Mechanisms in the pressor effects of hepatic portal venous fatty acid infusion

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 273, Issue 1 42-1, 1997, Pages

  Grekin, Roger J ^a,b   Dumont, Craig J ^a   Vollmer, Alan P ^a   Watts, Stephanie W ^a   Webb, R Clinton ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b NONE   (United States)

Author keywords

Angiotensin; Hypertension; Obesity; Sympathetic activity

Indexed keywords

LOSARTAN; PRAZOSIN;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTINUOUS INFUSION; CONTROLLED STUDY; FATTY ACID METABOLISM; HEART RATE; HORMONE RESPONSE; HYPERTENSION; NONHUMAN; OBESITY; PORTAL VEIN BLOOD; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SYMPATHETIC TONE;

EID: 0030739937     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.1997.273.1.r324     Document Type: Article

References (28)

1. Bergman, R. N., L. S. Phillips, and C. Cobelli. Physiologic evaluation of factors controlling glucose tolerance in man. Measurement of insulin sensitivity and beta-cell sensitivity from the response to intravenous glucose. J. Clin. Invest. 68: 1456-1467, 1981.
2. Dustan, H. P. Mechanisms of hypertension associated with obesity. Ann. Intern. Med. 98: 860-864, 1983.
3. Egan, B. M., M. M. I. Hennes, K. T. Stepniakowski, I. M. O'Shaughnessy, A. H. Kissebah, and T. L. Goodfriend. Obesity hypertension is related more to insulin's fatty acid than glucose action. Hypertension 27: 723-728, 1996.
4. Friedman, M. I. Hepatic nerve function. In: The Liver: Biology and Pathobiology, edited by I. M. Arias, W. B. Jakoby, H. Popper, D. Schachter, and D. A. Shafritz. New York: Raven, 1988, p. 949-959.
5. Grekin, R. J., A. P. Vollmer, and R. S. Sider. Pressor effects of portal venous oleate infusion. A proposed mechanism for obesity hypertension. Hypertension 26: 193-198, 1995.
6. Haffner, S. M., D. Fong, H. P. Hazuda, J. A. Pugh, and J. K. Patterson. Hyperinsulinemia, upper body adiposity and cardiovascular risk factors in non-diabetics. Metabolism 37: 333-345, 1988.
7. Hall, J. E. Renal and cardiovascular mechanisms of hypertension in obesity. Hypertension 23: 381-394, 1994.
8. Havlik, R. J., H. B. Hubert, R. R. Fabsitz, and M. Feinleib. Weight and hypertension. Ann. Intern. Med. 98: 855-859, 1983.
9. Jensen, M. D., M. W. Haymond, R. A. Rizza, P. E. Cryer, and J. M. Miles. Influence of body fat distribution on free fatty acid metabolism in obesity. J. Clin. Invest. 83: 1168-1173, 1989.
10. Kassab, S., T. Kato, F. C. Wilkins, R. Chen, J. E. Hall, and J. P. Granger. Renal denervation attenuates the sodium retention and hypertension associated with obesity. Hypertension 25: 893-897, 1995.
11. Lapidus, L., C. Bengtsson, B. Larsson, K. Pennert, E. Rybo, and L. Sjöström. Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden. Br. Med. J. 289: 1257-1261, 1984.
12. Licata, G., M. Volpe, R. Scaglione, and S. Rubattu. Salt-regulating hormones in young normotensive obese subjects. Hypertension 23, Suppl. I: I-20-I-24, 1994.
13. MacMahon, S. W., R. B. Blacket, G. J. Macdonald, and W. Hall. Obesity, alcohol consumption and blood pressure in Australian men and women: the National Heart Foundation of Australia Risk Factor Prevalence Study. J. Hypertens. 2: 85-91, 1984.
14. Morgan, D. A., E. A. Anderson, and A. L. Mark. Renal sympathetic nerve activity is increased in obese Zucker rats. Hypertension 25: 834-838, 1995.
15. Nijima, A. The effect of D-glucose on the firing rate of glucose-sensitive vagal afferents in the liver in comparison with the effect of 2-deoxy-D-glucose. J. Auton. Nerv. Syst. 10: 255-260, 1984.
16. Orbach, J., and W. H. H. Andrews. Stimulation of afferent nerve terminals in the perfused rabbit liver by sodium salts of some long-chain fatty acids. Q. J. Exp. Physiol. 58: 267-274, 1973.
17. Peiris, A. N., M. S. Sothmann, R. G. Hoffmann, M. I. Hennes, C. R. Wilson, A. B. Gustafson, and A. H. Kissebah. Adiposity, fat distribution, and cardiovascular risk. Ann. Intern. Med. 110: 867-872, 1989.
18. Reisen, E., R. Abel, M. Modan, D. S. Silverberg, H. E. Eliahou, and B. Modan. Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patients. N. Engl. J. Med. 298: 1-6, 1978.
19. Rocchini, A. P., V. L. Katch, R. Grekin, C. Moorehead, and J. Anderson. Role for aldosterone in blood pressure regulation of obese adolescents. Am. J. Cardiol. 57: 613-618, 1986.
20. Rocchini, A. P., V. Katch, A. Schork, and R. P. Kelch. Insulin and blood pressure during weight loss in obese adolescents. Hypertension 10: 267-273, 1987.
21. Rocchini, A. P., C. P. Moorehead, S. DeRemer, and D. Bondie. Pathogenesis of weight related changes in blood pressure in dogs. Hypertension 13: 922-928, 1989.
22. Roust, L. R., and M. D. Jensen. Postprandial free fatty acid kinetics are abnormal in upper body obesity. Diabetes 42: 1567-1573, 1993.
23. Scherrer, U., D. Randin, L. Tappy, P. Vollenweider, E. Jéquier, and P. Nicod. Body fat and sympathetic nerve activity in healthy subjects. Circulation 89: 2634-2640, 1994.
24. Sowers, J. R., M. Nyby, N. Stern, F. Beck, S. Baron, R. Catania, and N. Vlachis. Blood pressure and hormone changes associated with weight reduction in the obese. Hypertension 4: 686-691, 1982.
25. Spraul, M., E. Ravussin, A. M. Fontvieille, R. Rising, D. E. Larson, and E. A. Anderson. Reduced sympathetic nervous activity. J. Clin. Invest. 92: 1730-1735, 1993.
26. Stamler, R. A., J. Stamler, W. F. Reidlinger, G. Algera, and R. H. Roberts. Weight and blood pressure findings in hypertension screening of 1 million Americans. JAMA 240: 1607-1610, 1978.
27. Yamakawa, T., T. Shun-ichi, K. Tamura, F. Isoda, K. Ukawa, Y. Yamakura, Y. Takanishi, Y. Kiuchi, S. Umemura, M. Ishii, and H. Sekihara. Wistar Fatty rat is obese and spontaneously hypertensive. Hypertension 25: 146-150, 1995.
28. Young, J. B., and I. A. Macdonald. Sympathoadrenal activity in human obesity: heterogeneity of findings since 1980. Int. J. Obes. 16: 959-967, 1992.