Early keratocyte apoptosis after epithelial scrape injury in the human cornea

Experimental Eye Research

Volumn 89, Issue 4, 2009, Pages 597-599

  Ambrósio Jr , Renato ^a   Kara José, Newton ^b   Wilson, Steven E ^c  

^a Instituto de Olhos Renato Ambrosio   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

apoptosis; corneal wound healing; epithelial scrape; human; keratocyte

Indexed keywords

BALANCED SALT SOLUTION;

ADULT; APOPTOSIS; ARTICLE; CASE REPORT; CONTROLLED STUDY; CORNEA CELL; CORNEA EPITHELIUM; CORNEA INJURY; ENUCLEATION; EYE CANCER; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NICK END LABELING; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; WOUND HEALING;

ADULT; APOPTOSIS; CORNEA; EPITHELIAL CELLS; EPITHELIUM, CORNEAL; EYE DISEASES; EYE ENUCLEATION; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IN SITU NICK-END LABELING; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MIDDLE AGED; WOUND HEALING; WOUNDS AND INJURIES;

EID: 69749083900     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2009.06.003     Document Type: Article

References (25)

1. Arends M.J., and Wyllie A.H. Apoptosis: mechanisms and roles in pathology. Int. Rev. Exp. Pathol. 32 (1991) 223-254
2. Campos M., Szerenyi K., Lee M., McDonnell J.M., and McDonnell P.J. Keratocyte loss after corneal deepithelialization in primates and rabbits. Arch. Ophthalmol. 112 (1994) 254-260
3. Dohlman C.H., Gasset A.R., and Rose J. The effect of the absence of corneal epithelium or endothelium on stromal keratocytes. Invest. Ophthalmol. Vis. Sci. 7 (1968) 520-534
4. Dupps Jr. W.J., and Wilson S.E. Biomechanics and wound healing in the cornea. Exp. Eye Res. 83 (2006) 709-720
5. Gao J., Gelber-Schwalb T.A., Addeo J.V., and Stern M.E. Apoptosis in the rabbit cornea after photorefractive keratectomy. Cornea 16 (1997) 200-208
6. Helena M.C., Baerveldt F., Kim W.-J., and Wilson S.E. Keratocyte apoptosis after corneal surgery. Invest. Ophthalmol. Vis. Sci. 39 (1998) 276-283
7. Martínez-García M.C., Merayo-Llovés J., Blanco-Mezquita T., and Mar-Sardaña S. Wound healing following refractive surgery in hens. Exp. Eye Res. 83 (2006) 728-735
8. Mohan R.R., Hutcheon A.E., Choi R., Hong J., Lee J., Mohan R.R., Ambrósio Jr. R., Zieske J.D., and Wilson S.E. Apoptosis, necrosis, proliferation, and myofibroblast generation in the stroma following LASIK and PRK. Exp. Eye Res. 76 (2003) 71-87
9. Mohan R.R., Kim W.-J., Mohan R.R., Chen L., and Wilson S.E. Bone morphogenic proteins 2 and 4 and their receptors in the adult human cornea. Invest. Ophthalmol. Vis. Sci. 39 (1998) 2626-2636
10. Mohan R.R., Liang Q., Kim W.-J., Helena M.C., Baerveldt F., and Wilson S.E. Apoptosis in the cornea: further characterization of Fas-Fas ligand system. Exp. Eye Res. 65 (1997) 575-589
11. Mohan R.R., Mohan R.R., Kim W.J., and Wilson S.E. Modulation of TNF alpha-induced apoptosis in corneal fibroblasts by transcription factor NF-kb. Invest. Ophthalmol. Vis. Sci. 41 (2000) 1327-1336
12. Mohan R.R., Mohan R.R., Kim W.J., Stark G.R., and Wilson S.E. Defective keratocyte apoptosis in response to epithelial injury in stat 1 null mice. Exp. Eye Res. 70 (2000) 485-491
13. Nakayasu K. Stromal changes following removal of epithelium in rat cornea. Jpn. J. Ophthalmol. 32 (1988) 113-125
14. Netto M.V., Mohan R.R., Ambrósio Jr. R., Hutcheon A.E., Zieske J.D., and Wilson S.E. Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy. Cornea 24 (2005) 509-522
15. Reynolds E.S. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J. Cell Biol. 17 (1963) 208-214
16. In: Robards A.W., and Wilson A.J. (Eds). Procedures in Electron Microscopy (1993), Wiley, New York, NY 5:4.9
17. Spurr A.R. A low-viscosity epoxy resin embedding medium for electron microscopy. J. Ultrastruct. Res. 26 (1969) 31-43
18. Wilson S.E. Molecular cell biology for the refractive corneal surgeon: programmed cell death and wound healing. J. Refract. Surg. 13 (1997) 171-175
19. Wilson S.E. Keratocyte apoptosis in refractive surgery: Everett Kinsey Lecture. CLAO J. 24 (1998) 181-185
20. Wilson S.E., Chaurasia S.S., and Medeiros F.W. Apoptosis in the initiation, modulation and termination of the corneal wound healing response. Exp. Eye Res. 85 (2007) 305-311
21. Wilson S.E., He Y.-G., Weng J., Li Q., Vital M., and Chwang E.L. Epithelial injury induces keratocyte apoptosis: hypothesized role for the interleukin-1 system in the modulation of corneal tissue organization. Exp. Eye Res. 62 (1996) 325-338
22. Wilson S.E., and Kim W.-J. Keratocyte apoptosis: implications on corneal wound healing, tissue organization, and disease. Invest. Ophthalmol. Vis. Sci. 39 (1998) 220-226
23. Wilson S.E., Mohan R.R., Hutcheon A.E., Mohan R.R., Ambrósio R., Zieske J.D., Hong J., and Lee J. Effect of ectopic epithelial tissue within the stroma on keratocyte apoptosis, mitosis, and myofibroblast transformation. Exp. Eye Res. 76 (2003) 193-201
24. Wilson S.E., Pedroza L., Beuerman R., and Hill J.M. Herpes simplex virus type-1 infection of corneal epithelial cells induces apoptosis of the underlying keratocytes. Exp. Eye Res. 64 (1997) 775-779
25. Wyllie A.H., Kerr J.F., and Currie A.R. Cell death: the significance of apoptosis. Int. Rev. Cytol. 68 (1980) 251-306