Important role of epiregulin in inflammatory responses during corneal epithelial wound healing

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 4, 2012, Pages 2414-2423

  Zhang, Yuan ^a   Kobayashi, Takeshi ^a   Hayashi, Yasuhito ^a   Yoshioka, Ryuji ^a   Shiraishi, Atsushi ^a   Shirasawa, Senji ^b   Higashiyama, Shigeki ^a   Ohashi, Yuichi ^a  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b FUKUOKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; EPIREGULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOPEROXIDASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CORNEA EPITHELIUM; CORNEA INJURY; CORNEA OPACITY; FLUORESCENCE ANGIOGRAPHY; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WOUND HEALING;

ANIMALS; CHEMOKINES; CYTOKINES; DISEASE MODELS, ANIMAL; EPIDERMAL GROWTH FACTOR; EPITHELIUM, CORNEAL; EYE INJURIES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; WOUND HEALING;

EID: 84861166802     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-8869     Document Type: Article

References (38)

1. Cohen S. Isolation and biological effects of an epidermal growth-stimulating protein. Natl Cancer Inst Monogr. 1964; 13:13-37.
2. Derynck R, Roberts AB, Winkler ME, Chen EY, Goeddel DV. Human transforming growth factor-alpha: precursor structure and expression in E. coli. Cell. 1984;38:287-297.
3. Higashiyama S, Abraham JA, Miller J, Fiddes JC, Klagsbrun M. A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science. 1991;251:936-939.
4. Kenchegowda S, Bazan NG, Bazan HE. EGF stimulates lipoxin A4 synthesis and modulates repair in corneal epithelial cells through ERK and p38 activation. Invest Ophthalmol Vis Sci. 2011;52:2240-2249.
5. McClintock JL, Ceresa BP. Transforming growth factor-{alpha} enhances corneal epithelial cell migration by promoting EGFR recycling. Invest Ophthalmol Vis Sci. 2010;51:3455-3461.
6. Yoshioka R, Shiraishi A, Kobayashi T, et al. Corneal epithelial wound healing impaired in keratinocyte-specific HB-EGFdeficient mice in vivo and in vitro. Invest Ophthalmol Vis Sci. 2010;51:5630-5639.
7. Toyoda H, Komurasaki T, Uchida D, et al. Epiregulin. A novel epidermal growth factor with mitogenic activity for rat primary hepatocytes. J Biol Chem. 1995;270:7495-7500.
8. Toyoda H, Komurasaki T, Uchida D, Morimoto S. Distribution of mRNA for human epiregulin, a differentially expressed member of the epidermal growth factor family. Biochem J. 1997;326(Pt 1);69-75.
9. Ullrich A, Coussens L, Hayflick JS, et al. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature. 1984;309:418-425.
10. Yamamoto T, Ikawa S, Akiyama T, et al. Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature. 1986;319:230-234.
11. Kraus MH, Issing W, Miki T, Popescu NC, Aaronson SA. Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci U S A. 1989;86:9193-9197.
12. Plowman GD, Culouscou JM, Whitney GS, et al. Ligandspecific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family. Proc Natl Acad Sci U S A. 1993;90:1746-1750.
13. Komurasaki T, Toyoda H, Uchida D, Morimoto S. Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4. Oncogene. 1997;15: 2841-2848.
14. Shelly M, Pinkas-Kramarski R, Guarino BC, et al. Epiregulin is a potent pan-ErbB ligand that preferentially activates heterodimeric receptor complexes. J Biol Chem. 1998;273:10496-10505.
15. Riese DJ, 2nd, Komurasaki T, Plowman GD, Stern DF. Activation of ErbB4 by the bifunctional epidermal growth factor family hormone epiregulin is regulated by ErbB2. J Biol Chem. 1998;273:11288-11294.
16. Shirakata Y, Komurasaki T, Toyoda H, et al. Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes. J Biol Chem. 2000;275:5748-5753.
17. Draper BK, Komurasaki T, Davidson MK, Nanney LB. Topical epiregulin enhances repair of murine excisional wounds. Wound Repair Regen. 2003;11:188-197.
18. Draper BK, Komurasaki T, Davidson MK, Nanney LB. Epiregulin is more potent than EGF or TGFalpha in promoting in vitro wound closure due to enhanced ERK/MAPK activation. J Cell Biochem. 2003;89:1126-1137.
19. Shirasawa S, Sugiyama S, Baba I, et al. Dermatitis due to epiregulin deficiency and a critical role of epiregulin in immune-related responses of keratinocyte and macrophage. Proc Natl Acad Sci U S A. 2004;101:13921-13926.
20. Kobayashi T, Yoshioka R, Shiraishi A, Ohashi Y. New technique for culturing corneal epithelial cells of normal mice. Mol Vis. 2009;15:1589-1593.
21. Hayashi Y, Call MK, Chikama T, et al. Lumican is required for neutrophil extravasation following corneal injury and wound healing. J Cell Sci. 2010;123:2987-2995.
22. Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol. 2007;127:514-525.
23. Ambrosio R Jr, Kara-Jose N, Wilson SE. Early keratocyte apoptosis after epithelial scrape injury in the human cornea. Exp Eye Res. 2009;89:597-599.
24. Spandau UH, Toksoy A, Verhaart S, Gillitzer R, Kruse FE. High expression of chemokines Gro-alpha (CXCL-1), IL-8 (CXCL-8), and MCP-1 (CCL-2) in inflamed human corneas in vivo. Arch Ophthalmol. 2003;121:825-831.
25. Narayanan S, Glasser A, Hu YS, McDermott AM. The effect of interleukin-1 on cytokine gene expression by human corneal epithelial cells. Exp Eye Res. 2005;80:175-183.
26. Stapleton WM, Chaurasia SS, Medeiros FW, Mohan RR, Sinha S, Wilson SE. Topical interleukin-1 receptor antagonist inhibits inflammatory cell infiltration into the cornea. Exp Eye Res. 2008;86:753-757.
27. Wilson SE, Mohan RR, Ambrosio R Jr, Hong J, Lee J. The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells. Prog Retin Eye Res. 2001;20:625-637.
28. Rudner XL, Kernacki KA, Barrett RP, Hazlett LD. Prolonged elevation of IL-1 in Pseudomonas aeruginosa ocular infection regulates macrophage-inflammatory protein-2 production, polymorphonuclear neutrophil persistence, and corneal perforation. J Immunol. 2000;164:6576-6582.
29. Yang HT, Cohen P, Rousseau S. IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells. Cell Signal. 2008;20:375-380.
30. Fenton RR, Molesworth-Kenyon S, Oakes JE, Lausch RN. Linkage of IL-6 with neutrophil chemoattractant expression in virus-induced ocular inflammation. Invest Ophthalmol Vis Sci. 2002;43:737-743.
31. Xue ML, Thakur A, Willcox MD, Zhu H, Lloyd AR, Role Wakefield D. Role and regulation of CXC-chemokines in acute experimental keratitis. Exp Eye Res. 2003;76:221-231.
32. Oshima T, Sonoda KH, Tsutsumi-Miyahara C, et al. Analysis of corneal inflammation induced by cauterisation in CCR2 and MCP-1 knockout mice. Br J Ophthalmol. 2006;90:218-222.
33. Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic- Canic M. Growth factors and cytokines in wound healing. Wound Repair Regen. 2008;16:585-601.
34. Chusid MJ, Davis SD. Experimental bacterial keratitis in neutropenic guinea pigs: polymorphonuclear leukocytes in corneal host defense. Infect Immun. 1979;24:948-952.
35. Wagoner MD, Kenyon KR, Gipson IK, Hanninen LA, Seng WL. Polymorphonuclear neutrophils delay corneal epithelial wound healing in vitro. Invest Ophthalmol Vis Sci. 1984;25: 1217-1220.
36. Polverini PJ, Cotran PS, Gimbrone MA Jr, Unanue ER. Activated macrophages induce vascular proliferation. Nature. 1977;269: 804-806.
37. Meszaros AJ, Reichner JS, Albina JE. Macrophage phagocytosis of wound neutrophils. J Leukoc Biol. 1999;65:35-42.
38. Repertinger SK, Campagnaro E, Fuhrman J, El-Abaseri T, Yuspa SH, Hansen LA. EGFR enhances early healing after cutaneous incisional wounding. J Invest Dermatol. 2004;123:982-989.