Attenuated influenza virus construct with enhanced hemagglutinin protein expression

Journal of Virology

Volumn 86, Issue 10, 2012, Pages 5782-5790

  Maamary, Jad ^a   Pica, Natalie ^a   Belicha Villanueva, Alan ^a   Chou, Yi Ying ^a   Krammer, Florian ^a   Gao, Qinshan ^a   García Sastre, Adolfo ^a   Palese, Peter ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INFLUENZA VACCINE; INFLUENZA VIRUS HEMAGGLUTININ; NONSTRUCTURAL PROTEIN 1; VIRUS MESSENGER RNA; VIRUS RNA;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EMBRYO; FEMALE; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; INFLUENZA; INFLUENZA VIRUS A H1N1; INFLUENZA VIRUS A H5N1; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIROGENESIS; VIRUS CARRIER; VIRUS GENOME; VIRUS MUTATION; VIRUS RECOMBINANT; VIRUS VIRULENCE; WILD TYPE;

AMINO ACID MOTIFS; ANIMALS; ANTIBODIES, VIRAL; CELL LINE; CHICKENS; FEMALE; GENE EXPRESSION REGULATION, VIRAL; HEMAGGLUTININ GLYCOPROTEINS, INFLUENZA VIRUS; HUMANS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H5N1 SUBTYPE; INFLUENZA, HUMAN; MICE; MICE, INBRED BALB C; UP-REGULATION; VIRAL NONSTRUCTURAL PROTEINS;

INFLUENZA A VIRUS; MUS; ORTHOMYXOVIRIDAE;

EID: 84861309359     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00190-12     Document Type: Article

References (33)

1. Baskin CR, et al. 2007. Functional genomic and serological analysis of the protective immune response resulting from vaccination of macaques with an NS1-truncated influenza virus. J. Virol. 81:11817-11827. doi:10.1128 /JVI.00590-07.
2. Belshe RB, et al. 2007. Live attenuated versus inactivated influenza vaccine in infants and young children. N. Engl. J. Med. 356:685- 696. doi:10.1056/NEJMoa065368.
3. Bortz E, et al. 2011. Host- and strain-specific regulation of influenza virus polymerase activity by interacting cellular proteins. mBio 2(4):e00151-11. doi:10.1128/mBio.00151-11.
4. Campbell RE, et al. 2002. A monomeric red fluorescent protein. Proc. Natl. Acad. Sci. U. S. A. 99:7877-7882. doi:10.1073/pnas.082243699.
5. Carnero E, et al. 2009. Optimization of human immunodeficiency virus Gag expression by Newcastle disease virus vectors for the induction of potent immune responses. J. Virol. 83:584-597. doi:10.1128/JVI.01443-08.
6. de la Luna S, Fortes P, Beloso A, Ortin J. 1995. Influenza virus NS1 protein enhances the rate of translation initiation of viral mRNAs. J. Virol. 69:2427-2433.
7. Falcon AM, et al. 2004. Defective RNA replication and late gene expression in temperature-sensitive influenza viruses expressing deleted forms of the NS1 protein. J. Virol. 78:3880 -3888.
8. Ferko B, et al. 2004. Immunogenicity and protection efficacy of replication-deficient influenza A viruses with altered NS1 genes. J. Virol. 78: 13037-13045. doi:10.1128/JVI.78.23.13037-13045.2004.
9. Gao Q, Palese P. 2009. Rewiring the RNAs of influenza virus to prevent reassortment. Proc. Natl. Acad. Sci. U. S. A. 106:15891-15896. doi:10.1073 /pnas.0908897106.
10. Garcia-Sastre A, et al. 1998. Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems. Virology 252:324 -330.
11. Garfinkel MS, Katze MG. 1993. Translational control by influenza virus. Selective translation is mediated by sequences within the viral mRNA 5'-untranslated region. J. Biol. Chem. 268:22223-22226.
12. Gorse GJ, Belshe RB. 1990. Enhancement of anti-influenza A virus cytotoxicity following influenza A virus vaccination in older, chronically ill adults. J. Clin. Microbiol. 28:2539 -2550.
13. Gorse GJ, Belshe RB. 1991. Enhanced lymphoproliferation to influenza A virus following vaccination of older, chronically ill adults with liveattenuated viruses. Scand. J. Infect. Dis. 23:7-17.
14. Hale BG, Albrecht RA, Garcia-Sastre A. 2010. Innate immune evasion strategies of influenza viruses. Future Microbiol. 5:23- 41. doi:10.2217 /fmb.09.108.
15. Hale BG, Randall RE, Ortin J, Jackson D. 2008. The multifunctional NS1 protein of influenza A viruses. J. Gen. Virol. 89:2359 -2376. doi:10.1099 /vir.0.2008/004606-0.
16. Hatada E, Hasegawa M, Shimizu K, Hatanaka M, Fukuda R. 1990. Analysis of influenza A virus temperature-sensitive mutants with mutations in RNA segment 8. J. Gen. Virol. 71(Pt 6):1283-1292.
17. Hatada E, Saito S, Okishio N, Fukuda R. 1997. Binding of the influenza virus NS1 protein to model genome RNAs. J. Gen. Virol. 78(Pt 5):1059- 1063.
18. Hatada E, Takizawa T, Fukuda R. 1992. Specific binding of influenza A virus NS1 protein to the virus minus-sense RNA in vitro. J. Gen. Virol. 73(Pt 1):17-25.
19. Haye K, Burmakina S, Moran T, Garcia-Sastre A, Fernandez-Sesma A. 2009. The NS1 protein of a human influenza virus inhibits type I interferon production and the induction of antiviral responses in primary human dendritic and respiratory epithelial cells. J. Virol. 83: 6849 - 6862. doi:10.1128/JVI.02323-08.
20. Levy DE, Garcia-Sastre A. 2001. The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Cytokine Growth Factor Rev. 12:143-156.
21. Ludwig S, Vogel U, Scholtissek C. 1995. Amino acid replacements leading to temperature-sensitive defects of the NS1 protein of influenza A virus. Arch. Virol. 140:945-950.
22. Marion RM, Zurcher T, de la Luna S, Ortin J. 1997. Influenza virus NS1 protein interacts with viral transcription-replication complexes in vivo. J. Gen. Virol. 78(Pt 10):2447-2451.
23. Martinez-Sobrido L, et al. 2010. Hemagglutinin-pseudotyped green fluorescent protein-expressing influenza viruses for the detection of influenza virus neutralizing antibodies. J. Virol. 84:2157-2163. doi:10.1128 /JVI.01433-09.
24. Mikulasova A, Vareckova E, Fodor E. 2000. Transcription and replication of the influenza A virus genome. Acta Virol. 44:273-282.
25. Min JY, Li S, Sen GC, Krug RM. 2007. A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis. Virology 363:236 -243. doi:10.1016 /j.virol.2007.01.038.
26. Neumann G, Hobom G. 1995. Mutational analysis of influenza virus promoter elements in vivo. J. Gen. Virol. 76(Pt 7):1709 -1717.
27. Quinlivan M, et al. 2005. Attenuation of equine influenza viruses through truncations of the NS1 protein. J. Virol. 79:8431- 8439. doi:10.1128 /JVI.79.13.8431-8439.2005.
28. Reed LJ, Muench H. 1938. A simple method of estimating fifty per cent endpoints. Am. J. Epidemiol. 27:493- 497.
29. Solorzano A, et al. 2005. Mutations in the NS1 protein of swine influenza virus impair anti-interferon activity and confer attenuation in pigs. J. Virol. 79:7535-7543. doi:10.1128/JVI.79.12.7535-7543.2005.
30. Steel J, et al. 2009. Live attenuated influenza viruses containing NS1 truncations as vaccine candidates against H5N1 highly pathogenic avian influenza. J. Virol. 83:1742-1753. doi:10.1128/JVI.01920-08.
31. Talon J, et al. 2000. Influenza A and B viruses expressing altered NS1 proteins: a vaccine approach. Proc. Natl. Acad. Sci. U. S. A. 97:4309-4314. doi:10.1073/pnas.070525997.
32. Wacheck V, et al. 2010. A novel type of influenza vaccine: safety and immunogenicity of replication-deficient influenza virus created by deletion of the interferon antagonist NS1. J. Infect. Dis. 201:354 -362. doi:10.1086/649428.
33. Wolstenholme AJ, Barrett T, Nichol ST, Mahy BW. 1980. Influenza virus-specific RNA and protein syntheses in cells infected with temperature-sensitive mutants defective in the genome segment encoding nonstructural proteins. J. Virol. 35:1-7.