Surface protein variation by expression site switching in the relapsing fever agent Borrelia hermsii

Infection and Immunity

Volumn 68, Issue 12, 2000, Pages 7114-7121

  Barbour, Alan G ^a   Carter, Carol J ^b   Sohaskey, Charles D ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^c VA LONG BEACH HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN;

ANIMAL EXPERIMENT; ANTIGENIC VARIATION; ARTICLE; BORRELIA HERMSII; BORRELIA INFECTION; FEMALE; GENE EXPRESSION; GENE LOCATION; GENE LOCUS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE ISOLATION; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN VARIANT; SEROTYPE;

ANIMALS; BACTERIAL OUTER MEMBRANE PROTEINS; BORRELIA; ESCHERICHIA COLI; FEMALE; MICE; MICE, INBRED BALB C; PLASMIDS; PROMOTER REGIONS (GENETICS); RELAPSING FEVER; TELOMERE; TRANSCRIPTION, GENETIC;

EID: 0034445518     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.12.7114-7121.2000     Document Type: Article

References (46)

1. Barbour, A. G. 1990. Antigenic variation of a relapsing fever Borrelia species. Annu. Rev. Microbiol. 44:155-171.
2. Barbour, A. G. 1984. Isolation and cultivation of Lyme disease spirochetes. Yale J. Biol. Med. 57:521-525.
3. Barbour, A. G. 1993. Linear DNA of Borrelia species and antigenic variation. Trends Microbiol. 1:236-239.
4. Barbour, A. G., O. Barrera, and R. C. Judd. 1983. Structural analysis of the variable major proteins of Borrelia hermsii. J. Exp. Med. 158:2127-2140.
5. Barbour, A. G., N. Burman, C. J. Carter, T. Kitten, and S. Bergstrom. 1991. Variable antigen genes of the relapsing fever agent Borrelia hermsii are activated by promoter addition. Mol. Microbiol. 5:489-493.
6. Barbour, A. G., and C. F. Garon. 1987. Linear plasmids of the bacterium Borrelia burgdorferi have covalently closed ends. Science 237:409-411.
7. Barbour, A. G., and S. F. Hayes. 1986. Biology of Borrelia species. Microbiol. Rev. 50:381-400.
8. Barbour, A. G., S. F. Hayes, R. A. Heiland, M. E. Schrumpf, and S. L. Tessier. 1986. A Borrelia-specific monoclonal antibody binds to a flagellar epitope. Infect. Immun. 52:549-554.
9. Barbour, A. G., and H. Stoenner. 1985. Antigenic variation of Borrelia hermsii, p. 123-135. In I. Herskowitz and M. I. Simon (ed.). Genome rearrangement. Alan R. Liss, Inc., New York, N.Y.
10. Barbour, A. G., S. L. Tessier, and S. F. Hayes. 1984. Variation in a major surface protein of Lyme disease spirochetes. Infect. Immun. 45:94-100.
11. Barbour, A. G., S. L. Tessier, and H. G. Stoenner. 1982. Variable major proteins of Borrelia hermsii. J. Exp. Med. 156:1312-1324.
12. Barbour, A. G., W. J. Todd, and H. G. Stoenner. 1982. Action of penicillin on Borrelia hermsii. Antimicrob. Agents Chemother. 21:823-829.
13. Barstad, P. A., J. E. Collgan, M. G. Raum, and A. G. Barbour. 1985. Variable major proteins of Borrelia hermsii. Epitope mapping and partial sequence analysis of CNBr peptides. J. Exp. Med. 161:1302-1314.
14. [4. Burman, N., S. Bergstrom, B. I. Restrepo, and A. G. Barbour. 1990. The variable antigens Vmp7 and Vmp21 of the relapsing fever bacterium Borrelia hermsii are structurally analogous to the VSG proteins of the African trypanosome. Mol. Microbiol. 4:1715-1726.
15. Cadavid, D., P. M. Pennington, T. A. Kerentseva, S. Bergstrom, and A. G. Barbour. 1997. Immunologic and genetic analyses of VmpA of a neurotropic strain of Borrelia turicatae. Infect. Immun. 65:3352-3360.
16. Carter, C. J., S. Bergstrom, S. J. Norris, and A. G. Barbour. 1994. A family of surface-exposed proteins of 20 kilodaltons in the genus Borrelia. Infect. Immun. 62:2792-2799.
17. Deitsch, K. W., E. R. Moxon, and T. E. Wellems. 1997. Shared themes of antigenic variation and virulence in bacterial, protozoal, and fungal infections. Microbiol. Mol. Biol. Rev. 61:281-293.
18. Ferdows, M. S., and A. G. Barbour. 1989. Megabase-sized linear DNA in the bacterium Borrelia burgdorferi, the Lyme disease agent. Proc. Natl. Acad. Sci. USA 86:5969-5973.
19. Ferdows, M. S., P. Serwer, G. A. Griess, S. J. Norris, and A. G. Barbour. 1996. Conversion of a linear to a circular plasmid in the relapsing fever agent Borrelia hermsii. J. Bacteriol. 178:793-800.
20. Fraser, C. M., S. Casjens, W. M. Huang, G. G. Sutton, R. Clayton, R. Lathigra, O. White, K. A. Ketchum, R. Dodson, E. K. Hickey, M. Gwinn, B. Dougherty, J. F. Tomb, R. D. Fleischmann, D. Richardson, J. Peterson, A. R. Kerlavage, J. Quackenbush, S. Salzberg, M. Hanson, R. van Vugt, N. Palmer, M. D. Adams, J. Gocayne, J. C. Venter, et al. 1997. Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature 390: 580-586.
21. Hinnebusch, J., and A. G. Barbour. 1991. Linear plasmids of Borrelia burgdorferi have a telomeric structure and sequence similar to those of a eukaryotic virus. J. Bacteriol. 173:7233-7239.
22. Hinnebusch, J., and A. G. Harbour. 1992. Linear- and circular-plasmid copy numbers in Borrelia burgdorferi. J. Bacteriol. 174:5251-5257.
23. Hinnebusch, J., S. Bergstrom, and A. G. Barbour. 1990. Cloning and sequence analysis of linear plasmid telomeres of the bacterium Borrelia burgdorferi. Mol. Microbiol. 4:811-820.
24. Indest, K. J., and M. T. Philipp. 2000. DNA-binding proteins possibly involved in regulation of the post-logarithmic-phase expression of lipoprotein P35 in Borrlia burgdorferi. J. Bacteriol. 182:522-525.
25. Kitten, T., and A. G. Barbour. 1990. Juxtaposition of expressed variable antigen genes with a conserved telomere in the bacterium Borrelia hermsii. Proc. Natl. Acad. Sci. USA 87:6077-6081.
26. Kitten, T., A. V. Barrera, and A. G. Barbour. 1993. Intragenic recombination and a chimeric outer membrane protein in the relapsing fever agent Borrelia hermsii. J. Bacteriol. 175:2516-2522.
27. Marconi, R. T., D. S. Samuels, T. G. Schwan, and C. F. Garon. 1993. Identification of a protein in several Borrelia species related to OspC of the Lyme disease spirochetes. J. Clin. Microbiol. 31:2577-2583.
28. Margolis, N., D. Hogan, W. Cieplak, Jr., T. G. Schwan, and P. A. Rosa. 1994. Homology between Borrelia burgdorferi OspC and members of the family of Borrelia hermsii variable major proteins. Gene 143:105-110.
29. Margolis, N., D. Hogan, K. Tilly, and P. A. Rosa. 1994. Plasmid location of Borrelia purine biosynthesis gene homologs. J. Bacteriol. 176:6427-6432.
30. Meier, J. T., M. I. Simon, and A. G. Barbour. 1985. Antigenic variation is associated with DNA rearrangements in a relapsing fever Borrelia. Cell 41:403-409.
31. Pennington, P. M., C. D. Allred, C. S. West, R. Alvarez, and A. G. Barbour. 1997. Arthritis severity and spirochete burden are determined by serotype in the Borrelia turicatae-mouse model of Lyme disease. Infect. Immun. 65:285-292.
32. Pennington, P. M., D. Cadavid, and A. G. Barbour. 1999. Characterization of VspB of Borrelia turicatae, a major outer membrane protein expressed in blood and tissues of mice. Infect. Immun. 67:4637-4645.
33. Pennington, P. M., D. Cadavid, J. Bunikis, S. J. Norris, and A. G. Barbour. 1999. Extensive interplasmidic duplications change the virulence phenotype of the relapsing fever agent Borrelia turicatae. Mol. Microbiol. 34:1120-1132.
34. Plasterk, R. H., M. I. Simon, and A. G. Barbour. 1985. Transposition of structural genes to an expression sequence on a linear plasmid causes antigenie variation in the bacterium Borrelia hermsii. Nature 318:257-263.
35. Restrepo, B. I., and A. G. Barbour. 1994. Antigen diversity in the bacterium B. hermsii through "somatic" mutations in rearranged vmp genes. Cell 78: 867-876.
36. Restrepo, B. I., C. J. Carter, and A. G. Barbour. 1994. Activation of a vmp pseudogene in Borrelia hermsii: an alternate mechanism of antigenic variation during relapsing fever. Mol. Microbiol. 13:287-299.
37. Restrepo, B. I., T. Kitten, C. J. Carter, D. Infante, and A. G. Barbour. 1992. Subtelomeric expression regions of Borrelia hermsii linear plasmids are highly polymorphic. Mol. Microbiol. 6:3299-3311.
38. Sadziene, A., D. D. Thomas, and A. G. Barbour. 1995. Borrelia burgdorferi mutant lacking Osp: biological and immunological characterization. Infect. Immun. 63:1573-1580.
39. Sadziene, A., D. D. Thomas, V. G. Bundoc, S. H. Holt, and A. G. Barbour. 1991. A flagella-less mutant of Borrelia burgdorferi. J. Clin. Investig. 88:82-92.
40. Sadziene, A., B. Wilske, M. S. Ferdows, and A. G. Barbour. 1993. The cryptic ospC gene of Borrelia burgdorferi B31 is located on a circular plasmid. Infect. Immun. 61:2192-2195.
41. Schwan, T. G., and B. J. Hinnebusch. 1998. Bloodstream-versus tick-associated variants of a relapsing fever bacterium. Science 280:1938-1940.
42. Sohaskey, C. D., C. Arnold, and A. G. Barbour. 1997. Analysis of promoters in Borrelia burgdorferi by use of a transiently expressed reporter gene. J. Bacteriol. 179:6837-6842.
43. Sohaskey, C. D., W. R. Zückert, and A. G. Barbour. 1999. The extended promoters for two outer membrane lipoprotein genes of Borrelia spp. uniquely include a T-rich region. Mol. Microbiol. 33:41-51.
44. Stevenson, B., S. F. Porcella, K. L. Oie, C. A. Fitzpatrick, S. J. Raffel, L. Lubke, M. E. Schrumpf, and T. G. Schwan. 2000. The relapsing fever spirochete Borrelia hermsii contains multiple, antigen-encoding circular plasmids that are homologous to the cp32 plasmids of Lyme disease spirochetes. Infect. Immun. 68:3900-3908.
45. Stoenner, H. G., T. Dodd, and C. Larsen. 1982. Antigenic variation of Borrelia hermsii. J. Exp. Med. 156:1297-1311.
46. Zhang, J. R., J. M. Hardham, A. G. Barbour, and S. J. Norris. 1997. Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes. Cell 89:275-285.