and cellular actions. Annu Rev Pharmacol Toxicol 2002;42:527-552. (Pubitemid 34160535)
34. Barnes K, Ingram JC, Bennett MD, Stewart GW, Baldwin SA: Methyl-betacyclodextrin stimulates glucose uptake in clone 9 cells: A possible role for lipid rafts. Biochem J 2004;378:343-351. (Pubitemid 38367225)
35. Lam RS, Shaw AR, Duszyk M: Membrane cholesterol content modulates activation of BK channels in colonic epithelia. Biochim Biophys Acta 2004;1667:241-248. (Pubitemid 39576089)
36. Troost J, Lindenmaier H, Haefeli WE, Weiss J: Modulation of cellular cholesterol alters P-glycoprotein activity in multidrug-resistant cells. Mol Pharmacol 2004;66:1332-1339. (Pubitemid 39411074)
37. Scheel-Toellner D, Wang K, Singh R, Majeed S, Raza K, Curnow SJ, Salmon M, Lord JM: The death-inducing signalling complex is recruited to lipid rafts in fasinduced apoptosis. Biochem Biophys Res Commun 2002;297:876-879. (Pubitemid 35230331)
38. Pike LJ, Casey L: Cholesterol levels modulate egf receptor-mediated signaling by altering receptor function and trafficking. Biochemistry 2002;41:10315-10322. (Pubitemid 34856457)
39. 2+ entry. Biochim Biophys Acta 2010;1803:1083-1093.
40. Krueger B, Haerteis S, Yang L, Hartner A, Rauh R, Korbmacher C, Diakov A: Cholesterol depletion of the plasma membrane prevents activation of the epithelial sodium channel (ENaC) by SGK1. Cell Physiol Biochem 2009;24:605-618.
41. + translocation. Mol Cell 2000;6:1425-1436. (Pubitemid 32045934)
42. Mukhin YV, Garnovskaya MN, Ullian ME, Raymond JR: Erk is regulated by sodium-proton exchanger in rat aortic vascular smooth muscle cells. J Biol Chem 2004;279:1845-1852. (Pubitemid 38084452)
43. + exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival. J Biol Chem 2004;279:26280-26286. (Pubitemid 38798777)
44. Lasserre R, Guo XJ, Conchonaud F, Hamon Y, Hawchar O, Bernard AM, Soudja SM, Lenne PF, Rigneault H, Olive D, Bismuth G, Nunes JA, Payrastre B, Marguet D, He HT: Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation. Nat Chem Biol 2008;4:538-547.
45. + -sensing". Proc Natl Acad Sci USA 1992;89:2424-2428.
46. 2+ /calmodulin. J Biol Chem 2001;276:17339-17346.
47. 2+ /calmodulin. Biochemistry 2003;42:7178-7187. (Pubitemid 36706501)
48. + exchanger in podocytes through a mechanism that involves janus kinase and calmodulin. Biochim Biophys Acta 2009;1793:1174-1181.
49. + exchange through janus kinase 2 and calmodulin. J Biol Chem 2003;278:16908-16915. (Pubitemid 36799563)