Parameters in dynamic models of complex traits are containers of missing heritability

PLoS Computational Biology

Volumn 8, Issue 4, 2012, Pages

  Wang, Yunpeng ^a   Gjuvsland, Arne B ^a   Vik, Jon Olav ^a   Smith, Nicolas P ^b   Hunter, Peter J ^c   Omholt, Stig W ^a  

^a NORWEGIAN UNIVERSITY OF LIFE SCIENCES   (Norway)

^b ST THOMAS HOSPITAL   (United Kingdom)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

DYNAMIC MODELS; GENES; PHYSIOLOGICAL MODELS;

'CURRENT; COMPLEX TRAITS; DYNAMICS MODELS; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDIES; HUMAN TRAITS; MODELING PARAMETERS; PHENOTYPIC TRAITS; PHYSIOLOGICAL TRAIT; VALIDATED DYNAMIC MODELS;

PHYSIOLOGY;

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CALMODULIN; POTASSIUM CHANNEL; RYANODINE RECEPTOR; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SODIUM CALCIUM EXCHANGE PROTEIN;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CHLORIDE CURRENT; COHESIVE GENOTYPE PHENOTYPE MODEL; CONTROLLED STUDY; CYTOGENETICS; GENE FREQUENCY; GENE MAPPING; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC MODEL; GENETIC PARAMETERS; GENETIC TRAIT; GENETIC VARIABILITY; GENOTYPE; GENOTYPE PHENOTYPE CORRELATION; HEART MUSCLE CELL; HERITABILITY; MOUSE; NONHUMAN; PHENOTYPIC VARIATION; POTASSIUM CURRENT; QUANTITATIVE GENETICS; QUANTITATIVE TRAIT LOCUS; SARCOPLASMIC RETICULUM; SINGLE CELL ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SODIUM CURRENT; ACTION POTENTIAL; ANIMAL; BIOLOGICAL MODEL; CALCIUM SIGNALING; CELL CULTURE; COMPUTER SIMULATION; GENETICS; PHYSIOLOGY; QUANTITATIVE TRAIT;

ACTION POTENTIALS; ANIMALS; CALCIUM SIGNALING; CELLS, CULTURED; COMPUTER SIMULATION; MICE; MODELS, GENETIC; MYOCYTES, CARDIAC; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT, HERITABLE;

EID: 84861165394     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002459     Document Type: Article

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