The sodium-hydrogen exchange system in the heart: Its role in ischemic and reperfusion injury and therapeutic implications

Canadian Journal of Cardiology

Volumn 12, Issue 10, 1996, Pages 1074-1082

  Karmazyn, Morris ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Cardioprotection; Myocardial ischemia; Reperfusion; Sodium hydrogen exchange

Indexed keywords

(3 METHYLSULFONYL 4 PIPERIDINOBENZOYL)GUANIDINE METHANESULFONATE; 5 (N ETHYL N ISOPROPYL)AMILORIDE; 5 (N,N DIMETHYL)AMILORIDE; ALPHA 1 ADRENERGIC RECEPTOR; AMILORIDE; ENDOTHELIN 1; HYDROGEN; PROTEIN KINASE C; SODIUM;

ACIDOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; CALCIUM CELL LEVEL; CELL DAMAGE; CELL PH; DOG; GUINEA PIG; HEART ARRHYTHMIA; HEART INJURY; HEART MUSCLE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; INCIDENCE; MAMMAL; MEDICAL INFORMATION; NONHUMAN; PROTON SODIUM EXCHANGE; RABBIT; RAT; REPERFUSION INJURY; REVIEW; SIGNAL TRANSDUCTION; SODIUM TRANSPORT; SWINE;

ANIMALS; CALCIUM; MODELS, CARDIOVASCULAR; MYOCARDIAL REPERFUSION INJURY; SODIUM-HYDROGEN ANTIPORTER;

EID: 0029822840     PISSN: 0828282X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (73)

1. Orchard CH, Kentish JC. Effects of changes of pH on the contractile function of cardiac muscle. Am J Physiol 1990;258:C967-81.
2. + exchanger: an update on structure, regulation and cardiac physiology. Biochem J 1993;296:273-85.
3. Yun CH, Tse C-M, Nath S, et al. Structure/function studies of mammalian Na-H exchangers - an update. J Physiol 1995;482:1S-6S.
4. + exchanger isoforms. Am J Physiol 1995;268:C283-96.
5. Counillon L, Pouysségur J. Structure-function studies and molecular regulation of the growth factor activatable sodium-hydrogen exchanger (NHE-1). Cardiovasc Res 1995;29:147-54.
6. + exchange in cardiac physiology and pathophysiology: mediation of myocardial reperfusion injury by the pH paradox. Cardiovasc Res 1993;27:915-24.
7. Kleyman TR, Cragoe EJ. Amiloride and its analogs as tools in the study of ion transport. J Membr Biol 1988;105:1-21.
8. Scholz W, Albus U, Counillon L, et al. Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc Res 1995;29:260-8.
9. + exchanger. Circ Res 1991;68:269-79.
10. 1-Adrenoceptor a purinoceptor agonists modulate Na-H antiport in single rat cardiac cells. Am J Physiol 1993;264:H310-9.
11. Matsui H, Barry WH, Livsey C, Spitzer KW. Angiotensin II stimulates sodium-hydrogen exchange in adult rabbit ventricular myocytes. Cardiovasc Res 1995;29:215-21.
12. + concentration. A molecular basis for the antagonistic effect of ouabain and amiloride on the heart. J Biol Chem 1984;259:8880-5.
13. Kim D, Smith TW. Effects of amiloride and ouabain on contractile state, Ca and Na fluxes, and Na content in cultured chick heart cells. Mol Pharmacol 1986;29:363-71.
14. Finet M, Godfraind T. Selective inhibition by ethylisopropylamilotide of the positive inotropic effect evoked by low concentrations of ouabain in rat isolated ventricles. Br J Pharmacol 1986;89:533-8.
15. Lazdunski M, Frelin C, Vigne P. The sodium/hydrogen exchange system in cardiac cells: its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH. J Mol Cell Cardiol 1985;17:1029-42.
16. Frelin C, Vigne P, Ladoux A, Lazdunski M. The regulation of the intracellular pH in cells from vertebrates. Eur J Biochem 1988;174:3-14.
17. Piwnica-Worms D, Jacob R, Shigeto N, et al. Na/H exchange in cultured heart cells: secondary stimulation of electrogenic transport during recovery from intracellular acidosis. J Mol Cell Cardiol 1986;18:1109-16.
18. Kim D, Cragoe EJ, Smith TW. Relations among sodium pump inhibition, NA-Ca and Na-H exchange activities and Ca-H interactions in cultured chick heart cells. Circ Res 1987;60:185-93.
19. 2+ influx. FEBS Lett 1989;259:1-4.
20. Piwnica-Worms D, Jacob R, Horres CR, Lieberman M. Na/H exchange in cultured chick heart cells. J Gen Physiol 1985;85:43-64.
21. 1. Adv Exp Med Biol 1992;311:435-6.
22. Karmazyn M. Ischemic and reperfusion injury in the heart. Cellular mechanisms and pharmacological interventions. Can J Physiol Pharmacol 1991;69:719-30.
23. Bond JM, Herman B, Lemasters JJ. Protection by acidotic pH against anoxia/reoxygenation injury to rat neonatal cardiac myocytes. Biochem Biphys Res Commun 1991;179:798-803.
24. 2+ homeostasis in the pH paradox of reperfusion injury to neonatal rat cardiac myocytes. Am J Physiol 1993;265:C129-37.
25. Karmazyn M. The role of endothelins in cardiac function in health and disease. In: Karmazyn M, ed. Myocardial Ischemia: Mechanisms, Reperfusion, Protection. Basel: Birkhäuser Verlag, 1996:209-30.
26. + exchange in mediating effects of endothelin-1 on normal and ischemic/reperfused hearts. Circ Res 1994;75:369-78.
27. 1 adrenergic stimulation: a potential role for receptor mediated activation of sarcolemmal sodium-hydrogen exchange. Cardiovasc Res 1995;29:222-30.
28. Neely JR, Grotyohann LW. Role of glycolytic products in damage to ischemic myocardium. Dissociation of adenosine triphosphate levels and recovery of function of reperfused ischemic hearts. Circ Res 1984;55:816-24.
29. Cross HR, Clarke K, Opie LH, Radda GK. Is lactate-induced myocardial ischaemic injury mediated by decreased pH or increased intracellular lactate? J Mol Cell Cardiol 1995;27:1369-81.
30. 2+ exchange. Circ Res 1989;65:1045-56.
31. + exchange inhibitors reverse lactate-induced depression in postischaemic ventricular recovery. Br J Pharmacol 1993;108:50-6.
32. + exchange. Am J Physiol 1988;255:H608-15.
33. Duan J, Karmazyn M. Protective effects of amiloride on the ischemic reperfused rat heart. Relation to mitochondrial function. Eur J Pharmacol 1992;210:149-57.
34. + exchanger in reperfusion stunning in isolated perfused rat heart. J Cardiovasc Pharmacol 1993;22:877-83.
35. 2+ overload in isolated perfused rabbit heart. Circulation 1994;89:2787-98.
36. + exchange inhibition in ischemic, reperfused porcine hearts. Circulation 1995;92:912-7.
37. Moffat MP, Karmazyn M. Protective effects of the potent Na/H exchange inhibitor methylisobutyl amiloride against post-ischemic contractile dysfunction in rat and guinea-pig hearts. J Mol Cell Cardiol 1993;25:959-71.
38. Meng H-P, Pierce GN. Protective effects of 5-(N,N-dimethyl) amiloride on ischemia-reperfusion injury in hearts. Am J Physiol 1990,258:H1615-9.
39. Meng H-P, Maddaford TG, Pierce GN. Effect of amiloride and selected analogues on postischemic recovery of cardiac contractile function Am J Physiol 1993;264:H1831-5.
40. Anderson SE, Murphy E, Steenbergen C, London RE, Cala PM. Na-H exchange in myocardium: effects of hypoxia and acidification on Na and Ca. Am J Physiol 1990;259:C940-8.
41. Murphy E, Perlman M, London RE, Steenbergen C. Amiloride delays the ischemia-induced rise in cytosolic calcium. Circ Res 1991;68:1250-8.
42. Murry CE, Richard VJ, Reimer KA, Jennings RB. Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode. Circ Res 1990;66:913-31.
43. Asimakis OK, Inners-McBride K, Medellin G, Conti VR. Ischemic preconditioning attenuates acidosis and postischemic dyfunction in isolated rat heart. Am J Physiol 1992;263:H887-94.
44. Steenbergen C, Perlman ME, London RE, Murphy E. Mechanisms of preconditioning. Ionic alterations. Circ Res 1993;72:112-35.
45. de Albuquerque CP, Gerstenblith G, Weiss RG. Importance of metabolic inhibition and cellular pH in mediating preconditioning contractile and metabolic effects in rat hearts. Circ Res 1994;74:139-50.
46. Ramasamy R, Liu H, Anderson S, et al. Ischemic preconditioning stimulates sodium and proton transport in isolated rat hearts. J Clin Invest 1995;96:1464-72.
47. Bugge E, Ytrehus K. Inhibition of sodium-hydrogen exchange reduces infarct size in the isolated rat heart - a protective additive to ischaemic preconditioning. Cardiovasc Res 1995;29:269-74.
48. Mullane JM, Westlin W, Kraemer R. Activated neutrophils release mediators that may contribute to myocardial injury and dysfunction associated with ischemia and reperfusion. Ann NY Acad Sci 1988;524:103-21.
49. Smith EF, Egan JW, Bugelski PJ, et al. Temporal relation between neutrophil accumulation and myocardial reperfusion injury. Am J Physiol 1988;255:H1060-8.
50. Westlin W, Mullane KM. Alleviation of myocardial stunning by leukocyte and platelet depletion. Circ Res 1989;80:1828-36.
51. 2. Fed Proc 1987;46:133-8.
52. + exchange block stimulus-provoked arachidonic acid release in human platelets. J Biol Chem 1985;260:12910-9.
53. 2 activation in human platelets. J Biol Chem 1986;261:8667-73.
54. 2+ mobilization start simultaneously in thrombin-stimulated platelets. Biochem J 1989;258:521-7.
55. 2+ mobilization in human platelets stimulated by ADP and the thromboxane mimetic U 46619. J Biol Chem 1990;264:719-25.
56. Simchovitz L, Roos A. Regulation of intracellular pH in human neutrophils. J Gen Physiol 1985;85:443-70.
57. Simchowitz L, Cragoe EJ. Regulation of human neutrophil chemotaxis by intracellular pH. J Biol Chem 1986;261:6492-500.
58. 4 by human neutrophils. Biochem J 1989;257:751-8.
59. + exchanger attenuates neutrophil-mediated reperfusion injury. Ann Thorac Surg 1995;60:377-81.
60. + exchange inhibitor HOE 694. Ann Thorac Surg 1996;61:1400-6.
61. Duff HJ, Lester WM, Rahmberg M. Amiloride. Antiarrhythmic and electrophysiological activity in the dog. Circulation 1988;78:1469-77.
62. + exchange during ischaemia and reperfusion of normal and diabetic rat hearts. Cardiovasc Res 1990;24:873-8.
63. Weiss RG, Lakatta EG, Gerstenblith G. Effects of amiloride on metabolism and contractility during reoxygenation in perfused rat hearts. Circ Res 1990;66:1012-22.
64. + exchange. Circ Res 1990;66-1156-9.
65. + exchange inhibitor and its effects on cardiac ischaemia. Br J Pharmacol 1993;109:562-8.
66. + exchanger and reperfusion-induced ventricular arrhythmias in isolated perfused heart: possible role of amiloride. Mol Cell Biochem 1993;119:151-7.
67. 2+ paradox. J Cardiovasc Pharmacol 1993;21:172-8.
68. + antiporter inhibitor on postischemic reperfusion in pig heart. J Cardiovasc Pharmacol 1994;23:72-8.
69. + exchange system. Circ Res 1994;74:794-805.
70. Myers ML, Mathur S, Li G-H, Karmazyn M. Sodium-hydrogen exchange inhibitors improve postischaemic recovery of function in the perfused rabbit heart. Cardiovasc Res 1995;29:209-14.
71. 1 and cell shortening. Cardiovasc Res 1995;29:247-53.
72. + exchange. Am J Physiol 1995;268:H1531-9.
73. Kaplan SH, Yang H, Gilliam DE, et al. Hypercapnic acidosis and dimethylamiloride reduce reperfusion-induced cell death in ischaemic ventricular myocardium. Cardiovasc Res 1995;29:231-8.