The use of single particle mechanical properties for predicting the compressibility of pharmaceutical materials

Powder Technology

Volumn 225, Issue , 2012, Pages 43-51

  Govedarica, Biljana ^a   Ilić, Ilija ^a   Šibanc, Rok ^a   Dreu, Rok ^a   Srčič, Stane ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Deformation mechanism; Heckel model; Nanoindentation; Single and bulk mechanical properties; Walker model

Indexed keywords

BULK MECHANICAL PROPERTIES; BULK PARAMETERS; DEFORMATION BEHAVIOUR; DEFORMATION MECHANISM; ELASTIC AND PLASTIC DEFORMATION; ELASTIC PROPERTIES; ELASTIC RELAXATION; LACK-OF-FIT; MECHANICAL STRESS; NANO-INDENTATION HARDNESS; PHARMACEUTICAL MATERIALS; SINGLE LEVEL; SINGLE PARTICLE; YOUNG'S MODULUS;

BONDING; BRITTLE FRACTURE; COMPACTION; ELASTIC DEFORMATION; ELASTICITY; HARDNESS; NANOINDENTATION; PLASTIC DEFORMATION; STRESSES;

COMPRESSIBILITY;

ANISOTROPY; ARTICLE; HECKEL MODEL; MATHEMATICAL MODEL; MECHANICS; PARTICLE SIZE; PLASTICITY; PRESSURE; SCANNING ELECTRON MICROSCOPY; TABLET COMPRESSION; TABLET HARDNESS; TABLET POROSITY; TABLET PROPERTY; TABLET THICKNESS; WALKER MODEL;

EID: 84861189358     PISSN: 00325910     EISSN: 1873328X     Source Type: Journal    
DOI: 10.1016/j.powtec.2012.03.030     Document Type: Article

References (33)

1. Pharr G.M. Measurement of mechanical properties by ultra-low load indentation. Materials Science and Engineering A 1998, 253:151-159.
2. Oliver W.C., Pharr G.M. An improved technique for determining hardness and elastic-modulus using load and displacement sensing indentation experiments. Journal of Materials Research 1992, 7:1564-1583.
3. Khossravi D., Morehead W.T. Consolidation mechanism of pharmaceutical solids: a multi-compression cycle approach. Pharmaceutical Research 1997, 14:1039-1045.
4. Heckel R.W. Density-pressure relationships in powder compression. Transactions of the Metallurgical Society of AIME 1961, 221:671-675.
5. Celik M., Marshall K. Use of a compaction simulator system in tabletting research. Part 1. Introduction to and initial experiments with the system. Drug Development and Industrial Pharmacy 1989, 15:759-800.
6. Duberg M., Nyström C. Studies on direct compression of tablets XVII. Porosity-pressure curves for the characterization of volume reduction mechanisms in powder compression. Powder Technology 1986, 46:67-75.
7. Ilkka J., Paronen P. Prediction of the compression behavior of powder mixtures by the Heckel equation. International Journal of Pharmaceutics 1993, 94:181-187.
8. Walker E.E. The properties of powders VI: the compressibility of powders. Transactions of the Faraday Society 1923, 19:73-82.
9. Sonnergaard J.M. Quantification of the compactibility of pharmaceutical powders. European Journal of Pharmaceutics and Biopharmaceutics 2006, 63:270-277.
10. Horisawa E., Danjo K., Sunada H. Influence of granulating method on physical and mechanical properties, compression behavior, and compactility of lactose and microcrystalline cellulose granules. Drug Development and Industrial Pharmacy 2000, 26:583-593.
11. Santl M., Ilic I., Vrecer F., Baumgartner S. A compressibility and compactability study of real tableting mixtures: The impact of wet and dry granulation vs. direct tableting mixtures. International Journal of Pharmaceutics 2011, 414:131-139.
12. Buckner I., Wurster D.E., Aktham A. Interpreting deformation behavior in pharmaceutical materials using multiple consolidation models and compaction energetic. Pharmaceutical Development and Technology 2010, 15:492-499.
13. Roberts R.J., Rowe R.C. Relationship between the modulus of elasticity and tensile strength for pharmaceutical drugs and excipients. The Journal of Pharmacy and Pharmacology 1999, 51:975-977.
14. Meier M., John E., Wieckhusen D., Wirth W., Peukert W. Influence of mechanical properties on impact fracture: prediction of the milling behavior of pharmaceutical powders by nanoindentation. Powder Technology 2009, 188:301-313.
15. Taylor L.J., Papadopoulos D.G., Dunn P.J., Bentham A.C., Mitchell J.C., Snowden M.J. Mechanical characterization of powders using nanoindentation. Powder Technology 2004, 143-144:179-185.
16. Czichos H., Saito T., Smith L. Springer handbook of materials measurement methods 2006, 285-305. Springer Berlin Heidelburg, Berlin.
17. Cheng L., Xia X., Scriven L.E., Gerberich W.W. Spherical-Tip indentation of viscoelastic material. Mechanics of Materials 2005, 37:213-226.
18. Ilić I., Kása P., Dreu R., Pintye-Hόdi K., Srčič S. The compressibility and compactibility of different types of lactose. Drug Development and Industrial Pharmacy 2009, 35(10):1271-1280.
19. Sneddon I.N. The relaxation between load and penetration in the axisymmetric Boussinesq problem for a punch of arbitrary profile. International Journal of Engineering Science 1965, 3:45-57.
20. Morin-Alcazar S., Munaz-Saldana J., Aguilar-Palazeulos E., Jimenez-Arevalo O., Ramirez-Bon R., Martinez-Bustos F. Nanoindentation and structural characterization of molded starch. Physica Status Solidi C 2007, 4:4242-4247.
21. Bassam F., York P., Rowe R.C., Roberts R.J. Young's modulus of powders used as pharmaceutical excipients. International Journal of Pharmaceutics 1990, 64:55-60.
22. Perkins M., Ebbens S.J., Hayes S., Roberts C.J., Madden C.E., Luk S.Y., Patel N. Elastic modulus measurements from individual lactose particles using atomic force microscopy. International Journal of Pharmaceutics 2007, 332:168-175.
23. Johnson K.L. Contact Mechanics 1987, Cambridge University Press.
24. Aktham A., Mishra D. Use of compaction energetic for understanding particle deformation mechanism. Pharmaceutical Development and Technology 2007, 12:405-414.
25. Buckner I., Friedman R.A., Wurster D.E. Using compression calorimetry to characterize powder compaction behavior of pharmaceutical materials. Journal of Pharmaceutical Sciences 2010, 99:861-869.
26. Busignies V., Leclerc B., Porion P., Evesque P., Couarraze G., Choreloff P.T. Compaction behavior and new predictive approach to the compressibility of binary mixtures of pharmaceutical excipients. European Journal of Pharmaceutics and Biopharmaceutics 2006, 64:66-74.
27. Yap S.F., Adams M.J., Seville J.P.K., Zhang Z. Single and bulk compression of pharmaceutical excipients: evaluation of mechanical properties. Powder Technology 2008, 185:1-10.
28. Roberts R.J., Rowe R.C. The compaction of pharmaceutical and other model materials - a pragmatic approach. Chemical Engineering Science 1987, 42:903-911.
29. Samimi A., Hassanpour A., Ghadiri M. Single and bulk compressions of soft granules: experimental study and DEM evaluation. Chemical Engineering Science 2005, 60:3993-4004.
30. Hassanpour A., Ghadiri M. Distinct element analysis and experimental evaluation of the Heckel analysis of bulk powder compression. Powder Technology 2004, 141:251-261.
31. DeCrosta M.T., Schwartz J.B., Wigent R.J., Marshall K. Thermodynamic analysis of compact formation: compaction, unloading, and ejection II. Mechanical energy (work) and thermal energy (heat) determinations of compact unloading and ejection. International Journal of Pharmaceutics 2001, 213:45-62.
32. Anuar M.S., Briscoe B.J. The elastic relaxation of starch tablets during ejection. Powder Technology 2009, 195:96-104.
33. Armstrong N.A., Haines-Nutt R.F. Elastic recovery and surface area changes in compacted powder systems. The Journal of Pharmacy and Pharmacology 1972, 24:135-136.