Elastic modulus measurements from individual lactose particles using atomic force microscopy

International Journal of Pharmaceutics

Volumn 332, Issue 1-2, 2007, Pages 168-175

  Perkins, Mark ^a   Ebbens, Stephen J ^a   Hayes, Simon ^b   Roberts, Clive J ^a   Madden, Claire E ^a   Luk, Shen Y ^a   Patel, Nikin ^a  

^a Molecular Profiles Ltd   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Atomic force microscopy; Elastic modulus; Lactose; Nanoindentation

Indexed keywords

LACTOSE; RESPITOSE SV001; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; ATOMIC FORCE MICROSCOPY; CRYSTAL; FORCE; INTERMETHOD COMPARISON; NANOTECHNOLOGY; PRESSURE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; THEORY; YOUNG MODULUS;

CHEMISTRY, PHARMACEUTICAL; ELASTICITY; LACTOSE; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, ELECTRON, SCANNING; MODELS, CHEMICAL; NANOTECHNOLOGY; POWDERS; REPRODUCIBILITY OF RESULTS; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL;

EID: 33846981178     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.09.032     Document Type: Article

References (36)

1. Bar G., Ganter M., Brandsch R., Delineau L., and Whangbo M.H. Examination of butadiene/styrene-co-butadiene rubber blends by tapping mode atomic force microscopy. Importance of the indentation depth and reduced tip-sample energy dissipation in tapping mode atomic force microscopy study of elastomers. Langmuir 16 (2000) 5702-5711
2. Bassam F., York P., Rowe R.C., and Roberts R.J. The young modulus of binary powder mixtures. Powder Technol. 65 (1991) 103-111
3. Begat P., Morton D.A.V., Staniforth J.N., and Price R. The cohesive-adhesive balances in dry powder inhaler formulations. I. Direct quantification by atomic force microscopy. Pharm. Res. 21 (2004) 1591-1597
4. BinBaie S., Newton J.M., and Podczeck F. The characterization of the mechanical properties of pharmaceutical materials. Eur. J. Pharm. Biopharm. 42 (1996) 138-141
5. Bowen W.R., Lovitt R.W., and Wright C.J. Application of atomic force microscopy to the study of micromechanical properties of biological materials. Biotechnol. Lett. 22 (2000) 893-903
6. Brittain H.G. Effects of mechanical processing on phase composition. J. Pharm. Sci. 91 (2002) 1573-1580
7. Busignies V., Tchoreloff P., Leclerc B., Besnard M., and Couarraze G. Compaction of crystallographic forms of pharmaceutical granular lactoses. I. Compressibility. Eur. J. Pharm. Biopharm. 58 (2004) 569-576
8. Chen X., McGurk S.L., Davies M.C., Roberts C.J., Shakesheff K.M., Tendler S.J.B., Williams P.M., Davies J., and Dawkes A.C. Chemical and morphological analysis of surface enrichment in a biodegradable polymer blend by phase-detection imaging atomic force microscopy. Macromolecules 31 (1998) 2278-2283
9. Cumpson P.J., Hedley J., Clifford C.A., Chen X.Y., and Allen S. Microelectromechanical system device for calibration of atomic force microscope cantilever spring constants, between 0.01 and 4 N/m. J. Vac. Sci. Technol. A. 22 (2004) 1444-1449
10. Cumpson P.J., Clifford C.A., and Hedley J. Quantitative analytical atomic force microscopy: a cantilever reference device for easy and accurate AFM spring-constant calibration. Meas. Sci. Technol. 15 (2004) 1337-1346
11. Danesh A., Chen X., Davies M.C., Roberts C.J., Sanders G.W.H., Tendler S.J.B., Williams P.M., and Wilkins M.J. Polymorphic discrimination using atomic force microscopy: distinguishing between two polymorphs of the drug cimetidine. Langmuir 16 (2000) 866-870
12. Davies M.C., Shakesheff K.M., Shard A.G., Domb A., Roberts C.J., Tendler S.J.B., and Williams P.M. Surface analysis of biodegradable polymer blends of poly(sebacic anhydride) and poly(dl-lactic acid). Macromolecules 29 (1996) 2205-2212
13. Drapier-Beche N., and Parmentier M. Physical and chemical properties of molecular compounds of lactose. J. Dairy Sci. 82 (1999) 2558-2563
14. Du B.Y., Tsui O.K.C., Zhang Q.L., and He T.B. Study of elastic modulus and yield strength of polymer thin films using atomic force microscopy. Langmuir 17 (2001) 3286-3291
15. Durandurdu M., and Drabold D.A. High-pressure phases of amorphous and crystalline silicon. Phys. Rev. B 67 (2003) 212101-212103
16. Hancock B.C., Clas S.D., and Christensen K. Micro-scale measurement of the mechanical properties of compressed pharmaceutical powders. 1. The elasticity and fracture behaviour of microcrystalline cellulose. Int. J. Pharm. 209 (2000) 27-35
17. Heuberger M., Dietler G., and Schlapbach L. Mapping the local Youngs modulus by analysis of the elastic deformations occurring in atomic-force microscopy. Nanotechnology 6 (1995) 12-23
18. Jain S. Mechanical properties of powders for compaction and tableting: an overview. Pharm. Sci. Technol. Today 2 (1999) 20-31
19. Kwan C.C., Chena Y.Q., Ding Y.L., Papadopoulos D.G., Bentham A.C., and Ghadiri M. Development of a novel approach towards predicting the milling behaviour of pharmaceutical powders. Eur. J. Pharm. Sci. 23 (2004) 327-336
20. Levitas V.I. A microscale model for strain-induced phase transformations and chemical reactions under high pressure. Europhys. Lett. 66 (2004) 687-693
21. Liao X.M., and Wiedmann T.S. Characterization of pharmaceutical solids by scanning probe microscopy. J. Pharm. Sci. 93 (2004) 2250-2258
22. Liao X.M., and Wiedmann T.S. Measurement of process-dependent material properties of pharmaceutical solids by nanoindentation. J. Pharm. Sci. 94 (2005) 79-92
23. Narayan P., and Hancock B.C. The relationship between the particle properties, mechanical behavior, and surface roughness of some pharmaceutical excipient compacts. Mater. Sci. Eng. A 355 (2003) 24-36
24. Oliver W.C., and Pharr G.M. An improved technique for determining hardness and elastic-modulus using load and displacement sensing indentation experiments. J. Mater. Res. 7 (1992) 1564-1583
25. Podczeck F. Investigations into the fracture mechanics of acetylsalicylic acid and lactose monohydrate. J. Mater. Sci. 36 (2001) 4687-4693
26. Radmacher M., Fritz M., Cleveland J.P., Walters D.A., and Hansma P.K. Imaging adhesion forces and elasticity of lysozyme adsorbed on mica with the atomic-force microscope. Langmuir 10 (1994) 3809-3814
27. Roberts C.J. What can we learn from atomic force microscopy adhesion measurements with single drug particles?. Eur. J. Pharm. Sci. 24 (2005) 153-157
28. Sader J., Larson I., Mulvaney P., and White. Method for the calibration of atomic force microscope cantilevers. Rev. Sci. Inst. 66 (1995) 3789-3798
29. Schmitt E.A., Law D., and Zhang G.G.Z. Nucleation and crystallization kinetics of hydrated amorphous lactose above the glass transition temperature. J. Pharm. Sci. 88 (1999) 291-296
30. Sneddon I.N. The relationship between load and penetration in the axisymmetric Boussineq problem for a punch of arbitrary profile. Int. J. Eng. Sci. 3 (1965) 47-57
31. Taylor L.J., Papadopoulos D.G., Dunn P.J., Bentham A.C., Mitchell J.C., and Snowden M.J. Mechanical characterisation of powders using nanoindentation. Powder Technol. 143/144 (2004) 179-185
32. Ward S., Perkins M., Zhang J.X., Roberts C.J., Madden C.E., Luk S.Y., Patel N., and Ebbens S.J. Identifying and mapping surface amorphous domains. Pharm. Res. 22 (2005) 1195-1202
33. Williams P.M., Shakesheff K.M., Davies M.C., Jackson D.E., Roberts C.J., and Tendler S.J.B. Blind reconstruction of scanning probe image data. J. Vac. Sci. Technol. B 14 (1996) 1557-1562
34. Williams P.M., Davies M.C., Roberts C.J., and Tendler S.J.B. Noise-compliant tip-shape derivation. Appl. Phys. A: Mater. Sci. Process. 66 (1998) S911-S914
35. Wong D.Y.T., and Aulton M.E. Elucidation of the mechanical characteristics of alpha-lactose single crystals from microindentation data. In: Wells J.I., and Rubinstein M.H. (Eds). Pharmaceutical Technology: Tableting Technology, vol. 2: Compression (1993), Ellis Horwood, New York 169-186
36. Zhang J., Ebbens S., Chen X., Zheng J., Luk S., Madden C., Patel N., and Roberts C.J. Determination of the surface free energy of crystalline and amorphous lactose by atomic force microscopy adhesion measurement. Pharm. Res. 23 (2006) 401-407