Corneal epithelial wound healing impaired in keratinocyte-specific HB-EGF-Deficient mice in vivo and in vitro

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 11, 2010, Pages 5630-5639

  Yoshioka, Ryuji ^a   Shiraishi, Atsushi ^a   Kobayashi, Takeshi ^a   Morita, Shin ichi ^a   Hayashi, Yasuhito ^a   Higashiyama, Shigeki ^a   Ohashi, Yuichi ^a  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA6 INTEGRIN; BETA1 INTEGRIN; EPIDERMAL GROWTH FACTOR; EPIREGULIN; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ADHESION; CELL PROLIFERATION; CONTROLLED STUDY; CORNEA EPITHELIUM; IN VITRO STUDY; IN VIVO STUDY; KERATINOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; WOUND CLOSURE; WOUND HEALING IMPAIRMENT;

ANIMALS; CELL ADHESION MOLECULES; CELL PROLIFERATION; CELLS, CULTURED; EPIDERMAL GROWTH FACTOR; EPITHELIUM, CORNEAL; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KERATINOCYTES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; WOUND HEALING;

EID: 79956008666     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-5158     Document Type: Article

References (41)

1. Cohen S. Isolation and biological effects of an epidermal growthstimulating protein. Natl Cancer Inst Monogr. 1964;13:13-37.
2. Derynck R, Roberts AB, Winkler ME, Chen EY. Goeddel DV. Human transforming growth factor-alpha: precursor structure and expression in E. coli. Cell. 1984;38:287-297.
3. Toyoda H, Komurasaki T, Uchida, D. et al. Epiregulin: a novel epidermal growth factor with mitogenic activity for rat primary hepatocytes. J Biol Chem. 1995;270:7495-7500.
4. Shoyab M, Plowman GD, McDonald VL, Bradley JG. Todaro GJ. Structure and function of human amphiregulin: a member of the epidermal growth factor family. Science. 1989;243:1074-1076.
5. Shing Y, Christofori G, Hanahan D, et al. Betacellulin: a mitogen from pancreatic beta cell tumors. Science. 1993;259:1604-1607.
6. Chang H, Riese DJ 2nd, Gilbert W, Stern DF, McMahan UJ. Ligands for ErbB-family receptors encoded by a neuregulin-like gene. Nature. 1997;387:509-512.
7. Carraway KL 3rd, Weber JL, Unger MJ, et al. Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. Nature. 1997; 387:512-516.
8. Kraus MH, Issing W, Miki T, Popescu NC. Aaronson SA. Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci U S A. 1989;86:9193-9197.
9. Ullrich A, Coussens L, Hayflick JS, et al. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells. Nature. 1984; 309:418-425.
10. Yamamoto T, Ikawa S, Akiyama T, et al. Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Nature. 1986;319:230-234.
11. Plowman GD, Culouscou JM, Whitney GS, et al. Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family. Proc Natl Acad Sci U S A. 1993;90: 1746-1750.
12. Inui Y, Higashiyama S, Kawata S, et al. Expression of heparinbinding epidermal growth factor in human hepatocellular carcinoma. Gastroenterology. 1994;107:1799-1804.
13. Kobrin MS, Funatomi H, Friess H, et al. Induction and expression of heparin-binding EGF-like growth factor in human pancreatic cancer. Biochem Biophys Res Commun. 1994;202:1705-1709.
14. Iwamoto R, Yamazaki S, Asakura M, et al. Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function. Proc Natl Acad Sci U S A. 2003;100:3221-3226.
15. Luetteke NC, Qiu TH, Fenton SE, et al. Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. Development. 1999;126:2739-2750.
16. Shirasawa S, Sugiyama S, Baba I, et al. Dermatitis due to epiregulin deficiency and a critical role of epiregulin in immune-related responses of keratinocyte and macrophage. Proc Natl Acad Sci U S A. 2004;101:13921-13926.
17. Lee D, Pearsall RS, Das S, et al. Epiregulin is not essential for development of intestinal tumors but is required for protection from intestinal damage. Mol Cell Biol. 2004;24:8907-8916.
18. Wilson SE, He YG, Weng J, et al. Effect of epidermal growth factor, hepatocyte growth factor, and keratinocyte growth factor, on proliferation, motility, and differentiation of human corneal epithelial cells. Exp Eye Res. 1994;59:665-678.
19. Block ER, Matela AR, SundarRaj N, Iszkula ER, Klarlund JK. Wounding induces motility in sheets of corneal epithelial cells through loss of spatial constraints: role of heparin-binding epidermal growth factor-like growth factor signaling. J Biol Chem. 2004;279: 24307-24312.
20. Xu KP, Ding Y, Ling J, Dong Z, Yu FS. Wound-induced HB-EGF ectodomain shedding and EGFR activation in corneal epithelial cells. Invest Ophthalmol Vis Sci. 2004;45:813-820.
21. Shirakata Y, Kimura R, Nanba, D. et al. Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing. J Cell Sci. 2005;118:2363-2370.
22. Tarutani M, Itami S, Okabe, M. et al. Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development. Proc Natl Acad Sci U S A. 1997;94: 7400-7405.
23. Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet. 1999;21:70-71.
24. Kobayashi T, Yoshioka R, Shiraishi A, Ohashi Y. New technique for culturing corneal epithelial cells of normal mice. Mol Vis. 2009; 15:1589-1593.
25. Kawakita T, Espana EM, He H, et al. Calcium-induced abnormal epidermal-like differentiation in cultures of mouse corneallimbal epithelial cells. Invest Ophthalmol Vis Sci. 2004;45: 3507-3512.
26. Rubin JS, Chan AM, Bottaro DP, et al. A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor. Proc Natl Acad Sci U S A. 1991;88:415-419.
27. Shimizu M, Minakuchi K, Tsuda A, et al. Role of stem cell factor and c-kit signaling in regulation of fetal intestinal epithelial cell adhesion to fibronectin. Exp Cell Res. 2001;266:311-322.
28. Loeser RF. Wallin, R. Cell adhesion to matrix Gla protein and its inhibition by an Arg-Gly-Asp-containing peptide. J Biol Chem. 1992;267:9459-9462.
29. Rutledge RG, Cote C. Mathematics of quantitative kinetic PCR and the application of standard curves. Nucleic Acids Res. 2003;31:e93.
30. Stepp MA. Corneal integrins and their functions. Exp Eye Res. 2006;83:3-15.
31. Xu KP, Riggs A, Ding Y, Yu FS. Role of ErbB2 in corneal epithelial wound healing. Invest Ophthalmol Vis Sci. 2004;45: 4277-4283.
32. Yin J, Yu FS. Rho kinases regulate corneal epithelial wound healing. Am J Physiol Cell Physiol. 2008;295:C378-C387.
33. Faull RJ, Stanley JM, Fraser S, Power DA. Leavesley DI. HB-EGF is produced in the peritoneal cavity and enhances mesothelial cell adhesion and migration. Kidney Int. 2001;59:614-624.
34. Stepp MA, Spurr-Michaud S, Tisdale A, Elwell J, Gipson IK. Alpha 6 beta 4 integrin heterodimer is a component of hemidesmosomes. Proc Natl Acad Sci U S A. 1990;87:8970-8974.
35. Stepp MA, Spurr-Michaud S Gipson IK. Integrins in the wounded and unwounded stratified squamous epithelium of the cornea. Invest Ophthalmol Vis Sci. 1993;34:1829-1844.
36. Raab G, Higashiyama S, Hetelekidis S, et al. Biosynthesis and processing by phorbol ester of the cells surface-associated pre-cursor form of heparin-binding EGF-like growth factor. Biochem Biophys Res Commun. 1994;204:592-597.
37. Goishi K, Higashiyama S, Klagsbrun M, et al. Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity. Mol Biol Cell. 1995;6:967-980.
38. Nanba D, Mammoto A, Hashimoto K, Higashiyama S. Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF. J Cell Biol. 2003;163:489-502.
39. Nanba D, Inoue H, Shigemi Y, et al. An intermediary role of proHB-EGF shedding in growth factor-induced c-Myc gene expression. J Cell Physiol. 2008;214:465-473.
40. Morita S, Shirakata Y, Shiraishi A, et al. Human corneal epithelial cell proliferation by epiregulin and its cross-induction by other EGF family members. Mol Vis. 2007;13:2119-2128.
41. Shirakata Y, Komurasaki T, Toyoda H, et al. Epiregulin, a novel member of the epidermal growth factor family, is an autocrine growth factor in normal human keratinocytes. J Biol Chem. 2000;275:5748-5753.