메뉴 건너뛰기




Volumn 9, Issue 4, 1998, Pages 451-458

Liposomal formulations of synthetic MUC1 peptides: Effects of encapsulation versus surface display of peptides on immune responses

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; CYTOLOGY; EPITOPES; IMMUNE SYSTEM; PEPTIDES; T-CELLS; VACCINES;

EID: 0032127618     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc970183n     Document Type: Article
Times cited : (96)

References (54)
  • 1
    • 0023741252 scopus 로고
    • A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats
    • Gendler, S., Taylor-Papadimitriou, J., Duhig, T., Rothbard, J., and Burchell, J. (1988) A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats. J. Biol Chem. 263, 12820-12823.
    • (1988) J. Biol Chem. , vol.263 , pp. 12820-12823
    • Gendler, S.1    Taylor-Papadimitriou, J.2    Duhig, T.3    Rothbard, J.4    Burchell, J.5
  • 2
    • 0024155364 scopus 로고
    • Tissue and tumor distribution of human polymorphic epithelial mucin
    • Zotter, S., Hageman, P. C., Lossnitzer, A., Mooi, W. J., and Hiljers, J. (1988) Tissue and tumor distribution of human polymorphic epithelial mucin. Cancer Rev. 11, 55-58.
    • (1988) Cancer Rev. , vol.11 , pp. 55-58
    • Zotter, S.1    Hageman, P.C.2    Lossnitzer, A.3    Mooi, W.J.4    Hiljers, J.5
  • 3
    • 0023617395 scopus 로고
    • Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin
    • Burchell, J., Gendler, S., Taylor-Papadimitriou, J., Girling, A., Lewis, A., Millis, R., and Lamport, D. (1987) Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin. Cancer Res. 47, 5476-5482.
    • (1987) Cancer Res. , vol.47 , pp. 5476-5482
    • Burchell, J.1    Gendler, S.2    Taylor-Papadimitriou, J.3    Girling, A.4    Lewis, A.5    Millis, R.6    Lamport, D.7
  • 4
    • 0024798333 scopus 로고
    • Oligosaccharide differences in the DF3 sialomucin antigen from normal human milk and the BT-20 human breast carcinoma cell line
    • Hull, S. R., Bright, A., Carraway, K. L., Abe, M., Hayes, D. F., and Kufe, D. W. (1989) Oligosaccharide differences in the DF3 sialomucin antigen from normal human milk and the BT-20 human breast carcinoma cell line. Cancer Commun. 1, 261-267.
    • (1989) Cancer Commun. , vol.1 , pp. 261-267
    • Hull, S.R.1    Bright, A.2    Carraway, K.L.3    Abe, M.4    Hayes, D.F.5    Kufe, D.W.6
  • 5
    • 0026536162 scopus 로고
    • Antigen-specific, MHC-unrestricted T cells
    • Finn, O. J. (1992) Antigen-specific, MHC-unrestricted T cells. Biotherapy 4, 239-249.
    • (1992) Biotherapy , vol.4 , pp. 239-249
    • Finn, O.J.1
  • 6
    • 0027321847 scopus 로고
    • Tumor-specific cytotoxic T cell clones from patients with breast and pancreatic adenocarcinoma recognize EBV-immortalized B cells transfected with polymorphic epithelial mucin complementary DNA
    • Jerome, K. R., Domenech, N., and Finn, O. J. (1993) Tumor-specific cytotoxic T cell clones from patients with breast and pancreatic adenocarcinoma recognize EBV-immortalized B cells transfected with polymorphic epithelial mucin complementary DNA. J. Immunol. 151, 1654-1662.
    • (1993) J. Immunol. , vol.151 , pp. 1654-1662
    • Jerome, K.R.1    Domenech, N.2    Finn, O.J.3
  • 7
    • 0003102364 scopus 로고
    • Prospects for mucin epitopes in cancer vaccines
    • Longenecker, B. M., and MacLean, G. D. (1993) Prospects for mucin epitopes in cancer vaccines. Immunologist 1, 89-93.
    • (1993) Immunologist , vol.1 , pp. 89-93
    • Longenecker, B.M.1    MacLean, G.D.2
  • 8
    • 0029190261 scopus 로고
    • Development of Active Specific Immunotherapeutic Agents Based on Cancer-associated Mucins
    • (M. F. Powell and M. J. Newman, Eds.) Plenum Press, New York
    • Samuel, J., and Longenecker, B. M. (1995) Development of Active Specific Immunotherapeutic Agents Based on Cancer-associated Mucins. In Vaccine design-the subunit and adjuvant approach (M. F. Powell and M. J. Newman, Eds.) pp 875-890, Plenum Press, New York.
    • (1995) Vaccine Design-the Subunit and Adjuvant Approach , pp. 875-890
    • Samuel, J.1    Longenecker, B.M.2
  • 11
    • 0030239830 scopus 로고    scopus 로고
    • In vitro induction of MUC-1 peptide-specific type 1 T lymphocyte and cytotoxic T lymphocyte responses from healthy multiparous donors
    • Agrawal, B., Reddish, M. A., and Longenecker, B. M. (1996) In vitro induction of MUC-1 peptide-specific type 1 T lymphocyte and cytotoxic T lymphocyte responses from healthy multiparous donors. J. Immunol. 157, 2089-2095.
    • (1996) J. Immunol. , vol.157 , pp. 2089-2095
    • Agrawal, B.1    Reddish, M.A.2    Longenecker, B.M.3
  • 12
    • 0030615097 scopus 로고    scopus 로고
    • A survivor of breast cancer with immunity to MUC-1 mucin, and lactational mastitis
    • Jerome, K. R., Kirk, A. D., Pecher, G., Ferguson, W. W., and Finn, O. J. (1997) A survivor of breast cancer with immunity to MUC-1 mucin, and lactational mastitis. Cancer Immunol. Immunother. 43, 355-360.
    • (1997) Cancer Immunol. Immunother. , vol.43 , pp. 355-360
    • Jerome, K.R.1    Kirk, A.D.2    Pecher, G.3    Ferguson, W.W.4    Finn, O.J.5
  • 13
    • 0027234998 scopus 로고
    • Immunogenicity of synthetic peptides related to the core peptide sequence encoded by the human MUC1 mucin gene: Effect of immunization on the growth of murine mammary adenocarcinoma cells transfected with the human MUC1 gene
    • Ding, L., Lalani, E. N., Reddish, M., Koganty, R., Wong, T., Samuel, J., Yacyshyn, M. B., Meikle, A., Fung, P. Y. S., Taylor-Papadimitriou, J., and Longenecker, B. M. (1993) Immunogenicity of synthetic peptides related to the core peptide sequence encoded by the human MUC1 mucin gene: effect of immunization on the growth of murine mammary adenocarcinoma cells transfected with the human MUC1 gene Cancer Immunol. Immunother. 36, 9-17.
    • (1993) Cancer Immunol. Immunother. , vol.36 , pp. 9-17
    • Ding, L.1    Lalani, E.N.2    Reddish, M.3    Koganty, R.4    Wong, T.5    Samuel, J.6    Yacyshyn, M.B.7    Meikle, A.8    Fung, P.Y.S.9    Taylor-Papadimitriou, J.10    Longenecker, B.M.11
  • 14
    • 0016328268 scopus 로고
    • Liposomes as immunological adjuvants
    • Allison, A. G., and Gregoriadis, G. (1974) Liposomes as immunological adjuvants. Nature 252, 252.
    • (1974) Nature , vol.252 , pp. 252
    • Allison, A.G.1    Gregoriadis, G.2
  • 15
    • 0025854178 scopus 로고
    • Liposomes as carriers of antigens and adjuvants
    • Alving, C. R. (1991) Liposomes as carriers of antigens and adjuvants. J. Immunol. Methods 140, 1-13.
    • (1991) J. Immunol. Methods , vol.140 , pp. 1-13
    • Alving, C.R.1
  • 16
    • 0025129271 scopus 로고
    • Immunological adjuvants: A role for liposomes
    • Gregoriadis, G. (1990) Immunological adjuvants: a role for liposomes. Immunol. Today 11, 89-97.
    • (1990) Immunol. Today , vol.11 , pp. 89-97
    • Gregoriadis, G.1
  • 17
    • 0027935983 scopus 로고
    • Activation of systemic and mucosal immune response following nasal administration of liposomes
    • Aramaki, Y., Fujii, Y., Yachi, K., Kikuchi, H., and Tsuchiya, S. (1994) Activation of systemic and mucosal immune response following nasal administration of liposomes. Vaccine 12, 1241-1245.
    • (1994) Vaccine , vol.12 , pp. 1241-1245
    • Aramaki, Y.1    Fujii, Y.2    Yachi, K.3    Kikuchi, H.4    Tsuchiya, S.5
  • 18
    • 0029082952 scopus 로고
    • Murine IgG subclass antibodies to antigens incorporated in liposomes containing lipid A
    • Glenn, G. M., Rao, M., Richards, R. L., Matyas, G. R., and Alving, C. R. (1995) Murine IgG subclass antibodies to antigens incorporated in liposomes containing lipid A. Immunol. Lett. 47, 73-78.
    • (1995) Immunol. Lett. , vol.47 , pp. 73-78
    • Glenn, G.M.1    Rao, M.2    Richards, R.L.3    Matyas, G.R.4    Alving, C.R.5
  • 20
    • 0025613985 scopus 로고
    • Liposomal vaccine: Influence of antigen association on the kinetics of the humoral response
    • Therien, H. M., Lair, D., and Shahum, E. (1990) Liposomal vaccine: influence of antigen association on the kinetics of the humoral response. Vaccine 8, 558-562.
    • (1990) Vaccine , vol.8 , pp. 558-562
    • Therien, H.M.1    Lair, D.2    Shahum, E.3
  • 22
    • 20744456789 scopus 로고
    • Solid-phase protein synthesis: I. The synthesis of a tetrapeptide
    • Merrifield, R. B. (1963) Solid-phase protein synthesis: I. The synthesis of a tetrapeptide. J. Am. Chem. Soc. 85, 2149-2154.
    • (1963) J. Am. Chem. Soc. , vol.85 , pp. 2149-2154
    • Merrifield, R.B.1
  • 23
    • 0022358633 scopus 로고
    • Improvement of encapsulation efficiency of water-soluble drugs in liposomes formed by the freeze-thawing method
    • Ohsawa, T., Miura, H., and Harada, K. (1985) Improvement of encapsulation efficiency of water-soluble drugs in liposomes formed by the freeze-thawing method. Chem. Pharm. Bull. 33, 3945-3952.
    • (1985) Chem. Pharm. Bull. , vol.33 , pp. 3945-3952
    • Ohsawa, T.1    Miura, H.2    Harada, K.3
  • 24
    • 0022423485 scopus 로고
    • Solute distributions and trapping efficiencies observed in freeze-thawed multilamellar vesicles
    • Mayer, L. D., Hope, M. J., Cullis, P. R., and Janoff, A. S. (1985) Solute distributions and trapping efficiencies observed in freeze-thawed multilamellar vesicles. Biochim. Biophys. Acta 817, 193-196.
    • (1985) Biochim. Biophys. Acta , vol.817 , pp. 193-196
    • Mayer, L.D.1    Hope, M.J.2    Cullis, P.R.3    Janoff, A.S.4
  • 25
    • 0001258132 scopus 로고
    • T cell enrichment by non-adherence to nylon
    • (J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, Eds.) Green Publishing and Wiley-Interscience, New York
    • Hathcock, K. S. (1991) T cell enrichment by non-adherence to nylon. In Current Protocols in Immunology (J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, Eds.) p 3.2.1, Green Publishing and Wiley-Interscience, New York.
    • (1991) Current Protocols in Immunology , pp. 321
    • Hathcock, K.S.1
  • 26
    • 0037529925 scopus 로고
    • Measurement of mouse and human interferon-gamma
    • (J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, Eds.) Green Publishing and Wiley-Interscience, New York
    • Schreiber, R. D. (1991) Measurement of mouse and human interferon-gamma. In Current Protocols in Immunology (J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, Eds.) p 6.8.1, Green Publishing and Wiley-Interscience, New York.
    • (1991) Current Protocols in Immunology , pp. 681
    • Schreiber, R.D.1
  • 27
    • 0026500979 scopus 로고
    • IL-4 induces a Th2 response in Leishmania major-infected mice
    • Chtelain, R., Varkila, K., and Coffman, R. L. ( 1992) IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 148, 1182-1187.
    • (1992) J. Immunol. , vol.148 , pp. 1182-1187
    • Chtelain, R.1    Varkila, K.2    Coffman, R.L.3
  • 28
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann, T. R., Cherwinski, H., Bond, M. W., Giedlin, M. A., and Coffman, R. L. (1986) Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136, 2348-2357.
    • (1986) J. Immunol. , vol.136 , pp. 2348-2357
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 29
    • 0020699653 scopus 로고
    • Association of an albumin antigen with phosphatidylcholine liposomes alters the nature of immunoglobulins produced during the immune response against the antigen
    • Van Rooijen, N., and Van Nieuwmegen, R. (1983) Association of an albumin antigen with phosphatidylcholine liposomes alters the nature of immunoglobulins produced during the immune response against the antigen. Biochim. Biophys. Acta 755, 434-438.
    • (1983) Biochim. Biophys. Acta , vol.755 , pp. 434-438
    • Van Rooijen, N.1    Van Nieuwmegen, R.2
  • 30
    • 0029856658 scopus 로고    scopus 로고
    • Mucosal immunoadjuvant activity of liposomes: Role of alveolar macrophages
    • de Haan, A., Groen, G., Prop, J., van Rooijen, N., and Wilschut, J. (1996) Mucosal immunoadjuvant activity of liposomes: role of alveolar macrophages. Immunology 89, 488-493.
    • (1996) Immunology , vol.89 , pp. 488-493
    • De Haan, A.1    Groen, G.2    Prop, J.3    Van Rooijen, N.4    Wilschut, J.5
  • 31
    • 0028920588 scopus 로고
    • Liposomal adjuvanticity: Effect of encapsulation and surface-linkage on antibody production and proliferative response
    • Shahum, E., and Therien, H. M. (1995) Liposomal adjuvanticity: effect of encapsulation and surface-linkage on antibody production and proliferative response. Int. J. Immunopharmacol. 17, 9-20.
    • (1995) Int. J. Immunopharmacol. , vol.17 , pp. 9-20
    • Shahum, E.1    Therien, H.M.2
  • 32
    • 0028038426 scopus 로고
    • MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation
    • Germain, R. N. (1994) MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell 76, 287-299.
    • (1994) Cell , vol.76 , pp. 287-299
    • Germain, R.N.1
  • 33
    • 0029023980 scopus 로고
    • Liposomal vaccines: Clinical status and immunological presentation for humoral and cellular immunity
    • Alving, C. R. (1995) Liposomal vaccines: clinical status and immunological presentation for humoral and cellular immunity. Ann. N.Y. Acad. Sci. 754, 143-152.
    • (1995) Ann. N.Y. Acad. Sci. , vol.754 , pp. 143-152
    • Alving, C.R.1
  • 34
    • 0025217412 scopus 로고
    • Phospholipids enhance the binding of peptides to class II major histocompatibility molecules
    • Roof, R. W., Luescher, I. F., and Unanue, E. R. (1990) Phospholipids enhance the binding of peptides to class II major histocompatibility molecules. Proc. Natl. Acad. Sci. U.S.A. 87, 1735-1739.
    • (1990) Proc. Natl. Acad. Sci. U.S.A. , vol.87 , pp. 1735-1739
    • Roof, R.W.1    Luescher, I.F.2    Unanue, E.R.3
  • 35
  • 36
    • 0026784588 scopus 로고
    • Induction of cytotoxic T lymphocytes in vivo with protein antigen entrapped in membranous vehicles
    • Zhou, F., Rouse, B. T., and Huang, L. (1992) Induction of cytotoxic T lymphocytes in vivo with protein antigen entrapped in membranous vehicles. J. Immunol. 149, 1599-1604.
    • (1992) J. Immunol. , vol.149 , pp. 1599-1604
    • Zhou, F.1    Rouse, B.T.2    Huang, L.3
  • 37
    • 0028107033 scopus 로고
    • Correlation between in vitro and in vivo behaviour of liposomal antigens
    • Shahum, E., and Therien, H. M. (1994) Correlation between in vitro and in vivo behaviour of liposomal antigens. Vaccine 12, 1125-1131.
    • (1994) Vaccine , vol.12 , pp. 1125-1131
    • Shahum, E.1    Therien, H.M.2
  • 38
    • 0029046307 scopus 로고
    • Uptake of microparticle-adsorbed protein antigen by bone marrow-derived dendritic cells results in up-regulation of interleukin-1 alpha and interleukin-12 p40/p35 and triggers prolonged, efficient antigen presentation
    • Scheicher, C., Mehlig, M., Dienes, H. P., and Reske, K. (1995) Uptake of microparticle-adsorbed protein antigen by bone marrow-derived dendritic cells results in up-regulation of interleukin-1 alpha and interleukin-12 p40/p35 and triggers prolonged, efficient antigen presentation. Eur. J. Immunol. 25, 1566-1572.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 1566-1572
    • Scheicher, C.1    Mehlig, M.2    Dienes, H.P.3    Reske, K.4
  • 39
    • 0000782803 scopus 로고
    • Monophosphoryl Lipid a as an Adjuvant: Past experiences and new directions
    • (M. F. Powell, and M. J. Newman, Eds.) Plenum Press, New York and London
    • Ulrich, J. T., and Myers, K. R. (1995) Monophosphoryl Lipid A as an Adjuvant: past experiences and new directions. In Vaccine design-the subunit and adjuvant approach (M. F. Powell, and M. J. Newman, Eds.) p 516, Plenum Press, New York and London.
    • (1995) Vaccine Design-the Subunit and Adjuvant Approach , pp. 516
    • Ulrich, J.T.1    Myers, K.R.2
  • 40
    • 0030795735 scopus 로고    scopus 로고
    • Molecular mechanisms in B cell antigen receptor signaling
    • Kurosaki, T. (1997) Molecular mechanisms in B cell antigen receptor signaling. Curr. Opin. Immunol. 9, 309-318.
    • (1997) Curr. Opin. Immunol. , vol.9 , pp. 309-318
    • Kurosaki, T.1
  • 41
    • 23444461024 scopus 로고
    • How B and T cells talk to each other
    • Clark, E. A., and Ledbetter, J. A. (1994) How B and T cells talk to each other. Nature 367, 425-428.
    • (1994) Nature , vol.367 , pp. 425-428
    • Clark, E.A.1    Ledbetter, J.A.2
  • 42
    • 0024449492 scopus 로고
    • Antigen presentation by B cells and macrophages of cytochrome c and its antigenic fragment when conjugated to the surface of liposomes
    • Dal Monte, P. R., and Szoka, F. C., Jr. (1989) Antigen presentation by B cells and macrophages of cytochrome c and its antigenic fragment when conjugated to the surface of liposomes. Vaccine 7, 401-408.
    • (1989) Vaccine , vol.7 , pp. 401-408
    • Dal Monte, P.R.1    Szoka F.C., Jr.2
  • 43
    • 0024565148 scopus 로고
    • Effect of liposome encapsulation on antigen presentation in vitro. Comparison of presentation by peritoneal macrophages and B cell tumors
    • Dal Monte, P., and Szoka, F. C., Jr. (1989) Effect of liposome encapsulation on antigen presentation in vitro. Comparison of presentation by peritoneal macrophages and B cell tumors. J. Immunol. 142, 1437-1443.
    • (1989) J. Immunol. , vol.142 , pp. 1437-1443
    • Dal Monte, P.1    Szoka F.C., Jr.2
  • 44
  • 45
    • 0028866639 scopus 로고
    • Improvement of transdermal delivery of tetragastrin by lipophilic modification with fatty acids
    • Setoh, K., Murakami, M., Araki, N., Fujita, T., Yamamoto, A., and Muranishi, S. (1995) Improvement of transdermal delivery of tetragastrin by lipophilic modification with fatty acids. J. Pharm. Pharmacol. 47, 808-811.
    • (1995) J. Pharm. Pharmacol. , vol.47 , pp. 808-811
    • Setoh, K.1    Murakami, M.2    Araki, N.3    Fujita, T.4    Yamamoto, A.5    Muranishi, S.6
  • 46
    • 0027070864 scopus 로고
    • Peptide stability in drug development: A comparison of peptide reactivity in different biological media
    • Powell, M. F., Grey, H., Gaeta, F., Sette, A., and Colon, S. (1992) Peptide stability in drug development: a comparison of peptide reactivity in different biological media. J. Pharm. Sci. 81, 731-735.
    • (1992) J. Pharm. Sci. , vol.81 , pp. 731-735
    • Powell, M.F.1    Grey, H.2    Gaeta, F.3    Sette, A.4    Colon, S.5
  • 47
    • 0026556490 scopus 로고
    • Enhanced antibody response to liposome-associated protein antigens: Preferential stimulation of IgG2a/b production
    • Phillips, N. C., and Emili, A. (1992) Enhanced antibody response to liposome-associated protein antigens: preferential stimulation of IgG2a/b production. Vaccine 10, 151-158.
    • (1992) Vaccine , vol.10 , pp. 151-158
    • Phillips, N.C.1    Emili, A.2
  • 48
    • 0344743863 scopus 로고
    • Liposomes and macrophage functions
    • Phillips, N. C. (1992) Liposomes and macrophage functions. Res. Immunol. 143, 251-252.
    • (1992) Res. Immunol. , vol.143 , pp. 251-252
    • Phillips, N.C.1
  • 49
    • 0027310573 scopus 로고
    • Lyophilized liposomes as shelf items for the preparation of immunogenic liposome-peptide conjugates
    • Friede, M., Van Regenmortel, M. H., and Schuber, F. (1993) Lyophilized liposomes as shelf items for the preparation of immunogenic liposome-peptide conjugates. Anal. Biochem. 211, 117-122.
    • (1993) Anal. Biochem. , vol.211 , pp. 117-122
    • Friede, M.1    Van Regenmortel, M.H.2    Schuber, F.3
  • 50
    • 0028926776 scopus 로고
    • Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo
    • Germann, T., Bongartz, M., Dlugonska, H., Hess, H., Schmitt, E., Kolbe, L., Kolsch, E., Podlaski, F. J., Gately, M. K., and Rude, E. (1995) Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo. Eur. J. Immunol. 25, 823-829.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 823-829
    • Germann, T.1    Bongartz, M.2    Dlugonska, H.3    Hess, H.4    Schmitt, E.5    Kolbe, L.6    Kolsch, E.7    Podlaski, F.J.8    Gately, M.K.9    Rude, E.10
  • 51
    • 0030062937 scopus 로고    scopus 로고
    • Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice
    • Guery, J. C., Galbiati, F., Smiroldo, S., and Adorini, L. (1996) Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice. J. Exp. Med. 183, 485-497.
    • (1996) J. Exp. Med. , vol.183 , pp. 485-497
    • Guery, J.C.1    Galbiati, F.2    Smiroldo, S.3    Adorini, L.4
  • 52
    • 0031087227 scopus 로고    scopus 로고
    • Analysis of immunoglobulin classes and subclasses in response to infection of Balb/cJ and C57BL/6J mice with Coxiella burnetii
    • Schmeer, N., Hoffmeister, E., Weiss, R., Hofer, R., and Baumgartner, W. (1997) Analysis of immunoglobulin classes and subclasses in response to infection of Balb/cJ and C57BL/6J mice with Coxiella burnetii. J. Vet. Med., Ser. B 44, 49-59.
    • (1997) J. Vet. Med., Ser. B , vol.44 , pp. 49-59
    • Schmeer, N.1    Hoffmeister, E.2    Weiss, R.3    Hofer, R.4    Baumgartner, W.5
  • 53
    • 0024526524 scopus 로고
    • The mouse Igh-1a and Igh-1b H chain constant regions are derived from two distinct isotypic genes
    • Jouvin-Marche, E., Morgado, M. G., Leguern, C., Voegtle, D., Bonhomme, F., and Cazenave, P. A. (1989) The mouse Igh-1a and Igh-1b H chain constant regions are derived from two distinct isotypic genes. Immunogenetics 29, 92-97.
    • (1989) Immunogenetics , vol.29 , pp. 92-97
    • Jouvin-Marche, E.1    Morgado, M.G.2    Leguern, C.3    Voegtle, D.4    Bonhomme, F.5    Cazenave, P.A.6
  • 54
    • 0031602351 scopus 로고    scopus 로고
    • Is IgG2a a good Th1 marker in mice?
    • Martin, R. M., and Lew, A. M. (1998) Is IgG2a a good Th1 marker in mice? Immunol. Today 19, 49.
    • (1998) Immunol. Today , vol.19 , pp. 49
    • Martin, R.M.1    Lew, A.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.