Access of antibody or trypsin to an integral outer membrane protein (P66) of Borrelia burgdorferi is hindered by Osp lipoproteins

Infection and Immunity

Volumn 67, Issue 6, 1999, Pages 2874-2883

  Bunikis, Jonas ^a   Barbour, Alan G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLAGELLIN; FORMALDEHYDE; LIPOPROTEIN; MONOCLONAL ANTIBODY; OUTER MEMBRANE PROTEIN; PROTEIN P66; TRYPSIN; UNCLASSIFIED DRUG;

ANTIGEN BINDING; ARTICLE; BACTERIAL GROWTH; BORRELIA BURGDORFERI; CROSS LINKING; GROWTH INHIBITION; IMMUNOFLUORESCENCE TEST; LYME DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; VACCINATION;

EID: 0033016382     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.6.2874-2883.1999     Document Type: Article

References (62)

1. Anonymous. 1995. Recomendations for test performance and interpretation from the Second International Conference on Serologic Diagnosis of Lyme Disease. Morbid. Mortal. Weekly Rep. 44:590-591.
2. Asbrink, E., A. Hovmark, and B. Hederstedt. 1984. The spirochetal etiology of acrodermatitis chronica atrophicans Herxheimer. Acta Dermatol. Venereol. 64:506-512.
3. Barbour, A. G. 1984. Isolation and cultivation of Lyme disease spirochetes. Yale J. Biol. Med. 57:521-525.
4. Barbour, A. G., W. Burgdorfer, E. Grunwaldt, and A. C. Steere. 1983. Antibodies of patients with Lyme disease to components of the Ixodes dammini spirochete. J. Clin. Investig. 72:504-515.
5. Barbour, A. G., and C. F. Garon. 1987. Linear plasmids of the bacterium Borrelia burgdorferi have covalently closed ends. Science 237:409-411.
6. Barbour, A. G., S. F. Hayes, R. A. Heiland, M. E. Schrumpf, and S. L. Tessier. 1986. A Borrelia-specific monoclonal antibody binds to a flagellar epitope. Infect. Immun. 52:549-554.
7. Barbour, A. G., S. L. Tessier, and S. F. Hayes. 1984. Variation in a major surface protein of Lyme disease spirochetes. Infect. Immun. 45:94-100.
8. Barbour, A. G., S. L. Tessier, and W. J. Todd. 1983. Lyme disease spirochetes and Ixodes tick spirochetes share a common surface antigen determinant defined by a monoclonal antibody. Infect. Immun. 41:795-804.
9. Barthold, S. W., E. Fikrig, L. K. Bockenstedt, and D. H. Persing. 1995. Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi. Infect. Immun. 63:2255-2261.
10. Billingsley, P. F., and W. Rudin. 1992. The role of the mosquito peritrophic membrane in bloodmeal digestion and infectivity of Plasmodium species. J. Parasitol. 78:430-440.
11. Brunet, L. R., C. Sellitto, A. Spielman, and S. R. Telford III. 1995. Antibody response of the mouse reservoir of Bomlia burgdorferi in nature. Infect. Immun. 63:3030-3036.
12. Bunikis, J., C. J. Luke, E. Bunikiene, S. Bergström, and A. G. Barbour. 1998. A surface-exposed region of a novel outer membrane protein (P66) of Borrelia spp. is variable in size and sequence. J. Bacteriol. 180:1618-1623.
13. Bunikis, J., L. Noppa, and S. Bergström. 1995. Molecular analysis of a 66-kDa protein associated with the outer membrane of Lyme disease Borrelia. FEMS Microbiol. Lett. 131:139-145.
14. Bunikis, J., L. Noppa, Y. Östberg, A. G. Barbour, and S. Bergström. 1996. Surface exposure and species specificity of an immunoreactive domain of a 66-kilodalton outer membrane protein (P66) of the Borrelia spp. that cause Lyme disease. Infect. Immun. 64:5111-5116.
15. Cadavid, D., P. M. Pennington, T. A. Kerentseva, S. Bergström, and A. G. Barbour. 1997. Immunologic and genetic analyses of VmpA of a neurotropic strain of Borrelia turicatae. Infect. Immun. 65:3352-3360.
16. Charon, N. W., C. W. Lawrence, and S. O'Brien. 1981. Movement of antibody-coated latex beads attached to the spirochete Leptospira interrogans. Proc. Natl. Acad. Sci. USA 78:7166-7170.
17. Cox, D. L., D. R. Akins, K. W. Bourell, P. Lahdenne, M. V. Norgard, and J. D. Radolf. 1996. Limited surface exposure of Borrelia burgdorferi outer surface lipoproteins. Proc. Natl. Acad. Sci. USA 93:7973-7978.
18. de Silva, A. M., S. R. Telford III, L. R. Brunet, S. W. Barthold, and E. Fikrig. 1996. Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine. J. Exp. Med. 183:271-275.
19. Dressler, F., J. A. Whalen, B. N. Reinhardt, and A. C. Steere. 1993. Western blotting in the serodiagnosis of Lyme disease. J. Infect. Dis. 167:392-400.
20. Dunn, J. J., B. N. Lade, and A. G. Barbour. 1990. Outer surface protein A (OspA) from the Lyme disease spirochete, Borrelia burgdorferi: high level expression and purification of a soluble recombinant form of OspA. Protein Expression Purif. 1:159-168.
21. Elkins, C., N. H. Carbonetti, V. A. Varela, D. Stirewalt, D. G. Klapper, and P. F. Sparling. 1992. Antibodies to N-terminal peptides of gonococcal porin are bactericidal when gonococcal lipopolysaccharide is not sialyted. Mol. Microbiol. 6:2617-2628.
22. Fikrig, E., S. W. Barthold, F. S. Kantor, and R. A. Flavell. 1990. Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Science 250:553-556.
23. Fikrig, E., S. W. Barthold, F. S. Kantor, and R. A. Flavell. 1991. Protection of mice from Lyme borreliosis by oral vaccination with Escherichia coli expressing OspA. J. Infect. Dis. 164:1224-1227.
24. Fikrig, E., S. W. Barthold, N. Marcantonio, K. Deponte, F. S. Kantor, and R. A. Klavell. 1992. Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice. Infect. Immun. 60:657-661.
25. Fikrig, E., S. R. Telford III, R. Wallich, M. Chen, Y. Lobet, F. R. Matuschka, R. B. Kimsey, F. S. Kantor, S. W. Barthold, A. Spielman, and R. A. Flavell. 1995. Vaccination against Lyme disease caused by diverse Borrelia burgdorferi. J. Exp. Med. 181:215-221.
26. Fikrig, E., S. R. Telford, S. W. Barthold, F. S. Kantor, A. Spielman, and R. A. Flavell. 1992. Elimination of Borrelia burgdorferi from vector ticks feeding on OspA-immunized mice. Proc. Natl. Acad. Sci. USA 89:5418-5421.
27. Fraser, C. M., S. Casjens, W. M. Huang, G. G. Sutton, R. Clayton, R. Lathigra, O. White, K. A. Ketchum, R. Dodson, E. K. Hickey, M. Gwinn, B. Dougherty, J. F. Tomb, R. D. Fleischmann, D. Richardson, J. Peterson, A. R. Kerlavage, J. Quackenbush, S. Salzberg, M. Hanson, R. van Vugt, N. Palmer, M. D. Adams, J. Gocayne, J. C. Venter, et al. 1997. Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature 390: 580-586.
28. Greene, R. T., R. L. Walker, W. L. Nicholson, H. W. Heidner, J. F. Levine, E. C. Burgess, M. Wyand, E. B. Breitschwerdt, and H. A. Berkhoff. 1988. Immunoblot analysis of immunoglobulin G response to the Lyme disease agent (Borrelia burgdorferi) in experimentally and naturally exposed dogs. J. Clin. Microbiol. 26:648-653.
29. Hackstadt, T. 1988. Steric hindrance of antibody binding to surface proteins of Coxiella burnetii by phase I lipopolysaccharide. Infect. Immun. 56:802-807.
30. Hanson, M. S., D. R. Cassatt, B. P. Guo, N. K. Patel, M. P. McCarthy, D. W. Dorward, and M. Hook. 1998. Active and passive immunity against Borrelia burgdorferi decorin binding protein A (DbpA) protects against infection. Infect. Immun. 66:2143-2153.
31. Holt, S. C. 1978. Anatomy and chemistry of spirochetes. Microbiol. Rev. 38:114-160.
32. Howe, T. R., F. W. LaQuier, and A. G. Barbour. 1986. Organization of genes encoding two outer membrane proteins of the Lyme disease agent Borrelia burgdorferi within a single transcriptional unit. Infect. Immun. 54:207-212.
33. Howe, T. R., L. W. Mayer, and A. G. Barbour. 1985. A single recombinant plasmid expressing two major outer surface proteins of the Lyme disease spirochete. Science 227:645-646.
34. Lam, T. T., T.-P. K. Nguyen, R. R. Montgomery, F. S. Kantor, E. Fikrig, and R. A. Flavell. 1994. Outer surface proteins E and F of Borrelia burgdorferi, the agent of Lyme disease. Infect. Immun. 62:290-298.
35. Li, H., J. J. Dunn, B. J. Luft, and C. L. Lawson. 1997. Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab. Proc. Natl. Acad. Sci. USA 94:3584-3589.
36. Luke, C. J., R. C. Huebner, V. Kasmiersky, and A. G. Barbour. 1997. Oral delivery of purified lipoprotein OspA protects mice from systemic infection with Borrelia burgdorferi. Vaccine 15:739-746.
37. Mendiola, J., M. Alonso, M. C. Marquetti, and C. Finlay. 1996. Boophilus microplus: multiple proteolytic activities in the midgut. Exp. Parasitol. 82: 27-33.
38. Nguyen, T.-P. K., Y. T. Lam, S. W. Barthold, S. R. Telford III, R. A. Flavel, and E. Fikrig. 1994. Partial destruction of Borrelia burgdorferi within ticks that engorged on OspE- or OspF immunized mice. Infect. Immun. 62:2079-2084.
39. Norris, S. J., C. J. Carter, J. K. Howell, and A. G. Barbour. 1992. Low passage-associated proteins of Borrelia burgdorferi: characterization and molecular cloning of OspD, a surface-exposed, plasmid-encoded lipoprotein. Infect. Immun. 60:4662-4672.
40. Philipp, M. T., M. K. Aydintug, R. P. Bohm, Jr., F. B. Cogswell, V. A. Dennis, H. N. Lanners, R. C. Lowrie, Jr., E. D. Roberts, M. D. Conway, M. Karacorlu, et al. 1993. Early and early disseminated phases of Lyme disease in the rhesus monkey: a model for infection in humans. Infect. Immun. 61:3047-3059.
41. Probert, W. S., K. M. Allsup, and R. B. LeFebre. 1995. Identification and characterization of a surface-exposed 66-kilodalton protein from Borrelia burgdorferi. Infect. Immun. 63:1933-1939.
42. Probert, W. S., M. Crawford, R. B. Cadiz, and R. B. LeFebvre. 1997. Immunization with outer surface protein (Osp) A, but not OspC, provides cross-protection of mice challenged with North American isolates of Borrelia burgdorferi. J. Infect. Dis. 175:400-405.
43. Probert, W. S., and R. B. LeFebvre. 1994. Protection of C3H/HeN mice from challenge with Borrelia burgdorferi through active immunization with OspA, OspB, or OspC, but not with OspD or the 83-kilodalton antigen. Infect. Immun. 62:1920-1926.
44. Pugsley, A. P. 1996. Multimers of the precursor of a type IV pilin-like component of the general secretory pathway are unrelated to pili. Mol Microbiol. 20:1235-1245.
45. Radolf, J. D. 1994. Role of outer membrane architecture in immune evasion by Treponema pallidum and Borrelia burgdorferi. Trends Microbiol. 9:307-311.
46. Rosenfeld, A., and J. P. Vanderberg. 1998. Identification of electrophoretically separated proteases from midgut and hemolymph of adult Anopheles stephensi mosquitoes. J. Parasitol. 84:361-365.
47. Sadziene, A., M. Jonsson, S. Bergström, R. K. Bright, R. C. Kennedy, and A. G. Barbour. 1994. A bactericidal antibody to Borrelia burgdorferi is directed against a variable region of the OspB protein. Infect. Immun. 62: 2037-2045.
48. Sadziene, A., P. A. Rosa, P. A. Thompson, D. M. Hogan, and A. G. Barbour. 1992. Antibody-resistant mutants of Borrelia burgdorferi: in vitro selection and characterization. J. Exp. Med. 176:799-809.
49. Sadziene, A., D. D. Thomas, and A. G. Barbour. 1995. Borrelia burgdorferi mutant lacking Osp: biological and immunological characterization. Infect. Immun. 63:1573-1580.
50. Sadziene, A., P. A. Thompson, and A. G. Barbour. 1993. In vitro inhibition of Borrelia burgdorferi growth by antibodies. J. Infect. Dis. 167:165-172.
51. Sadziene, A., B. Wilske, M. S. Ferdows, and A. G. Barbour. 1993. The cryptic ospC gene of Borrelia burgdorferi B31 is located on a circular plasmid. Infect. Immun. 61:2192-2195.
52. Schwan, T. G., J. Piesman, W. T. Golde, M. C. Dolan, and P. A. Rosa. 1995. Induction of an outer surface protein on Borrelia burgdorferi during tick feeding. Proc. Natl. Acad. Sci. USA 92:2909-2913.
53. Sigal, L. H., J. M. Zahradnik, P. Lavin, S. J. Patella, G. Bryant, R. Haselby, E. Hilton, M. Kunkel, D. Adler-Klein, T. Doherty, J. Evans, S. E. Malawista, and the Lyme Disease Vaccine Study Consortium. 1998. A vaccine consisting of recombinant Borrelia burgdorferi outer-surface protein A to prevent Lyme disease. N. Engl. J. Med. 339:216-222.
54. Simon, M. M., U. E. Schaible, M. D. Kramer, C. Eckerskorn, C. Museteanu, H. K. Muller-Hermelink, and R. Wallich. 1991. Recombinant outer surface protein a from Borrelia burgdorferi induces antibodies protective against spirochetal infection in mice. J. Infect. Dis. 164:123-132.
55. Simpson, W. J., W. Cleplak, M. E. Schrumpf, A. G. Barbour, and T. G. Schwan. 1994. Nucleotide sequence and analysis of the gene in Borrelia burgdorferi encoding the immunogenic P39 antigen. FEMS Microbiol. Lett. 119:381-387.
56. Skare, J. T., B. M. Ahmer, C. L. Seachord, R. P. Darveau, and K. Postle. 1993. Energy transduction between membranes. TonB, a cytoplasmic membrane protein, can be chemically cross-linked in vivo to the outer membrane receptor FepA. J. Biol. Chem. 268:16302-16308.
57. Skare, J. T., T. A. Mirzabekov, E. S. Shang, D. R. Blanco, H. Erdjument-Bromage, J. Bunikis, S. Bergstrom, P. Tempst, B. L. Kagan, J. N. Miller, and M. A. Lovett. 1997. The Oms66 (p66) protein is a Borrelia burgdorferi porin. Infect. Immun. 65:3654-3661.
58. Steere, A. C., V. K. Sikand, F. Meurice, D. L. Parenti, E. Fikrig, R. T. Schoen, J. Nowakowski, C. H. Schmid, S. Laukamp, C. Buscarino, D. S. Krause, and the Recombinant Outer-Surface Protein A Lyme Disease Vaccine Study Group. 1998. Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. N. Engl. J. Med. 339: 209-215.
59. Takayama, K., R. J. Rothenberg, and A. G. Barbour. 1987. Absence of lipopolysaccharide in the Lyme disease spirochete, Borrelia burgdorferi. Infect. Immun. 55:2311-2313.
60. van der Ley, P., P. de Graaff, and J. Tommassen. 1986. Shielding of Escherichia coli outer membrane proteins as receptors for bacteriophages and colicins by O-antigenic chains of lipopolysaccharides. J. Bacteriol. 168:449-451.
61. Walker, E. M., G. A. Zampighi, D. R. Blanco, J. N. Miller, and M. A. Lovett. 1989. Demonstration of rare protein in the outer membrane of Treponema pallidum subsp. pallidum by freeze-fracture analysis. J. Bacteriol. 171:5005-5011.
62. Ziegelbauer, K., and P. Overath. 1993. Organization of two invariant surface glycoproteins in the surface coat of Trypanosoma brucei. Infect. Immun. 61:4540-4545.