Blockade of paeoniflorin on sodium current in mouse hippocampal CA 1 neurons

Acta Pharmacologica Sinica

Volumn 24, Issue 12, 2003, Pages 1248-1252

  Zhang, Guang Qin ^a   Hao, Xue Mei ^a   Chen, Shi Zhong ^b   Zhou, Pei Ai ^a   Cheng, He Ping ^a   Wu, Cai Hong ^a  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Hippocampus; Paeoniflorin; Patch clamp techniques; Sodium channels

Indexed keywords

PAEONIFLORIN; SODIUM CHANNEL;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; HIPPOCAMPUS; IC 50; MOUSE; NEUROPHARMACOLOGY; NONHUMAN; PATCH CLAMP; SODIUM CURRENT;

ANIMALS; BENZOIC ACIDS; BRIDGED COMPOUNDS; GLUCOSIDES; HIPPOCAMPUS; MEMBRANE POTENTIALS; MICE; NEURONS; NEUROPROTECTIVE AGENTS; PAEONIA; PLANTS, MEDICINAL; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 0344667674     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Tabata K, Matsumoto K, Murakami Y, Watanabe H. Ameliorative effects of paeoniflorin, a major constituent of peony root, on adenosine A1 receptor-mediated impairment of passive avoidance performance and long-term potentiation in the hippocampus. Biol Pharm Bull 2001; 24: 496-500.
2. Tabata K, Matsumoto K, Watanabe H. Paeoniflorin, a major constituent of peony root, reverses muscarinic M1-receptor antagonist-induced suppression of long-term potentiation in the rat hippocampal slice. Jpn J Pharmacol 2000; 83: 25-30.
3. Ohta H, Matsumoto K, Shimizu M, Watanabe H. Paeoniflorin attenuates learning impairment of aged rats in operant brightness discrimination task. Pharmacol Biochem Behav 1994; 49: 213-7.
4. Yang J, He LN, He SB, Li GR. Protective effect of paeoniflorin on calcium overloading injury in cultured primary cortex neurons. Chin J Pharmacol Toxicol 2001; 15: 164-8.
5. Tsuda T, Sugaya A, Ohguchi H, Kishida N, Sugaga E. Protective effects of peony root extract and its components on neuron damage in the hippocampus induced by the cobalt focus epilepsy model. Exp Neurol 1997; 146: 518-25.
6. Wu HP, Zhu XG. Protective effect of TGP on local cerebral ischemia in rat. Chin Pharmacol Bull 2001; 17: 223-5.
7. Liu W, Wu HP, Zhu XG, Ming L, Dong SY, Tong XH. Protective effect of TGP on acute cerebral ischemia in mice and rat. Acta Univ Med Anhui 2001; 36: 186-8.
8. Imaizumi S, Suzuki J, Kinouchi H, Yoshimoto T. Superior protective effects of phenytoin against hypoxia in a pharmacological screening test. Neurol Res 1988; 10: 18-24.
9. Rasool N, Faroqui M, Rubinstein EH. Lidocaine accelerates neuroelectrical recovery after incomplete global ischemia in rabbits. Stroke 1990; 21: 929-35.
10. Zhang XS, Wang TY. Protection of mexiletine against hypoxic damage of synaptic function in hippocampal slices. Acta Pharmacol Sin 1993; 14: 426-9.
11. 1 neurons. Acta Pharmacol Sin 2001; 22: 253-6.
12. Li M, West JW, Numann R, Murphy BJ, Scheuer T, Catterall WA. Convergent regulation of sodium channels by protein kinase C and cAMP-dependent protein kinase. Science 1993; 261: 1439-42.
13. Haigney MCP, Lakatta EG, Stern MD, Silverman Hs. Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading. Circulation 1994; 90: 391-9.