Functional and Crystal Structure Analysis of Active Site Adaptations of a Potent Anti-Angiogenic Human tRNA Synthetase

Structure

Volumn 15, Issue 7, 2007, Pages 793-805

  Yang, Xiang Lei ^a   Guo, Min ^a   Kapoor, Mili ^a   Ewalt, Karla L ^a   Otero, Francella J ^a   Skene, Robert J ^b   McRee, Duncan E ^b   Schimmel, Paul ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Takeda San Diego Inc   (United States)

Author keywords

RNA

Indexed keywords

AMINO TERMINAL SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME SUBSTRATE COMPLEX; GEOBACILLUS STEAROTHERMOPHILUS; HUMAN; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

ACETYLATION; AMINO ACID SEQUENCE; ANGIOGENESIS INHIBITORS; BACILLUS STEAROTHERMOPHILUS; BACTERIAL PROTEINS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RNA SPLICING; SUBSTRATE SPECIFICITY; TRYPTOPHAN-TRNA LIGASE;

EUKARYOTA;

EID: 34447307157     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.str.2007.05.009     Document Type: Article

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