Enoxacin directly inhibits osteoclastogenesis without inducing apoptosis

Journal of Biological Chemistry

Volumn 287, Issue 21, 2012, Pages 17894-17904

  Toro, Edgardo J ^a   Zuo, Jian ^a   Ostrov, David A ^b   Catalfamo, Dana ^a   Bradaschia Correa, Vivian ^c   Arana Chavez, Victor ^c   Caridad, Aliana R ^a   Neubert, John K ^a   Wronski, Thomas J ^d   Wallet, Shannon M ^a   Holliday, L Shannon ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF DENTISTRY   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING INTERACTION; BONE RESORPTION; CASPASE-3; CELL VIABILITY; CYTOSKELETAL PROTEINS; CYTOSKELETONS; ENOXACIN; H+-ATPASE; IMMUNOBLOTS; MICROFILAMENTS; MRNA LEVEL; MULTINUCLEAR CELLS; OSTEOCLAST FORMATION; OSTEOCLAST PRECURSOR; OSTEOCLASTOGENESIS; POST-TRANSLATIONAL PROCESSING; PROTEOLYTIC PROCESSING; QUANTITATIVE PCR; SMALL MOLECULE INHIBITOR; TARTRATE-RESISTANT ACID PHOSPHATASE; V-ATPASE;

BINDING ENERGY; CELL CULTURE; CELL MEMBRANES; FLOW CYTOMETRY; PHOSPHATASES; POLYMERASE CHAIN REACTION; PROTEINS;

CELL DEATH;

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ACTIN; CASPASE 3; CYTOSKELETON PROTEIN; ENOXACIN; L PLASTIN; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN TRAP5B; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVITY; ENZYME ASSAY; FLOW CYTOMETRY; IMMUNOBLOTTING; MICROFILAMENT; MOUSE; NICK END LABELING; NONHUMAN; OSTEOCLAST; OSTEOCLASTOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INTERACTION;

ACTINS; ANIMALS; APOPTOSIS; CYTOSKELETON; ENOXACIN; GENE EXPRESSION REGULATION; MEMBRANE PROTEINS; MICE; NERVE TISSUE PROTEINS; NUCLEIC ACID SYNTHESIS INHIBITORS; OSTEOCLASTS; PHOSPHOPROTEINS; PROTEOLYSIS; RNA, MESSENGER; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84861205631     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.280511     Document Type: Article

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