Exon-I is involved in positive as well as negative regulation of human angiotensinogen gene expression

Gene

Volumn 224, Issue 1-2, 1998, Pages 97-107

  Cui, Yanning ^a   Narayanan, Chittampalli S ^a   Zhou, Jie ^a   Kumar, Ashok ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

AP4; HepG2; HNF 3; Transcriptional regulation

Indexed keywords

ANGIOTENSINOGEN; ESTROGEN RECEPTOR; NUCLEOSIDE; TRANSCRIPTION FACTOR;

ARTICLE; CONTROLLED STUDY; ESSENTIAL HYPERTENSION; EXON; GENE EXPRESSION REGULATION; GENE LOCUS; GENE MUTATION; GENE REPRESSION; GENETIC POLYMORPHISM; GENETIC TRANSFECTION; HORMONAL REGULATION; HUMAN; HUMAN CELL; LIVER; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR BINDING; TATA BOX;

ANGIOTENSINOGEN; BASE SEQUENCE; BINDING SITES; CYTOMEGALOVIRUS; DNA; DNA-BINDING PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESTROGENS; EXONS; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; GENES; GENES, REPORTER; HEPATOCYTE NUCLEAR FACTOR 3-ALPHA; HEPATOCYTE NUCLEAR FACTOR 3-BETA; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEAR PROTEINS; OLIGONUCLEOTIDES; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN BIOSYNTHESIS; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; REGULATORY SEQUENCES, NUCLEIC ACID; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0032509332     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(98)00512-5     Document Type: Article

References (38)

1. Arngrimsson R., Purandare S., Connor M., Walker J.J., Bjornsson S., Soubrier F., Kotelevtsev Y.V., Geirsson R.T., Bjornsson H. Angiotensinogen: a candidate gene involved in preeclampsia? [letter; comment]. Nat. Genet. 4:1993;114-115.
2. Behrens J., Lowrick O., Klein Hitpass L., Birchmeier W. The E-cadherin promoter: functional analysis of a G.C-rich region and an epithelial cell-specific palindromic regulatory element. Proc. Natl. Acad. Sci. USA. 88:1991;11495-11499.
3. Campbell D.J., Habener J.F. Angiotensinogen gene is expressed and differentially regulated in multiple tissues of the rat. J. Clin. Invest. 78:1986;31-39.
4. Cardinaux J.R., Chapel S., Wahli W. Complex organization of CTF/NF-I, C/EBP, and HNF3 binding sites within the promoter of the liver-specific vitellogenin gene. J. Biol. Chem. 269:1994;32947-32956.
5. Carter R.S., Bhat N.K., Basu A., Avadhani N.G. The basal promoter elements of murine cytochrome c oxidase subunit IV gene consist of tandemly duplicated ets motifs that bind to GABP-related transcription factors. J. Biol. Chem. 267:1992;23418-23426.
6. Corvol P., Jeunemaitre X., Charru A., Kotelevtsev Y., Soubrier F. Role of the renin-angiotensin system in blood pressure regulation and in human hypertension: new insights from molecular genetics. Recent. Prog. Horm. Res. 50:1995;287-308.
7. Desmarais D., Filion M., Lapointe L., Royal A. Cell-specific transcription of the peripherin gene in neuronal cell lines involves a cis-acting element surrounding the TATA box. EMBO J. 11:1992;2971-2980.
8. Dignam J.D., Lebovitz R.M., Roeder R.G. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1983;1475-1489.
9. Fasola A.F., Martz B.L., Helmer O.M. Renin activity during supine exercise in normotensives and hypertensives. J. Appl. Physiol. 21:1966;1709-1712.
10. Fukamizu A., Takahashi S., Seo M.S., Tada M., Tanimoto K., Uehara S., Murakami K. Structure and expression of the human angiotensinogen gene. Identification of a unique and highly active promoter. J. Biol. Chem. 265:1990;7576-7582.
11. Gaillard I., Clauser E., Corvol P. Structure of human angiotensinogen gene. DNA. 8:1989;87-99.
12. Galson D.L., Tsuchiya T., Tendler D.S., Huang L.E., Ren Y., Ogura T., Bunn H.F. The orphan receptor hepatic nuclear factor 4 functions as a transcriptional activator for tissue-specific and hypoxia-specific erythropoietin gene expression and is antagonized by EAR3/COUP-TF1. Mol. Cell. Biol. 15:1995;2135-2144.
13. Gould A.B., Green D. Kinetics of the human renin and human substrate reaction. Cardiovasc. Res. 5:1971;86-89.
14. Harnish D.C., Malik S., Karathanasis S.K. Activation of apolipoprotein AI gene transcription by the liver-enriched factor HNF-3. J. Biol. Chem. 269:1994;28220-28226.
15. Howard T., Balogh R., Overbeek P., Bernstein K.E. Sperm-specific expression of angiotensin-converting enzyme (ACE) is mediated by a 91-base-pair promoter containing a CRE-like element. Mol. Cell. Biol. 13:1993;18-27.
16. Hu Y.F., Luscher B., Admon A., Mermod N., Tjian R. Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity. Genes Dev. 4:1990;1741-1752.
17. Ishigami T., Umemura S., Iwamoto T., Tamura K., Hibi K., Yamaguchi S., Nyuui N., Kimura K., Miyazaki N., Ishii M. Molecular variant of angiotensinogen gene is associated with coronary atherosclerosis [see comments]. Circulation. 91:1995;951-954.
18. Jackson D.A., Rowader K.E., Stevens K., Jiang C., Milos P., Zaret K.S. Modulation of liver-specific transcription by interactions between hepatocyte nuclear factor 3 and nuclear factor 1 binding DNA in close apposition. Mol. Cell. Biol. 13:1993;2401-2410.
19. Jeunemaitre X., Soubrier F., Kotelevtsev Y.V., Lifton R.P., Williams C.S., Charru A., Hunt S.C., Hopkins P.N., Williams R.R., Lalouel J.M.et al. Molecular basis of human hypertension: role of angiotensinogen. Cell. 71:1992;169-180.
20. Jiang J.G., Zarnegar R. A novel transcriptional regulatory region within the core promoter of the hepatocyte growth factor gene is responsible for its inducibility by cytokines via the C/EBP family of transcription factors. Mol. Cell. Biol. 17:1997;5758-5770.
21. Kim H.S., Krege J.H., Kluckman K.D., Hagaman J.R., Hodgin J.B., Best C.F., Jennette J.C., Coffman T.M., Maeda N., Smithies O. Genetic control of blood pressure and the angiotensinogen locus. Proc. Natl. Acad. Sci. USA. 92:1995;2735-2739.
22. Kimura A., Nishiyori A., Murakami T., Tsukamoto T., Hata S., Osumi T., Okamura R., Mori M., Takiguchi M. Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) represses transcription from the promoter of the gene for ornithine transcarbamylase in a manner antagonistic to hepatocyte nuclear factor-4 (HNF-4). J. Biol. Chem. 268:1993;11125-11133.
23. Kimura S., Mullins J.J., Bunnemann B., Metzger R., Hilgenfeldt U., Zimmermann F., Jacob H., Fuxe K., Ganten D., Kaling M. High blood pressure in transgenic mice carrying the rat angiotensinogen gene. EMBO J. 11:1992;821-827.
24. Kuiper G.G., Gustafsson J.A. The novel estrogen receptor-beta subtype: potential role in the cell- and promoter-specific actions of estrogens and anti-estrogens. FEBS Lett. 410:1997;87-90.
25. Lowings P., Yavuzer U., Goding C.R. Positive and negative elements regulate a melanocyte-specific promoter. Mol. Cell. Biol. 12:1992;3653-3662.
26. McCormick A., Brady H., Fukushima J., Karin M. The pituitary-specific regulatory gene GHF1 contains a minimal cell type-specific promoter centered around its TATA box. Genes Dev. 5:1991;1490-1503.
27. McGlynn L.K., Mueller C.R., Begbie M., Notley C.R., Lillicrap D. Role of the liver-enriched transcription factor hepatocyte nuclear factor 1 in transcriptional regulation of the factor V111 gene. Mol. Cell. Biol. 16:1996;1936-1945.
28. Mermod N., Williams T.J., Tjian R. Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro. Nature. 332:1988;557-561.
29. Ohkubo H., Kawakami H., Kakehi Y., Takumi T., Arai H., Yokota Y., Iwai M., Tanabe Y., Masu M., Hata J.et al. Generation of transgenic mice with elevated blood pressure by introduction of the rat renin and angiotensinogen genes. Proc. Natl. Acad. Sci. USA. 87:1990;5153-5157.
30. Overdier D.G., Porcella A., Costa R.H. The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino-acid residues adjacent to the recognition helix. Mol. Cell. Biol. 14:1994;2755-2766.
31. Paul M., Wagner J., Dzau V.J. Gene expression of the renin-angiotensin system in human tissues. Quantitative analysis by the polymerase chain reaction. J. Clin. Invest. 91:1993;2058-2064.
32. Pennisi E. Differing roles found for estrogen's two receptors [news; comment]. Science. 277:1997;1439.
33. Riegel A.T., Remenick J., Wolford R.G., Berard D.S., Hager G.L. A novel transcriptional activator (PO-B) binds between the TATA box and cap site of the pro-opiomelanocortin gene. Nucleic Acids Res. 18:1990;4513-4521.
34. Smale S.T., Baltimore D. The 'initiator' as a transcription control element. Cell. 57:1989;103-113.
35. Tanimoto K., Sugiyama F., Goto Y., Ishida J., Takimoto E., Yagami K., Fukamizu A., Murakami K. Angiotensinogen-deficient mice with hypotension. J. Biol. Chem. 269:1994;31334-31337.
36. Walker W.G., Whelton P.K., Saito H., Russell R.P., Hermann J. Relation between blood pressure and renin, renin substrate, angiotensin II, aldosterone and urinary sodium and potassium in 574 ambulatory subjects. Hypertension. 1:1979;287-291.
37. Ward K., Hata A., Jeunemaitre X., Helin C., Nelson L., Namikawa C., Farrington P.F., Ogasawara M., Suzumori K., Tomoda S.et al. A molecular variant of angiotensinogen associated with preeclampsia [see comments]. Nat. Genet. 4:1993;59-61.
38. Watt G.C., Harrap S.B., Foy C.J., Holton D.W., Edwards H.V., Davidson H.R., Connor J.M., Lever A.F., Fraser R. Abnormalities of glucocorticoid metabolism and the renin-angiotensin system: a four-corners approach to the identification of genetic determinants of blood pressure. J. Hypertens. 10:1992;473-482.