Alp, an arthropod-associated outer membrane protein of borrelia species that cause relapsing fever

Infection and Immunity

Volumn 80, Issue 5, 2012, Pages 1881-1890

  Marcsisin, Renee A ^a,c   Campeau, Shelley A ^a   Lopez, Job E ^b,d   Barbour, Alan G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c MONASH UNIVERSITY   (Australia)

^d MISSISSIPPI STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALP PROTEIN; ANTIGEN; MONOCLONAL ANTIBODY; OUTER MEMBRANE PROTEIN; UNCLASSIFIED DRUG; VARIABLE MAJOR PROTEIN;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DETECTION; ANTIGEN ANTIBODY REACTION; ANTIGEN FUNCTION; ARTICLE; BORRELIA; BORRELIA HERMSII; BORRELIA INFECTION; BORRELIA RECURRENTIS; CONTROLLED STUDY; ESCHERICHIA COLI; FEMALE; LYME DISEASE; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODY SPECIFICITY; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BASE SEQUENCE; BORRELIA; BORRELIA INFECTIONS; FEMALE; GENOME, BACTERIAL; MICE; MICE, SCID; MOLECULAR SEQUENCE DATA; MUTATION; PHYLOGENY; SALIVARY GLANDS; TEMPERATURE; TICKS;

EID: 84861137833     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.06419-11     Document Type: Article

References (57)

1. Altschul SF, et al. 2005. Protein database searches using compositionally adjusted substitution matrices. FEBS J. 272:5101-5109.
2. Barbour AG. 1984. Isolation and cultivation of Lyme disease spirochetes. Yale J. Biol. Med. 57:521-525.
3. Barbour AG, Bundoc V. 2001. In vitro and in vivo neutralization of the relapsing fever agent Borrelia hermsii with serotype-specific immunoglobulin M antibodies. Infect. Immun. 69:1009-1015.
4. Barbour AG, Carter CJ, Sohaskey CD. 2000. Surface protein variation by expression site switching in the relapsing fever agent Borrelia hermsii. Infect. Immun. 68:7114-7121.
5. Barbour AG, Dai Q, Restrepo BI, Stoenner HG, Frank SA. 2006. Pathogen escape from host immunity by a genome program for antigenic variation. Proc. Natl. Acad. Sci. U. S. A. 103:18290-18295.
6. Barbour AG, Guo BP. 2010. Pathogenesis of relapsing fever, p 333-358. In Radolf JD, Samuels DS (ed), Borrelia: molecular biology, host interaction, and pathogenesis. Caister Academic Press, Norfolk, United Kingdom.
7. Barbour AG, Hayes SF, Heiland RA, Schrumpf ME, Tessier SL. 1986. A Borrelia-specific monoclonal antibody binds to a flagellar epitope. Infect. Immun. 52:549-554.
8. Barbour AG, Tessier SL, Hayes SF. 1984. Variation in a major surface protein of Lyme disease spirochetes. Infect. Immun. 45:94-100.
9. Barbour AG, Tessier SL, Todd WJ. 1983. Lyme disease spirochetes and ixodid tick spirochetes share a common surface antigenic determinant defined by a monoclonal antibody. Infect. Immun. 41:795-804.
10. Barstad PA, Coligan JE, Raum MG, Barbour AG. 1985. Variable major proteins of Borrelia hermsii. Epitope mapping and partial sequence analysis of CNBr peptides. J. Exp. Med. 161:1302-1314.
11. Bergström S, Zückert WR. 2010. Structure, function and biogenesis of the Borrelia cell envelope, p 139-166. In Radolf JD, Samuels DS (ed), Borrelia: molecular biology, host interaction, and pathogenesis. Caister Academic Press, Norfolk, United Kingdom.
12. Brandt ME, Riley BS, Radolf JD, Norgard MV. 1990. Immunogenic integral membrane proteins of Borrelia burgdorferi are lipoproteins. Infect. Immun. 58:983-991.
13. Bunikis J, Barbour AG. 1999. Access of antibody or trypsin to an integral outer membrane protein (P66) of Borrelia burgdorferi is hindered by Osp lipoproteins. Infect. Immun. 67:2874-2883.
14. Bunikis J, Noppa L, Ostberg Y, Barbour AG, Bergstrom S. 1996. Surface exposure and species specificity of an immunoreactive domain of a 66-kilodalton outer membrane protein (P66) of the Borrelia spp. that cause Lyme disease. Infect. Immun. 64:5111-5116.
15. Bunikis J, et al. 2004. Typing of Borrelia relapsing fever group strains. Emerg. Infect. Dis. 10:1661-1664.
16. Burgdorfer W, et al. 1982. Lyme disease-a tick-borne spirochetosis? Science 216:1317-1319.
17. Cadavid D, Thomas DD, Crawley R, Barbour AG. 1994. Variability of a bacterial surface protein and disease expression in a possible mouse model of systemic Lyme borreliosis. J. Exp. Med. 179:631-642.
18. Carter CJ, Bergstrom S, Norris SJ, Barbour AG. 1994. A family of surface-exposed proteins of 20 kilodaltons in the genus Borrelia. Infect. Immun. 62:2792-2799.
19. Casjens S. 2000. Borrelia genomes in the year 2000. J. Mol. Microbiol. Biotechnol. 2:401-410.
20. Cheng J, Randall AZ, Sweredoski MJ, Baldi P. 2005. SCRATCH: a protein structure and structural feature prediction server. Nucleic Acids Res. 33:W72-W76.
21. Dai Q, et al. 2006. Antigenic variation by Borrelia hermsii occurs through recombination between extragenic repetitive elements on linear plasmids. Mol. Microbiol. 60:1329-1343.
22. Eng JK, McCormack AJ, Yates JR III. 1994. An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J. Am. Soc. Mass Spectrom. 5:976-986.
23. Guindon S, Gascuel O. 2003. A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst. Biol. 52:696-704.
24. Hinnebusch BJ, Barbour AG, Restrepo BI, Schwan TG. 1998. Population structure of the relapsing fever spirochete Borrelia hermsii as indicated by polymorphism of two multigene families that encode immunogenic outer surface lipoproteins. Infect. Immun. 66:432-440.
25. Hotez PJ, Kamath A. 2009. Neglected tropical diseases in sub-Saharan Africa: review of their prevalence, distribution, and disease burden. PLoS Negl. Trop. Dis. 3:e412.
26. Hovis KM, McDowell JV, Griffin L, Marconi RT. 2004. Identification and characterization of a linear-plasmid-encoded factor H-binding protein (FhbA) of the relapsing fever spirochete Borrelia hermsii. J. Bacteriol. 186:2612-2618.
27. Huelsenbeck JP, Ronquist F. 2001. MRBAYES: Bayesian inference of phylogenetic trees. Bioinformatics 17:754-755.
28. Johansson J, et al. 2002. An RNA thermosensor controls expression of virulence genes in Listeria monocytogenes. Cell 110:551-561.
29. Larkin MA, et al. 2007. Clustal W and Clustal X version 2.0. Bioinformatics 23:2947-2948.
30. Lescot M, et al. 2008. The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii. PLoS Genet. 4:e1000185.
31. Liberles DA. 2001. Evaluation of methods for determination of a reconstructed history of gene sequence evolution. Mol. Biol. Evol. 18:2040-2047.
32. Librado P, Rozas J. 2009. DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. Bioinformatics 25:1451-1452.
33. Longo D, Hasty J. 2006. Dynamics of single-cell gene expression. Mol. Syst. Biol. 2:64.
34. Lopez JE, et al. 2009. Identification of conserved antigens for early serodiagnosis of relapsing fever Borrelia. Microbiology 155:2641-2651.
35. Lynch M, Crease TJ. 1990. The analysis of population survey data on DNA sequence variation. Mol. Biol. Evol. 7:377-394.
36. Marchler-Bauer A, et al. 2011. CDD: a conserved domain database for the functional annotation of proteins. Nucleic Acids Res. 39:D225-D229.
37. Martin DP, et al. 2010. RDP3: a flexible and fast computer program for analyzing recombination. Bioinformatics 26:2462-2463.
38. Meier JT, Simon MI, Barbour AG. 1985. Antigenic variation is associated with DNA rearrangements in a relapsing fever Borrelia. Cell 41:403-409.
39. Noppa L, Ostberg Y, Lavrinovicha M, Bergstrom S. 2001. P13, an integral membrane protein of Borrelia burgdorferi, is C-terminally processed and contains surface-exposed domains. Infect. Immun. 69:3323-3334.
40. Nordstrand A, et al. 2007. Tickborne relapsing fever diagnosis obscured by malaria, Togo. Emerg. Infect. Dis. 13:117-123.
41. Pennington PM, Allred CD, West CS, Alvarez R, Barbour AG. 1997. Arthritis severity and spirochete burden are determined by serotype in the Borrelia turicatae-mouse model of Lyme disease. Infect. Immun. 65:285-292.
42. Petsko GA, Ringe D. 2004. Protein structure and function. New Science Press, London, United Kingdom.
43. Porcella SF, et al. 2005. Variable tick protein in two genomic groups of the relapsing fever spirochete Borrelia hermsii in western North America. Infect. Immun. 73:6647-6658.
44. Restrepo BI, Kitten T, Carter CJ, Infante D, Barbour AG. 1992. Subtelomeric expression regions of Borrelia hermsii linear plasmids are highly polymorphic. Mol. Microbiol. 6:3299-3311.
45. Sadziene A, Thomas DD, Barbour AG. 1995. Borrelia burgdorferi mutant lacking Osp: biological and immunological characterization. Infect. Immun. 63:1573-1580.
46. Schwan TG, Hinnebusch BJ. 1998. Bloodstream- versus tick-associated variants of a relapsing fever bacterium. Science 280:1938-1940.
47. Schwan TG, Piesman J. 2000. Temporal changes in outer surface proteins A and C of the Lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice. J. Clin. Microbiol. 38:382-388.
48. Schwan TG, Piesman J. 2002. Vector interactions and molecular adaptations of Lyme disease and relapsing fever spirochetes associated with transmission by ticks. Emerg. Infect. Dis. 8:115-121.
49. Schwan TG, Raffel SJ, Schrumpf ME, Porcella SF. 2007. Diversity and distribution of Borrelia hermsii. Emerg. Infect. Dis. 13:436-442.
50. Schwan TG, Schrumpf ME, Hinnebusch BJ, Anderson DE, Jr, Konkel ME. 1996. GlpQ: an antigen for serological discrimination between relapsing fever and Lyme borreliosis. J. Clin. Microbiol. 34:2483-2492.
51. Shevchenko A, Wilm M, Vorm O, Mann M. 1996. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal. Chem. 68:850-858.
52. Stoenner HG, Dodd T, Larsen C. 1982. Antigenic variation of Borrelia hermsii. J. Exp. Med. 156:1297-1311.
53. Tsao J, Barbour AG, Luke CJ, Fikrig E, Fish D. 2001. OspA immunization decreases transmission of Borrelia burgdorferi spirochetes from infected Peromyscus leucopus mice to larval Ixodes scapularis ticks. Vector Borne Zoonotic Dis. 1:65-74.
54. Tsao JI, et al. 2004. An ecological approach to preventing human infection: vaccinating wild mouse reservoirs intervenes in the Lyme disease cycle. Proc. Natl. Acad. Sci. U. S. A. 101:18159-18164.
55. van der Woude MW, Baumler AJ. 2004. Phase and antigenic variation in bacteria. Clin. Microbiol. Rev. 17:581-611.
56. Zhong J, Barbour AG. 2004. Cross-species hybridization of a Borrelia burgdorferi DNA array reveals infection- and culture-associated genes of the unsequenced genome of the relapsing fever agent Borrelia hermsii. Mol. Microbiol. 51:729-748.
57. Zhong J, Skouloubris S, Dai Q, Myllykallio H, Barbour AG. 2006. Function and evolution of plasmid-borne genes for pyrimidine biosynthesis in Borrelia spp. J. Bacteriol. 188:909-918.