메뉴 건너뛰기




Volumn 31, Issue 18, 2012, Pages 2258-2269

Four proteins governing overangiogenic endothelial cell phenotype in patients with multiple myeloma are plausible therapeutic targets

Author keywords

angiogenesis; antiangiogenesis; endothelial cells; multiple myeloma; proteomic analysis

Indexed keywords

ALPHA CRYSTALLIN; BORTEZOMIB; FILAMIN A; LENALIDOMIDE; PANOBINOSTAT; PROTEIN 14 3 3; VIMENTIN;

EID: 84861348702     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.412     Document Type: Article
Times cited : (29)

References (49)
  • 1
    • 33846849237 scopus 로고    scopus 로고
    • Phenotypic heterogeneity of the endothelium
    • Aird WC. (2007). Phenotypic heterogeneity of the endothelium. Circ Res 100: 174-190.
    • (2007) Circ Res , vol.100 , pp. 174-190
    • Aird, W.C.1
  • 2
    • 33646926129 scopus 로고    scopus 로고
    • 14-3-3 proteins: A historic overview
    • DOI 10.1016/j.semcancer.2006.03.005, PII S1044579X06000253
    • Aitken A. (2006). 14-3-3 proteins: a historic overview. Semin Cancer Biol 16: 162-172. (Pubitemid 43796128)
    • (2006) Seminars in Cancer Biology , vol.16 , Issue.3 , pp. 162-172
    • Aitken, A.1
  • 3
    • 33845425645 scopus 로고    scopus 로고
    • Crystallins in the eye: Function and pathology
    • DOI 10.1016/j.preteyeres.2006.10.003, PII S1350946206000553
    • Andley UP. (2007). Crystallins in the eye: Function and pathology. Prog Retin Eye Res 26: 78-98. (Pubitemid 44894995)
    • (2007) Progress in Retinal and Eye Research , vol.26 , Issue.1 , pp. 78-98
    • Andley, U.P.1
  • 5
    • 61349085591 scopus 로고    scopus 로고
    • Nuclear versus cytoplasmic localization of filamin A in prostate cancer: Immunohistochemical correlation with metastases
    • Bedolla RG, Wang Y, Asuncion A, Chamie K, Siddiqui S, Mudryj MM ,et al. (2009). Nuclear versus cytoplasmic localization of filamin A in prostate cancer: immunohistochemical correlation with metastases. Clin Cancer Res 15: 788-796.
    • (2009) Clin Cancer Res , vol.15 , pp. 788-796
    • Bedolla, R.G.1    Wang, Y.2    Asuncion, A.3    Chamie, K.4    Siddiqui, S.5    Mudryj, M.M.6
  • 6
    • 12244257557 scopus 로고    scopus 로고
    • Vimentin intermediate filament reorganization by Cdc42: Involvement of PAK and p70 S6 kinase
    • DOI 10.1078/0171-9335-00281
    • Chan W, Kozma R, Yasui Y, Inagaki M, Leung T, Manser E ,et al. (2002). Vimentin intermediate filament reorganization by Cdc42: involvement of PAK and p70 S6 kinase. Eur J Cell Biol 81: 692-701. (Pubitemid 36104764)
    • (2002) European Journal of Cell Biology , vol.81 , Issue.12 , pp. 692-701
    • Chan, W.1    Kozma, R.2    Yasui, Y.3    Inagaki, M.4    Leung, T.5    Manser, E.6    Lim, L.7
  • 7
    • 51649116942 scopus 로고    scopus 로고
    • Validation of PDGFRbeta and c-Src tyrosine kinases as tumor/vessel targets in patients with multiple myeloma: Preclinical efficacy of the novel, orally available inhibitor dasatinib
    • Coluccia AML, Cirulli T, Neri P, Mangieri D, Colanardi MC, Gnoni A ,et al. (2008). Validation of PDGFRbeta and c-Src tyrosine kinases as tumor/vessel targets in patients with multiple myeloma: preclinical efficacy of the novel, orally available inhibitor dasatinib. Blood 112: 1346-1356.
    • (2008) Blood , vol.112 , pp. 1346-1356
    • Coluccia, A.M.L.1    Cirulli, T.2    Neri, P.3    Mangieri, D.4    Colanardi, M.C.5    Gnoni, A.6
  • 8
    • 79953300083 scopus 로고    scopus 로고
    • Lenalidomide restrains motility and overangiogenic potential of bone marrow endothelial cells in patients with active multiple myeloma
    • De Luisi A, Ferrucci A, Coluccia AML, Ria R, Moschetta M, De Luca E ,et al. (2011). Lenalidomide restrains motility and overangiogenic potential of bone marrow endothelial cells in patients with active multiple myeloma. Clin Cancer Res 17: 1935-1946.
    • (2011) Clin Cancer Res , vol.17 , pp. 1935-1946
    • De Luisi, A.1    Ferrucci, A.2    Coluccia, A.M.L.3    Ria, R.4    Moschetta, M.5    De Luca, E.6
  • 10
    • 76549114687 scopus 로고    scopus 로고
    • RCAS1 MT and vimentin as potential markers of tumor microenvironment remodeling
    • Dutsch-Wicherek M. (2010). RCAS1, MT, and vimentin as potential markers of tumor microenvironment remodeling. Am J Reprod Immunol 63: 181-188.
    • (2010) Am J Reprod Immunol , vol.63 , pp. 181-188
    • Dutsch-Wicherek, M.1
  • 14
    • 67049115481 scopus 로고    scopus 로고
    • Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells
    • Ge F, Lu XP, Zeng HL, He QY, Xiong S, Jin L ,et al. (2009). Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res 8: 3006-3019.
    • (2009) J Proteome Res , vol.8 , pp. 3006-3019
    • Ge, F.1    Lu, X.P.2    Zeng, H.L.3    He, Q.Y.4    Xiong, S.5    Jin, L.6
  • 17
    • 31044436397 scopus 로고    scopus 로고
    • Is the small heat shock protein αB-crystallin an oncogene?
    • DOI 10.1172/JCI27462
    • Gruvberger Saal SK, Parsons R. (2006). Is the small heat shock protein aB-crystallin an oncogene? J Clin Invest 116: 30-32. (Pubitemid 43121787)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.1 , pp. 30-32
    • Gruvberger-Saal, S.K.1    Parsons, R.2
  • 18
    • 0033621703 scopus 로고    scopus 로고
    • αB-crystallin regulates intermediate filament organization in situ
    • Head MW, Hurwitz L, Kegel K, Goldman JE. (2000). AlphaBcrystallin regulates intermediate filament organization in situ. Neuroreport 11: 361-365. (Pubitemid 30074650)
    • (2000) NeuroReport , vol.11 , Issue.2 , pp. 361-365
    • Head, M.W.1    Hurwitz, L.2    Kegel, K.3    Goldman, J.E.4
  • 20
    • 54949142530 scopus 로고    scopus 로고
    • Molecular chaperones as regulators of cell death
    • Hishiya A, Takayama S. (2008). Molecular chaperones as regulators of cell death. Oncogene 27: 6489-6506.
    • (2008) Oncogene , vol.27 , pp. 6489-6506
    • Hishiya, A.1    Takayama, S.2
  • 21
    • 0035844174 scopus 로고    scopus 로고
    • The small heat shock protein alpha B-crystallin negatively regulates cytochrome c-and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation
    • Kamradt MC, Chen F, Cryns VL. (2001). The small heat shock protein alpha B-crystallin negatively regulates cytochrome c-and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation. J Biol Chem 276: 16059-16063.
    • (2001) J Biol Chem , vol.276 , pp. 16059-16063
    • Kamradt, M.C.1    Chen, F.2    Cryns, V.L.3
  • 22
    • 77951448229 scopus 로고    scopus 로고
    • AlphaB-crystallin regulation of angiogenesis by modulation of VEGF
    • Kase S, He S, Sonoda S, Kitamura M, Spee C, Wawrousek E ,et al. (2010). AlphaB-crystallin regulation of angiogenesis by modulation of VEGF. Blood 115: 3398-3406.
    • (2010) Blood , vol.115 , pp. 3398-3406
    • Kase, S.1    He, S.2    Sonoda, S.3    Kitamura, M.4    Spee, C.5    Wawrousek, E.6
  • 24
    • 0036512435 scopus 로고    scopus 로고
    • Multiple myeloma: Evolving genetic events and host interactions
    • Kuehl WM, Bergsagel PL. (2002). Multiple myeloma: evolving genetics events and host interactions. Nat Rev Cancer 2: 175-187. (Pubitemid 37328787)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.3 , pp. 175-187
    • Kuehl, W.M.1    Bergsagel, P.L.2
  • 25
    • 44549085698 scopus 로고    scopus 로고
    • HSP27 regulates cell adhesion and invasion via modulation of focal adhesion kinase and MMP-2 expression
    • Lee JW, Kwak HJ, Lee JJ, Kim YN, Lee JW, Park MJ ,et al. (2008). HSP27 regulates cell adhesion and invasion via modulation of focal adhesion kinase and MMP-2 expression. Eur J Cell Biol 87: 377-387.
    • (2008) Eur J Cell Biol , vol.87 , pp. 377-387
    • Lee, J.W.1    Kwak, H.J.2    Lee, J.J.3    Kim, Y.N.4    Lee, J.W.5    Park, M.J.6
  • 26
    • 38349103951 scopus 로고    scopus 로고
    • Down-regulation of 14-3-3z suppresses anchorage independent growth of lung cancer cells through anoikis activation
    • Li Z, Zhao J, Du Y, Park HR, Sun S-Y, Bernal-Mizrachi L ,et al. (2008). Down-regulation of 14-3-3z suppresses anchorage independent growth of lung cancer cells through anoikis activation. Proc Natl Acad Sci USA 105: 162-167.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 162-167
    • Li, Z.1    Zhao, J.2    Du, Y.3    Park, H.R.4    Sun, S.-Y.5    Bernal-Mizrachi, L.6
  • 27
    • 0035710746 scopus 로고    scopus 로고
    • -ΔΔCT method
    • DOI 10.1006/meth.2001.1262
    • Livak KJ, Schmittgen TD. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)). Method Methods 25: 402-408. (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 30
    • 78049263875 scopus 로고    scopus 로고
    • Microtentacles tip the balance of cytoskeletal forces in circulating tumor cells
    • Matrone MA, Whipple RA, Balzer EM, Martin SS. (2010). Microtentacles tip the balance of cytoskeletal forces in circulating tumor cells. Cancer Res 70: 7737-7741.
    • (2010) Cancer Res , vol.70 , pp. 7737-7741
    • Matrone, M.A.1    Whipple, R.A.2    Balzer, E.M.3    Martin, S.S.4
  • 31
    • 0034693241 scopus 로고    scopus 로고
    • Cdc42Hs and Rac1 GTPases induce the collapse of the vimentin intermediate filament network
    • Meriane M, Mary S, Comunale F, Vignal E, Fort P, Gauthier-Rouviére C. (2010). Cdc42Hs and Rac1 GTPases induce the collapse of the vimentin intermediate filament network. J Biol Chem 275: 33046-33052.
    • (2010) J Biol Chem , vol.275 , pp. 33046-33052
    • Meriane, M.1    Mary, S.2    Comunale, F.3    Vignal, E.4    Fort, P.5    Gauthier-Rouviére, C.6
  • 32
    • 58149488988 scopus 로고    scopus 로고
    • The 14-3-3 proteins: Integrators of diverse signaling cues that impact cell fate and cancer development
    • Morrison DK. (2009). The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development. Trends Cell Biol 19: 16-23.
    • (2009) Trends Cell Biol , vol.19 , pp. 16-23
    • Morrison, D.K.1
  • 35
    • 0035880256 scopus 로고    scopus 로고
    • Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration
    • Podar K, Tai YT, Davies FE, Lentzsch S, Sattler M, Hideshima T ,et al. (2001). Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration. Blood 98: 428-435.
    • (2001) Blood , vol.98 , pp. 428-435
    • Podar, K.1    Tai, Y.T.2    Davies, F.E.3    Lentzsch, S.4    Sattler, M.5    Hideshima, T.6
  • 36
  • 37
    • 69949084408 scopus 로고    scopus 로고
    • Gene expression profiling of bone marrow endothelial cells in patients with multiple myeloma
    • Ria R, Todoerti K, Berardi S, Coluccia AML, De Luisi A, Mattioli M ,et al. (2009). Gene expression profiling of bone marrow endothelial cells in patients with multiple myeloma. Clin Cancer Res 15: 5369-5378.
    • (2009) Clin Cancer Res , vol.15 , pp. 5369-5378
    • Ria, R.1    Todoerti, K.2    Berardi, S.3    Aml, C.4    De Luisi, A.5    Mattioli, M.6
  • 38
    • 33746257305 scopus 로고    scopus 로고
    • Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma
    • DOI 10.1038/sj.onc.1209456, PII 1209456
    • Ribatti D, Nico B, Vacca A. (2006). Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma. Oncogene 25: 4257-4266. (Pubitemid 44100496)
    • (2006) Oncogene , vol.25 , Issue.31 , pp. 4257-4266
    • Ribatti, D.1    Nico, B.2    Vacca, A.3
  • 40
    • 34548178909 scopus 로고    scopus 로고
    • In-gel digestion for mass spectrometric characterization of proteins and proteomes
    • Shevchenko A, Tomas H, Havlis J, Olsen JV, Mann M. (2006). In-gel digestion for mass spectrometric characterization of proteins and proteomes. Nat Protoc 1: 2856-2860.
    • (2006) Nat Protoc , vol.1 , pp. 2856-2860
    • Shevchenko, A.1    Tomas, H.2    Havlis, J.3    Olsen, J.V.4    Mann, M.5
  • 42
    • 0347513188 scopus 로고    scopus 로고
    • The vimentin cytoskeleton regulates focal contact size and adhesion of endothelial cells subjected to shear stress
    • DOI 10.1242/jcs.00823
    • Tsuruta D, Jones JC. (2003). The vimentin cytoskeleton regulates focal contact size and adhesion of endothelial cells subjected to shear stress. J Cell Sci 116: 4977-4984. (Pubitemid 38016704)
    • (2003) Journal of Cell Science , vol.116 , Issue.24 , pp. 4977-4984
    • Tsuruta, D.1    Jones, J.C.R.2
  • 45
    • 0036711657 scopus 로고    scopus 로고
    • Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1
    • DOI 10.1038/ncb838
    • Vadlamudi RK, Li F, Adam L, Nguyen D, Ohta Y, Stossel TP ,et al. (2002). Filamin is essential in actin cytoskeletal assembly mediated by p21-activated kinase 1. Nat Cell Biol 4: 681-690. (Pubitemid 34993704)
    • (2002) Nature Cell Biology , vol.4 , Issue.9 , pp. 681-690
    • Vadlamudi, R.K.1    Li, F.2    Adam, L.3    Nguyen, D.4    Ohta, Y.5    Stossel, T.P.6    Kumar, R.7
  • 46
    • 0043205911 scopus 로고    scopus 로고
    • Nuclear speckle localisation of the small heat shock protein αB-crystallin and its inhibition by the R120G cardiomyopathy-linked mutation
    • DOI 10.1016/S0014-4827(03)00092-2
    • Van den IJssel P, Wheelock R, Prescott A, Russell P, Quinlan RA. (2003). Nuclear speckle localisation of the small heat shock protein alpha B-crystallin and its inhibition by the R120G cardiomyopathylinked mutation. Exp Cell Res 287: 249-261. (Pubitemid 37323839)
    • (2003) Experimental Cell Research , vol.287 , Issue.2 , pp. 249-261
    • Van Den IJssel, P.1    Wheelock, R.2    Prescott, A.3    Russell, P.4    Quinlan, R.A.5
  • 47
    • 0043132253 scopus 로고    scopus 로고
    • Nuclear staining for the small heat shock protein αB-crystallin colocalizes with splicing factor SC35
    • DOI 10.1078/0171-9335-00321
    • Van Rijk AE, Stege GJ, Bennink EJ, May A, Bloemendal H. (2003). Nuclear staining for the small heat shock protein alphaBcrystallin colocalizes with splicing factor SC35. Eur J Cell Biol 82: 361-368. (Pubitemid 36944165)
    • (2003) European Journal of Cell Biology , vol.82 , Issue.7 , pp. 361-368
    • Van Rijk, A.F.1    Stege, G.J.J.2    Bennink, E.J.3    May, A.4    Bloemendal, H.5
  • 48
    • 75149145088 scopus 로고    scopus 로고
    • Filamins in cell signaling, transcription and organ development
    • Zhou AX, Hartwig JH, Akyü rek LM. (2010). Filamins in cell signaling, transcription and organ development. Trends Cell Biol 20: 113-123.
    • (2010) Trends Cell Biol , vol.20 , pp. 113-123
    • Zhou, A.X.1    Hartwig, J.H.2    Akyü Rek, L.M.3
  • 49
    • 55949136396 scopus 로고    scopus 로고
    • The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas
    • 1186/1471-2407-8-308
    • Wang Z, Tropè CG, Suo Z, Tren G, Yang G, Nesland JM ,et al. (2008). The clinicopathological and prognostic impact of 14-3-3 sigma expression on vulvar squamous cell carcinomas. BMC Cancer 10: 1186/1471-2407-8-308.
    • (2008) BMC Cancer , vol.10
    • Wang, Z.1    Tropè, C.G.2    Suo, Z.3    Tren, G.4    Yang, G.5    Nesland, J.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.