Hedgehog signaling in glioblastoma multiforme

Cancer Biology and Therapy

Volumn 13, Issue 7, 2012, Pages 487-495

  Braun, Stefanie ^a   Oppermann, Henry ^a   Mueller, Antje ^a   Renner, Christof ^a   Hovhannisyan, Amalya ^b   Baran Schmidt, Rainer ^a   Gebhardt, Rolf ^b   Hipkiss, Alan R ^c   Thiery, Joachim ^a   Meixensberger, Jürgen ^a   Gaunitz, Frank ^a  

^a UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c ASTON UNIVERSITY   (United Kingdom)

Author keywords

Cyclopamine; Gaussia; Gli; Glioblastoma; Hedgehog

Indexed keywords

CYCLOPAMINE; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

ARTICLE; CANCER CELL CULTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG RESPONSE; GLIOBLASTOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPORTER GENE; SIGNAL TRANSDUCTION;

CELL LINE, TUMOR; CELL SURVIVAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; GLIOBLASTOMA; HEDGEHOG PROTEINS; HUMANS; ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION; VERATRUM ALKALOIDS;

EID: 84861132861     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.19591     Document Type: Article

References (28)

1. Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJB, et al.; European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005; 352:987-96; PMID:15758009; http://dx.doi.org/10.1056/NEJMoa043330.
2. Hegi ME, Diserens AC, Gorlia T, Hamou MF, de Tribolet N, Weller M, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 2005; 352:997-1003; PMID:15758010; http:// dx.doi.org/10.1056/NEJMoa043331.
3. Nüsslein-Volhard C, Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 1980; 287:795-801; PMID:6776413; http://dx.doi. org/10.1038/287795a0.
4. Ingham PW, McMahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes Dev 2001; 15:3059-87; PMID:11731473; http:// dx.doi.org/10.1101/gad.938601.
5. Barakat MT, Humke EW, Scott MP. Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer. Trends Mol Med 2010; 16:337-48; PMID:20696410; http://dx.doi.org/10.1016/j.molmed. 2010.05.003.
6. Pasca di Magliano M, Hebrok M. Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer 2003; 3:903-11; PMID:14737121; http:// dx.doi.org/10.1038/nrc1229.
7. Kasper M, Regl G, Frischauf AM, Aberger F. GLI transcription factors: mediators of oncogenic Hedgehog signalling. Eur J Cancer 2006; 42:437- 45; PMID:16406505; http://dx.doi.org/10.1016/j. ejca.2005.08.039.
8. Rohatgi R, Scott MP. Patching the gaps in Hedgehog signalling. Nat Cell Biol 2007; 9:1005-9; PMID:17762891; http://dx.doi.org/10.1038/ncb435.
9. Rubin LL, de Sauvage FJ. Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov 2006; 5:1026- 33; PMID:17139287; http://dx.doi.org/10.1038/ nrd2086.
10. Stecca B, Ruiz I Altaba A. Context-dependent regulation of the GLI code in cancer by HEDGEHOG and non-HEDGEHOG signals. J Mol Cell Biol 2010; 2:84-95; PMID:20083481; http://dx.doi.org/10.1093/ jmcb/mjp052.
11. Yoon JW, Gilbertson R, Iannaccone S, Iannaccone P, Walterhouse D. Defining a role for Sonic hedgehog pathway activation in desmoplastic medulloblastoma by identifying GLI1 target genes. Int J Cancer 2009; 124:109-19; PMID:18924150; http://dx.doi. org/10.1002/ijc.23929.
12. Ulasov IV, Nandi S, Dey M, Sonabend AM, Lesniak MS. Inhibition of Sonic hedgehog and Notch pathways enhances sensitivity of CD133(+) glioma stem cells to temozolomide therapy. Mol Med 2011; 17:103- 12; PMID:20957337; http://dx.doi.org/10.2119/molmed. 2010.00062.
13. Kinzler KW, Bigner SH, Bigner DD, Trent JM, Law ML, O'Brien SJ, et al. Identification of an amplified, highly expressed gene in a human glioma. Science 1987; 236:70-3; PMID:3563490; http://dx.doi. org/10.1126/science.3563490.
14. Rossi M, Magnoni L, Miracco C, Mori E, Tosi P, Pirtoli L, et al. β-catenin and Gli1 are prognostic markers in glioblastoma. Cancer Biol Ther 2011; 11:753- 61; PMID:21321483; http://dx.doi.org/10.4161/ cbt.11.8.14894.
15. Wang K, Pan L, Che XM, Cui DM, Li C. Sonic Hedgehog/GLI1 signaling pathway inhibition restricts cell migration and invasion in human gliomas. Neurol Res 2010; 32:975-80; PMID:20444323; http://dx.doi. org/10.1179/ 016164110X12681290831360.
16. Shahi MH, Lorente A, Castresana JS. Hedgehog signalling in medulloblastoma, glioblastoma and neuroblastoma. Oncol Rep 2008; 19:681-8; PMID:18288402.
17. Sasaki H, Hui C, Nakafuku M, Kondoh H. A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 1997; 124:1313-22; PMID:9118802.
18. Sasaki H, Nishizaki Y, Hui C, Nakafuku M, Kondoh H. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 1999; 126:3915-24; PMID:10433919.
19. Kasperczyk H, Baumann B, Debatin KM, Fulda S. Characterization of sonic hedgehog as a novel NFkappaB target gene that promotes NFkappaB-mediated apoptosis resistance and tumor growth in vivo. FASEB J 2009; 23:21-33; PMID:18772349; http://dx.doi.org/10.1096/fj.08-111096.
20. Bigner SH, Wong AJ, Mark J, Muhlbaier LH, Kinzler KW, Vogelstein B, et al. Relationship between gene amplification and chromosomal deviations in malignant human gliomas. Cancer Genet Cytogenet 1987; 29:165-70; PMID:3478127; http://dx.doi. org/10.1016/0165-4608(87)90045-8.
21. Forus A, Flørenes VA, Maelandsmo GM, Meltzer PS, Fodstad O, Myklebost O. Mapping of amplification units in the q13-14 region of chromosome 12 in human sarcomas: some amplica do not include MDM2. Cell Growth Differ 1993; 4:1065-70; PMID:8117620.
22. Rao SK, Edwards J, Joshi AD, Siu IM, Riggins GJ. A survey of glioblastoma genomic amplifications and deletions. J Neurooncol 2010; 96:169-79; PMID:19609742; http://dx.doi.org/10.1007/s11060-009-9959-4.
23. Wang K, Pan L, Che X, Cui D, Li C. Gli1 inhibition induces cell cycle arrest and enhanced apoptosis in brain glioma cell lines. J Neurooncol 2010; 98:319-27; PMID:20024601; http://dx.doi.org/10.1007/s11060- 009-0082-3.
24. Takezaki T, Hide T, Takanaga H, Nakamura H, Kuratsu J, Kondo T. Essential role of the Hedgehog signaling pathway in human glioma-initiating cells. Cancer Sci 2011; 102:1306-12; PMID:21453386; http://dx.doi. org/10.1111/j.1349-7006. 2011.01943.x.
25. Renner C, Seyffarth A, de Arriba SG, Meixensberger J, Gebhardt R, Gaunitz F. Carnosine inhibits growth of cells isolated from human glioblastoma multiforme. Int J Pept Res Ther 2008; 14:127-35; http://dx.doi. org/10.1007/s10989-007-9121-0.
26. Nordeen SK. Luciferase reporter gene vectors for analysis of promoters and enhancers. Biotechniques 1988; 6:454-8; PMID:2908509.
27. Gaunitz F, Heise K. HTS compatible assay for antioxidative agents using primary cultured hepatocytes. Assay Drug Dev Technol 2003; 1:469-77; PMID:15090184; http://dx.doi.org/10.1089/154065803322163786.
28. Laurendeau I, Ferrer M, Garrido D, D'Haene N, Ciavarelli P, Basso A, et al. Gene expression profiling of the hedgehog signaling pathway in human meningiomas. Mol Med 2010; 16:262-70; PMID:20386868; http://dx.doi.org/10.2119/ molmed.2010.00005.