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Volumn 18, Issue 10, 2012, Pages 2861-2871

L-BLP25 vaccine plus letrozole induces a T H1 immune response and has additive antitumor activity in MUC1-expressing mammary tumors in mice

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; EMEPEPIMUT S; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LETROZOLE; MUCIN 1; TAMOXIFEN CITRATE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84861128128     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-12-0168     Document Type: Article
Times cited : (13)

References (44)
  • 2
    • 53449088766 scopus 로고    scopus 로고
    • Chemoprevention of breast and prostate cancers: Where do we stand?
    • Senn HJ, Morant R. Chemoprevention of breast and prostate cancers: where do we stand? Ann Oncol 2008;19 Suppl 7:vii234-7.
    • (2008) Ann Oncol , vol.19 , Issue.SUPPL. 7
    • Senn, H.J.1    Morant, R.2
  • 3
    • 26944486309 scopus 로고    scopus 로고
    • Muc1 affects c-Src signaling in PyV MT-induced mammary tumorigenesis
    • DOI 10.1038/sj.onc.1208738, PII 1208738
    • Al Masri A, Gendler SJ. Muc1 affects c-Src signaling in PyV MT-induced mammary tumorigenesis. Oncogene 2005;24:5799-808. (Pubitemid 43080071)
    • (2005) Oncogene , vol.24 , Issue.38 , pp. 5799-5808
    • Al, M.A.1    Gendler, S.J.2
  • 4
    • 0027968669 scopus 로고
    • Expression of MUC1 on myeloma cells and induction of HLA-unrestricted CTL against MUC1 from a multiple myeloma patient
    • Takahashi T, Makiguchi Y, Hinoda Y, Kakiuchi H, Nakagawa N, Imai K, et al. Expression of MUC1 on myeloma cells and induction of HLA-unrestricted CTL against MUC1 from a multiple myeloma patient. J Immunol 1994;153:2102-9. (Pubitemid 24256681) (Pubitemid 24256681)
    • (1994) Journal of Immunology , vol.153 , Issue.5 , pp. 2102-2109
    • Takahashi, T.1    Makiguchi, Y.2    Hinoda, Y.3    Kakiuchi, H.4    Nakagawa, N.5    Imai, K.6    Yachi, A.7
  • 6
    • 84856000561 scopus 로고    scopus 로고
    • Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine
    • Lakshminarayanan V, Thompson P, Wolfert MA, Buskas T, Bradley JM, Pathangey LB, et al. Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine. Proc Natl Acad Sci U S A 2012;109:261-6.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 261-266
    • Lakshminarayanan, V.1    Thompson, P.2    Wolfert, M.A.3    Buskas, T.4    Bradley, J.M.5    Pathangey, L.B.6
  • 7
    • 80053916384 scopus 로고    scopus 로고
    • Synthetic antitumor vaccines containing muc1 glycopeptides with two immunodominant domains-induction of a strong immune response against breast tumor tissues
    • Sep 9. Epub ahead of print
    • Gaidzik N, Kaiser A, Kowalczyk D, Westerlind U, Gerlitzki B, Sinn HP, et al. Synthetic antitumor vaccines containing muc1 glycopeptides with two immunodominant domains-induction of a strong immune response against breast tumor tissues. Angew Chem Int Ed Engl. 2011 Sep 9. [Epub ahead of print].
    • (2011) Angew Chem Int Ed Engl
    • Gaidzik, N.1    Kaiser, A.2    Kowalczyk, D.3    Westerlind, U.4    Gerlitzki, B.5    Sinn, H.P.6
  • 8
    • 80955158806 scopus 로고    scopus 로고
    • Recombinant plant-expressed tumour-associated MUC1 peptide is immunogenic and capable of breaking tolerance in MUC1.Tg mice
    • Pinkhasov J, Alvarez ML, Rigano MM, Piensook K, Larios D, Pabst M, et al. Recombinant plant-expressed tumour-associated MUC1 peptide is immunogenic and capable of breaking tolerance in MUC1.Tg mice. Plant Biotechnol J 2011;9:991-1001.
    • (2011) Plant Biotechnol J , vol.9 , pp. 991-1001
    • Pinkhasov, J.1    Alvarez, M.L.2    Rigano, M.M.3    Piensook, K.4    Larios, D.5    Pabst, M.6
  • 9
    • 79851470018 scopus 로고    scopus 로고
    • Selfadjuvanting multicomponent cancer vaccine candidates combining per-glycosylated MUC1 glycopeptides and the Toll-like receptor 2 agonist Pam3CysSer
    • Wilkinson BL, Day S, Malins LR, Apostolopoulos V, Payne RJ. Selfadjuvanting multicomponent cancer vaccine candidates combining per-glycosylated MUC1 glycopeptides and the Toll-like receptor 2 agonist Pam3CysSer. Angew Chem Int Ed Engl 2011;50:1635-9.
    • (2011) Angew Chem Int Ed Engl , vol.50 , pp. 1635-1639
    • Wilkinson, B.L.1    Day, S.2    Malins, L.R.3    Apostolopoulos, V.4    Payne, R.J.5
  • 10
    • 79961167686 scopus 로고    scopus 로고
    • Importance of MUC1 and spontaneous mouse tumor models for understanding the immunobiology of human adenocarcinomas
    • Finn OJ, Gantt KR, Lepisto AJ, Pejawar-Gaddy S, Xue J, Beatty PL. Importance of MUC1 and spontaneous mouse tumor models for understanding the immunobiology of human adenocarcinomas. Immunol Res 2011;50:261-8.
    • (2011) Immunol Res , vol.50 , pp. 261-268
    • Finn, O.J.1    Gantt, K.R.2    Lepisto, A.J.3    Pejawar-Gaddy, S.4    Xue, J.5    Beatty, P.L.6
  • 12
    • 0027234878 scopus 로고
    • Cytotoxic T cells from ovarian malignant tumors can recognize polymorphic epithelial mucin core peptides
    • Ioannides CG, Fisk B, Jerome KR, Irimura T, Wharton JT, Finn OJ. Cytotoxic T-cells from ovarian malignant-tumors can recognize polymorphic epithelial mucin core peptides. J Immunol 1993;151: 3693-703. (Pubitemid 23282681) (Pubitemid 23282681)
    • (1993) Journal of Immunology , vol.151 , Issue.7 , pp. 3693-3703
    • Ioannides, C.G.1    Fisk, B.2    Jerome, K.R.3    Irimura, T.4    Wharton, J.T.5    Finn, O.J.6
  • 13
    • 51349116036 scopus 로고    scopus 로고
    • Strategies used for MUC1 immunotherapy: Human clinical studies
    • Tang CK, Katsara M, Apostolopoulos V. Strategies used for MUC1 immunotherapy: human clinical studies. Expert Rev Vaccines 2008;7: 963-75.
    • (2008) Expert Rev Vaccines , vol.7 , pp. 963-975
    • Tang, C.K.1    Katsara, M.2    Apostolopoulos, V.3
  • 14
    • 0035291835 scopus 로고    scopus 로고
    • MUC1-specific cytotoxic T lymphocytes eradicate tumors when adoptively transferred in vivo
    • Mukherjee P, Ginardi AR, Tinder TL, Sterner CJ, Gendler SJ. MUC1-specific cytotoxic T lymphocytes eradicate tumors when adoptively transferred in vivo. Clin Cancer Res 2001;7:848s-55s. (Pubitemid 33600936) (Pubitemid 33600936)
    • (2001) Clinical Cancer Research , vol.7 , Issue.11 SUPPL.
    • Mukherjee, P.1    Ginardi, A.R.2    Tinder, T.L.3    Sterner, C.J.4    Gendler, S.J.5
  • 15
    • 24744434192 scopus 로고    scopus 로고
    • MUC1 as a target antigen for cancer immunotherapy
    • DOI 10.1586/14760584.4.4.493
    • Acres B, Limacher JM. MUC1 as a target antigen for cancer immunotherapy. Expert Rev Vaccines 2005;4:493-502. (Pubitemid 41297296) (Pubitemid 41297296)
    • (2005) Expert Review of Vaccines , vol.4 , Issue.4 , pp. 493-502
    • Acres, B.1    Limacher, J.-M.2
  • 16
    • 0031701743 scopus 로고    scopus 로고
    • + T cell responses against cancer-associated MUC1 peptide epitopes
    • Agrawal B, Krantz MJ, Reddish MA, Longenecker BM. Rapid induction of primary human CD4+ and CD8+ T cell responses against cancer-associated MUC1 peptide epitopes. Int Immunol 1998;10:1907-16. (Pubitemid 28566053) (Pubitemid 28566053)
    • (1998) International Immunology , vol.10 , Issue.12 , pp. 1907-1916
    • Agrawal, B.1    Krantz, M.J.2    Reddish, M.A.3    Longenecker, B.M.4
  • 17
    • 0032127618 scopus 로고    scopus 로고
    • Liposomal formulations of synthetic MUC1 peptides: Effects of encapsulation versus surface display of peptides on immune responses
    • DOI 10.1021/bc970183n
    • Guan HH, Budzynski W, Koganty RR, Krantz MJ, Reddish MA, Rogers JA, et al. Liposomal formulations of synthetic MUC1 peptides: effects of encapsulation versus surface display of peptides on immune responses. Bioconjug Chem 1998;9:451-8. (Pubitemid 28338759) (Pubitemid 28338759)
    • (1998) Bioconjugate Chemistry , vol.9 , Issue.4 , pp. 451-458
    • Guan, H.H.1    Budzynski, W.2    Koganty, R.R.3    Krantz, M.J.4    Reddish, M.A.5    Rogers, J.A.6    Longenecker, B.M.7    Samuel, J.8
  • 18
    • 80054742888 scopus 로고    scopus 로고
    • Updated survival analysis in patients with stage IIIB or IV non-small-cell lung cancer receiving BLP25 liposome vaccine (L-BLP25): Phase IIB randomized, multicenter, open-label trial
    • Butts C, Maksymiuk A, Goss G, Soulieres D, Marshall E, Cormier Y, et al. Updated survival analysis in patients with stage IIIB or IV non-small-cell lung cancer receiving BLP25 liposome vaccine (L-BLP25): phase IIB randomized, multicenter, open-label trial. J Cancer Res Clin Oncol 2011;137:1337-42.
    • (2011) J Cancer Res Clin Oncol , vol.137 , pp. 1337-1342
    • Butts, C.1    Maksymiuk, A.2    Goss, G.3    Soulieres, D.4    Marshall, E.5    Cormier, Y.6
  • 19
    • 77954373051 scopus 로고    scopus 로고
    • Tamoxifen counteracts the allergic immune response and improves allergen-induced dermatitis in mice
    • Babina M, Kirn F, Hoser D, Ernst D, Rohde W, Zuberbier T, et al. Tamoxifen counteracts the allergic immune response and improves allergen-induced dermatitis in mice. Clin Exp Allergy 2010;40: 1256-65.
    • (2010) Clin Exp Allergy , vol.40 , pp. 1256-1265
    • Babina, M.1    Kirn, F.2    Hoser, D.3    Ernst, D.4    Rohde, W.5    Zuberbier, T.6
  • 20
    • 70350710184 scopus 로고    scopus 로고
    • The effects of tamoxifen on immunity
    • Behjati S, Frank MH. The effects of tamoxifen on immunity. Curr Med Chem 2009;16:3076-80.
    • (2009) Curr Med Chem , vol.16 , pp. 3076-3080
    • Behjati, S.1    Frank, M.H.2
  • 21
    • 0029863344 scopus 로고    scopus 로고
    • Tamoxifen induces TGF-β1 activity and apoptosis of human MCF-7 breast cancer cells in vitro
    • DOI 10.1002/(SICI)1097-4644(19960401)61:1<9::AID-JCB2>3.0.CO;2-Z
    • Chen HM, Tritton TR, Kenny N, Absher M, Chiu JF. Tamoxifen induces TGF-beta 1 activity and apoptosis of humanMCF-7 breast cancer cells in vitro. J Cell Biochem 1996;61:9-17. (Pubitemid 26134170) (Pubitemid 26134170)
    • (1996) Journal of Cellular Biochemistry , vol.61 , Issue.1 , pp. 9-17
    • Chen, H.1    Tritton, T.R.2    Kenny, N.3    Absher, M.4    Chiu, J.-F.5
  • 22
    • 0034192259 scopus 로고    scopus 로고
    • Nonsteroidal anti-estrogens inhibit the functional differentiation of human monocyte-derived dendritic cells
    • Komi J, Lassila O. Nonsteroidal anti-estrogens inhibit the functional differentiation of human monocyte-derived dendritic cells. Blood 2000;95:2875-82. (Pubitemid 30235898) (Pubitemid 30235898)
    • (2000) Blood , vol.95 , Issue.9 , pp. 2875-2882
    • Komi, J.1    Lassila, O.2
  • 23
    • 76749135760 scopus 로고    scopus 로고
    • Antiestrogens induce transforming growth factor beta-mediated immunosuppression in breast cancer
    • Joffroy CM, Buck MB, Stope MB, Popp SL, Pfizenmaier K, Knabbe C. Antiestrogens induce transforming growth factor beta-mediated immunosuppression in breast cancer. Cancer Res 2010;70:1314-22.
    • (2010) Cancer Res , vol.70 , pp. 1314-1322
    • Joffroy, C.M.1    Buck, M.B.2    Stope, M.B.3    Popp, S.L.4    Pfizenmaier, K.5    Knabbe, C.6
  • 24
    • 67349182119 scopus 로고    scopus 로고
    • Immoderate inhibition of estrogen by anastrozole enhances the severity of experimental polyarthritis
    • Wang JX, Zhang QY, Jin S, Feng MY, Kang XM, Zhao S, et al. Immoderate inhibition of estrogen by anastrozole enhances the severity of experimental polyarthritis. Exp Gerontol 2009;44:398-405.
    • (2009) Exp Gerontol , vol.44 , pp. 398-405
    • Wang, J.X.1    Zhang, Q.Y.2    Jin, S.3    Feng, M.Y.4    Kang, X.M.5    Zhao, S.6
  • 25
    • 22144439081 scopus 로고    scopus 로고
    • Tumor antigen-specific T helper cells in cancer immunity and immunotherapy
    • DOI 10.1007/s00262-004-0653-2
    • Knutson KL, Disis ML. Tumor antigen-specific T helper cells in cancer immunity and immunotherapy. Cancer Immunol Immunother 2005;54: 721-8. (Pubitemid 40977140) (Pubitemid 40977140)
    • (2005) Cancer Immunology, Immunotherapy , vol.54 , Issue.8 , pp. 721-728
    • Knutson, K.L.1    Disis, M.L.2
  • 27
    • 0026632964 scopus 로고
    • Identification of estrogenic tamoxifen metabolite(s) in tamoxifen-resistant human breast tumors
    • Wiebe VJ, Osborne CK,McGuire WL, DeGregorio MW.Identification of estrogenic tamoxifen metabolite(s) in tamoxifen-resistant human breast tumors. J Clin Oncol 1992;10:990-4.
    • (1992) J Clin Oncol , vol.10 , pp. 990-994
    • Wiebe, V.J.1    Osborne, C.K.2    McGuire, W.L.3    DeGregorio, M.W.4
  • 28
    • 34047276117 scopus 로고    scopus 로고
    • Quantification of carvedilol in human plasma by liquid chromatography using fluorescence detection: Application in pharmacokinetic studies
    • DOI 10.1016/j.jpba.2007.01.026, PII S0731708507000660
    • Zarghi A, Foroutan SM, Shafaati A, Khoddam A. Quantification of carvedilol in human plasma by liquid chromatography using fluorescence detection: application in pharmacokinetic studies. J Pharm Biomed Anal 2007;44:250-3. (Pubitemid 46551580) (Pubitemid 46551580)
    • (2007) Journal of Pharmaceutical and Biomedical Analysis , vol.44 , Issue.1 , pp. 250-253
    • Zarghi, A.1    Foroutan, S.M.2    Shafaati, A.3    Khoddam, A.4
  • 29
    • 0030606808 scopus 로고    scopus 로고
    • High-performance liquid chromatography of the aromatase inhibitor, letrozole, and its metabolite in biological fluids with automated liquid-solid extraction and fluorescence detection
    • DOI 10.1016/0378-4347(96)00118-1
    • Marfil F, Pineau V, Sioufi A, Godbillon SJ. High-performance liquid chromatography of the aromatase inhibitor, letrozole, and its metabolite in biological fluids with automated liquid-solid extraction and fluorescence detection. J Chromatogr B Biomed Appl 1996;683: 251-8. (Pubitemid 26319570) (Pubitemid 26319570)
    • (1996) Journal of Chromatography B: Biomedical Applications , vol.683 , Issue.2 , pp. 251-258
    • Marfil, F.1    Pineau, V.2    Sioufi, A.3    Godbillon, J.4
  • 31
    • 0020047427 scopus 로고
    • Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells
    • DOI 10.1084/jem.155.4.1063
    • North RJ. Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells. J Exp Med 1982;155:1063-74. (Pubitemid 12142723) (Pubitemid 12142723)
    • (1982) Journal of Experimental Medicine , vol.155 , Issue.4 , pp. 1063-1074
    • North, R.J.1
  • 32
    • 15944410592 scopus 로고    scopus 로고
    • + T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
    • DOI 10.1182/blood-2004-06-2410
    • Lutsiak ME, Semnani RT, De Pascalis R, Kashmiri SV, Schlom J, Sabzevari H. Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide. Blood 2005;105:2862-8. (Pubitemid 40446280) (Pubitemid 40446280)
    • (2005) Blood , vol.105 , Issue.7 , pp. 2862-2868
    • Lutsiak, M.E.C.1    Semnani, R.T.2    De Pascalis, R.3    Kashmiri, S.V.S.4    Schlom, J.5    Sabzevari, H.6
  • 33
    • 0031710507 scopus 로고    scopus 로고
    • Immunopotentiation with low-dose cyclophosphamide in the active specific immunotherapy of cancer
    • DOI 10.1007/s002620050498
    • Bass KK, Mastrangelo MJ. Immunopotentiation with low-dose cyclophosphamide in the active specific immunotherapy of cancer. Cancer Immunol Immunother 1998;47:1-12. (Pubitemid 28430525) (Pubitemid 28430525)
    • (1998) Cancer Immunology Immunotherapy , vol.47 , Issue.1 , pp. 1-12
    • Bass, K.K.1    Mastrangelo, M.J.2
  • 34
    • 0024333021 scopus 로고
    • Induction of cytotoxicity from fresh splenocytes after in vivo administration of cyclophosphamide. Importance of long-term culture with high-dose recombinant interleukin-2
    • DOI 10.1007/BF01744895
    • Kim R, Lafreniere R, Borkenhagen K, Bryant LD. Induction of cytotoxicity from fresh splenocytes after in vivo administration of cyclophosphamide. Importance of long-term culture with high-dose recombinant interleukin-2. Cancer Immunol Immunother 1989;30: 283-8. (Pubitemid 20002342) (Pubitemid 20002342)
    • (1989) Cancer Immunology Immunotherapy , vol.30 , Issue.5 , pp. 283-288
    • Kim, R.1    Lafreniere, R.2    Borkenhagen, K.3    Bryant, L.D.4
  • 35
    • 0141720783 scopus 로고    scopus 로고
    • Cancer vaccines: Between the idea and the reality
    • Finn OJ. Cancer vaccines: between the idea and the reality. Nat Rev Immunol 2003;3:630-41. (Pubitemid 37328666) (Pubitemid 37328666)
    • (2003) Nature Reviews Immunology , vol.3 , Issue.8 , pp. 630-641
    • Finn, O.J.1
  • 36
    • 44849119143 scopus 로고    scopus 로고
    • Specific active immunotherapy of cancer: Potential and perspectives
    • Srinivasan R, Van Epps DE. Specific active immunotherapy of cancer: potential and perspectives. Rev Recent Clin Trials 2006;1:283-92.
    • (2006) Rev Recent Clin Trials , vol.1 , pp. 283-292
    • Srinivasan, R.1    Van Epps, D.E.2
  • 37
    • 33750716845 scopus 로고    scopus 로고
    • Challenges for cancer vaccine development
    • DOI 10.1016/j.addr.2006.05.004, PII S0169409X06001281
    • Tabi Z, Man S. Challenges for cancer vaccine development. Adv Drug Deliv Rev 2006;58:902-15. (Pubitemid 44709261) (Pubitemid 44709261)
    • (2006) Advanced Drug Delivery Reviews , vol.58 , Issue.8 , pp. 902-915
    • Tabi, Z.1    Man, S.2
  • 39
    • 34248214791 scopus 로고    scopus 로고
    • Hormone receptor status, tumor characteristics, and prognosis: A prospective cohort of breast cancer patients
    • Dunnwald LK, Rossing MA, Li CI. Hormone receptor status, tumor characteristics, and prognosis: a prospective cohort of breast cancer patients. Breast Cancer Res 2007;9:R6.
    • (2007) Breast Cancer Res , vol.9
    • Dunnwald, L.K.1    Rossing, M.A.2    Li, C.I.3
  • 42
    • 0029960161 scopus 로고    scopus 로고
    • Parity, age at first and last birth, and risk of breast cancer: A population-based study in Sweden
    • DOI 10.1007/BF01806150
    • Lambe M, Hsieh CC, Chan HW, Ekbom A, Trichopoulos D, Adami HO. Parity, age at first and last birth, and risk of breast cancer: a population-based study in Sweden. Breast Cancer Res Treat 1996;38:305-11. (Pubitemid 26126665) (Pubitemid 26126665)
    • (1996) Breast Cancer Research and Treatment , vol.38 , Issue.3 , pp. 305-311
    • Lambe, M.1    Hsieh, C.-C.2    Chan, H.-W.3    Ekbom, A.4    Trichopoulos, D.5    Adami, H.-O.6
  • 43
    • 77951647824 scopus 로고    scopus 로고
    • Mimicking pregnancy to reduce breast cancer risk
    • Tuma R. Mimicking pregnancy to reduce breast cancer risk. J Natl Cancer Inst 2010;102:517-8.
    • (2010) J Natl Cancer Inst , vol.102 , pp. 517-518
    • Tuma, R.1
  • 44
    • 83955164294 scopus 로고    scopus 로고
    • Circulating estrogens and progesterone during primiparous pregnancies and risk of maternal breast cancer
    • Lukanova A, Surcel HM, Lundin E, Kaasila M, Lakso HA, Schock H, et al. Circulating estrogens and progesterone during primiparous pregnancies and risk of maternal breast cancer. Int J Cancer 2012; 130:910-20.
    • (2012) Int J Cancer , vol.130 , pp. 910-920
    • Lukanova, A.1    Surcel, H.M.2    Lundin, E.3    Kaasila, M.4    Lakso, H.A.5    Schock, H.6


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