Population structure of the relapsing fever spirochete Borrelia hermsii as indicated by polymorphism of two multigene families that encode immunogenic outer surface lipoproteins

Infection and Immunity

Volumn 66, Issue 2, 1998, Pages 432-440

  Hinnebusch, Joseph ^a,d   Barbour, Alan G ^b,c   Restrepo, Blanca I ^c,e   Schwan, Tom G ^a  

^a Natl Inst Allerg and Infect Dis

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^e NONE   (Colombia)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; OUTER MEMBRANE PROTEIN;

ARTICLE; BACTERIAL OUTER MEMBRANE; BORRELIA; BORRELIA HERMSII; BORRELIA INFECTION; GENETIC POLYMORPHISM; IMMUNOGENICITY; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SPIROCHETE; STRAIN DIFFERENCE;

EID: 2642612784     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.2.432-440.1998     Document Type: Article

References (58)

1. Balanant, J., S. Guillot, A. Candrea, F. Delpeyroux, and R. Crainic. 1991. The natural genomic variability of poliovirus analyzed by a restriction fragment length polymorphism assay. Virology 184:645-654.
2. Barbour, A. G. Unpublished data.
3. Barbour, A. G. 1985. Clonal polymorphism of surface antigens in a relapsing fever Borrelia species, p. 235-245. In G. G. Jackson and H. Thomas (ed), Bayer-Symposium VIII: the pathogensis of bacterial infections. Springer-Verlag, Berlin, Germany.
4. Barbour, A. G. 1990. Antigenic variation of a relapsing fever Borrelia species. Annu. Rev. Microbiol. 44:155-171.
5. Barbour, A. G., N. Burman, C. J. Carter, T. Kitten, and S. Bergström. 1991. Variable antigen genes of the relapsing fever agent Borrelia hermsii are activated by promoter addition. Mol. Microbiol. 5:489-493.
6. Barbour, A. G., and S. F. Hayes. 1986. Biology of Borrelia species. Microbiol. Rev. 50:381-400.
7. Barbour, A. G., and B. I. Restrepo. Unpublished data.
8. Barbour, A. G., and H. G. Stoenner. 1985. Antigenic variation of Borrelia hermsii. UCLA Symp. Mol. Cell. Biol. 20:123-135.
9. Barstad, P. A., J. E. Coligan, M. G. Raum, and A. G. Barbour. 1985. Variable major proteins of Borrelia hermsii. Epitope mapping and partial sequence analysis of CNBr peptides. J. Exp. Med. 161:1302-1314.
10. Boerlin, P., O. Peter, A.-G. Bretz, D. Postic, G. Baranton, and J.-C. Piffaretti. 1992. Population genetic analysis of Borrelia burgdorferi isolates by multilocus enzyme electrophoresis. Infect. Immun. 60:1677-1683.
11. Borst, P., and D. R. Greaves. 1987. Programmed gene rearrangements altering gene expression. Science 235:658-667.
12. Brunham, R. C., F. A. Plummer, and R. S. Stephens. 1993. Bacterial antigenic variation, host immune response, and pathogen-host coevolution. Infect. Immun. 61:2273-2276.
13. Burgdorfer, W., A. G. Barbour, S. F. Hayes, J. L. Benach, E. Grunwaldt, and J. P. Davis. 1982. Lyme disease - a tick-borne spirochetosis? Science 216: 1317-1319.
14. Burman, N., S. Bergström, B. I. Restrepo, and A. G. Barbour. 1990. The variable antigens Vmp7 and Vmp21 of the relapsing fever bacterium Borrelia hermsii are structurally analogous to the VSG proteins of the African try panosome. Mol. Microbiol. 4:1715-1726.
15. Cadavid, D., P. M. Pennington, T. A. Kerentseva, S. Bergström, and A. G. Barbour. 1997. Immunologic and genetic analyses of VmpA of a neurotropic strain of Borrelia turicatae. Infect. Immun. 65:3352-3360.
16. Carcy, B., S. Bonnefoy, J. Schrevel, and O. Mercereau-Puijalon. 1995. Plasmodium falciparum: typing of malaria parasites based on polymorphism of a novel multigene family. Exp. Parasitol. 80:463-472.
17. Carter, C. J., S. Bergström, S. J. Norris, and A. G. Barbour. 1994. A family of surface-exposed proteins of 20 kilodaltons in the genus Borrelia. Infect. Immun. 62:2792-2799.
18. Dykhuizen, D. E., D. S. Polin, J. Dunn, B. Wilske, V. Preac-Mursic, R. J. Dattwyler, and B. J. Luft. 1993. Borrelia burgdorferi is clonal: implications for taxonomy and vaccine development. Proc. Natl. Acad. Sci. USA 90:10163-10167.
19. Ferdows, M. S., and A. G. Barbour. 1989. Megabase-sized linear DNA in the bacterium Borrelia burgdorferi, the Lyme disease agent. Proc. Natl. Acad. Sci. USA 86:5969-5973.
20. Fung, B. P., G. L. McHugh, J. M. Leong, and A. C. Steere. 1994. Humoral immune response to outer surface protein C of Borrelia burgdorferi in Lyme disease: role of the immunoglobulin M response in the serodiagnosis of early infection. Infect. Immun. 62:3213-3221.
21. Gupta, S., M. C. J. Maiden, I. M. Feavers, S. Nee, R. M. May, and R. M. Anderson. 1996. The maintenance of strain structure in populations of recombining infectious agents. Nat. Med. 2:437-442.
22. Gupta, S., K. Trenholme, R. M. Anderson, and K. P. Day. 1994. Antigenic diversity and the transmission dynamics of Plasmodium falciparum. Science 263:961-963.
23. Hinnebusch, B. J. Unpublished data.
24. Jauris-Heipke, S., R. Fuchs, M. Motz, V. Preac-Mursic, E. Schwab, E. Soutschek, G. Will, and B. Wilske. 1993. Genetic heterogeneity of the genes coding for the outer surface protein C (OspC) and the flagellin of Borrelia burgdorferi. Med. Microbiol. Immunol. (Berlin) 182:37-50.
25. Jauris-Heipke, S., G. Liegl, V. Preac-Mursic, D. Robler, E. Schwab, E. Soutschek, G. Will, and B. Wilske. 1995. Molecular analysis of genes encoding outer surface protein C (OspC) of Borrelia burgdorferi sensu lato: relationship to ospA genotype and evidence of lateral gene exchange of ospC. J. Clin. Microbiol. 33:1860-1866.
26. Kimura, M. 1983. The neutral theory of molecular evolution. Cambridge University Press, Cambridge, United Kingdom.
27. Kitten, T., and A. G. Barbour. 1990. Juxtaposition of expressed variable antigen genes with a conserved telomere in the bacterium Borrelia hermsii. Proc. Natl. Acad. Sci. USA 87:6077-6081.
28. Kitten, T., A. V. Barrera, and A. G. Barbour. 1993. Intragenic recombination and a chimeric outer membrane protein in the relapsing fever agent Borrelia hermsii. J. Bacteriol. 175:2516-2522.
29. Lane, R. S., W. Burgdorfer, S. F. Hayes, and A. G. Barbour. 1985. Isolation of a spirochete from the soft tick, Ornithodoros coriaceus: a possible agent of epizootic bovine abortion. Science 230:85-87.
30. Lebech, A.-M., K. Hansen, B. Wilske, and M. Theisen. 1994. Taxonomic classification of 29 Borrelia burgdorferi strains isolated from patients with Lyme borreliosis: a comparison of five different phenotypic and genotypic typing schemes. Med. Microbiol. Immunol. (Berlin) 183:325-341.
31. Livey, I., C. P. Gibbs, R. Schuster, and F. Dorner. 1995. Evidence for lateral transfer and recombination in OspC variation in Lyme disease Borrelia. Mol. Microbiol. 18:257-269.
32. Marconi, R. T., D. S. Samuels, R. K. Landry, and C. F. Garon. 1994. Analysis of the distribution and molecular heterogeneity of the ospD gene among the Lyme disease spirochetes: evidence for lateral gene exchange. J. Bacteriol. 176:4572-4582.
33. Marconi, R. T., D. S. Samuels, T. G. Schwan, and C. T. Garon. 1993. Identification of a protein in several species of Borrelia related to OspC of the Lyme disease spirochetes. J. Clin. Microbiol. 31:2577-2583.
34. Margolis, N., D. Hogan, W. Cieplak, Jr., T. G. Schwan, and P. A. Rosa. 1994. Homology between Borrelia burgdorferi OspC and members of the family of Borrelia hermsii variable major proteins. Gene 143:105-110.
35. Masake, R. A., V. M. Nantulya, A. J. Musoke, S. K. Moloo, and K. Nguli. 1987. Characterization of Trypanosoma congolense serodemes in stocks isolated from cattle introduced onto a ranch in Kilifi, Kenya. Parasitology 94:349-357.
36. Meier, J. T., M. I. Simon, and A. G. Barbour. 1985. Antigenic variation is associated with DNA rearrangements in a relapsing fever Borrelia. Cell 41:403-109.
37. Nei, M., and W.-H. Li. 1979. Mathematical model for studying genetic variation in terms of restriction endonucleases. Proc. Natl. Acad. Sci. USA 76:5269-5273.
38. Padula, S. J., A. Sampieri, F. Dias, A. Szczepanski, and R. W. Ryan. 1993. Molecular characterization and expression of p23 (OspC) from a North American strain of Borrelia burgdorferi. Infect. Immun. 61:5097-5105.
39. Picken, R. N. 1992. Polymerase chain reaction primers and probes derived from flagellin gene sequences for specific detection of the agents of Lyme disease and North American relapsing fever. J. Clin. Microbiol. 30:99-114.
40. Plasterk, R. H. A., M. I. Simon, and A. G. Barbour. 1985. Transposition of structural genes to an expression sequence on a linear plasmid causes antigenic variation in the bacterium Borrelia hermsii. Nature 318:257-263.
41. Restrepo, B. I., and A. G. Barbour. 1994. Antigen diversity in the bacterium B. hermsii through "somatic" mutations in rearranged vmp genes. Cell 78: 867-876.
42. Restrepo, B. I., C. J. Carter, and A. G. Barbour 1994. Activation of a vmp pseudogene in Borrelia hermsii. an alternate mechanism of antigenic variation during relapsing fever. Mol. Microbiol. 13:287-299.
43. Restrepo, B. I., T. Kitten, C. J. Carter, D. Infante, and A. G. Barbour. 1992. Subtelomeric expression regions of Borrelia hermsii linear plasmids are highly polymorphic. Mol. Microbiol. 6:3299-3311.
44. Robertson, D. L., P. M. Sharp, F. E. McCautchan, and B. H. Hahn. 1995. Recombinations in HIV-1. Nature 374:124-126.
45. Saitou, N., and M. Nei. 1986. Polymorphism and evolution of influenza A virus genes. Mol. Biol. Evol. 5:57-74.
46. Schwan, T. G. Unpublished data.
47. Schwan, T. G., K. L. Gage, and J. Hinnebusch. 1995. Analysis of relapsing fever spirochetes from the western United States. J. Spiroehetal Tick-borne Dis. 2:3-8.
48. Schwan, T. G., and B. J. Hinnebusch, Unpublished data.
49. Schwan, T. G., J. Piesman, W. T. Golde, M. C. Dolan, and P. A. Rosa. 1995. Induction of an outer surface protein on Borrelia burgdorferi during tick feeding. Proc. Natl. Acad. Sci. USA 92:2909-2913.
50. Selander, R. K., and J. M. Musser. 1990. Population genetics of bacterial pathogens, p. 11-36. In B. H. Iglewski and V. L. Clark (ed.), Molecular basis of bacterial pathogenesis. Academic Press, London, United Kingdom.
51. Smith, J. M., N. H. Smith, M. O'Rourke, and B. G. Spratt. 1993. How clonal are bacteria? Proc. Natl. Acad. Sci. USA 90:4384-4388.
52. Stevenson, B., and S. W. Barthold. 1994. Expression and sequence of outer surface protein C among North American isolates of Borrelia burgdorferi. FEMS Microbiol. Lett. 124:367-372.
53. Stoenner, H. G., T. Dodd, and C. Larsen. 1982. Antigenic variation in B. hermsii. J. Exp. Med. 156:1297-1311.
54. Theisen, M., M. Borre, M. J. Mathiesen, B. Mikkelson, A.-M. Lebech, and K. Hansen. 1995. Evolution of the Borrelia burgdorferi outer surface protein OspC. J. Bacteriol. 177:3036-3044.
55. Theisen, M., B. Frederiksen, A.-M. Lebech, J. Vuust, and K. Hansen. 1993. Polymorphism in ospC gene of Borrelia burgdorferi and immunoreactivity of OspC protein: implications for taxonomy and for use of OspC protein as a diagnostic antigen. J. Clin. Microbiol. 31:2570-2576.
56. Thompson, R. S., W. Burgdorfer, R. Russell, and B. J. Francis. 1969. Outbreak of tick-borne relapsing fever in Spokane County, Washington. JAMA 210:1045-1050.
57. Tibayrenc, M. 1945. Population genetics of parasitic protozoa and other microorganisms. Adv. Parasitol. 36:48-115.
58. Wilske, B., V. Preac-Mursic, S. Jauris, A. Hofmann, I. Pradel, E. Soutschek, E. Schwab, G. Will, and G. Wanner 1993. Immunological and molecular polymorphisms of OspC, an immunodominant major outer surface protein of Borrelia burgdorferi. Infect. Immun. 61:2182-2191.