Replication analysis for severe diabetic retinopathy

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 4, 2012, Pages 2377-2381

  Grassi, Michael A ^a,e   Tikhomirov, Anna ^a   Ramalingam, Sudha ^b   Lee, Kristine E ^c   Mohsen Hosseini, S ^d   Klein, Barbara E K ^c   Klein, Ronald ^c   Lussier, Yves A ^a   Cox, Nancy J ^a   Nicolae, Dan L ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b PSG INSTITUTE OF MEDICAL SCIENCES AND RESEARCH   (India)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

^e UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN A1C;

ADULT; ARTICLE; BLOOD PRESSURE; BODY MASS; CEP135 GENE; CHROMOSOME 1; CHROMOSOME 4; CONTROLLED STUDY; DIABETIC RETINOPATHY; FEMALE; GENE; GENE LOCUS; GENE REPLICATION; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

DIABETES MELLITUS, TYPE 1; DIABETIC RETINOPATHY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MACULAR EDEMA; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84861129502     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-8068     Document Type: Article

References (28)

1. Centers for Disease Control and Prevention. National diabetes fact sheet. Atlanta, GA: Centers for Disease Control and Prevention; 2011.
2. Klein R, Klein BE, Moss SE, Davis MD, DeMets DL. The Wisconsin epidemiologic study of diabetic retinopathy. III. Prevalence and risk of diabetic retinopathy when age at diagnosis is 30 or more years. Arch Ophthalmol. 1984;102: 527-532.
3. Klein BE, Davis MD, Segal P, et al. Diabetic retinopathy. Assessment of severity and progression. Ophthalmology. 1984;91:10-17.
4. Arar NH, Freedman BI, Adler SG, et al. Heritability of the severity of diabetic retinopathy: the FIND-Eye study. Invest Ophthalmol Vis Sci. 2008;49:3839-3845.
5. Hietala K, Forsblom C, Summanen P, Groop PH. Heritability of proliferative diabetic retinopathy. Diabetes. 2008;57:2176-2180.
6. Hallman DM, Boerwinkle E, Gonzalez VH, Klein BEK, Klein R, Hanis CL. A genome-wide linkage scan for diabetic retinopathy susceptibility genes in Mexican Americans with type 2 diabetes from Starr County, Texas. Diabetes. 2007;56:1167-1173.
7. Saxena R, Voight BF, Lyssenko V, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science. 2007;316:1331-1336.
8. Looker HC, Nelson RG, Chew E, et al. Genome-wide linkage analyses to identify loci for diabetic retinopathy. Diabetes. 2007;56:1160-1166.
9. Scott LJ, Mohlke KL, Bonnycastle LL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science. 2007;1142382.
10. Zeggini E, Weedon MN, Lindgren CM, et al. Replication of genome-wide association signals in U.K. Samples reveals risk loci for type 2 diabetes. Science. 2007;1142364.
11. Grassi MA, Tikhomirov A, Ramalingam S, Below JE, Cox NJ, Nicolae DL. Genome-wide meta-analysis for severe diabetic retinopathy. Hum Mol Genet. 2011;20:2472-2481.
12. Warpeha KM, Chakravarthy U. Molecular genetics of microvascular disease in diabetic retinopathy. Eye (Lond). 2003;17: 305-311.
13. Ko BC, Lam KS, Wat NM, Chung SS. An (A-C)n dinucleotide repeat polymorphic marker at the 50 end of the aldose reductase gene is associated with early-onset diabetic retinopathy in NIDDM patients. Diabetes. 1995;44:727-732.
14. Barnett AH, Dallinger K, Jennings P, Fletcher J, Odugbesan O. Microalbuminuria and diabetic retinopathy. Lancet. 1985;1: 53-54.
15. Gilbert RE, Tsalamandris C, Allen TJ, Colville D, Jerums G. Early nephropathy predicts vision-threatening retinal disease in patients with type I diabetes mellitus. J Am Soc Nephrol. 1998;9:85-89.
16. Klein R, Klein BE, Moss SE, Cruickshanks KJ. The Wisconsin Epidemiologic Study of Diabetic Retinopathy: XVII. The 14-year incidence and progression of diabetic retinopathy and associated risk factors in type 1 diabetes. Ophthalmology. 1998;105:1801-1815.
17. Klein R, Klein BE, Moss SE, Davis MD, DeMets DL. The Wisconsin epidemiologic study of diabetic retinopathy. II. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30 years. Arch Ophthalmol. 1984;102: 520-526.
18. Early Treatment Diabetic Retinopathy Study (ETDRS). Manual of Operations. Baltimore, MD: National Technical Information Service; 1985;1-49.
19. Korn JM, Kuruvilla FG, McCarroll SA, et al. Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs. Nat Genet. 2008;40:1253-1260.
20. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nature Genetics. 2006;38:904-909.
21. Pe'er I, Yelensky R, Altshuler D, Daly MJ. Estimation of the multiple testing burden for genomewide association studies of nearly all common variants. Genet Epidemiol. 2008;32:381-385.
22. Sandirasegarane L, Kester M. Enhanced stimulation of Akt-3/ protein kinase B-gamma in human aortic smooth muscle cells. Biochem Biophys Res Commun. 2001;283:158-163.
23. Herder C, Zierer A, Koenig W, Roden M, Meisinger C, Thorand B. Transforming growth factor-beta1 and incident type 2 diabetes: results from the MONICA/KORA case-cohort study, 1984-2002. Diabetes Care. 2009;32:1921-1923.
24. Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR. The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. Nature. 2003;422:629-633.
25. Zukowska Z, Grant DS, Lee EW. Neuropeptide Y: a novel mechanism for ischemic angiogenesis. Trends Cardiovasc Med. 2003;13:86-92.
26. McCarthy MI, Abecasis GR, Cardon LR, et al. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet. 2008;9:356-369.
27. Bowcock AM. Genomics: guilt by association. Nature. 2007; 447:645-646.
28. Holmes D. Mind the IGAP. Lancet Neurol. 2011;10:502-503.